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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:sulfadiazine
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Accession:CHEBI:9328 term browser browse the term
Definition:A sulfonamide consisting of pyrimidine with a 4-aminobenzenesulfonamido group at the 2-position.
Synonyms:exact_synonym: 4-amino-N-(pyrimidin-2-yl)benzenesulfonamide
 related_synonym: 2-sulfanilamidopyrimidine;   2-sulfanilylaminopyrimidine;   4-amino-N-2-pyrimidinylbenzenesulfonamide;   Formula=C10H10N4O2S;   InChI=1S/C10H10N4O2S/c11-8-2-4-9(5-3-8)17(15,16)14-10-12-6-1-7-13-10/h1-7H,11H2,(H,12,13,14);   InChIKey=SEEPANYCNGTZFQ-UHFFFAOYSA-N;   N(1)-2-pyrimidinylsulfanilamide;   N(1)-2-pyrimidylsulfanilamide;   SMILES=Nc1ccc(cc1)S(=O)(=O)Nc1ncccn1;   sulfadiazin;   sulfadiazina;   sulfadiazinum;   sulfapyrimidine;   sulphadiazine
 xref: Beilstein:235192;   CAS:68-35-9;   DrugBank:DB00359;   Drug_Central:2500;   Gmelin:219136;   HMDB:HMDB0014503;   KEGG:C07658;   KEGG:D00587;   LINCS:LSM-5457
 xref_mesh: MESH:D013411
 xref: PMID:11431418;   PMID:12811231;   PMID:13037579;   PMID:15907564;   PMID:18706672;   PMID:20244050;   PMID:23206954;   PMID:23245764;   PMID:23270807;   PMID:23322489;   PMID:23396336;   PMID:23411088;   PMID:23411170;   PMID:23704574;   PMID:23707894;   PMID:7378112;   PMID:8429812;   Patent:GB557055;   Patent:US2407966;   Patent:US2410793;   Reaxys:235192;   VSDB:1740;   Wikipedia:Sulfadiazine
 cyclic_relationship: is_conjugate_acid_of CHEBI:33127



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sulfadiazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases hydroxylation ISO CYP2C8 protein results in increased hydroxylation of Sulfadiazine CTD PMID:15843491
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 decreases expression ISO Sulfadiazine results in decreased expression of GRIN1 mRNA CTD PMID:34748853 NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603
JBrowse link
G Hmbs hydroxymethylbilane synthase decreases activity EXP Sulfadiazine decreases activity of purified Hmbs protein RGD PMID:6893114 RGD:26923963 NCBI chr 8:44,673,554...44,680,950
Ensembl chr 8:44,673,554...44,680,957
JBrowse link
G Il6 interleukin 6 multiple interactions ISO [Trimethoprim co-treated with Sulfadiazine] results in increased expression of IL6 protein CTD PMID:10888991 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Lpo lactoperoxidase decreases expression ISO Sulfadiazine results in decreased expression of LPO mRNA CTD PMID:34748853 NCBI chr10:72,606,944...72,626,535
Ensembl chr10:72,606,944...72,626,535
JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases expression ISO Sulfadiazine results in decreased expression of MTOR mRNA CTD PMID:34748853 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Nat2 N-acetyltransferase 2 increases acetylation ISO NAT2 protein results in increased acetylation of Sulfadiazine CTD PMID:15843491 NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520
JBrowse link
G Olig2 oligodendrocyte transcription factor 2 decreases expression ISO Sulfadiazine results in decreased expression of OLIG2 mRNA CTD PMID:34748853 NCBI chr11:30,475,510...30,478,886
Ensembl chr11:30,475,398...30,480,152
JBrowse link
G Shank2 SH3 and multiple ankyrin repeat domains 2 decreases expression ISO Sulfadiazine results in decreased expression of SHANK2 mRNA CTD PMID:34748853 NCBI chr 1:199,146,210...199,590,962
Ensembl chr 1:199,169,429...199,589,394
JBrowse link
G Slc6a4 solute carrier family 6 member 4 decreases expression ISO Sulfadiazine results in decreased expression of SLC6A4 mRNA CTD PMID:34748853 NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384
JBrowse link

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  CHEBI ontology 19659
    role 19634
      biological role 19633
        antimicrobial agent 17784
          sulfadiazine 10
Path 2
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  CHEBI ontology 19659
    subatomic particle 19658
      composite particle 19658
        hadron 19658
          baryon 19658
            nucleon 19658
              atomic nucleus 19700
                atom 19658
                  main group element atom 19607
                    main group molecular entity 19649
                      s-block molecular entity 19457
                        hydrogen molecular entity 19450
                          hydrides 18928
                            inorganic hydride 17765
                              pnictogen hydride 17748
                                nitrogen hydride 17633
                                  azane 17403
                                    ammonia 17402
                                      organic amino compound 17402
                                        aromatic amine 14884
                                          anilines 13948
                                            substituted aniline 13624
                                              sulfanilamide 260
                                                sulfadiazine 10
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