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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:indolizines
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Accession:CHEBI:38485 term browser browse the term


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Corynoxine B term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO corynoxine B inhibits the reaction [manganese chloride promotes the reaction [BCL2 protein binds to BECN1 protein]] CTD PMID:30578841 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Becn1 beclin 1 multiple interactions ISO corynoxine B affects the reaction [manganese chloride affects the reaction [HMGB1 protein binds to BECN1 protein]]; corynoxine B inhibits the reaction [manganese chloride promotes the reaction [BCL2 protein binds to BECN1 protein]] CTD PMID:30578841 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions
decreases phosphorylation
ISO corynoxine B promotes the reaction [manganese chloride results in decreased phosphorylation of EIF4EBP1 protein]
corynoxine B results in decreased phosphorylation of EIF4EBP1 protein
CTD PMID:30578841 NCBI chr16:68,954,860...68,968,248
Ensembl chr16:68,954,875...68,968,248
JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions ISO corynoxine B affects the reaction [manganese chloride affects the reaction [HMGB1 protein binds to BECN1 protein]]; corynoxine B inhibits the reaction [manganese chloride promotes the reaction [HMGB1 protein binds to SNCA protein]] CTD PMID:30578841 NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
decreases phosphorylation
ISO corynoxine B promotes the reaction [manganese chloride results in decreased phosphorylation of MTOR protein]
corynoxine B results in decreased phosphorylation of MTOR protein
CTD PMID:30578841 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions
decreases phosphorylation
ISO corynoxine B promotes the reaction [manganese chloride results in decreased phosphorylation of RPS6KB1 protein]
corynoxine B results in decreased phosphorylation of RPS6KB1 protein
CTD PMID:30578841 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G Snca synuclein alpha multiple interactions ISO corynoxine B inhibits the reaction [manganese chloride promotes the reaction [HMGB1 protein binds to SNCA protein]] CTD PMID:30578841 NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions ISO corynoxine B affects the reaction [manganese chloride affects the expression of SQSTM1 protein] CTD PMID:30578841 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
lycorine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccnd3 cyclin D3 decreases expression ISO lycorine results in decreased expression of CCND3 mRNA CTD PMID:23376478 NCBI chr 9:15,404,816...15,410,905
Ensembl chr 9:15,404,822...15,410,943
JBrowse link
G Cdh5 cadherin 5 decreases expression ISO lycorine results in decreased expression of CDH5 mRNA CTD PMID:23376478 NCBI chr19:1,025,122...1,074,333
Ensembl chr19:1,023,683...1,074,365
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO lycorine results in increased expression of CDKN1A mRNA CTD PMID:23376478 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Il6 interleukin 6 multiple interactions ISO lycorine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] CTD PMID:22155741 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO lycorine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK14 protein] CTD PMID:22155741 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO lycorine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; lycorine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:22155741 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO lycorine inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:22155741 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Sema4d semaphorin 4D decreases expression ISO lycorine results in decreased expression of SEMA4D mRNA CTD PMID:23376478 NCBI chr17:13,516,276...13,538,513
Ensembl chr17:13,488,376...13,553,974
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO lycorine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein] CTD PMID:22155741 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO lycorine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT3 protein] CTD PMID:22155741 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO lycorine inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:22155741 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO lycorine results in decreased expression of VEGFA mRNA CTD PMID:23376478 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
Rhynchophylline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B multiple interactions EXP rhyncophylline inhibits the reaction [Amphetamine results in increased expression of GRIN2B mRNA]; rhyncophylline inhibits the reaction [Amphetamine results in increased expression of GRIN2B protein] CTD PMID:20422365 NCBI chr 4:169,541,620...170,000,216
Ensembl chr 4:169,560,387...169,999,873
