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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:danazol
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Accession:CHEBI:4315 term browser browse the term
Definition:A terminal acetylenic compound that has formula C22H27NO2.
Synonyms:exact_synonym: [1,2]oxazolo[4',5':2,3]-17alpha-pregn-4-en-20-yn-17-ol
 related_synonym: Cyclomen;   Danocrine;   Formula=C22H27NO2;   InChI=1S/C22H27NO2/c1-4-22(24)10-8-18-16-6-5-15-11-19-14(13-23-25-19)12-20(15,2)17(16)7-9-21(18,22)3/h1,11,13,16-18,24H,5-10,12H2,2-3H3/t16-,17+,18+,20+,21+,22+/m1/s1;   InChIKey=POZRVZJJTULAOH-LHZXLZLDSA-N;   SMILES=[H][C@@]12CCC3=Cc4oncc4C[C@]3(C)[C@@]1([H])CC[C@@]1(C)[C@@]2([H])CC[C@@]1(O)C#C;   danazolum
 alt_id: CHEBI:505364;   CHEBI:554019
 xref: Beilstein:4851114;   CAS:17230-88-5;   Chemspider:26436;   DrugBank:DB01406;   Drug_Central:779;   KEGG:D00289
 xref_mesh: MESH:D003613
 xref: PMID:17929794;   PMID:18834112;   PMID:24134630;   PMID:27626530;   PMID:34462405;   Patent:GB905844;   Patent:US3135743;   Wikipedia:Danazol



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danazol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO Danazol results in decreased activity of ABCB11 protein CTD PMID:23956101 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Ace2 angiotensin I converting enzyme 2 decreases expression ISO
EXP
Danazol results in decreased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977
JBrowse link
G Ar androgen receptor increases activity
multiple interactions
ISO Danazol results in increased activity of AR protein
Danazol binds to and results in decreased activity of AR protein; Danazol binds to and results in increased activity of AR protein
CTD PMID:12730620 PMID:21543282 PMID:25752796 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G C3 complement C3 increases expression ISO Danazol results in increased expression of C3 protein CTD PMID:4014294 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Danazol results in increased expression of CDKN1A protein CTD PMID:27358234 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cfb complement factor B increases expression ISO Danazol results in increased expression of CFB protein CTD PMID:4014294 NCBI chr20:3,970,643...3,976,510
Ensembl chr20:3,951,474...3,976,505
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO Danazol results in decreased activity of CYP1A1 protein CTD PMID:33814510 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 decreases activity ISO Danazol results in decreased activity of CYP2J2 protein CTD PMID:29689254 PMID:30965050 NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Danazol binds to and results in increased activity of ESR1 protein CTD PMID:25752796 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Fshb follicle stimulating hormone subunit beta decreases expression EXP Danazol results in decreased expression of FSHB protein CTD PMID:3088269 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 decreases activity
multiple interactions
ISO Danazol results in decreased activity of HSD11B2 protein
Danazol inhibits the reaction [HSD11B2 protein results in decreased activity of Glucocorticoids]
CTD PMID:22273746 NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899
JBrowse link
G Il10 interleukin 10 multiple interactions EXP [peginterferon alfa-2a co-treated with Ribavirin co-treated with Danazol] results in decreased expression of IL10 mRNA CTD PMID:18007553 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il6 interleukin 6 multiple interactions EXP [peginterferon alfa-2a co-treated with Ribavirin co-treated with Danazol] results in decreased expression of IL6 mRNA CTD PMID:18007553 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Lhb luteinizing hormone subunit beta decreases expression EXP Danazol results in decreased expression of LHB protein CTD PMID:3088269 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Danazol inhibits the reaction [[Estradiol co-treated with TNF protein] results in increased activity of NFKB1 protein] CTD PMID:15866594 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Pgr progesterone receptor multiple interactions ISO Danazol binds to and results in decreased activity of PGR protein; Danazol binds to and results in increased activity of PGR protein CTD PMID:25752796 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Prl prolactin multiple interactions ISO Danazol inhibits the reaction [Penicillamine results in increased expression of PRL] CTD PMID:4087275 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
JBrowse link
G Serping1 serpin family G member 1 increases expression ISO Danazol results in increased expression of SERPING1 protein CTD PMID:4014294 NCBI chr 3:69,842,726...69,852,583
Ensembl chr 3:69,842,739...69,852,034
JBrowse link
G Sts steroid sulfatase decreases activity ISO Danazol results in decreased activity of STS protein CTD PMID:11600235 NCBI chr  X:42,225,131...42,233,403
Ensembl chr  X:42,225,372...42,233,402
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
Danazol inhibits the reaction [[Estradiol co-treated with TNF protein] results in increased activity of NFKB1 protein]; Danazol inhibits the reaction [[Estradiol co-treated with TNF protein] results in increased expression of CXCL8 mRNA]; Danazol inhibits the reaction [[Estradiol co-treated with TNF protein] results in increased expression of CXCL8 protein]
[peginterferon alfa-2a co-treated with Ribavirin co-treated with Danazol] results in decreased expression of TNF mRNA
CTD PMID:15866594 PMID:18007553 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20056
    role 20008
      application 19745
        pharmaceutical 19618
          drug 19618
            anti-estrogen 50
              danazol 20
Path 2
Term Annotations click to browse term
  CHEBI ontology 20056
    subatomic particle 20054
      composite particle 20054
        hadron 20054
          baryon 20054
            nucleon 20054
              atomic nucleus 20054
                atom 20054
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19875
                          organic molecular entity 19875
                            organic molecule 19822
                              organic cyclic compound 19575
                                organic polycyclic compound 17176
                                  steroid 14380
                                    hydroxy steroid 14096
                                      17-hydroxy steroid 13761
                                        17beta-hydroxy steroid 12911
                                          danazol 20
paths to the root