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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:D-alpha-amino acid
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Accession:CHEBI:16733 term browser browse the term
Synonyms:related_synonym: D-Amino acid;   D-alpha-amino acids;   Formula=C2H4NO2R;   SMILES=N[C@H]([*])C(O)=O
 alt_id: CHEBI:12909;   CHEBI:13625;   CHEBI:20906;   CHEBI:4097
 xref: KEGG:C00405
 cyclic_relationship: is_conjugate_acid_of CHEBI:60895;   is_tautomer_of CHEBI:59871


show annotations for term's descendants           Sort by:
 
metalaxyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases expression ISO metalaxyl results in decreased expression of CYP2C19 protein CTD PMID:32194361 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression ISO metalaxyl results in decreased expression of CYP7A1 protein CTD PMID:32194361 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
JBrowse link
N-methyl-D-aspartic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Elavl1 ELAV like RNA binding protein 1 increases phosphorylation
multiple interactions
ISO N-Methylaspartate results in increased phosphorylation of ELAVL1 protein
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [N-Methylaspartate results in increased phosphorylation of ELAVL1 protein]; ELAV1 protein mutant form inhibits the reaction [N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein]; ELAV1 protein mutant form inhibits the reaction [N-Methylaspartate results in decreased expression of SIRT1 mRNA]; Go 6976 inhibits the reaction [N-Methylaspartate results in increased phosphorylation of ELAVL1 protein]
CTD PMID:31945382 NCBI chr12:2,461,502...2,502,432
Ensembl chr12:2,461,502...2,502,432
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases expression
multiple interactions
EXP N-Methylaspartate results in increased expression of MAPK1 protein modified form
thieno(2,3-c)isoquinolin-5-one inhibits the reaction [N-Methylaspartate results in increased expression of MAPK1 protein modified form]
CTD PMID:22639866 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases expression
multiple interactions
EXP N-Methylaspartate results in increased expression of MAPK3 protein modified form
thieno(2,3-c)isoquinolin-5-one inhibits the reaction [N-Methylaspartate results in increased expression of MAPK3 protein modified form]
CTD PMID:22639866 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases ADP-ribosylation EXP N-Methylaspartate results in increased ADP-ribosylation of PARP1 protein CTD PMID:16903875 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Sirt1 sirtuin 1 multiple interactions
decreases expression
ISO 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [N-Methylaspartate results in decreased expression of SIRT1 mRNA]; Dizocilpine Maleate inhibits the reaction [N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein]; Dizocilpine Maleate inhibits the reaction [N-Methylaspartate results in decreased expression of SIRT1 mRNA]; ELAV1 protein mutant form inhibits the reaction [N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein]; ELAV1 protein mutant form inhibits the reaction [N-Methylaspartate results in decreased expression of SIRT1 mRNA]; Go 6976 inhibits the reaction [N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein]; Go 6976 inhibits the reaction [N-Methylaspartate results in decreased expression of SIRT1 mRNA]; N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein CTD PMID:31945382 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
nateglinide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc4 ATP binding cassette subfamily C member 4 affects binding ISO ABCC4 protein binds to nateglinide CTD PMID:17939016 NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592
JBrowse link
G Ins2 insulin 2 increases secretion ISO nateglinide results in increased secretion of INS protein CTD PMID:16403453 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions ISO Nateglinide inhibits the reaction [SLCO1B3 protein results in increased uptake of Atorvastatin]; Nateglinide inhibits the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein] CTD PMID:23121773 NCBI chr 4:175,814,118...175,881,775
Ensembl chr 4:175,814,118...175,881,768
JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 multiple interactions ISO Nateglinide inhibits the reaction [SLCO2B1 protein results in increased uptake of Atorvastatin]; Nateglinide inhibits the reaction [SLCO2B1 protein results in increased uptake of Sulfobromophthalein] CTD PMID:23121773 NCBI chr 1:164,623,313...164,671,612
Ensembl chr 1:164,623,599...164,671,577
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    role 19720
      application 19411
        refrigerant 17469
          ammonia 17002
            organic amino compound 17001
              amino acid 14108
                alpha-amino acid 11594
                  non-proteinogenic alpha-amino acid 1558
                    D-alpha-amino acid 11
                      (1S,2S)-2-[(1S)-1-amino-1-carboxyethyl]-1-cyclopropanecarboxylic acid 0
                      (3R)-3-methyl-D-ornithine 0
                      (3R,5R)-5-amino-3-methyl-D-proline 0
                      2-Amino-8-oxo-9,10-epoxy-decanoic acid 0
                      3-fluoro-D-tyrosine 0
                      3-hydroxy-D-aspartic acid + 0
                      3-nitro-D-tyrosine 0
                      4-methylene-D-glutamic acid 0
                      5-hydroxy-D-tryptophan 0
                      6-chloro-D-tryptophan 0
                      7-chloro-D-tryptophan 0
                      D-2-aminopentanoic acid 0
                      D-4-dihydroxyphenylglycine 0
                      D-alanine + 2
                      D-alloisoleucine + 0
                      D-allothreonine 0
                      D-alpha-amino acid residue + 0
                      D-alpha-aminobutyric acid + 0
                      D-arginine + 0
                      D-asparagine + 0
                      D-aspartic acid + 5
                      D-cysteine + 0
                      D-glutamic acid + 0
                      D-glutamine + 0
                      D-histidine + 0
                      D-homoserine + 0
                      D-isoleucine + 0
                      D-kynurenine 0
