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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:swainsonine
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Accession:CHEBI:9367 term browser browse the term
Definition:An indolizidine alkaloid isolated from the plant Swainsona canescens with three hydroxy substituents at positions 1, 2 and 8.
Synonyms:related_synonym: Formula=C8H15NO3;   InChI=1S/C8H15NO3/c10-5-2-1-3-9-4-6(11)8(12)7(5)9/h5-8,10-12H,1-4H2/t5-,6-,7-,8-/m1/s1;   InChIKey=FXUAIOOAOAVCGD-WCTZXXKLSA-N;   SMILES=[H][C@]12[C@H](O)CCCN1C[C@@H](O)[C@H]2O;   tridolgosir
 xref: CAS:72741-87-8;   DrugBank:DB02034;   KEGG:C10173;   KNApSAcK:C00002075
 xref_mesh: MESH:D017026
 xref: PDBeChem:SWA;   PMID:22281718;   PMID:22544335;   PMID:22578623;   Reaxys:4175740;   Wikipedia:Swainsonine


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swainsonine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm1 apoptosis inducing factor, mitochondria associated 1 increases expression EXP Swainsonine results in increased expression of AIFM1 protein CTD PMID:33186601 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256
JBrowse link
G Becn1 beclin 1 multiple interactions
increases expression
EXP [Swainsonine co-treated with bafilomycin A1] results in increased expression of BECN1 protein
Swainsonine results in increased expression of BECN1 protein
CTD PMID:33186601 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
EXP [Swainsonine co-treated with aloxistatin] results in increased cleavage of CASP3 protein; [Swainsonine co-treated with bafilomycin A1] results in increased cleavage of CASP3 protein
Swainsonine results in increased cleavage of CASP3 protein
CTD PMID:33186601 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases cleavage EXP Swainsonine results in increased cleavage of CASP8 protein CTD PMID:33186601 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases cleavage
multiple interactions
EXP Swainsonine results in increased cleavage of CASP9 protein
[Swainsonine co-treated with Sirolimus] results in increased cleavage of CASP9 protein
CTD PMID:33186601 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ctsd cathepsin D decreases expression EXP Swainsonine results in decreased expression of CTSD protein CTD PMID:33186601 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
JBrowse link
G Faslg Fas ligand increases expression EXP Swainsonine results in increased expression of FASLG protein CTD PMID:33186601 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Tfeb transcription factor EB decreases expression EXP Swainsonine results in decreased expression of TFEB protein CTD PMID:33186601 NCBI chr 9:13,198,890...13,254,726
Ensembl chr 9:13,198,891...13,254,714
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      biological role 19769
        immunomodulator 14893
          immunological adjuvant 601
            swainsonine 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic molecule 19569
                              organic cyclic compound 19360
                                organic heterocyclic compound 18591
                                  organic heteropolycyclic compound 18064
                                    organic heterobicyclic compound 16868
                                      indolizines 58
                                        indolizidine alkaloid 20
                                          swainsonine 8
paths to the root