Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:danazol
go back to main search page
Accession:CHEBI:4315 term browser browse the term
Definition:A terminal acetylenic compound that has formula C22H27NO2.
Synonyms:exact_synonym: [1,2]oxazolo[4',5':2,3]-17alpha-pregn-4-en-20-yn-17-ol
 related_synonym: Cyclomen;   Danocrine;   Formula=C22H27NO2;   InChI=1S/C22H27NO2/c1-4-22(24)10-8-18-16-6-5-15-11-19-14(13-23-25-19)12-20(15,2)17(16)7-9-21(18,22)3/h1,11,13,16-18,24H,5-10,12H2,2-3H3/t16-,17+,18+,20+,21+,22+/m1/s1;   InChIKey=POZRVZJJTULAOH-LHZXLZLDSA-N;   SMILES=[H][C@@]12CCC3=Cc4oncc4C[C@]3(C)[C@@]1([H])CC[C@@]1(C)[C@@]2([H])CC[C@@]1(O)C#C;   danazolum
 alt_id: CHEBI:505364;   CHEBI:554019
 xref: Beilstein:4851114;   CAS:17230-88-5;   DrugBank:DB01406;   Drug_Central:779;   KEGG:D00289
 xref_mesh: MESH:D003613
 xref: PMID:17929794;   PMID:18834112;   Patent:GB905844;   Patent:US3135743;   Wikipedia:Danazol


show annotations for term's descendants           Sort by:
 
danazol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO Danazol results in decreased activity of ABCB11 protein CTD PMID:23956101 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Ace2 angiotensin I converting enzyme 2 decreases expression ISO
EXP
Danazol results in decreased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:32,050,734...32,095,860
Ensembl chr  X:32,049,931...32,096,016
JBrowse link
G Ar androgen receptor increases activity
multiple interactions
ISO Danazol results in increased activity of AR protein
Danazol binds to and results in decreased activity of AR protein; Danazol binds to and results in increased activity of AR protein
CTD PMID:12730620 PMID:21543282 PMID:25752796 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G C3 complement C3 increases expression ISO Danazol results in increased expression of C3 protein CTD PMID:4014294 NCBI chr 9:9,721,137...9,747,084
Ensembl chr 9:9,721,105...9,747,167
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Danazol results in increased expression of CDKN1A protein CTD PMID:27358234 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cfb complement factor B increases expression ISO Danazol results in increased expression of CFB protein CTD PMID:4014294 NCBI chr20:4,536,206...4,542,073
Ensembl chr20:4,536,203...4,561,066
Ensembl chr20:4,536,203...4,561,066
JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 decreases activity ISO Danazol results in decreased activity of CYP2J2 protein CTD PMID:29689254 PMID:30965050 NCBI chr 5:119,546,458...119,564,843
Ensembl chr 5:119,546,461...119,564,846
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Danazol binds to and results in increased activity of ESR1 protein CTD PMID:25752796 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Fshb follicle stimulating hormone subunit beta decreases expression EXP Danazol results in decreased expression of FSHB protein CTD PMID:3088269 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 decreases activity
multiple interactions
ISO Danazol results in decreased activity of HSD11B2 protein
Danazol inhibits the reaction [HSD11B2 protein results in decreased activity of Glucocorticoids]
CTD PMID:22273746 NCBI chr19:37,476,083...37,481,326
Ensembl chr19:37,476,095...37,481,307
JBrowse link
G Il10 interleukin 10 multiple interactions EXP [peginterferon alfa-2a co-treated with Ribavirin co-treated with Danazol] results in decreased expression of IL10 mRNA CTD PMID:18007553 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il6 interleukin 6 multiple interactions EXP [peginterferon alfa-2a co-treated with Ribavirin co-treated with Danazol] results in decreased expression of IL6 mRNA CTD PMID:18007553 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Lhb luteinizing hormone subunit beta decreases expression EXP Danazol results in decreased expression of LHB protein CTD PMID:3088269 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Danazol inhibits the reaction [[Estradiol co-treated with TNF protein] results in increased activity of NFKB1 protein] CTD PMID:15866594 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Pgr progesterone receptor multiple interactions ISO Danazol binds to and results in decreased activity of PGR protein; Danazol binds to and results in increased activity of PGR protein CTD PMID:25752796 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Prl prolactin multiple interactions ISO Danazol inhibits the reaction [Penicillamine results in increased expression of PRL] CTD PMID:4087275 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Serping1 serpin family G member 1 increases expression ISO Danazol results in increased expression of SERPING1 protein CTD PMID:4014294 NCBI chr 3:72,161,230...72,171,109
Ensembl chr 3:72,161,189...72,171,078
JBrowse link
G Sts steroid sulfatase decreases activity ISO Danazol results in decreased activity of STS protein CTD PMID:11600235 NCBI chr  X:45,420,418...45,428,748
Ensembl chr  X:45,420,596...45,428,750
JBrowse link
G Tmprss2 transmembrane serine protease 2 increases expression ISO
EXP
Danazol results in increased expression of TMPRSS2 mRNA CTD PMID:32808185 NCBI chr11:38,063,914...38,103,406
Ensembl chr11:38,063,915...38,103,290
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
Danazol inhibits the reaction [[Estradiol co-treated with TNF protein] results in increased activity of NFKB1 protein]; Danazol inhibits the reaction [[Estradiol co-treated with TNF protein] results in increased expression of CXCL8 mRNA]; Danazol inhibits the reaction [[Estradiol co-treated with TNF protein] results in increased expression of CXCL8 protein]
[peginterferon alfa-2a co-treated with Ribavirin co-treated with Danazol] results in decreased expression of TNF mRNA
CTD PMID:15866594 PMID:18007553 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19773
    role 19719
      application 19403
        pharmaceutical 19303
          drug 19303
            anti-estrogen 44
              danazol 20
Path 2
Term Annotations click to browse term
  CHEBI ontology 19773
    subatomic particle 19772
      composite particle 19772
        hadron 19772
          baryon 19772
            nucleon 19772
              atomic nucleus 19772
                atom 19772
                  main group element atom 19662
                    p-block element atom 19662
                      carbon group element atom 19579
                        carbon atom 19569
                          organic molecular entity 19569
                            organic molecule 19502
                              organic cyclic compound 19329
                                organic polycyclic compound 16514
                                  steroid 13053
                                    hydroxy steroid 12651
                                      17-hydroxy steroid 12168
                                        17beta-hydroxy steroid 10921
                                          danazol 20
paths to the root