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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:ketimine
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Accession:CHEBI:33272 term browser browse the term
Definition:Any imine derived from a ketone.
Synonyms:related_synonym: ketimines


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N-acetyl-1,4-benzoquinone imine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle increases expression
multiple interactions		 ISO N-acetyl-4-benzoquinoneimine results in increased expression of ACTA2 mRNA; N-acetyl-4-benzoquinoneimine results in increased expression of ACTA2 protein
andrographolide inhibits the reaction [N-acetyl-4-benzoquinoneimine results in increased expression of ACTA2 mRNA]; andrographolide inhibits the reaction [N-acetyl-4-benzoquinoneimine results in increased expression of ACTA2 protein]		 CTD PMID:28286204 PMID:29355602 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Adarb2 adenosine deaminase RNA specific B2 affects response to substance ISO ADARB2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr17:61,750,437...62,300,984
Ensembl chr17:61,756,067...62,300,831 		JBrowse link
G Alcam activated leukocyte cell adhesion molecule affects response to substance ISO ALCAM gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr11:48,336,123...48,536,296
Ensembl chr11:48,336,169...48,537,954 		JBrowse link
G Aldh1a3 aldehyde dehydrogenase 1 family, member A3 affects response to substance ISO ALDH1A3 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 1:119,982,272...120,017,416
Ensembl chr 1:119,982,277...120,017,436 		JBrowse link
G Bmp2 bone morphogenetic protein 2 increases expression ISO N-acetyl-4-benzoquinoneimine results in increased expression of BMP2 mRNA CTD PMID:28286204 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397 		JBrowse link
G Bpnt2 3'(2'), 5'-bisphosphate nucleotidase 2 affects response to substance ISO BPNT2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 5:17,775,684...17,802,570
Ensembl chr 5:17,772,608...17,802,570 		JBrowse link
G C11h3orf38 similar to human chromosome 3 open reading frame 38 affects response to substance ISO C3ORF38 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr11:2,483,983...2,488,631
Ensembl chr11:2,481,189...2,488,660 		JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H affects response to substance ISO CACNA1H gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr10:14,390,104...14,448,204
Ensembl chr10:14,390,113...14,448,376 		JBrowse link
G Cald1 caldesmon 1 affects response to substance ISO CALD1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 4:63,265,781...63,446,938
Ensembl chr 4:63,265,942...63,446,932 		JBrowse link
G Ccdc25 coiled-coil domain containing 25 affects response to substance ISO CCDC25 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr15:40,055,368...40,087,758
Ensembl chr15:40,055,368...40,087,758 		JBrowse link
G Cd9 CD9 molecule affects response to substance ISO CD9 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 4:158,256,328...158,289,136
Ensembl chr 4:158,256,328...158,289,222 		JBrowse link
G Cep44 centrosomal protein 44 affects response to substance ISO CEP44 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr16:33,711,548...33,733,226
Ensembl chr16:33,711,559...33,733,225 		JBrowse link
G Cnr1 cannabinoid receptor 1 affects response to substance ISO CNR1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099 		JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression
multiple interactions		 ISO N-acetyl-4-benzoquinoneimine results in increased expression of COL1A1 mRNA
andrographolide inhibits the reaction [N-acetyl-4-benzoquinoneimine results in increased expression of COL1A1 mRNA]		 CTD PMID:28286204 PMID:29355602 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Col1a2 collagen type I alpha 2 chain increases expression ISO N-acetyl-4-benzoquinoneimine results in increased expression of COL1A2 mRNA CTD PMID:28286204 NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867 		JBrowse link
G Col3a1 collagen type III alpha 1 chain increases expression
multiple interactions		 ISO N-acetyl-4-benzoquinoneimine results in increased expression of COL3A1 mRNA
andrographolide inhibits the reaction [N-acetyl-4-benzoquinoneimine results in increased expression of COL3A1 mRNA]		 CTD PMID:28286204 PMID:29355602 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547 		JBrowse link
