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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:sulfadiazine
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Accession:CHEBI:9328 term browser browse the term
Definition:A sulfonamide consisting of pyrimidine with a 4-aminobenzenesulfonamido group at the 2-position.
Synonyms:exact_synonym: 4-amino-N-(pyrimidin-2-yl)benzenesulfonamide
 related_synonym: 2-sulfanilamidopyrimidine;   2-sulfanilylaminopyrimidine;   4-amino-N-2-pyrimidinylbenzenesulfonamide;   Formula=C10H10N4O2S;   InChI=1S/C10H10N4O2S/c11-8-2-4-9(5-3-8)17(15,16)14-10-12-6-1-7-13-10/h1-7H,11H2,(H,12,13,14);   InChIKey=SEEPANYCNGTZFQ-UHFFFAOYSA-N;   N(1)-2-pyrimidinylsulfanilamide;   N(1)-2-pyrimidylsulfanilamide;   SMILES=Nc1ccc(cc1)S(=O)(=O)Nc1ncccn1;   sulfadiazin;   sulfadiazina;   sulfadiazinum;   sulfapyrimidine;   sulphadiazine
 xref: Beilstein:235192;   CAS:68-35-9;   DrugBank:DB00359;   Drug_Central:2500;   Gmelin:219136;   HMDB:HMDB0014503;   KEGG:C07658;   KEGG:D00587;   LINCS:LSM-5457
 xref_mesh: MESH:D013411
 xref: PMID:11431418;   PMID:12811231;   PMID:13037579;   PMID:15907564;   PMID:18706672;   PMID:20244050;   PMID:23206954;   PMID:23245764;   PMID:23270807;   PMID:23322489;   PMID:23396336;   PMID:23411088;   PMID:23411170;   PMID:23704574;   PMID:23707894;   PMID:7378112;   PMID:8429812;   Patent:GB557055;   Patent:US2407966;   Patent:US2410793;   Reaxys:235192;   VSDB:1740;   Wikipedia:Sulfadiazine
 cyclic_relationship: is_conjugate_acid_of CHEBI:33127


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sulfadiazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases hydroxylation ISO CYP2C8 protein results in increased hydroxylation of Sulfadiazine CTD PMID:15843491
G Hmbs hydroxymethylbilane synthase decreases activity EXP Sulfadiazine decreases activity of purified Hmbs protein RGD PMID:6893114 RGD:26923963 NCBI chr 8:44,673,554...44,680,950
Ensembl chr 8:44,673,554...44,680,957
JBrowse link
G Il6 interleukin 6 multiple interactions ISO [Trimethoprim co-treated with Sulfadiazine] results in increased expression of IL6 protein CTD PMID:10888991 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Nat2 N-acetyltransferase 2 increases acetylation ISO NAT2 protein results in increased acetylation of Sulfadiazine CTD PMID:15843491 NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      biological role 19769
        antimicrobial agent 17408
          sulfadiazine 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    main group molecular entity 19716
                      s-block molecular entity 19502
                        hydrogen molecular entity 19498
                          hydrides 18852
                            inorganic hydride 17691
                              pnictogen hydride 17672
                                nitrogen hydride 17545
                                  azane 17279
                                    ammonia 17278
                                      organic amino compound 17278
                                        aromatic amine 13704
                                          anilines 12359
                                            substituted aniline 11852
                                              sulfanilamide 248
                                                sulfadiazine 4
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