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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:lycorine
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Accession:CHEBI:6601 term browser browse the term
Definition:An indolizidine alkaloid that is 3,12-didehydrogalanthan substituted by hydroxy groups at positions and 2 and a methylenedioxy group across positions 9 and 10. Isolated from Crinum asiaticum, it has been shown to exhibit antimalarial activity.
Synonyms:exact_synonym: 9,10-(methylenedioxy)-3,12-didehydrogalanthan-1alpha,2beta-diol
 related_synonym: Amarylline;   Formula=C16H17NO4;   Galanthidine;   InChI=1S/C16H17NO4/c18-11-3-8-1-2-17-6-9-4-12-13(21-7-20-12)5-10(9)14(15(8)17)16(11)19/h3-5,11,14-16,18-19H,1-2,6-7H2/t11-,14-,15+,16+/m0/s1;   InChIKey=XGVJWXAYKUHDOO-DANNLKNASA-N;   Licorine;   Narcissine;   SMILES=[H][C@]12[C@H](O)[C@@H](O)C=C3CCN(Cc4cc5OCOc5cc14)[C@@]23[H]
 xref: Beilstein:93605;   CAS:476-28-8;   KEGG:C08532;   KNApSAcK:C00001576
 xref_mesh: MESH:C015330
 xref: PDBeChem:3KD;   PMID:12232602;   PMID:14669261;   PMID:15386196;   PMID:19788245;   Reaxys:93605


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lycorine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccnd3 cyclin D3 decreases expression ISO lycorine results in decreased expression of CCND3 mRNA CTD PMID:23376478 NCBI chr 9:15,404,816...15,410,905
Ensembl chr 9:15,404,822...15,410,943
JBrowse link
G Cdh5 cadherin 5 decreases expression ISO lycorine results in decreased expression of CDH5 mRNA CTD PMID:23376478 NCBI chr19:1,025,122...1,074,333
Ensembl chr19:1,023,683...1,074,365
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO lycorine results in increased expression of CDKN1A mRNA CTD PMID:23376478 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Il6 interleukin 6 multiple interactions ISO lycorine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] CTD PMID:22155741 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO lycorine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK14 protein] CTD PMID:22155741 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO lycorine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; lycorine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:22155741 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO lycorine inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:22155741 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Sema4d semaphorin 4D decreases expression ISO lycorine results in decreased expression of SEMA4D mRNA CTD PMID:23376478 NCBI chr17:13,516,276...13,538,513
Ensembl chr17:13,488,376...13,553,974
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO lycorine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein] CTD PMID:22155741 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO lycorine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT3 protein] CTD PMID:22155741 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO lycorine inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:22155741 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO lycorine results in decreased expression of VEGFA mRNA CTD PMID:23376478 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        antimicrobial agent 17312
          antiviral agent 10246
            anticoronaviral agent 8941
              lycorine 12
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic molecule 19488
                              organic cyclic compound 19285
                                organic heterocyclic compound 18410
                                  organic heteropolycyclic compound 17824
                                    organic heterobicyclic compound 16744
                                      indolizines 50
                                        indolizidine alkaloid 12
                                          galanthan 12
                                            lycorine 12
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