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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:indolizines
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Accession:CHEBI:38485 term browser browse the term


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Corynoxine B term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO corynoxine B inhibits the reaction [manganese chloride promotes the reaction [BCL2 protein binds to BECN1 protein]] CTD PMID:30578841 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Becn1 beclin 1 multiple interactions ISO corynoxine B affects the reaction [manganese chloride affects the reaction [HMGB1 protein binds to BECN1 protein]]; corynoxine B inhibits the reaction [manganese chloride promotes the reaction [BCL2 protein binds to BECN1 protein]] CTD PMID:30578841 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions
decreases phosphorylation		 ISO corynoxine B promotes the reaction [manganese chloride results in decreased phosphorylation of EIF4EBP1 protein]
corynoxine B results in decreased phosphorylation of EIF4EBP1 protein		 CTD PMID:30578841 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984 		JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions ISO corynoxine B affects the reaction [manganese chloride affects the reaction [HMGB1 protein binds to BECN1 protein]]; corynoxine B inhibits the reaction [manganese chloride promotes the reaction [HMGB1 protein binds to SNCA protein]] CTD PMID:30578841 NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
decreases phosphorylation		 ISO corynoxine B promotes the reaction [manganese chloride results in decreased phosphorylation of MTOR protein]
corynoxine B results in decreased phosphorylation of MTOR protein		 CTD PMID:30578841 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions
decreases phosphorylation		 ISO corynoxine B promotes the reaction [manganese chloride results in decreased phosphorylation of RPS6KB1 protein]
corynoxine B results in decreased phosphorylation of RPS6KB1 protein		 CTD PMID:30578841 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G Snca synuclein alpha multiple interactions ISO corynoxine B inhibits the reaction [manganese chloride promotes the reaction [HMGB1 protein binds to SNCA protein]] CTD PMID:30578841 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions ISO corynoxine B affects the reaction [manganese chloride affects the expression of SQSTM1 protein] CTD PMID:30578841 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
lycorine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccnd3 cyclin D3 decreases expression ISO lycorine results in decreased expression of CCND3 mRNA CTD PMID:23376478 NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371 		JBrowse link
G Cdh5 cadherin 5 decreases expression ISO lycorine results in decreased expression of CDH5 mRNA CTD PMID:23376478 NCBI chr19:815,415...854,478
Ensembl chr19:815,411...854,368 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO lycorine results in increased expression of CDKN1A mRNA CTD PMID:23376478 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO lycorine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] CTD PMID:22155741 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO lycorine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK14 protein] CTD PMID:22155741 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO lycorine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; lycorine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:22155741 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO lycorine inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:22155741 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Sema4d semaphorin 4D decreases expression ISO lycorine results in decreased expression of SEMA4D mRNA CTD PMID:23376478 NCBI chr17:13,430,324...13,537,146
Ensembl chr17:13,430,379...13,537,138 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO lycorine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein] CTD PMID:22155741 NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO lycorine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT3 protein] CTD PMID:22155741 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO lycorine inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:22155741 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO lycorine results in decreased expression of VEGFA mRNA CTD PMID:23376478 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Rhynchophylline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one affects the reaction [[gastrodin co-treated with rhyncophylline] affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of CASP3 mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [[gastrodin co-treated with rhyncophylline] affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of CASP3 mRNA]]; [gastrodin co-treated with rhyncophylline] affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of CASP3 mRNA]; Lithium Chloride affects the reaction [[gastrodin co-treated with rhyncophylline] affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of CASP3 mRNA]] CTD PMID:33645131 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B multiple interactions EXP rhyncophylline inhibits the reaction [Amphetamine results in increased expression of GRIN2B mRNA]; rhyncophylline inhibits the reaction [Amphetamine results in increased expression of GRIN2B protein] CTD PMID:20422365 NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP
