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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:sulfamethazine
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Accession:CHEBI:102265 term browser browse the term
Definition:A sulfonamide consisting of pyrimidine with methyl substituents at the 4- and 6-positions and a 4-aminobenzenesulfonamido group at the 2-position.
Synonyms:related_synonym: (p-Aminobenzolsulfonyl)-2-amino-4,6-dimethylpyrimidin;   2-(4-Aminobenzenesulfonamido)-4,6-dimethylpyrimidine;   2-(p-Aminobenzenesulfonamido)-4,6-dimethylpyrimidine;   2-Sulfanilamido-4,6-dimethylpyrimidine;   4,6-Dimethyl-2-sulfanilamidopyrimidine;   4-Amino-N-(2,6-dimethyl-4-pyrimidinyl)benzenesulfonamide;   4-Amino-N-(4,6-dimethyl-pyrimidin-2-yl)-benzenesulfonamide;   4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide;   6-(4'-Aminobenzol-sulfonamido)-2,4-dimethylpyrimidin;   Formula=C12H14N4O2S;   InChI=1S/C12H14N4O2S/c1-8-7-9(2)15-12(14-8)16-19(17,18)11-5-3-10(13)4-6-11/h3-7H,13H2,1-2H3,(H,14,15,16);   InChIKey=ASWVTGNCAZCNNR-UHFFFAOYSA-N;   N(1)-(4,6-Dimethyl-2-pyrimidinyl)sulfanilamide;   N(1)-(4,6-Dimethyl-2-pyrimidyl)sulfanilamide;   N-(4,6-Dimethyl-2-pyrimidyl)sulfanilamide;   SMILES=Cc1cc(C)nc(NS(=O)(=O)c2ccc(N)cc2)n1;   SMZ;   Sulfadimethyldiazine;   Sulfadimethylpyrimidine;   Sulfametazina;   Sulfametazyny;   Sulfamezathine;   Sulphadimethylpyrimidine;   Sulphamethazine;   sulfadimidina;   sulfadimidine;   sulfadimidinum;   sulfamethazone
 xref: Beilstein:261304;   CAS:57-68-1;   DrugBank:DB01582;   Drug_Central:2502;   Gmelin:1009759;   HMDB:HMDB0015522;   KEGG:C19530;   KEGG:D02436;   LINCS:LSM-5295
 xref_mesh: MESH:D013418
 xref: PMID:11431418;   PMID:14552772;   PMID:15603963;   PMID:17311370;   PMID:17596632;   PMID:20028131;   PMID:22903812;   PMID:23218311;   PMID:23384282;   PMID:23434485;   PMID:23454458;   PMID:23562141;   PMID:23636590;   PMID:23673752;   PMID:23673946;   PMID:23704574;   PMID:6864729;   PMID:7021831;   PMID:7328159;   PMID:8199304;   PMID:9886437;   Patent:EP1861101;   Patent:GB546158;   Patent:GB552887;   Patent:US2407966;   Patent:US3119818;   Patent:WO2005016386;   Reaxys:261304;   VSDB:1829;   Wikipedia:Sulfadimidine


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sulfamethazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nat2 N-acetyltransferase 2 increases acetylation
affects acetylation
increases metabolic processing
ISO NAT2 protein results in increased acetylation of Sulfamethazine
NAT2 polymorphism affects the acetylation of Sulfamethazine
NAT2 protein results in increased metabolism of Sulfamethazine
CTD PMID:12222688 PMID:15627487 PMID:15880531 PMID:21317369 PMID:28516247 PMID:30358977 NCBI chr16:23,960,709...23,991,570
Ensembl chr16:23,961,067...23,991,570
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G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO Sulfamethazine results in increased activity of NR1I2 protein CTD PMID:12065438 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19767
    role 19714
      biological role 19714
        antimicrobial agent 17370
          sulfamethazine 2
            sulfabromomethazine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19767
    subatomic particle 19766
      composite particle 19766
        hadron 19766
          baryon 19766
            nucleon 19766
              atomic nucleus 19766
                atom 19766
                  main group element atom 19657
                    main group molecular entity 19657
                      s-block molecular entity 19421
                        hydrogen molecular entity 19414
                          hydrides 18754
                            inorganic hydride 17459
                              pnictogen hydride 17434
                                nitrogen hydride 17281
                                  azane 17016
                                    ammonia 17015
                                      organic amino compound 17014
                                        aromatic amine 13683
                                          anilines 12360
                                            substituted aniline 11856
                                              sulfanilamide 249
                                                sulfamethazine 2
                                                  sulfabromomethazine 0
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