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G |
Ccnd3 |
cyclin D3 |
decreases expression |
ISO |
lycorine results in decreased expression of CCND3 mRNA |
CTD |
PMID:23376478 |
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NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371
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G |
Cdh5 |
cadherin 5 |
decreases expression |
ISO |
lycorine results in decreased expression of CDH5 mRNA |
CTD |
PMID:23376478 |
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NCBI chr19:815,415...854,478
Ensembl chr19:815,411...854,368
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
increases expression |
ISO |
lycorine results in increased expression of CDKN1A mRNA |
CTD |
PMID:23376478 |
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NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
lycorine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] |
CTD |
PMID:22155741 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Mapk14 |
mitogen activated protein kinase 14 |
multiple interactions |
ISO |
lycorine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK14 protein] |
CTD |
PMID:22155741 |
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NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
lycorine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; lycorine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] |
CTD |
PMID:22155741 |
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NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
lycorine inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] |
CTD |
PMID:22155741 |
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NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Sema4d |
semaphorin 4D |
decreases expression |
ISO |
lycorine results in decreased expression of SEMA4D mRNA |
CTD |
PMID:23376478 |
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NCBI chr17:13,430,324...13,537,146
Ensembl chr17:13,430,379...13,537,138
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G |
Stat1 |
signal transducer and activator of transcription 1 |
multiple interactions |
ISO |
lycorine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein] |
CTD |
PMID:22155741 |
|
NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
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G |
Stat3 |
signal transducer and activator of transcription 3 |
multiple interactions |
ISO |
lycorine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT3 protein] |
CTD |
PMID:22155741 |
|
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
lycorine inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] |
CTD |
PMID:22155741 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Vegfa |
vascular endothelial growth factor A |
decreases expression |
ISO |
lycorine results in decreased expression of VEGFA mRNA |
CTD |
PMID:23376478 |
|
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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G |
Aifm1 |
apoptosis inducing factor, mitochondria associated 1 |
increases expression |
EXP |
Swainsonine results in increased expression of AIFM1 protein |
CTD |
PMID:33186601 |
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NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256
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G |
Akt1 |
AKT serine/threonine kinase 1 |
decreases phosphorylation |
ISO |
Swainsonine results in decreased phosphorylation of AKT1 protein |
CTD |
PMID:36402259 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Atg5 |
autophagy related 5 |
multiple interactions increases expression |
ISO EXP |
[bafilomycin A1 co-treated with Swainsonine] results in increased expression of ATG5 mRNA; [bafilomycin A1 co-treated with Swainsonine] results in increased lipidation of ATG5 protein Swainsonine results in increased expression of ATG5 mRNA; Swainsonine results in increased expression of ATG5 protein |
CTD |
PMID:36402259 PMID:37442287 |
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NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209
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G |
Becn1 |
beclin 1 |
multiple interactions increases expression |
EXP ISO |
[Swainsonine co-treated with bafilomycin A1] results in increased expression of BECN1 protein Swainsonine results in increased expression of BECN1 protein Swainsonine results in increased expression of BECN1 mRNA; Swainsonine results in increased expression of BECN1 protein |
CTD |
PMID:33186601 PMID:36402259 |
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NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
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G |
Casp3 |
caspase 3 |
multiple interactions increases cleavage |
EXP |
[Swainsonine co-treated with aloxistatin] results in increased cleavage of CASP3 protein; [Swainsonine co-treated with bafilomycin A1] results in increased cleavage of CASP3 protein Swainsonine results in increased cleavage of CASP3 protein |
CTD |
PMID:33186601 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp8 |
caspase 8 |
increases cleavage |
EXP |
Swainsonine results in increased cleavage of CASP8 protein |
CTD |
PMID:33186601 |
|
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Casp9 |
caspase 9 |
increases cleavage multiple interactions |
EXP |
Swainsonine results in increased cleavage of CASP9 protein [Swainsonine co-treated with Sirolimus] results in increased cleavage of CASP9 protein |
CTD |
PMID:33186601 |
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NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Ctsd |
cathepsin D |
decreases expression multiple interactions |
EXP |
Swainsonine results in decreased expression of CTSD protein [Swainsonine affects the glycosylation of CTSD protein] which results in decreased expression of CTSD protein modified form |
CTD |
PMID:33186601 PMID:37442287 |