ISO		 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one affects the reaction [[gastrodin co-treated with rhyncophylline] affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of HMOX1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [[gastrodin co-treated with rhyncophylline] affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of HMOX1 protein]]; [gastrodin co-treated with rhyncophylline] affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of HMOX1 protein]; Lithium Chloride affects the reaction [[gastrodin co-treated with rhyncophylline] affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of HMOX1 protein]]
rhyncophylline inhibits the reaction [Paraquat results in decreased expression of HMOX1 mRNA]		 CTD PMID:33645131 PMID:33838153 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP rhyncophylline inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of and results in increased secretion of IL1B protein] CTD PMID:31231976 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP rhyncophylline inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of and results in increased secretion of IL6 protein] CTD PMID:31231976 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 multiple interactions ISO rhyncophylline inhibits the reaction [Paraquat results in increased phosphorylation of IRAK1 protein]; TOLLIP protein promotes the reaction [rhyncophylline inhibits the reaction [Paraquat results in increased phosphorylation of IRAK1 protein]] CTD PMID:33838153 NCBI chr  X:151,768,621...151,778,521
Ensembl chr  X:151,768,777...151,778,521 		JBrowse link
G Jak2 Janus kinase 2 multiple interactions EXP rhyncophylline inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased phosphorylation of JAK2 protein] CTD PMID:31231976 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Lcn2 lipocalin 2 multiple interactions ISO rhyncophylline inhibits the reaction [Paraquat results in increased secretion of LCN2 protein] CTD PMID:33838153 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO rhyncophylline inhibits the reaction [Paraquat results in decreased expression of NFE2L2 protein] CTD PMID:33838153 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP rhyncophylline inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased phosphorylation of NFKBIA protein] CTD PMID:31231976 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP
ISO		 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one affects the reaction [[gastrodin co-treated with rhyncophylline] affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of NQO1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [[gastrodin co-treated with rhyncophylline] affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of NQO1 protein]]; [gastrodin co-treated with rhyncophylline] affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of NQO1 protein]; Lithium Chloride affects the reaction [[gastrodin co-treated with rhyncophylline] affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of NQO1 protein]]
rhyncophylline inhibits the reaction [Paraquat results in decreased expression of NQO1 mRNA]		 CTD PMID:33645131 PMID:33838153 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP rhyncophylline inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased phosphorylation of RELA protein] CTD PMID:31231976 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions EXP rhyncophylline inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased phosphorylation of STAT3 protein] CTD PMID:31231976 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP rhyncophylline inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of and results in increased secretion of TNF protein] CTD PMID:31231976 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tollip toll interacting protein increases expression
multiple interactions		 ISO rhyncophylline results in increased expression of TOLLIP mRNA; rhyncophylline results in increased expression of TOLLIP protein
rhyncophylline promotes the reaction [Paraquat results in increased expression of TOLLIP mRNA]; rhyncophylline promotes the reaction [Paraquat results in increased expression of TOLLIP protein]; TOLLIP protein promotes the reaction [rhyncophylline inhibits the reaction [Paraquat results in increased phosphorylation of IRAK1 protein]]		 CTD PMID:33838153 NCBI chr 1:196,961,585...196,984,252
Ensembl chr 1:196,950,771...196,983,625 		JBrowse link
Securinine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arhgap36 Rho GTPase activating protein 36 decreases expression ISO securinine results in decreased expression of ARHGAP36 mRNA CTD PMID:32662633 NCBI chr  X:128,780,148...128,787,169
