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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:EC 2.5.1.15 (dihydropteroate synthase) inhibitor
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Accession:CHEBI:50502 term browser browse the term
Definition:An EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor that interferes with the action of dihydropteroate synthase (EC 2.5.1.15), an enzyme that catalyzes the formation of dihydropteroate from p-aminobenzoic acid and dihydropteridine-hydroxymethyl-pyrophosphate.
Synonyms:related_synonym: (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase inhibitor;   (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase inhibitors;   2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase inhibitor;   2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase inhibitors;   7,8-dihydropteroate synthase inhibitor;   7,8-dihydropteroate synthase inhibitors;   7,8-dihydropteroate synthetase inhibitor;   7,8-dihydropteroate synthetase inhibitors;   7,8-dihydropteroic acid synthetase inhibitor;   7,8-dihydropteroic acid synthetase inhibitors;   DHPS inhibitor;   DHPS inhibitors;   EC 2.5.1.15 (dihydropteroate synthase) inhibitors;   EC 2.5.1.15 inhibitor;   EC 2.5.1.15 inhibitors;   dihydropteroate diphosphorylase inhibitor;   dihydropteroate diphosphorylase inhibitors;   dihydropteroate pyrophosphorylase inhibitor;   dihydropteroate pyrophosphorylase inhibitors;   dihydropteroate synthase inhibitor;   dihydropteroate synthase inhibitors;   dihydropteroate synthetase inhibitor;   dihydropteroate synthetase inhibitors;   dihydropteroic synthetase inhibitor;   dihydropteroic synthetase inhibitors
 xref: Wikipedia:Dihydropteroate_synthase_inhibitor


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co-trimoxazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ins2 insulin 2 increases secretion ISO Trimethoprim, Sulfamethoxazole Drug Combination results in increased secretion of INS protein modified form CTD PMID:14714756 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
N-succinylsulfathiazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ddit4 DNA-damage-inducible transcript 4 multiple interactions
increases expression		 ISO [Folic Acid deficiency co-treated with succinylsulfathiazole] results in decreased expression of DDIT4 protein
succinylsulfathiazole results in increased expression of DDIT4 protein		 CTD PMID:33957263 NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105 		JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 decreases phosphorylation ISO succinylsulfathiazole results in decreased phosphorylation of EIF4EBP1 protein CTD PMID:33957263 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984 		JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation ISO succinylsulfathiazole results in decreased phosphorylation of MTOR protein CTD PMID:33957263 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 multiple interactions
decreases expression		 ISO Folic Acid deficiency inhibits the reaction [succinylsulfathiazole results in decreased expression of PDPK1 protein] CTD PMID:33957263 NCBI chr10:13,105,435...13,182,664
Ensembl chr10:13,105,498...13,174,623 		JBrowse link
nitrososulfamethoxazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b10 aldo-keto reductase family 1 member B10 increases expression ISO 4-nitrososulfamethoxazole results in increased expression of AKR1B10 mRNA CTD PMID:28444390 NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852 		JBrowse link
G Hmgb1 high mobility group box 1 increases secretion ISO 4-nitrososulfamethoxazole results in increased secretion of HMGB1 protein CTD PMID:28444390 NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565 		JBrowse link
G Ifng interferon gamma increases secretion ISO 4-nitrososulfamethoxazole results in increased secretion of IFNG protein CTD PMID:22331489 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il13 interleukin 13 increases secretion ISO 4-nitrososulfamethoxazole results in increased secretion of IL13 protein CTD PMID:22331489 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737 		JBrowse link
G Il1a interleukin 1 alpha increases secretion ISO 4-nitrososulfamethoxazole results in increased secretion of IL1A protein CTD PMID:28444390 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta increases secretion ISO 4-nitrososulfamethoxazole results in increased secretion of IL1B protein CTD PMID:28444390 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il5 interleukin 5 increases secretion ISO 4-nitrososulfamethoxazole results in increased secretion of IL5 protein CTD PMID:22331489 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213 		JBrowse link
G Il6 interleukin 6 increases secretion ISO 4-nitrososulfamethoxazole results in increased secretion of IL6 protein CTD PMID:28444390 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mpo myeloperoxidase affects binding
multiple interactions		 ISO 4-nitrososulfamethoxazole binds to MPO protein
[[MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Sulfamethoxazole] which results in increased chemical synthesis of 4-nitrososulfamethoxazole		 CTD PMID:25531135 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO 4-nitrososulfamethoxazole results in increased expression of NQO1 mRNA CTD PMID:28444390 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO 4-nitrososulfamethoxazole results in increased expression of SRXN1 mRNA CTD PMID:28444390 NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448 		JBrowse link