G Cpa6 carboxypeptidase A6 affects response to substance ISO CPA6 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 5:8,526,708...8,888,492
Ensembl chr 5:8,526,741...8,888,485 		JBrowse link
G Cst5 cystatin D affects response to substance ISO CST5 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 3:137,573,194...137,577,754
Ensembl chr 3:137,573,194...137,577,754 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases abundance		 ISO CYP1A2 protein results in increased chemical synthesis of and results in increased abundance of N-acetyl-4-benzoquinoneimine
CYP1A2 protein results in increased abundance of N-acetyl-4-benzoquinoneimine		 CTD PMID:19679878 PMID:24661219 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases abundance ISO CYP2D6 protein results in increased abundance of N-acetyl-4-benzoquinoneimine CTD PMID:24661219 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
increases abundance
increases chemical synthesis		 ISO
EXP		 CYP2E1 protein results in increased chemical synthesis of and results in increased abundance of N-acetyl-4-benzoquinoneimine
CYP2E1 protein results in increased abundance of N-acetyl-4-benzoquinoneimine
CYP2E1 results in increased chemical synthesis of N-acetyl-4-benzoquinoneimine		 CTD PMID:19679878 PMID:20566340 PMID:24661219 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases abundance ISO CYP3A4 protein results in increased abundance of N-acetyl-4-benzoquinoneimine CTD PMID:24661219 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Dmrt1 doublesex and mab-3 related transcription factor 1 affects response to substance ISO DMRT1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 1:223,142,859...223,241,333
Ensembl chr 1:223,142,859...223,241,333 		JBrowse link
G Dnttip1 deoxynucleotidyltransferase, terminal, interacting protein 1 affects response to substance ISO DNTTIP1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 3:153,481,718...153,505,403
Ensembl chr 3:153,481,705...153,505,759 		JBrowse link
G Dsc3 desmocollin 3 affects response to substance ISO DSC3 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr18:11,379,759...11,413,797
Ensembl chr18:11,377,347...11,413,797 		JBrowse link
G Etnk2 ethanolamine kinase 2 affects response to substance ISO ETNK2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr13:44,811,012...44,829,052
Ensembl chr13:44,811,015...44,829,037 		JBrowse link
G Fbxo39 F-box protein 39 affects response to substance ISO FBXO39 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr10:56,929,699...56,934,911
Ensembl chr10:56,932,297...56,934,906 		JBrowse link
G Frk fyn-related Src family tyrosine kinase affects response to substance ISO FRK gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr20:38,265,416...38,371,038
Ensembl chr20:38,265,280...38,371,114 		JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions
affects response to substance		 ISO [GPX1 protein co-treated with SOD1 protein] affects the susceptibility to N-acetyl-4-benzoquinoneimine
GPX1 protein affects the susceptibility to N-acetyl-4-benzoquinoneimine		 CTD PMID:16636302 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 affects metabolic processing
multiple interactions
increases glutathionylation
increases metabolic processing		 ISO
EXP		 GSTP1 protein polymorphism affects the metabolism of N-acetyl-4-benzoquinoneimine metabolite
NQO1 protein inhibits the reaction [GSTP1 protein results in increased glutathionylation of N-acetyl-4-benzoquinoneimine]
GSTP1 protein results in increased metabolism of N-acetyl-4-benzoquinoneimine		 CTD PMID:24185126 PMID:24552538 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Hdac4 histone deacetylase 4 affects response to substance ISO HDAC4 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 9:92,503,467...92,750,164
Ensembl chr 9:92,507,611...92,750,164 		JBrowse link
G Hid1 HID1 domain containing affects response to substance ISO HID1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr10:100,589,555...100,610,050
Ensembl chr10:100,589,555...100,610,041 		JBrowse link
G Il23r interleukin 23 receptor affects response to substance ISO IL23R gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 4:96,580,568...96,672,540
Ensembl chr 4:96,580,714...96,674,021 		JBrowse link
G Kcnj3 potassium inwardly-rectifying channel, subfamily J, member 3 affects response to substance ISO KCNJ3 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 3:39,944,896...40,106,646
