CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: sulfadiazine
Accession: CHEBI:9328
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Definition: A sulfonamide consisting of pyrimidine with a 4-aminobenzenesulfonamido group at the 2-position.
Synonyms: exact_synonym: 4-amino-N-(pyrimidin-2-yl)benzenesulfonamide
related_synonym: 2-sulfanilamidopyrimidine; 2-sulfanilylaminopyrimidine; 4-amino-N-2-pyrimidinylbenzenesulfonamide; Formula=C10H10N4O2S; InChI=1S/C10H10N4O2S/c11-8-2-4-9(5-3-8)17(15,16)14-10-12-6-1-7-13-10/h1-7H,11H2,(H,12,13,14); InChIKey=SEEPANYCNGTZFQ-UHFFFAOYSA-N; N(1)-2-pyrimidinylsulfanilamide; N(1)-2-pyrimidylsulfanilamide; SMILES=Nc1ccc(cc1)S(=O)(=O)Nc1ncccn1; sulfadiazin; sulfadiazina; sulfadiazinum; sulfapyrimidine; sulphadiazine
xref: Beilstein:235192; CAS:68-35-9; DrugBank:DB00359; Drug_Central:2500; Gmelin:219136; HMDB:HMDB0014503; KEGG:C07658; KEGG:D00587; LINCS:LSM-5457
xref_mesh: MESH:D013411
xref: PMID:11431418; PMID:12811231; PMID:13037579; PMID:15907564; PMID:18706672; PMID:20244050; PMID:23206954; PMID:23245764; PMID:23270807; PMID:23322489; PMID:23396336; PMID:23411088; PMID:23411170; PMID:23704574; PMID:23707894; PMID:7378112; PMID:8429812; Patent:GB557055; Patent:US2407966; Patent:US2410793; Reaxys:235192; VSDB:1740; Wikipedia:Sulfadiazine
cyclic_relationship: is_conjugate_acid_of CHEBI:33127
G
Cyp2c11
cytochrome P450, subfamily 2, polypeptide 11
increases hydroxylation
ISO
CYP2C9 protein results in increased hydroxylation of Sulfadiazine
CTD
PMID:15843491
NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
G
Cyp2c79
cytochrome P450, family 2, subfamily c, polypeptide 79
increases hydroxylation
ISO
CYP2C8 protein results in increased hydroxylation of Sulfadiazine
CTD
PMID:15843491
G
Grin1
glutamate ionotropic receptor NMDA type subunit 1
decreases expression
ISO
Sulfadiazine results in decreased expression of GRIN1 mRNA
CTD
PMID:34748853
NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603
G
Hmbs
hydroxymethylbilane synthase
decreases activity
EXP
Sulfadiazine decreases activity of purified Hmbs protein
RGD
PMID:6893114
RGD:26923963
NCBI chr 8:44,673,554...44,680,950
Ensembl chr 8:44,673,554...44,680,957
G
Il6
interleukin 6
multiple interactions
ISO
[Sulfadiazine co-treated with Pyrimethamine] results in decreased expression of IL6 protein; [Trimethoprim co-treated with Sulfadiazine] results in increased expression of IL6 protein
CTD
PMID:10888991 PMID:37722575
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
G
Lpo
lactoperoxidase
decreases expression
ISO
Sulfadiazine results in decreased expression of LPO mRNA
CTD
PMID:34748853
NCBI chr10:72,606,950...72,626,220
Ensembl chr10:72,606,944...72,626,535
G
Mtor
mechanistic target of rapamycin kinase
decreases expression
ISO
Sulfadiazine results in decreased expression of MTOR mRNA
CTD
PMID:34748853
NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
G
Nat2
N-acetyltransferase 2
increases acetylation
ISO
NAT2 protein results in increased acetylation of Sulfadiazine
CTD
PMID:15843491
NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520
G
Olig2
oligodendrocyte transcription factor 2
decreases expression
ISO
Sulfadiazine results in decreased expression of OLIG2 mRNA
CTD
PMID:34748853
NCBI chr11:30,475,510...30,478,886
Ensembl chr11:30,475,398...30,480,152
G
Shank2
SH3 and multiple ankyrin repeat domains 2
decreases expression
ISO
Sulfadiazine results in decreased expression of SHANK2 mRNA
CTD
PMID:34748853
NCBI chr 1:199,146,210...199,590,962
Ensembl chr 1:199,169,429...199,589,394
G
Slc6a4
solute carrier family 6 member 4
decreases expression
ISO
Sulfadiazine results in decreased expression of SLC6A4 mRNA
CTD
PMID:34748853
NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384
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