Ensembl chr  X:128,751,900...128,787,161 		JBrowse link
G Chga chromogranin A decreases expression ISO securinine results in decreased expression of CHGA mRNA CTD PMID:32662633 NCBI chr 6:121,696,051...121,707,399
Ensembl chr 6:121,696,051...121,707,398 		JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 decreases expression ISO securinine results in decreased expression of CHRM3 mRNA CTD PMID:32662633 NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278 		JBrowse link
G Ddc dopa decarboxylase decreases expression ISO securinine results in decreased expression of DDC mRNA CTD PMID:32662633 NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208 		JBrowse link
G Eda2r ectodysplasin A2 receptor increases expression ISO securinine results in increased expression of EDA2R mRNA CTD PMID:32662633 NCBI chr  X:62,224,763...62,269,333
Ensembl chr  X:62,228,229...62,269,268 		JBrowse link
G Fat1 FAT atypical cadherin 1 increases expression ISO securinine results in increased expression of FAT1 mRNA CTD PMID:32662633 NCBI chr16:47,177,253...47,296,261
Ensembl chr16:47,177,248...47,296,107 		JBrowse link
G Fgf14 fibroblast growth factor 14 decreases expression ISO securinine results in decreased expression of FGF14 mRNA CTD PMID:32662633 NCBI chr15:101,045,033...101,679,888
Ensembl chr15:101,045,036...101,679,900 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO securinine results in increased expression of GCLM mRNA CTD PMID:32662633 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO securinine results in increased expression of GDF15 mRNA CTD PMID:32662633 NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055 		JBrowse link
G Hgf hepatocyte growth factor decreases expression ISO securinine results in decreased expression of HGF mRNA CTD PMID:32662633 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409 		JBrowse link
G Hsf1 heat shock transcription factor 1 increases activity ISO securinine results in increased activity of HSF1 protein CTD PMID:34170685 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011 		JBrowse link
G Id1 inhibitor of DNA binding 1 increases expression ISO securinine results in increased expression of ID1 mRNA CTD PMID:32662633 NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419 		JBrowse link
G Id3 inhibitor of DNA binding 3 increases expression ISO securinine results in increased expression of ID3 mRNA CTD PMID:32662633 NCBI chr 5:148,372,784...148,374,353
Ensembl chr 5:148,372,762...148,374,349 		JBrowse link
G Insm2 INSM transcriptional repressor 2 decreases expression ISO securinine results in decreased expression of INSM2 mRNA CTD PMID:32662633 NCBI chr 6:72,973,861...72,976,453 JBrowse link
G Kif1c kinesin family member 1C increases expression ISO securinine results in increased expression of KIF1C mRNA CTD PMID:32662633 NCBI chr10:55,414,412...55,444,587
Ensembl chr10:55,415,900...55,443,545 		JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 decreases expression ISO securinine results in decreased expression of MAP2K6 mRNA CTD PMID:32662633 NCBI chr10:95,373,304...95,490,406
Ensembl chr10:95,373,204...95,488,293 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO securinine results in decreased expression of MYC mRNA CTD PMID:32662633 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Neurog2 neurogenin 2 decreases expression ISO securinine results in decreased expression of NEUROG2 mRNA CTD PMID:32662633 NCBI chr 2:216,092,709...216,095,276
Ensembl chr 2:216,093,363...216,094,154 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO securinine results in increased expression of NQO1 mRNA; securinine results in increased expression of NQO1 protein CTD PMID:32662633 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Pdzrn3 PDZ domain containing RING finger 3 decreases expression ISO securinine results in decreased expression of PDZRN3 mRNA CTD PMID:32662633 NCBI chr 4:133,770,736...133,996,959
Ensembl chr 4:133,770,736...133,996,959 		JBrowse link
G Plpp3 phospholipid phosphatase 3 decreases expression ISO securinine results in decreased expression of PLPP3 mRNA CTD PMID:32662633 NCBI chr 5:119,927,085...120,002,206
Ensembl chr 5:119,927,085...120,002,205 		JBrowse link
G Rab27b RAB27B, member RAS oncogene family decreases expression ISO securinine results in decreased expression of RAB27B mRNA CTD PMID:32662633 NCBI chr18:63,597,554...63,794,124
Ensembl chr18:63,600,937...63,757,180 		JBrowse link
G Rnu6atac RNA, U6atac small nuclear increases expression ISO securinine results in increased expression of RNU6ATAC mRNA CTD PMID:32662633 NCBI chr 2:211,550,817...211,550,946
Ensembl chr 2:211,550,817...211,550,946 		JBrowse link
G Serpine1 serpin family E member 1 increases expression ISO securinine results in increased expression of SERPINE1 mRNA CTD PMID:32662633 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Serpinf1 serpin family F member 1 decreases expression ISO securinine results in decreased expression of SERPINF1 mRNA CTD PMID:32662633 NCBI chr10:60,250,198...60,262,593
Ensembl chr10:60,249,708...60,262,646 		JBrowse link