G Tnf tumor necrosis factor increases secretion ISO 4-nitrososulfamethoxazole results in increased secretion of TNF protein CTD PMID:28444390 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO 4-nitrososulfamethoxazole results in increased expression of TXNRD1 mRNA CTD PMID:28444390 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863 		JBrowse link
sulfacetamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmbs hydroxymethylbilane synthase decreases activity EXP Sulfacetamide decreases activity of purified Hmbs protein RGD PMID:6893114 RGD:26923963 NCBI chr 8:44,673,554...44,680,950
Ensembl chr 8:44,673,554...44,680,957 		JBrowse link
sulfadiazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases hydroxylation ISO CYP2C8 protein results in increased hydroxylation of Sulfadiazine CTD PMID:15843491
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 decreases expression ISO Sulfadiazine results in decreased expression of GRIN1 mRNA CTD PMID:34748853 NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603 		JBrowse link
G Hmbs hydroxymethylbilane synthase decreases activity EXP Sulfadiazine decreases activity of purified Hmbs protein RGD PMID:6893114 RGD:26923963 NCBI chr 8:44,673,554...44,680,950
Ensembl chr 8:44,673,554...44,680,957 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO [Sulfadiazine co-treated with Pyrimethamine] results in decreased expression of IL6 protein; [Trimethoprim co-treated with Sulfadiazine] results in increased expression of IL6 protein CTD PMID:10888991 PMID:37722575 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Lpo lactoperoxidase decreases expression ISO Sulfadiazine results in decreased expression of LPO mRNA CTD PMID:34748853 NCBI chr10:72,606,950...72,626,220
Ensembl chr10:72,606,944...72,626,535 		JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases expression ISO Sulfadiazine results in decreased expression of MTOR mRNA CTD PMID:34748853 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Nat2 N-acetyltransferase 2 increases acetylation ISO NAT2 protein results in increased acetylation of Sulfadiazine CTD PMID:15843491 NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520 		JBrowse link
G Olig2 oligodendrocyte transcription factor 2 decreases expression ISO Sulfadiazine results in decreased expression of OLIG2 mRNA CTD PMID:34748853 NCBI chr11:30,475,510...30,478,886
Ensembl chr11:30,475,398...30,480,152 		JBrowse link
G Shank2 SH3 and multiple ankyrin repeat domains 2 decreases expression ISO Sulfadiazine results in decreased expression of SHANK2 mRNA CTD PMID:34748853 NCBI chr 1:199,146,210...199,590,962
Ensembl chr 1:199,169,429...199,589,394 		JBrowse link
G Slc6a4 solute carrier family 6 member 4 decreases expression ISO Sulfadiazine results in decreased expression of SLC6A4 mRNA CTD PMID:34748853 NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384 		JBrowse link
sulfamethazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases activity ISO Sulfamethazine results in increased activity of CYP3A4 protein CTD PMID:12065438 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Nat2 N-acetyltransferase 2 increases acetylation
increases metabolic processing
affects acetylation		 ISO NAT2 protein results in increased acetylation of Sulfamethazine
NAT2 protein results in increased metabolism of Sulfamethazine
NAT2 polymorphism affects the acetylation of Sulfamethazine		 CTD PMID:12222688 PMID:15627487 PMID:15880531 PMID:21317369 PMID:28516247 More... NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO Sulfamethazine results in increased activity of NR1I2 protein CTD PMID:12065438 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
sulfamethizole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il1b interleukin 1 beta multiple interactions ISO Sulfamethizole inhibits the reaction [Poloxalene results in increased expression of IL1B protein] CTD PMID:36799065 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO Sulfamethizole inhibits the reaction [Poloxalene results in increased expression of MTOR protein] CTD PMID:36799065 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Sulfamethizole inhibits the reaction [Poloxalene results in increased expression of TNF protein] CTD PMID:36799065 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
sulfamethoxazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity
multiple interactions		 ISO Sulfamethoxazole results in decreased activity of ABCB11 protein
Sulfamethoxazole inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]		 CTD PMID:24014644 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Acan aggrecan decreases expression EXP Sulfamethoxazole results in decreased expression of ACAN mRNA CTD PMID:26107568 NCBI chr 1:132,981,582...133,044,416
Ensembl chr 1:132,981,582...133,043,627 		JBrowse link
G Alb albumin multiple interactions ISO Sulfamethoxazole metabolite binds to and results in increased metabolism of ALB protein CTD PMID:19358516 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Col2a1 collagen type II alpha 1 chain decreases expression EXP Sulfamethoxazole results in decreased expression of COL2A1 mRNA CTD PMID:26107568 NCBI chr 7:129,098,489...129,127,560