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP rhyncophylline inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of and results in increased secretion of IL1B protein] CTD PMID:31231976 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions EXP rhyncophylline inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of and results in increased secretion of IL6 protein] CTD PMID:31231976 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Jak2 Janus kinase 2 multiple interactions EXP rhyncophylline inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased phosphorylation of JAK2 protein] CTD PMID:31231976 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP rhyncophylline inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased phosphorylation of NFKBIA protein] CTD PMID:31231976 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP rhyncophylline inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased phosphorylation of RELA protein] CTD PMID:31231976 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions EXP rhyncophylline inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased phosphorylation of STAT3 protein] CTD PMID:31231976 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP rhyncophylline inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of and results in increased secretion of TNF protein] CTD PMID:31231976 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
Securinine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arhgap36 Rho GTPase activating protein 36 decreases expression ISO securinine results in decreased expression of ARHGAP36 mRNA CTD PMID:32662633 NCBI chr  X:136,460,227...136,495,646
Ensembl chr  X:136,460,215...136,495,646
JBrowse link
G Chga chromogranin A decreases expression ISO securinine results in decreased expression of CHGA mRNA CTD PMID:32662633 NCBI chr 6:126,434,226...126,445,569
Ensembl chr 6:126,434,226...126,445,568
JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 decreases expression ISO securinine results in decreased expression of CHRM3 mRNA CTD PMID:32662633 NCBI chr17:63,990,599...64,463,222
Ensembl chr17:63,990,599...63,994,169
JBrowse link
G Ddc dopa decarboxylase decreases expression ISO securinine results in decreased expression of DDC mRNA CTD PMID:32662633 NCBI chr14:91,905,919...91,996,816
Ensembl chr14:91,905,919...91,996,774
JBrowse link
G Eda2r ectodysplasin A2 receptor increases expression ISO securinine results in increased expression of EDA2R mRNA CTD PMID:32662633 NCBI chr  X:66,560,200...66,602,509
Ensembl chr  X:66,561,286...66,602,506
JBrowse link
G Fat1 FAT atypical cadherin 1 increases expression ISO securinine results in increased expression of FAT1 mRNA CTD PMID:32662633 NCBI chr16:50,372,150...50,501,716
Ensembl chr16:50,372,128...50,501,921
JBrowse link
G Fgf14 fibroblast growth factor 14 decreases expression ISO securinine results in decreased expression of FGF14 mRNA CTD PMID:32662633 NCBI chr15:110,382,274...111,077,027
Ensembl chr15:110,385,217...110,612,681
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO securinine results in increased expression of GCLM mRNA CTD PMID:32662633 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO securinine results in increased expression of GDF15 mRNA CTD PMID:32662633 NCBI chr16:20,555,395...20,557,978
Ensembl chr16:20,555,395...20,557,978
JBrowse link
G Hgf hepatocyte growth factor decreases expression ISO securinine results in decreased expression of HGF mRNA CTD PMID:32662633 NCBI chr 4:15,435,460...15,505,377
Ensembl chr 4:15,433,295...15,505,362
JBrowse link
G Id1 inhibitor of DNA binding 1, HLH protein increases expression ISO securinine results in increased expression of ID1 mRNA CTD PMID:32662633 NCBI chr 3:148,214,623...148,216,715
Ensembl chr 3:148,215,540...148,216,718
JBrowse link
G Id3 inhibitor of DNA binding 3, HLH protein increases expression ISO securinine results in increased expression of ID3 mRNA CTD PMID:32662633 NCBI chr 5:154,489,603...154,491,172
Ensembl chr 5:154,489,590...154,491,223
JBrowse link
G Insm2 INSM transcriptional repressor 2 decreases expression ISO securinine results in decreased expression of INSM2 mRNA CTD PMID:32662633 NCBI chr 6:76,380,681...76,386,240
Ensembl chr 6:76,383,446...76,384,933
JBrowse link
G Kif1c kinesin family member 1C increases expression ISO securinine results in increased expression of KIF1C mRNA CTD PMID:32662633 NCBI chr10:57,322,259...57,352,395
Ensembl chr10:57,322,331...57,351,353
JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 decreases expression ISO securinine results in decreased expression of MAP2K6 mRNA CTD PMID:32662633 NCBI chr10:98,707,160...98,823,054
Ensembl chr10:98,706,960...98,823,287
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO securinine results in decreased expression of MYC mRNA CTD PMID:32662633 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Neurog2 neurogenin 2 decreases expression ISO securinine results in decreased expression of NEUROG2 mRNA CTD PMID:32662633 NCBI chr 2:231,962,517...231,963,441
Ensembl chr 2:231,962,517...231,963,308
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO securinine results in increased expression of NQO1 mRNA; securinine results in increased expression of NQO1 protein CTD PMID:32662633 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Pdzrn3 PDZ domain containing RING finger 3 decreases expression ISO securinine results in decreased expression of PDZRN3 mRNA CTD PMID:32662633 NCBI chr 4:133,717,139...133,951,282
Ensembl chr 4:133,717,139...133,951,264
JBrowse link