G Snord72 small nucleolar RNA, C/D box 72 decreases expression ISO securinine results in decreased expression of SNORD72 mRNA CTD PMID:32662633 NCBI chr 2:54,217,160...54,217,239
Ensembl chr 2:54,217,160...54,217,239 		JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO securinine results in increased expression of SQSTM1 mRNA CTD PMID:32662633 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Tfpi2 tissue factor pathway inhibitor 2 increases expression ISO securinine results in increased expression of TFPI2 mRNA CTD PMID:32662633 NCBI chr 4:31,981,786...31,986,707
Ensembl chr 4:31,982,178...31,986,600 		JBrowse link
G Txnip thioredoxin interacting protein decreases expression ISO securinine results in decreased expression of TXNIP mRNA CTD PMID:32662633 NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886 		JBrowse link
swainsonine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm1 apoptosis inducing factor, mitochondria associated 1 increases expression EXP Swainsonine results in increased expression of AIFM1 protein CTD PMID:33186601 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO Swainsonine results in decreased phosphorylation of AKT1 protein CTD PMID:36402259 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Atg5 autophagy related 5 multiple interactions
increases expression		 ISO
EXP		 [bafilomycin A1 co-treated with Swainsonine] results in increased expression of ATG5 mRNA; [bafilomycin A1 co-treated with Swainsonine] results in increased lipidation of ATG5 protein
Swainsonine results in increased expression of ATG5 mRNA; Swainsonine results in increased expression of ATG5 protein		 CTD PMID:36402259 PMID:37442287 NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209 		JBrowse link
G Atp6v1a ATPase H+ transporting V1 subunit A multiple interactions
decreases expression
increases expression		 EXP Trehalose inhibits the reaction [Swainsonine results in decreased expression of ATP6V1A protein]
Swainsonine results in increased expression of ATP6V1A mRNA		 CTD PMID:38579922 NCBI chr11:56,561,444...56,614,694
Ensembl chr11:56,560,974...56,614,694 		JBrowse link
G Becn1 beclin 1 multiple interactions
increases expression		 EXP
ISO		 [Swainsonine co-treated with bafilomycin A1] results in increased expression of BECN1 protein
Swainsonine results in increased expression of BECN1 protein
Swainsonine results in increased expression of BECN1 mRNA; Swainsonine results in increased expression of BECN1 protein		 CTD PMID:33186601 PMID:36402259 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage		 EXP [Swainsonine co-treated with aloxistatin] results in increased cleavage of CASP3 protein; [Swainsonine co-treated with bafilomycin A1] results in increased cleavage of CASP3 protein
Swainsonine results in increased cleavage of CASP3 protein		 CTD PMID:33186601 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 increases cleavage EXP Swainsonine results in increased cleavage of CASP8 protein CTD PMID:33186601 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases cleavage
multiple interactions		 EXP Swainsonine results in increased cleavage of CASP9 protein
[Swainsonine co-treated with Sirolimus] results in increased cleavage of CASP9 protein		 CTD PMID:33186601 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ctsb cathepsin B decreases expression
multiple interactions
increases expression		 EXP Swainsonine results in decreased expression of CTSB protein
Trehalose inhibits the reaction [Swainsonine results in decreased expression of CTSB protein]
Swainsonine results in increased expression of CTSB mRNA		 CTD PMID:38579922 NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500 		JBrowse link
G Ctsd cathepsin D decreases expression
multiple interactions
increases expression		 EXP Swainsonine results in decreased expression of CTSD protein
[Swainsonine affects the glycosylation of CTSD protein] which results in decreased expression of CTSD protein modified form; Trehalose inhibits the reaction [Swainsonine results in decreased expression of CTSD protein]
Swainsonine results in increased expression of CTSD mRNA		 CTD PMID:33186601 PMID:37442287 PMID:38579922 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488 		JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 decreases phosphorylation ISO Swainsonine results in decreased phosphorylation of EIF4EBP1 protein CTD PMID:36402259 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984 		JBrowse link
G Faslg Fas ligand increases expression EXP Swainsonine results in increased expression of FASLG protein CTD PMID:33186601 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Gfpt1 glutamine fructose-6-phosphate transaminase 1 decreases expression EXP Swainsonine results in decreased expression of GFAT1 protein CTD PMID:37442287 NCBI chr 4:119,496,691...119,546,472
Ensembl chr 4:119,496,714...119,546,471 		JBrowse link
G Lamp1 lysosomal-associated membrane protein 1 multiple interactions
increases expression		 ISO [bafilomycin A1 co-treated with Swainsonine] results in increased expression of LAMP1 mRNA; [bafilomycin A1 co-treated with Swainsonine] results in increased expression of LAMP1 protein
