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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:102265 term browser browse the term
Definition:A sulfonamide consisting of pyrimidine with methyl substituents at the 4- and 6-positions and a 4-aminobenzenesulfonamido group at the 2-position.
Synonyms:related_synonym: (p-Aminobenzolsulfonyl)-2-amino-4,6-dimethylpyrimidin;   2-(4-Aminobenzenesulfonamido)-4,6-dimethylpyrimidine;   2-(p-Aminobenzenesulfonamido)-4,6-dimethylpyrimidine;   2-Sulfanilamido-4,6-dimethylpyrimidine;   4,6-Dimethyl-2-sulfanilamidopyrimidine;   4-Amino-N-(2,6-dimethyl-4-pyrimidinyl)benzenesulfonamide;   4-Amino-N-(4,6-dimethyl-pyrimidin-2-yl)-benzenesulfonamide;   4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide;   6-(4'-Aminobenzol-sulfonamido)-2,4-dimethylpyrimidin;   Formula=C12H14N4O2S;   InChI=1S/C12H14N4O2S/c1-8-7-9(2)15-12(14-8)16-19(17,18)11-5-3-10(13)4-6-11/h3-7H,13H2,1-2H3,(H,14,15,16);   InChIKey=ASWVTGNCAZCNNR-UHFFFAOYSA-N;   N(1)-(4,6-Dimethyl-2-pyrimidinyl)sulfanilamide;   N(1)-(4,6-Dimethyl-2-pyrimidyl)sulfanilamide;   N-(4,6-Dimethyl-2-pyrimidyl)sulfanilamide;   SMILES=Cc1cc(C)nc(NS(=O)(=O)c2ccc(N)cc2)n1;   SMZ;   Sulfadimethyldiazine;   Sulfadimethylpyrimidine;   Sulfametazina;   Sulfametazyny;   Sulfamezathine;   Sulphadimethylpyrimidine;   Sulphamethazine;   sulfadimidina;   sulfadimidine;   sulfadimidinum;   sulfamethazone
 xref: Beilstein:261304;   CAS:57-68-1;   DrugBank:DB01582;   Drug_Central:2502;   Gmelin:1009759;   HMDB:HMDB0015522;   KEGG:C19530;   KEGG:D02436;   LINCS:LSM-5295
 xref_mesh: MESH:D013418
 xref: PMID:11431418;   PMID:14552772;   PMID:15603963;   PMID:17311370;   PMID:17596632;   PMID:20028131;   PMID:22903812;   PMID:23218311;   PMID:23384282;   PMID:23434485;   PMID:23454458;   PMID:23562141;   PMID:23636590;   PMID:23673752;   PMID:23673946;   PMID:23704574;   PMID:6864729;   PMID:7021831;   PMID:7328159;   PMID:8199304;   PMID:9886437;   Patent:EP1861101;   Patent:GB546158;   Patent:GB552887;   Patent:US2407966;   Patent:US3119818;   Patent:WO2005016386;   Reaxys:261304;   VSDB:1829;   Wikipedia:Sulfadimidine

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sulfamethazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases activity ISO Sulfamethazine results in increased activity of CYP3A4 protein CTD PMID:12065438 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Nat2 N-acetyltransferase 2 increases acetylation
affects acetylation
increases metabolic processing
ISO NAT2 protein results in increased acetylation of Sulfamethazine
NAT2 polymorphism affects the acetylation of Sulfamethazine
NAT2 protein results in increased metabolism of Sulfamethazine
CTD PMID:12222688 PMID:15627487 PMID:15880531 PMID:21317369 PMID:28516247 More... NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO Sulfamethazine results in increased activity of NR1I2 protein CTD PMID:12065438 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19900
    role 19875
      biological role 19873
        antimicrobial agent 18073
          sulfamethazine 3
            sulfabromomethazine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19900
    subatomic particle 19898
      composite particle 19898
        hadron 19898
          baryon 19898
            nucleon 19898
              atomic nucleus 19898
                atom 19898
                  main group element atom 19845
                    main group molecular entity 19845
                      s-block molecular entity 19678
                        hydrogen molecular entity 19667
                          hydrides 19146
                            inorganic hydride 18124
                              pnictogen hydride 18112
                                nitrogen hydride 18017
                                  azane 17816
                                    ammonia 17815
                                      organic amino compound 17815
                                        aromatic amine 15421
                                          anilines 14436
                                            substituted aniline 14072
                                              sulfanilamide 2919
                                                sulfamethazine 3
                                                  sulfabromomethazine 0
paths to the root