G Plpp3 phospholipid phosphatase 3 decreases expression ISO securinine results in decreased expression of PPAP2B mRNA CTD PMID:32662633 NCBI chr 5:124,690,214...124,765,499
Ensembl chr 5:124,690,214...124,765,498
JBrowse link
G Rab27b RAB27B, member RAS oncogene family decreases expression ISO securinine results in decreased expression of RAB27B mRNA CTD PMID:32662633 NCBI chr18:68,486,006...68,644,595
Ensembl chr18:68,488,942...68,551,558
JBrowse link
G Serpine1 serpin family E member 1 increases expression ISO securinine results in increased expression of SERPINE1 mRNA CTD PMID:32662633 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Serpinf1 serpin family F member 1 decreases expression ISO securinine results in decreased expression of SERPINF1 mRNA CTD PMID:32662633 NCBI chr10:62,241,750...62,254,145
Ensembl chr10:62,241,756...62,254,287
JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO securinine results in increased expression of SQSTM1 mRNA CTD PMID:32662633 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Tfpi2 tissue factor pathway inhibitor 2 increases expression ISO securinine results in increased expression of TFPI2 mRNA CTD PMID:32662633 NCBI chr 4:28,947,951...28,953,261
Ensembl chr 4:28,947,965...28,953,067
JBrowse link
G Txnip thioredoxin interacting protein decreases expression ISO securinine results in decreased expression of TXNIP mRNA CTD PMID:32662633 NCBI chr 2:198,683,168...198,686,971
Ensembl chr 2:198,683,159...198,686,974
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19853
    chemical entity 19853
      atom 19851
        nonmetal atom 19733
          nitrogen atom 18620
            nitrogen molecular entity 18620
              organonitrogen compound 18395
                organonitrogen heterocyclic compound 17564
                  indolizines 50
                    1-Indolizidinone 0
                    2-amino-5-[(1-methoxy-2-methylindolizin-3-yl)carbonyl]benzoic acid 0
                    2-methyl-3-[oxo(thiophen-2-yl)methyl]-1-indolizinecarboxaldehyde 0
                    3-methyl-4-(7-methyl-2-indolizinyl)-1,2,5-oxadiazole 0
                    Camoensine 0
                    Carapanaubine 0
                    Corynoxine 0
                    Corynoxine B 8
                    Isorhynchophylline 0
                    LSM-1411 0
                    Lentiginosine 0
                    Macrophylline A 0
                    Macrophylline B 0
                    Macrophyllionium 0
                    Mitraphylline 0
                    Rhynchophylline 8
                    Securinine 26
                    Uncarine A 0
                    Uncarine B 0
                    Uncarine C 0
                    Uncarine D 0
                    Uncarine E 0
                    Uncarine F 0
                    indolizidine alkaloid + 12
                    indolizine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19853
    subatomic particle 19851
      composite particle 19851
        hadron 19851
          baryon 19851
            nucleon 19851
              atomic nucleus 19851
                atom 19851
                  main group element atom 19744
                    p-block element atom 19744
                      p-block molecular entity 19744
                        carbon group molecular entity 19650
                          organic molecular entity 19639
                            organic molecule 19568
                              organic cyclic compound 19378
                                organic heterocyclic compound 18495
                                  organic heteropolycyclic compound 17883
                                    organic heterobicyclic compound 16814
                                      indolizines 50
                                        1-Indolizidinone 0
                                        2-amino-5-[(1-methoxy-2-methylindolizin-3-yl)carbonyl]benzoic acid 0
                                        2-methyl-3-[oxo(thiophen-2-yl)methyl]-1-indolizinecarboxaldehyde 0
                                        3-methyl-4-(7-methyl-2-indolizinyl)-1,2,5-oxadiazole 0
                                        Camoensine 0
                                        Carapanaubine 0
                                        Corynoxine 0
                                        Corynoxine B 8
                                        Isorhynchophylline 0
                                        LSM-1411 0
                                        Lentiginosine 0
                                        Macrophylline A 0
                                        Macrophylline B 0
                                        Macrophyllionium 0
                                        Mitraphylline 0
                                        Rhynchophylline 8
                                        Securinine 26
                                        Uncarine A 0
                                        Uncarine B 0
                                        Uncarine C 0
                                        Uncarine D 0
                                        Uncarine E 0
                                        Uncarine F 0
                                        indolizidine alkaloid + 12
                                        indolizine 0
paths to the root