Ensembl chr 7:129,098,786...129,127,546 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions EXP [SOD2 co-treated with CYP3A4] affects the susceptibility to Sulfamethoxazole CTD PMID:19501153 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Sulfamethoxazole metabolite binds to and results in increased metabolism of GSTP1 protein CTD PMID:19358516 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Ifng interferon gamma increases secretion ISO Sulfamethoxazole analog results in increased secretion of IFNG protein CTD PMID:15588915 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il5 interleukin 5 increases secretion ISO Sulfamethoxazole analog results in increased secretion of IL5 protein CTD PMID:15588915 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213 		JBrowse link
G Mir155 microRNA 155 increases expression ISO Sulfamethoxazole results in increased expression of MIR155 mRNA CTD PMID:29644860 NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718 		JBrowse link
G Mir18a microRNA 18a increases expression ISO Sulfamethoxazole results in increased expression of MIR18A mRNA CTD PMID:29644860 NCBI chr15:92,180,765...92,180,860
Ensembl chr15:92,180,765...92,180,860 		JBrowse link
G Mir21 microRNA 21 increases expression ISO Sulfamethoxazole results in increased expression of MIR21 mRNA CTD PMID:29644860 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO [[MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Sulfamethoxazole] which results in increased chemical synthesis of 4-nitrososulfamethoxazole; [MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Sulfamethoxazole CTD PMID:25531135 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Nat2 N-acetyltransferase 2 increases metabolic processing ISO NAT2 protein results in increased metabolism of Sulfamethoxazole CTD PMID:16847467 NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520 		JBrowse link
G Phyh phytanoyl-CoA 2-hydroxylase decreases expression ISO Sulfamethoxazole results in decreased expression of PHYH mRNA CTD PMID:15342952 NCBI chr17:73,329,461...73,346,359
Ensembl chr17:73,329,082...73,346,409 		JBrowse link
G Pir pirin increases expression ISO Sulfamethoxazole results in increased expression of PIR mRNA CTD PMID:22609641 NCBI chr  X:30,108,536...30,219,269
Ensembl chr  X:30,108,538...30,219,218 		JBrowse link
G RT1-M3-1 RT1 class Ib, locus M3, gene 1 affects expression ISO Sulfamethoxazole affects the expression of HLA-G mRNA CTD PMID:25811541 NCBI chr20:1,323,976...1,328,126
Ensembl chr20:1,287,521...1,328,117 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP [SOD2 co-treated with CYP3A4] affects the susceptibility to Sulfamethoxazole CTD PMID:19501153 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Sox9 SRY-box transcription factor 9 decreases expression EXP Sulfamethoxazole results in decreased expression of SOX9 mRNA CTD PMID:26107568 NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994 		JBrowse link
sulfamethoxazole hydroxylamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyb5b cytochrome b5 type B multiple interactions ISO [MTARC1 protein co-treated with CYB5B protein co-treated with CYB5R3 protein co-treated with NAD] results in increased reduction of sulfamethoxazole hydroxylamine; [MTARC2 protein co-treated with CYB5B protein co-treated with CYB5R3 protein co-treated with NAD] results in increased reduction of sulfamethoxazole hydroxylamine CTD PMID:25170804 NCBI chr19:35,062,871...35,096,741
Ensembl chr19:35,062,813...35,098,249 		JBrowse link
G Cyb5r3 cytochrome b5 reductase 3 multiple interactions ISO [MTARC1 protein co-treated with CYB5B protein co-treated with CYB5R3 protein co-treated with NAD] results in increased reduction of sulfamethoxazole hydroxylamine; [MTARC2 protein co-treated with CYB5B protein co-treated with CYB5R3 protein co-treated with NAD] results in increased reduction of sulfamethoxazole hydroxylamine CTD PMID:25170804 NCBI chr 7:114,306,686...114,324,247
Ensembl chr 7:114,306,685...114,324,298 		JBrowse link
G Mtarc1 mitochondrial amidoxime reducing component 1 multiple interactions ISO [MTARC1 protein co-treated with CYB5B protein co-treated with CYB5R3 protein co-treated with NAD] results in increased reduction of sulfamethoxazole hydroxylamine CTD PMID:25170804 NCBI chr13:96,324,377...96,362,677
Ensembl chr13:96,339,757...96,397,796 		JBrowse link
G Mtarc2 mitochondrial amidoxime reducing component 2 multiple interactions ISO [MTARC2 protein co-treated with CYB5B protein co-treated with CYB5R3 protein co-treated with NAD] results in increased reduction of sulfamethoxazole hydroxylamine CTD PMID:25170804 NCBI chr13:96,362,810...96,397,284 JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      biological role 19782
        biochemical role 19496
          enzyme inhibitor 18704
            EC 2.* (transferase) inhibitor 14863
              EC 2.5.* (non-methyl-alkyl or aryl transferase) inhibitor 3380
                EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor 3380
                  EC 2.5.1.15 (dihydropteroate synthase) inhibitor 45
                    asulam 0
                    asulam-potassium 0
                    asulam-sodium 0
                    sulfacetamide 1
                    sulfacetamide sodium 0
                    sulfacetamide sodium anhydrous + 0
                    sulfachloropyridazine 0
                    sulfadiazine 10
                    sulfamethazine + 3
                    sulfamethizole 3
                    sulfamethoxazole + 33
                    sulfamethoxypyridazine 0
                    sulfathiazole + 4
                    sulfathiourea 0
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