Ensembl chr 3:39,945,351...40,109,124 		JBrowse link
G Kcnu1 potassium calcium-activated channel subfamily U member 1 affects response to substance ISO KCNU1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr16:66,141,696...66,229,493
Ensembl chr16:66,141,976...66,229,465 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions
affects metabolic processing		 ISO KEAP1 protein inhibits the reaction [NQO1 protein results in increased metabolism of N-acetyl-4-benzoquinoneimine]
N-acetyl-4-benzoquinoneimine affects the metabolism of KEAP1 protein		 CTD PMID:18785192 PMID:19246624 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862 		JBrowse link
G Lama4 laminin subunit alpha 4 affects response to substance ISO LAMA4 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr20:42,392,268...42,533,347
Ensembl chr20:42,392,268...42,533,347 		JBrowse link
G Lmx1a LIM homeobox transcription factor 1 alpha affects response to substance ISO LMX1A gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr13:79,834,614...79,978,253
Ensembl chr13:79,835,019...79,978,253 		JBrowse link
G Magi2 membrane associated guanylate kinase, WW and PDZ domain containing 2 affects response to substance ISO MAGI2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 4:14,386,389...15,870,036
Ensembl chr 4:14,386,399...15,870,240 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO N-acetyl-4-benzoquinoneimine results in increased phosphorylation of MAPK1 protein CTD PMID:28286204 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO N-acetyl-4-benzoquinoneimine results in increased phosphorylation of MAPK3 protein CTD PMID:28286204 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mctp1 multiple C2 and transmembrane domain containing 1 affects response to substance ISO MCTP1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 2:6,071,408...6,761,833
Ensembl chr 2:6,065,808...6,761,833 		JBrowse link
G Mfsd4a major facilitator superfamily domain containing 4A affects response to substance ISO MFSD4A gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr13:43,469,488...43,510,467
Ensembl chr13:43,469,488...43,510,467 		JBrowse link
G Mir135a microRNA 135a affects response to substance ISO MIR135A2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 7:26,611,990...26,612,089
Ensembl chr 7:26,611,990...26,612,089 		JBrowse link
G Mmp2 matrix metallopeptidase 2 increases expression ISO N-acetyl-4-benzoquinoneimine results in increased expression of MMP2 mRNA CTD PMID:28286204 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mtus2 microtubule associated scaffold protein 2 affects response to substance ISO MTUS2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr12:6,706,531...7,078,331
Ensembl chr12:6,706,532...7,078,331 		JBrowse link
G Neb nebulin affects response to substance ISO NEB gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 3:36,613,677...36,811,618
Ensembl chr 3:36,613,716...36,811,574 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects localization
multiple interactions
increases activity		 ISO N-acetyl-4-benzoquinoneimine affects the localization of NFE2L2 protein
NFE2L2 protein affects the reaction [N-acetyl-4-benzoquinoneimine results in increased expression of NQO1 mRNA]; NFE2L2 protein promotes the reaction [NQO1 protein results in increased metabolism of N-acetyl-4-benzoquinoneimine]
N-acetyl-4-benzoquinoneimine results in increased activity of NFE2L2 protein		 CTD PMID:18785192 PMID:19246624 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nhlrc3 NHL repeat containing 3 affects response to substance ISO NHLRC3 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 2:137,527,843...137,542,258
Ensembl chr 2:137,530,012...137,534,879
Ensembl chr 2:137,530,012...137,534,879 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases reduction
increases metabolic processing
increases expression		 ISO KEAP1 protein inhibits the reaction [NQO1 protein results in increased metabolism of N-acetyl-4-benzoquinoneimine]; NFE2L2 protein affects the reaction [N-acetyl-4-benzoquinoneimine results in increased expression of NQO1 mRNA]; NFE2L2 protein promotes the reaction [NQO1 protein results in increased metabolism of N-acetyl-4-benzoquinoneimine]
NQO1 protein inhibits the reaction [GSTP1 protein results in increased glutathionylation of N-acetyl-4-benzoquinoneimine]
