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N-methyl-D-aspartic acid - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:N-methyl-D-aspartic acid
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Accession:CHEBI:31882 term browser browse the term
Definition:An aspartic acid derivative having an N-methyl substituent and D-configuration.
Synonyms:related_synonym: (R)-2-Methylamino-succinic acid;   2-Methylamino-succinic acid;   Formula=C5H9NO4;   InChI=1S/C5H9NO4/c1-6-3(5(9)10)2-4(7)8/h3,6H,2H2,1H3,(H,7,8)(H,9,10)/t3-/m1/s1;   InChIKey=HOKKHZGPKSLGJE-GSVOUGTGSA-N;   Methyl aspartic acid;   N-Methyl aspartic acid;   N-Methyl-D-aspartate;   N-Methylaspartate;   NMDA;   SMILES=CN[C@H](CC(O)=O)C(O)=O
 alt_id: CHEBI:164776
 xref: CAS:6384-92-5;   HMDB:HMDB0002393;   KEGG:C12269
 xref_mesh: MESH:D016202
 xref: MetaCyc:CPD-10705;   PDBeChem:OEM;   PMID:10514280;   PMID:10893301;   PMID:1967316;   PMID:2170646;   PMID:3351864;   PMID:8568805;   PMID:9572889;   Reaxys:1724431;   Wikipedia:N-Methyl-D-aspartic_acid

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N-methyl-D-aspartic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions		 ISO N-Methylaspartate results in decreased phosphorylation of AKT1 protein
kukoamine B inhibits the reaction [N-Methylaspartate results in decreased phosphorylation of AKT1 protein]		 CTD PMID:26065936 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Atf4 activating transcription factor 4 multiple interactions ISO N-Methylaspartate results in decreased expression of [Esketamine results in increased expression of ATF4 protein] CTD PMID:38219984 NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 multiple interactions ISO N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of ATP1A1 protein] CTD PMID:34389372 NCBI chr 2:191,709,311...191,737,414
Ensembl chr 2:189,020,722...189,048,837 		JBrowse link
G Atp1a2 ATPase Na+/K+ transporting subunit alpha 2 multiple interactions ISO N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of ATP1A2 protein] CTD PMID:34389372 NCBI chr13:87,261,964...87,286,911
Ensembl chr13:84,729,601...84,754,544 		JBrowse link
G Atp2b1 ATPase plasma membrane Ca2+ transporting 1 multiple interactions ISO N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of ATP2B1 protein] CTD PMID:34389372 NCBI chr 7:35,622,267...35,731,904
Ensembl chr 7:33,735,871...33,843,295 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions		 ISO N-Methylaspartate results in increased expression of BAX protein
kukoamine B inhibits the reaction [N-Methylaspartate results in increased expression of BAX protein]; N-Methylaspartate affects the reaction [Esketamine affects the expression of BAX mRNA]		 CTD PMID:26065936 PMID:38219984 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression		 ISO kukoamine B inhibits the reaction [N-Methylaspartate results in decreased expression of BCL2 protein]; N-Methylaspartate affects the reaction [Esketamine affects the expression of BCL2 mRNA] CTD PMID:26065936 PMID:38219984 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Cacna1a calcium voltage-gated channel subunit alpha1 A multiple interactions ISO N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of CACNA1A protein] CTD PMID:34389372 NCBI chr19:40,425,560...40,724,810
Ensembl chr19:23,520,741...23,823,225 		JBrowse link
G Cacna1b calcium voltage-gated channel subunit alpha1 B multiple interactions ISO N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of CACNA1B protein] CTD PMID:34389372 NCBI chr 3:27,779,133...27,944,292
Ensembl chr 3:7,380,922...7,546,091 		JBrowse link
G Cacnb1 calcium voltage-gated channel auxiliary subunit beta 1 multiple interactions ISO N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of CACNB1 protein] CTD PMID:34389372 NCBI chr10:83,494,509...83,515,164
Ensembl chr10:82,998,182...83,018,694 		JBrowse link
G Cacnb4 calcium voltage-gated channel auxiliary subunit beta 4 multiple interactions ISO N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of CACNB4 protein] CTD PMID:34389372 NCBI chr 3:57,315,900...57,578,271
Ensembl chr 3:36,910,427...37,168,944 		JBrowse link
G Capn2 calpain 2 increases activity EXP NMDA increases activity of Capn2 in rat hippocampal neuron cultures RGD PMID:19141074 RGD:13792555 NCBI chr13:96,681,902...96,732,625