                      D-leucine + 0
                      D-lysine + 0
                      D-methionine + 0
                      D-ornithine + 0
                      D-phenylalanine + 4
                      D-proline + 0
                      D-selenocysteine + 0
                      D-serine + 0
                      D-thioproline 0
                      D-threonine + 0
                      D-tryptophan + 0
                      D-tyrosine + 0
                      D-valine + 0
                      LSM-12459 0
                      N(6)-[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]-D-lysine 0
                      N-(5'-phosphopyridoxyl)-D-alanine 0
                      N-formyl-D-kynurenine 0
                      N-methyl-D-aspartic acid 5
                      O(4)-phospho-D-tyrosine 0
                      O-ureido-D-serine 0
                      Se-methyl-D-selenocysteine + 0
                      Se-methyl-D-selenomethionine + 0
                      beta-(2-thienyl)-D-alanine 0
                      gamma-D-glutamyl-meso-diaminopimelic acid 0
                      nocardicin A 0
                      nocardicin C 0
                      p-N,N-bis(2-chloroethyl)amino-D-phenylalanine 0
                      pradimicin + 0
                      tauropine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19662
                    p-block element atom 19662
                      carbon group element atom 19580
                        carbon atom 19571
                          organic molecular entity 19571
                            organic group 18602
                              organic divalent group 18593
                                organodiyl group 18593
                                  carbonyl group 18506
                                    carbonyl compound 18506
                                      carboxylic acid 18158
                                        amino acid 14108
                                          alpha-amino acid 11594
                                            non-proteinogenic alpha-amino acid 1558
                                              D-alpha-amino acid 11
                                                (1S,2S)-2-[(1S)-1-amino-1-carboxyethyl]-1-cyclopropanecarboxylic acid 0
                                                (3R)-3-methyl-D-ornithine 0
                                                (3R,5R)-5-amino-3-methyl-D-proline 0
                                                2-Amino-8-oxo-9,10-epoxy-decanoic acid 0
                                                3-fluoro-D-tyrosine 0
                                                3-hydroxy-D-aspartic acid + 0
                                                3-nitro-D-tyrosine 0
                                                4-methylene-D-glutamic acid 0
                                                5-hydroxy-D-tryptophan 0
                                                6-chloro-D-tryptophan 0
                                                7-chloro-D-tryptophan 0
                                                D-2-aminopentanoic acid 0
                                                D-4-dihydroxyphenylglycine 0
                                                D-alanine + 2
                                                D-alloisoleucine + 0
                                                D-allothreonine 0
                                                D-alpha-amino acid residue + 0
                                                D-alpha-aminobutyric acid + 0
                                                D-arginine + 0
                                                D-asparagine + 0
                                                D-aspartic acid + 5
                                                D-cysteine + 0
                                                D-glutamic acid + 0
                                                D-glutamine + 0
                                                D-histidine + 0
                                                D-homoserine + 0
                                                D-isoleucine + 0
                                                D-kynurenine 0
                                                D-leucine + 0
                                                D-lysine + 0
                                                D-methionine + 0
                                                D-ornithine + 0
                                                D-phenylalanine + 4
                                                D-proline + 0
                                                D-selenocysteine + 0
                                                D-serine + 0
                                                D-thioproline 0
                                                D-threonine + 0
                                                D-tryptophan + 0
                                                D-tyrosine + 0
                                                D-valine + 0
                                                LSM-12459 0
                                                N(6)-[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]-D-lysine 0
                                                N-(5'-phosphopyridoxyl)-D-alanine 0
                                                N-formyl-D-kynurenine 0
                                                N-methyl-D-aspartic acid 5
                                                O(4)-phospho-D-tyrosine 0
                                                O-ureido-D-serine 0
                                                Se-methyl-D-selenocysteine + 0
                                                Se-methyl-D-selenomethionine + 0
                                                beta-(2-thienyl)-D-alanine 0
                                                gamma-D-glutamyl-meso-diaminopimelic acid 0
                                                nocardicin A 0
                                                nocardicin C 0
                                                p-N,N-bis(2-chloroethyl)amino-D-phenylalanine 0
                                                pradimicin + 0
                                                tauropine 0
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