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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:sulfadiazine
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Accession:CHEBI:9328 term browser browse the term
Definition:A sulfonamide consisting of pyrimidine with a 4-aminobenzenesulfonamido group at the 2-position.
Synonyms:exact_synonym: 4-amino-N-(pyrimidin-2-yl)benzenesulfonamide
 related_synonym: 2-sulfanilamidopyrimidine;   2-sulfanilylaminopyrimidine;   4-amino-N-2-pyrimidinylbenzenesulfonamide;   Formula=C10H10N4O2S;   InChI=1S/C10H10N4O2S/c11-8-2-4-9(5-3-8)17(15,16)14-10-12-6-1-7-13-10/h1-7H,11H2,(H,12,13,14);   InChIKey=SEEPANYCNGTZFQ-UHFFFAOYSA-N;   N(1)-2-pyrimidinylsulfanilamide;   N(1)-2-pyrimidylsulfanilamide;   SMILES=Nc1ccc(cc1)S(=O)(=O)Nc1ncccn1;   sulfadiazin;   sulfadiazina;   sulfadiazinum;   sulfapyrimidine;   sulphadiazine
 xref: Beilstein:235192;   CAS:68-35-9;   DrugBank:DB00359;   Drug_Central:2500;   Gmelin:219136;   HMDB:HMDB0014503;   KEGG:C07658;   KEGG:D00587;   LINCS:LSM-5457
 xref_mesh: MESH:D013411
 xref: PMID:11431418;   PMID:12811231;   PMID:13037579;   PMID:15907564;   PMID:18706672;   PMID:20244050;   PMID:23206954;   PMID:23245764;   PMID:23270807;   PMID:23322489;   PMID:23396336;   PMID:23411088;   PMID:23411170;   PMID:23704574;   PMID:23707894;   PMID:7378112;   PMID:8429812;   Patent:GB557055;   Patent:US2407966;   Patent:US2410793;   Reaxys:235192;   VSDB:1740;   Wikipedia:Sulfadiazine
 cyclic_relationship: is_conjugate_acid_of CHEBI:33127



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sulfadiazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 increases hydroxylation ISO CYP2C9 protein results in increased hydroxylation of Sulfadiazine CTD PMID:15843491 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases hydroxylation ISO CYP2C8 protein results in increased hydroxylation of Sulfadiazine CTD PMID:15843491
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 decreases expression ISO Sulfadiazine results in decreased expression of GRIN1 mRNA CTD PMID:34748853 NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603
JBrowse link
G Hmbs hydroxymethylbilane synthase decreases activity EXP Sulfadiazine decreases activity of purified Hmbs protein RGD PMID:6893114 RGD:26923963 NCBI chr 8:44,673,554...44,680,950
Ensembl chr 8:44,673,554...44,680,957
JBrowse link
G Il6 interleukin 6 multiple interactions ISO [Sulfadiazine co-treated with Pyrimethamine] results in decreased expression of IL6 protein; [Trimethoprim co-treated with Sulfadiazine] results in increased expression of IL6 protein CTD PMID:10888991 PMID:37722575 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Lpo lactoperoxidase decreases expression ISO Sulfadiazine results in decreased expression of LPO mRNA CTD PMID:34748853 NCBI chr10:72,606,950...72,626,220
Ensembl chr10:72,606,944...72,626,535
JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases expression ISO Sulfadiazine results in decreased expression of MTOR mRNA CTD PMID:34748853 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Nat2 N-acetyltransferase 2 increases acetylation ISO NAT2 protein results in increased acetylation of Sulfadiazine CTD PMID:15843491 NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520
JBrowse link
G Olig2 oligodendrocyte transcription factor 2 decreases expression ISO Sulfadiazine results in decreased expression of OLIG2 mRNA CTD PMID:34748853 NCBI chr11:30,475,510...30,478,886
Ensembl chr11:30,475,398...30,480,152
JBrowse link
G Shank2 SH3 and multiple ankyrin repeat domains 2 decreases expression ISO Sulfadiazine results in decreased expression of SHANK2 mRNA CTD PMID:34748853 NCBI chr 1:199,146,210...199,590,962
Ensembl chr 1:199,169,429...199,589,394
JBrowse link
G Slc6a4 solute carrier family 6 member 4 decreases expression ISO Sulfadiazine results in decreased expression of SLC6A4 mRNA CTD PMID:34748853 NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19905
    role 19881
      biological role 19879
        antimicrobial agent 18156
          sulfadiazine 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 19905
    subatomic particle 19903
      composite particle 19903
        hadron 19903
          baryon 19903
            nucleon 19903
              atomic nucleus 19903
                atom 19903
                  main group element atom 19853
                    main group molecular entity 19853
                      s-block molecular entity 19685
                        hydrogen molecular entity 19671
                          hydrides 19149
                            inorganic hydride 18129
                              pnictogen hydride 18118
                                nitrogen hydride 18021
                                  azane 17819
                                    ammonia 17818
                                      organic amino compound 17818
                                        aromatic amine 15425
                                          anilines 14439
                                            substituted aniline 14080
                                              sulfanilamide 2922
                                                sulfadiazine 11
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