Ensembl chr13:94,150,240...94,200,969 		JBrowse link
G Cav1 caveolin 1 increases phosphorylation
multiple interactions		 ISO N-Methylaspartate results in increased phosphorylation of CAV1 protein
CAV1 protein affects the reaction [N-Methylaspartate results in decreased expression of TJP1 mRNA]; CAV1 protein affects the reaction [N-Methylaspartate results in decreased expression of TJP1 protein]; CAV1 protein affects the reaction [N-Methylaspartate results in increased phosphorylation of MAPK1 protein]; CAV1 protein affects the reaction [N-Methylaspartate results in increased phosphorylation of MAPK3 protein]		 CTD PMID:35257817 NCBI chr 4:46,606,538...46,639,616
Ensembl chr 4:45,634,918...45,673,705 		JBrowse link
G Cdk5 cyclin-dependent kinase 5 multiple interactions ISO N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of CDK5 protein] CTD PMID:34389372 NCBI chr 4:11,647,098...11,651,606
Ensembl chr 4:10,754,687...10,760,112 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions
decreases phosphorylation		 ISO kukoamine B inhibits the reaction [N-Methylaspartate results in decreased phosphorylation of CREB1 protein] CTD PMID:26065936 NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO N-Methylaspartate results in decreased expression of [Esketamine results in increased expression of DDIT3 protein] CTD PMID:38219984 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Ddo D-aspartate oxidase affects abundance ISO DDO protein affects the abundance of N-Methylaspartate CTD PMID:16516413 NCBI chr20:45,673,486...45,693,056
Ensembl chr20:44,090,914...44,133,095 		JBrowse link
G Dlgap1 DLG associated protein 1 multiple interactions ISO N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of DLGAP1 protein] CTD PMID:34389372 NCBI chr 9:117,304,144...118,173,463
Ensembl chr 9:110,167,448...110,726,817 		JBrowse link
G Elavl1 ELAV like RNA binding protein 1 increases phosphorylation
multiple interactions		 ISO N-Methylaspartate results in increased phosphorylation of ELAVL1 protein
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [N-Methylaspartate results in increased phosphorylation of ELAVL1 protein]; ELAV1 protein mutant form inhibits the reaction [N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein]; ELAV1 protein mutant form inhibits the reaction [N-Methylaspartate results in decreased expression of SIRT1 mRNA]; Go 6976 inhibits the reaction [N-Methylaspartate results in increased phosphorylation of ELAVL1 protein]		 CTD PMID:31945382 NCBI chr12:7,441,699...7,482,625
Ensembl chr12:2,645,061...2,684,784 		JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase multiple interactions ISO N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of FYN protein] CTD PMID:34389372 NCBI chr20:44,322,635...44,514,498
Ensembl chr20:42,766,369...42,959,911 		JBrowse link
G Gphn gephyrin multiple interactions ISO N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of GPHN protein] CTD PMID:34389372 NCBI chr 6:102,687,405...103,216,679
Ensembl chr 6:96,892,148...97,483,612 		JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B increases expression
multiple interactions		 ISO N-Methylaspartate results in increased expression of GRIN2B protein
kukoamine B inhibits the reaction [N-Methylaspartate results in increased expression of GRIN2B protein]		 CTD PMID:26065936 NCBI chr 4:170,297,811...170,775,420
Ensembl chr 4:168,599,546...169,042,279 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of GSK3B protein] CTD PMID:34389372 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Hcn2 hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 multiple interactions ISO N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of HCN2 protein] CTD PMID:34389372 NCBI chr 7:10,620,422...10,639,457
Ensembl chr 7:9,970,368...9,988,841 		JBrowse link
G Lmna lamin A/C multiple interactions ISO N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of LMNA protein] CTD PMID:34389372 NCBI chr 2:176,237,564...176,265,301
Ensembl chr 2:173,939,751...173,960,423 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases expression
multiple interactions
decreases phosphorylation
increases phosphorylation		 EXP
ISO		 N-Methylaspartate results in increased expression of MAPK1 protein modified form