Swainsonine results in increased expression of LAMP1 mRNA; Swainsonine results in increased expression of LAMP1 protein		 CTD PMID:36402259 NCBI chr16:76,355,982...76,380,700
Ensembl chr16:76,355,984...76,381,883 		JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 increases expression
decreases expression
multiple interactions		 EXP Swainsonine results in increased expression of LAMP2 mRNA
Swainsonine results in decreased expression of LAMP2 protein
Trehalose inhibits the reaction [Swainsonine results in decreased expression of LAMP2 protein]		 CTD PMID:38579922 NCBI chr  X:117,173,097...117,222,090
Ensembl chr  X:117,057,606...117,260,522 		JBrowse link
G Man2a1 mannosidase, alpha, class 2A, member 1 multiple interactions
decreases expression		 ISO bafilomycin A1 inhibits the reaction [Swainsonine results in decreased expression of MAN2A1 mRNA] CTD PMID:36402259 NCBI chr 9:104,252,001...104,408,349
Ensembl chr 9:104,252,001...104,408,349 		JBrowse link
G Man2b1 mannosidase, alpha, class 2B, member 1 multiple interactions
decreases expression		 ISO bafilomycin A1 inhibits the reaction [Swainsonine results in decreased expression of MAN2B1 mRNA] CTD PMID:36402259 NCBI chr19:23,055,092...23,074,398
Ensembl chr19:23,055,097...23,074,389 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
increases expression
increases lipidation		 ISO
EXP		 [bafilomycin A1 co-treated with Swainsonine] results in increased expression of MAP1LC3B mRNA; [bafilomycin A1 co-treated with Swainsonine] results in increased lipidation of MAP1LC3B protein
Swainsonine results in increased expression of MAP1LC3B mRNA
Swainsonine results in increased lipidation of MAP1LC3B protein
Swainsonine results in increased localization of and results in increased lipidation of MAP1LC3B protein
Swainsonine results in increased expression of MAP1LC3B protein		 CTD PMID:36402259 PMID:37442287 PMID:38579922 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO Swainsonine results in decreased phosphorylation of MAPK1 protein CTD PMID:36402259 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO Swainsonine results in decreased phosphorylation of MAPK3 protein CTD PMID:36402259 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation ISO Swainsonine results in decreased phosphorylation of MTOR protein CTD PMID:36402259 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 decreases phosphorylation ISO Swainsonine results in decreased phosphorylation of PIK3R1 protein CTD PMID:36402259 NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases phosphorylation ISO Swainsonine results in decreased phosphorylation of RPS6KB1 protein CTD PMID:36402259 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G Sqstm1 sequestosome 1 increases expression
multiple interactions		 ISO
EXP		 Swainsonine results in increased expression of SQSTM1 mRNA; Swainsonine results in increased expression of SQSTM1 protein
[bafilomycin A1 co-treated with Swainsonine] results in increased expression of SQSTM1 mRNA; [bafilomycin A1 co-treated with Swainsonine] results in increased lipidation of SQSTM1 protein
Trehalose inhibits the reaction [Swainsonine results in increased expression of SQSTM1 protein]		 CTD PMID:36402259 PMID:37442287 PMID:38579922 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Tfeb transcription factor EB decreases expression
increases expression
multiple interactions		 EXP Swainsonine results in decreased expression of TFEB protein
Swainsonine results in increased expression of TFEB mRNA
Trehalose inhibits the reaction [Swainsonine results in decreased expression of TFEB protein]		 CTD PMID:33186601 PMID:38579922 NCBI chr 9:13,198,890...13,254,726
Ensembl chr 9:13,198,891...13,254,714 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO Swainsonine results in increased expression of TRP53 protein CTD PMID:36402259 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19932
    chemical entity 19930
      atom 19930
        nonmetal atom 19859
          nitrogen atom 19024
            nitrogen molecular entity 19024
              organonitrogen compound 18871
                organonitrogen heterocyclic compound 18179
                  indolizines 79
                    (1S,2R,8aS)-1,2-Dihydroxyindolizidine 0
                    1-Indolizidinone 0
                    2-amino-5-[(1-methoxy-2-methylindolizin-3-yl)carbonyl]benzoic acid 0
                    2-methyl-3-[oxo(thiophen-2-yl)methyl]-1-indolizinecarboxaldehyde 0
                    3-((3R,5S)-3-butyloctahydroindolizin-5-yl)propan-1-ol 0
                    3-methyl-4-(7-methyl-2-indolizinyl)-1,2,5-oxadiazole 0
                    Allosecurinine 0
                    Camoensine 0
                    Carapanaubine 0
                    Corynoxine 0
                    Corynoxine B 8
                    Cyclizidine 0
                    Cyclizidine B 0
                    Cyclizidine C 0
                    Cyclizidine D 0
                    Cyclizidine G 0
                    Cyclizidine H 0
                    Cyclizidine I 0
                    Dihydrosecurinine 0