NQO1 protein results in increased reduction of N-acetyl-4-benzoquinoneimine		 CTD PMID:17188792 PMID:18785192 PMID:19246624 PMID:24552538 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nqo2 N-ribosyldihydronicotinamide:quinone dehydrogenase 2 multiple interactions ISO NQO2 protein results in increased reduction of and results in decreased glutathionylation of N-acetyl-4-benzoquinoneimine; Tacrine inhibits the reaction [NQO2 protein results in increased reduction of N-acetyl-4-benzoquinoneimine] CTD PMID:29281794 NCBI chr17:30,909,482...30,938,725
Ensembl chr17:30,909,187...30,938,320 		JBrowse link
G Pcbd2 pterin-4 alpha-carbinolamine dehydratase 2 affects response to substance ISO PCBD2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr17:8,845,161...8,896,343
Ensembl chr17:8,845,084...8,910,539 		JBrowse link
G Pvt1 Pvt1 oncogene affects response to substance ISO PVT1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 7:93,656,528...93,879,938 JBrowse link
G Rab3il1 RAB3A interacting protein-like 1 affects response to substance ISO RAB3IL1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 1:206,646,168...206,682,718
Ensembl chr 1:206,646,155...206,679,972 		JBrowse link
G Rap1gap2 RAP1 GTPase activating protein 2 affects response to substance ISO RAP1GAP2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr10:59,255,400...59,472,536
Ensembl chr10:59,255,278...59,472,170 		JBrowse link
G Slc39a11 solute carrier family 39, member 11 affects response to substance ISO SLC39A11 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr10:98,275,958...98,697,042
Ensembl chr10:98,275,960...98,611,295 		JBrowse link
G Slit2 slit guidance ligand 2 affects response to substance ISO SLIT2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr14:62,616,337...62,955,934
Ensembl chr14:62,617,067...62,955,948 		JBrowse link
G Snx16 sorting nexin 16 affects response to substance ISO SNX16 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 2:91,335,896...91,357,622
Ensembl chr 2:91,336,092...91,357,619 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO [GPX1 protein co-treated with SOD1 protein] affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:16636302 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Spag16 sperm associated antigen 16 affects response to substance ISO SPAG16 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 9:71,333,005...72,252,772
Ensembl chr 9:71,332,992...72,252,708 		JBrowse link
G Stab1 stabilin 1 affects response to substance ISO STAB1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr16:6,330,435...6,360,934
Ensembl chr16:6,330,444...6,360,923 		JBrowse link
G Syne3 spectrin repeat containing, nuclear envelope family member 3 affects response to substance ISO SYNE3 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 6:123,872,895...123,964,773
Ensembl chr 6:123,873,174...123,953,409 		JBrowse link
G Tac1 tachykinin, precursor 1 increases secretion EXP N-acetyl-4-benzoquinoneimine results in increased secretion of TAC1 protein CTD PMID:20720158 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression ISO N-acetyl-4-benzoquinoneimine results in increased expression of TGFB1 mRNA CTD PMID:28286204 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression ISO N-acetyl-4-benzoquinoneimine results in increased expression of TIMP1 mRNA CTD PMID:28286204 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Top2a DNA topoisomerase II alpha decreases activity ISO N-acetyl-4-benzoquinoneimine results in decreased activity of TOP2A protein CTD PMID:15035644 NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874 		JBrowse link
G Tpd52l1 TPD52 like 1 affects response to substance ISO TPD52L1 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 1:26,172,038...26,290,704
Ensembl chr 1:26,172,170...26,291,109 		JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 increases activity
affects response to substance
multiple interactions		 ISO
EXP		 N-acetyl-4-benzoquinoneimine results in increased activity of TRPA1 protein
TRPA1 affects the susceptibility to N-acetyl-4-benzoquinoneimine
2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-(4-isopropylphenyl)acetamide inhibits the reaction [N-acetyl-4-benzoquinoneimine results in increased activity of TRPA1 protein]		 CTD PMID:20720158 NCBI chr 5:4,379,862...4,434,133
Ensembl chr 5:4,379,999...4,433,570 		JBrowse link
G Txnrd1 thioredoxin reductase 1 decreases activity