thieno(2,3-c)isoquinolin-5-one inhibits the reaction [N-Methylaspartate results in increased expression of MAPK1 protein modified form]
CAV1 protein affects the reaction [N-Methylaspartate results in increased phosphorylation of MAPK1 protein]; kukoamine B inhibits the reaction [N-Methylaspartate results in decreased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [N-Methylaspartate results in increased phosphorylation of MAPK1 protein]		 CTD PMID:22639866 PMID:26065936 PMID:35257817 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases expression
multiple interactions
decreases phosphorylation
increases phosphorylation		 EXP
ISO		 N-Methylaspartate results in increased expression of MAPK3 protein modified form
thieno(2,3-c)isoquinolin-5-one inhibits the reaction [N-Methylaspartate results in increased expression of MAPK3 protein modified form]
N-Methylaspartate results in decreased phosphorylation of MAPK3 protein
CAV1 protein affects the reaction [N-Methylaspartate results in increased phosphorylation of MAPK3 protein]; kukoamine B inhibits the reaction [N-Methylaspartate results in decreased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [N-Methylaspartate results in increased phosphorylation of MAPK3 protein]		 CTD PMID:22639866 PMID:26065936 PMID:35257817 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of MAPT protein] CTD PMID:34389372 NCBI chr10:89,638,618...89,736,108
Ensembl chr10:89,138,627...89,236,129 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions
affects localization		 ISO acetovanillone inhibits the reaction [N-Methylaspartate affects the localization of NCF1 protein] CTD PMID:26065936 NCBI chr12:28,121,816...28,131,080
Ensembl chr12:22,485,451...22,494,646 		JBrowse link
G Nefl neurofilament light chain multiple interactions
decreases expression		 EXP 3-(2-((phenylamino)carbonyl)ethenyl)-4,6-dichloroindole-2-carboxylic acid inhibits the reaction [N-Methylaspartate results in decreased expression of NEFL mRNA]; 6-Cyano-7-nitroquinoxaline-2,3-dione inhibits the reaction [N-Methylaspartate results in decreased expression of NEFL mRNA]; Dizocilpine Maleate inhibits the reaction [N-Methylaspartate results in decreased expression of NEFL mRNA]; Memantine inhibits the reaction [N-Methylaspartate results in decreased expression of NEFL mRNA] CTD PMID:31969611 NCBI chr15:46,477,330...46,481,203
Ensembl chr15:42,301,916...42,305,793 		JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions ISO N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of NOS1 protein] CTD PMID:34389372 NCBI chr12:44,276,011...44,456,371
Ensembl chr12:38,626,714...38,710,945 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases ADP-ribosylation EXP N-Methylaspartate results in increased ADP-ribosylation of PARP1 protein CTD PMID:16903875 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Prkcg protein kinase C, gamma multiple interactions ISO N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of PRKCG protein] CTD PMID:34389372 NCBI chr 1:74,748,272...74,777,611
Ensembl chr 1:65,832,855...65,859,384 		JBrowse link
G Rab3a RAB3A, member RAS oncogene family multiple interactions ISO N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of RAB3A protein] CTD PMID:34389372 NCBI chr16:18,718,164...18,722,273
Ensembl chr16:18,684,188...18,688,336 		JBrowse link
G Rims1 regulating synaptic membrane exocytosis 1 multiple interactions ISO N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of RIMS1 protein] CTD PMID:34389372 NCBI chr 9:32,193,352...32,692,998
Ensembl chr 9:24,698,854...25,196,631 		JBrowse link
G Shank2 SH3 and multiple ankyrin repeat domains 2 decreases expression ISO N-Methylaspartate results in decreased expression of SHANK2 mRNA CTD PMID:34748853 NCBI chr 1:208,575,144...209,020,300
Ensembl chr 1:199,169,429...199,589,394 		JBrowse link
G Shank3 SH3 and multiple ankyrin repeat domains 3 multiple interactions ISO N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of SHANK3 protein] CTD PMID:34389372 NCBI chr 7:122,448,323...122,518,623
Ensembl chr 7:120,570,402...120,630,374 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions