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NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
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G |
Eif4ebp1 |
eukaryotic translation initiation factor 4E binding protein 1 |
decreases phosphorylation |
ISO |
Swainsonine results in decreased phosphorylation of EIF4EBP1 protein |
CTD |
PMID:36402259 |
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NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
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G |
Faslg |
Fas ligand |
increases expression |
EXP |
Swainsonine results in increased expression of FASLG protein |
CTD |
PMID:33186601 |
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NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
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G |
Gfpt1 |
glutamine fructose-6-phosphate transaminase 1 |
decreases expression |
EXP |
Swainsonine results in decreased expression of GFAT1 protein |
CTD |
PMID:37442287 |
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NCBI chr 4:119,496,691...119,546,472
Ensembl chr 4:119,496,714...119,546,471
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G |
Lamp1 |
lysosomal-associated membrane protein 1 |
multiple interactions increases expression |
ISO |
[bafilomycin A1 co-treated with Swainsonine] results in increased expression of LAMP1 mRNA; [bafilomycin A1 co-treated with Swainsonine] results in increased expression of LAMP1 protein Swainsonine results in increased expression of LAMP1 mRNA; Swainsonine results in increased expression of LAMP1 protein |
CTD |
PMID:36402259 |
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NCBI chr16:76,355,982...76,380,700
Ensembl chr16:76,355,984...76,381,883
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G |
Man2a1 |
mannosidase, alpha, class 2A, member 1 |
multiple interactions decreases expression |
ISO |
bafilomycin A1 inhibits the reaction [Swainsonine results in decreased expression of MAN2A1 mRNA] |
CTD |
PMID:36402259 |
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NCBI chr 9:104,252,001...104,408,349
Ensembl chr 9:104,252,001...104,408,349
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G |
Man2b1 |
mannosidase, alpha, class 2B, member 1 |
multiple interactions decreases expression |
ISO |
bafilomycin A1 inhibits the reaction [Swainsonine results in decreased expression of MAN2B1 mRNA] |
CTD |
PMID:36402259 |
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NCBI chr19:23,055,092...23,074,398
Ensembl chr19:23,055,097...23,074,389
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G |
Map1lc3b |
microtubule-associated protein 1 light chain 3 beta |
multiple interactions increases expression increases lipidation |
ISO EXP |
[bafilomycin A1 co-treated with Swainsonine] results in increased expression of MAP1LC3B mRNA; [bafilomycin A1 co-treated with Swainsonine] results in increased lipidation of MAP1LC3B protein Swainsonine results in increased expression of MAP1LC3B mRNA Swainsonine results in increased lipidation of MAP1LC3B protein Swainsonine results in increased localization of and results in increased lipidation of MAP1LC3B protein |
CTD |
PMID:36402259 PMID:37442287 |
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NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
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G |
Mapk1 |
mitogen activated protein kinase 1 |
decreases phosphorylation |
ISO |
Swainsonine results in decreased phosphorylation of MAPK1 protein |
CTD |
PMID:36402259 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
decreases phosphorylation |
ISO |
Swainsonine results in decreased phosphorylation of MAPK3 protein |
CTD |
PMID:36402259 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mtor |
mechanistic target of rapamycin kinase |
decreases phosphorylation |
ISO |
Swainsonine results in decreased phosphorylation of MTOR protein |
CTD |
PMID:36402259 |
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NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
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G |
Pik3r1 |
phosphoinositide-3-kinase regulatory subunit 1 |
decreases phosphorylation |
ISO |
Swainsonine results in decreased phosphorylation of PIK3R1 protein |
CTD |
PMID:36402259 |
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NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631
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G |
Rps6kb1 |
ribosomal protein S6 kinase B1 |
decreases phosphorylation |
ISO |
Swainsonine results in decreased phosphorylation of RPS6KB1 protein |
CTD |
PMID:36402259 |
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NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
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G |
Sqstm1 |
sequestosome 1 |
increases expression multiple interactions |
ISO EXP |
Swainsonine results in increased expression of SQSTM1 mRNA; Swainsonine results in increased expression of SQSTM1 protein [bafilomycin A1 co-treated with Swainsonine] results in increased expression of SQSTM1 mRNA; [bafilomycin A1 co-treated with Swainsonine] results in increased lipidation of SQSTM1 protein |
CTD |
PMID:36402259 PMID:37442287 |
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NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
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G |
Tfeb |
transcription factor EB |
decreases expression |
EXP |
Swainsonine results in decreased expression of TFEB protein |
CTD |
PMID:33186601 |
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NCBI chr 9:13,198,890...13,254,726
Ensembl chr 9:13,198,891...13,254,714
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G |
Tp53 |
tumor protein p53 |
increases expression |
ISO |
Swainsonine results in increased expression of TRP53 protein |
CTD |
PMID:36402259 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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