multiple interactions		 EXP N-acetyl-4-benzoquinoneimine results in decreased activity of TXNRD1 protein
Glutathione inhibits the reaction [N-acetyl-4-benzoquinoneimine results in decreased activity of TXNRD1 protein]		 CTD PMID:24661219 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863 		JBrowse link
G Ubash3a ubiquitin associated and SH3 domain containing, A affects response to substance ISO UBASH3A gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr20:9,291,471...9,334,685
Ensembl chr20:9,292,139...9,329,224 		JBrowse link
G Ube2e2 ubiquitin-conjugating enzyme E2E 2 affects response to substance ISO UBE2E2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr15:6,980,241...7,257,912
Ensembl chr15:6,980,474...7,257,532 		JBrowse link
G Vwc2 von Willebrand factor C domain containing 2 affects response to substance ISO VWC2 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr14:85,683,670...85,825,068
Ensembl chr14:85,684,414...85,818,524 		JBrowse link
G Wfdc3 WAP four-disulfide core domain 3 affects response to substance ISO WFDC3 gene SNP affects the susceptibility to N-acetyl-4-benzoquinoneimine CTD PMID:21177773 NCBI chr 3:153,464,862...153,478,952
Ensembl chr 3:153,464,862...153,478,952 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19893
    chemical entity 19891
      atom 19891
        nonmetal atom 19814
          carbon atom 19767
            organic molecular entity 19767
              imine 194
                ketimine 73
                  (4S,5R)-4,5,6-trihydroxy-2-iminohexanoic acid 0
                  2,5-diimino-3,4-bis(indol-3-yl)hexanedioic acid 0
                  2-Ethyl-5-imino-1-cyclopenten-1-ol 0
                  2-imino-3-(indol-3-yl)propanoic acid + 0
                  2-iminobutanoic acid 0
                  2-iminopropionic acid 0
                  3,4-bis(7-chloroindol-3-yl)-2,5-diiminohexanedioic acid 0
                  5-Imino-2-methyl-1-cyclopenten-1-ol 0
                  5-iminohexane-1,2,3,4,6-pentol 0
                  Hemsleyin imine A 0
                  NSC 56820 0
                  azomethine 0
                  beta-aminoorceimine + 0
                  gamma-aminoorceimine + 0
                  iminoarginine 0
                  iminoaspartic acid 0
                  iminomalononitrile 0
                  ketoimine + 73
                  porphyra-334 0
                  shinorine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19893
    subatomic particle 19891
      composite particle 19891
        hadron 19891
          baryon 19891
            nucleon 19891
              atomic nucleus 19891
                atom 19891
                  main group element atom 19830
                    p-block element atom 19830
                      p-block molecular entity 19830
                        carbon group molecular entity 19771
                          organic molecular entity 19767
                            heteroorganic entity 19525
                              organonitrogen compound 18847
                                imine 194
                                  ketimine 73
                                    (4S,5R)-4,5,6-trihydroxy-2-iminohexanoic acid 0
                                    2,5-diimino-3,4-bis(indol-3-yl)hexanedioic acid 0
                                    2-Ethyl-5-imino-1-cyclopenten-1-ol 0
                                    2-imino-3-(indol-3-yl)propanoic acid + 0
                                    2-iminobutanoic acid 0
                                    2-iminopropionic acid 0
                                    3,4-bis(7-chloroindol-3-yl)-2,5-diiminohexanedioic acid 0
                                    5-Imino-2-methyl-1-cyclopenten-1-ol 0
                                    5-iminohexane-1,2,3,4,6-pentol 0
                                    Hemsleyin imine A 0
                                    NSC 56820 0
                                    azomethine 0
                                    beta-aminoorceimine + 0
                                    gamma-aminoorceimine + 0
                                    iminoarginine 0
                                    iminoaspartic acid 0
                                    iminomalononitrile 0
                                    ketoimine + 73
                                    porphyra-334 0
                                    shinorine 0
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