                    Grandisine C 0
                    Isomajdine 0
                    Isopteropodin 0
                    Isorhynchophylline 0
                    JBIR-102 0
                    LSM-1411 0
                    Lentiginosine 0
                    Macrophylline A 0
                    Macrophylline B 0
                    Macrophyllionium 0
                    Methyl (1S,4aS,5aR,6R,10aS)-6',7'-dimethoxy-1-methyl-2'-oxospiro[1,4a,5,5a,7,8,10,10a-octahydropyrano[3,4-f]indolizine-6,3'-1H-indole]-4-carboxylate 0
                    Mitraphylline 0
                    Pyreudione E 0
                    Rhynchophylline 15
                    Securinine 29
                    Sorbicillamine A 0
                    Spathullin C 0
                    Uncarine A 0
                    Uncarine B 0
                    Uncarine C 0
                    Uncarine D 0
                    Uncarine E 0
                    Uncarine F 0
                    Virosecurinine 0
                    [(1S)-6-Acetamido-1,2,3,5,6,7,8,8a-octahydroindolizin-1-yl] acetate 0
                    indolizidine alkaloid + 38
                    indolizine 0
                    pantocin A 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19932
    subatomic particle 19930
      composite particle 19930
        hadron 19930
          baryon 19930
            nucleon 19930
              atomic nucleus 19930
                atom 19930
                  main group element atom 19876
                    p-block element atom 19876
                      p-block molecular entity 19876
                        carbon group molecular entity 19816
                          organic molecular entity 19812
                            organic molecule 19764
                              organic cyclic compound 19553
                                organic heterocyclic compound 18905
                                  organic heteropolycyclic compound 18317
                                    organic heterobicyclic compound 17256
                                      indolizines 79
                                        (1S,2R,8aS)-1,2-Dihydroxyindolizidine 0
                                        1-Indolizidinone 0
                                        2-amino-5-[(1-methoxy-2-methylindolizin-3-yl)carbonyl]benzoic acid 0
                                        2-methyl-3-[oxo(thiophen-2-yl)methyl]-1-indolizinecarboxaldehyde 0
                                        3-((3R,5S)-3-butyloctahydroindolizin-5-yl)propan-1-ol 0
                                        3-methyl-4-(7-methyl-2-indolizinyl)-1,2,5-oxadiazole 0
                                        Allosecurinine 0
                                        Camoensine 0
                                        Carapanaubine 0
                                        Corynoxine 0
                                        Corynoxine B 8
                                        Cyclizidine 0
                                        Cyclizidine B 0
                                        Cyclizidine C 0
                                        Cyclizidine D 0
                                        Cyclizidine G 0
                                        Cyclizidine H 0
                                        Cyclizidine I 0
                                        Dihydrosecurinine 0
                                        Grandisine C 0
                                        Isomajdine 0
                                        Isopteropodin 0
                                        Isorhynchophylline 0
                                        JBIR-102 0
                                        LSM-1411 0
                                        Lentiginosine 0
                                        Macrophylline A 0
                                        Macrophylline B 0
                                        Macrophyllionium 0
                                        Methyl (1S,4aS,5aR,6R,10aS)-6',7'-dimethoxy-1-methyl-2'-oxospiro[1,4a,5,5a,7,8,10,10a-octahydropyrano[3,4-f]indolizine-6,3'-1H-indole]-4-carboxylate 0
                                        Mitraphylline 0
                                        Pyreudione E 0
                                        Rhynchophylline 15
                                        Securinine 29
                                        Sorbicillamine A 0
                                        Spathullin C 0
                                        Uncarine A 0
                                        Uncarine B 0
                                        Uncarine C 0
                                        Uncarine D 0
                                        Uncarine E 0
                                        Uncarine F 0
                                        Virosecurinine 0
                                        [(1S)-6-Acetamido-1,2,3,5,6,7,8,8a-octahydroindolizin-1-yl] acetate 0
                                        indolizidine alkaloid + 38
                                        indolizine 0
                                        pantocin A 0
paths to the root