decreases expression		 ISO 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [N-Methylaspartate results in decreased expression of SIRT1 mRNA]; Dizocilpine Maleate inhibits the reaction [N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein]; Dizocilpine Maleate inhibits the reaction [N-Methylaspartate results in decreased expression of SIRT1 mRNA]; ELAV1 protein mutant form inhibits the reaction [N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein]; ELAV1 protein mutant form inhibits the reaction [N-Methylaspartate results in decreased expression of SIRT1 mRNA]; Go 6976 inhibits the reaction [N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein]; Go 6976 inhibits the reaction [N-Methylaspartate results in decreased expression of SIRT1 mRNA]; N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein CTD PMID:31945382 NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Stxbp1 syntaxin binding protein 1 multiple interactions ISO N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of STXBP1 protein] CTD PMID:34389372 NCBI chr 3:36,474,428...36,536,120
Ensembl chr 3:16,076,391...16,138,369 		JBrowse link
G Syn1 synapsin I multiple interactions ISO N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of SYN1 protein] CTD PMID:34389372 NCBI chr  X:3,725,745...3,780,940
Ensembl chr  X:1,172,208...1,227,396 		JBrowse link
G Tjp1 tight junction protein 1 decreases expression
multiple interactions		 ISO N-Methylaspartate results in decreased expression of TJP1 mRNA; N-Methylaspartate results in decreased expression of TJP1 protein
CAV1 protein affects the reaction [N-Methylaspartate results in decreased expression of TJP1 mRNA]; CAV1 protein affects the reaction [N-Methylaspartate results in decreased expression of TJP1 protein]; Dizocilpine Maleate inhibits the reaction [N-Methylaspartate results in decreased expression of TJP1 mRNA]; Dizocilpine Maleate inhibits the reaction [N-Methylaspartate results in decreased expression of TJP1 protein]; U 0126 inhibits the reaction [N-Methylaspartate results in decreased expression of TJP1 mRNA]; U 0126 inhibits the reaction [N-Methylaspartate results in decreased expression of TJP1 protein]		 CTD PMID:35257817 NCBI chr 1:128,260,330...128,505,018
Ensembl chr 1:118,849,838...119,094,432 		JBrowse link
G Tuba1b tubulin, alpha 1B multiple interactions ISO N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of TUBA1B protein] CTD PMID:34389372 NCBI chr 7:131,969,606...131,972,587
Ensembl chr 7:130,081,032...130,196,186 		JBrowse link
G Vdac2 voltage-dependent anion channel 2 multiple interactions ISO N-Methylaspartate inhibits the reaction [gelsenicine results in increased phosphorylation of VDAC2 protein] CTD PMID:34389372 NCBI chr15:2,512,214...2,526,105
Ensembl chr15:2,463,056...2,476,553 		JBrowse link
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Term Annotations click to browse term
  CHEBI ontology 19887
    role 19858
      biological role 19856
        pharmacological role 19088
          neurotransmitter agent 16802
            N-methyl-D-aspartic acid 43
Path 2
Term Annotations click to browse term
  CHEBI ontology 19887
    subatomic particle 19885
      composite particle 19885
        hadron 19885
          baryon 19885
            nucleon 19885
              atomic nucleus 19885
                atom 19885
                  main group element atom 19824
                    main group molecular entity 19824
                      s-block molecular entity 19658
                        hydrogen molecular entity 19640
                          hydrides 19145
                            inorganic hydride 18162
                              pnictogen hydride 18152
                                nitrogen hydride 18059
                                  azane 17869
                                    ammonia 17868
                                      organic amino compound 17868
                                        amino acid 16061
                                          non-proteinogenic amino acid 4017
                                            non-proteinogenic alpha-amino acid 3811
                                              D-alpha-amino acid 69
                                                D-aspartic acid 62
                                                  D-aspartic acid derivative 43
                                                    N-methyl-D-aspartic acid 43
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