Send us a Message



 Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) RatMine GViewer (Genome Viewer) Overgo Probe Designer ACP Haplotyper VCMap
Aging & Age-Related Disease Cancer Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:D-aspartic acid
go back to main search page
Accession:CHEBI:17364 term browser browse the term
Definition:The D-enantiomer of aspartic acid.
Synonyms:exact_synonym: (2R)-2-aminobutanedioic acid
 related_synonym: (R)-2-aminobutanedioic acid;   (R)-2-aminosuccinic acid;   D-Asparaginsaeure;   DAS;   Formula=C4H7NO4;   InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/t2-/m1/s1;   InChIKey=CKLJMWTZIZZHCS-UWTATZPHSA-N;   SMILES=N[C@H](CC(O)=O)C(O)=O;   aspartic acid D-form
 alt_id: CHEBI:20920;   CHEBI:4108
 xref: Beilstein:1723529;   CAS:1783-96-6;   DrugBank:DB02655;   Gmelin:602084;   HMDB:HMDB0006483;   KEGG:C00402
 xref_mesh: MESH:D026603
 xref: MetaCyc:CPD-302;   PDBeChem:DAS;   PMID:11419736;   PMID:17118457;   PMID:17407322;   PMID:18318836;   PMID:19860889;   Reaxys:1723529
 cyclic_relationship: is_conjugate_acid_of CHEBI:29990;   is_enantiomer_of CHEBI:17053


show annotations for term's descendants           Sort by:
 
D-aspartic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation ISO
EXP		 D-Aspartic Acid results in increased phosphorylation of AKT1 protein CTD PMID:26189884 PMID:31398714 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Ar androgen receptor affects expression
increases expression		 EXP D-Aspartic Acid affects the expression of AR mRNA
D-Aspartic Acid results in increased expression of AR protein		 CTD PMID:24439162 PMID:26044185 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Aurkb aurora kinase B increases expression ISO D-Aspartic Acid results in increased expression of AURKB protein CTD PMID:26189884 NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP D-Aspartic Acid results in increased activity of and results in increased cleavage of CASP3 protein; Dizocilpine Maleate inhibits the reaction [D-Aspartic Acid results in increased activity of and results in increased cleavage of CASP3 protein] CTD PMID:30822420 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cln8 CLN8, transmembrane ER and ERGIC protein multiple interactions
affects export		 ISO CLN8 protein affects the reaction [[Ionomycin co-treated with Calcium] results in increased transport of D-Aspartic Acid]; CLN8 protein affects the reaction [[Potassium Chloride co-treated with Calcium] results in increased transport of D-Aspartic Acid]
CLN8 protein affects the export of D-Aspartic Acid		 CTD PMID:22302580 NCBI chr16:74,749,662...74,759,553
Ensembl chr16:74,749,662...74,759,774 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 increases expression EXP D-Aspartic Acid results in increased expression of CYP11A1 mRNA CTD PMID:24713504 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases expression
decreases expression		 ISO
EXP		 D-Aspartic Acid results in increased expression of CYP19A1 mRNA; D-Aspartic Acid results in increased expression of CYP19A1 protein
D-Aspartic Acid results in decreased expression of CYP19A1 protein		 CTD PMID:24439162 PMID:26044185 PMID:26189884 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758 		JBrowse link
G Ddo D-aspartate oxidase affects abundance
increases metabolic processing
increases degradation		 ISO
EXP		 DDO protein affects the abundance of D-Aspartic Acid
DDO protein results in increased metabolism of D-Aspartic Acid
DDO protein results in increased degradation of D-Aspartic Acid		 CTD PMID:16516413 PMID:16525061 PMID:16725213 PMID:18842900 PMID:26961959 More... NCBI chr20:44,090,823...44,109,962
Ensembl chr20:44,090,914...44,133,095 		JBrowse link
G Esr1 estrogen receptor 1 increases expression
decreases expression		 EXP D-Aspartic Acid results in increased expression of ESR1 mRNA
D-Aspartic Acid results in decreased expression of ESR1 protein		 CTD PMID:24439162 PMID:26044185 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 increases expression ISO D-Aspartic Acid results in increased expression of ESR2 protein CTD PMID:26189884 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 increases expression EXP D-Aspartic Acid results in increased expression of GRIN1 mRNA CTD PMID:24439162 NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A increases expression EXP D-Aspartic Acid results in increased expression of GRIN2A mRNA CTD PMID:24439162 NCBI chr10:5,630,684...6,043,341
Ensembl chr10:5,631,369...6,044,637 		JBrowse link
G Itpr3 inositol 1,4,5-trisphosphate receptor, type 3 affects metabolic processing ISO ITPR3 mutant form affects the metabolism of D-Aspartic Acid CTD PMID:32853769 NCBI chr20:5,136,968...5,202,339
Ensembl chr20:5,136,441...5,202,337 		JBrowse link
G Lhb luteinizing hormone subunit beta increases expression EXP D-Aspartic Acid results in increased expression of LHB protein CTD PMID:24713504 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation EXP
ISO		 D-Aspartic Acid results in increased phosphorylation of MAPK1 protein CTD PMID:24439162 PMID:26189884 PMID:31398714 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO
EXP		 D-Aspartic Acid results in increased phosphorylation of MAPK3 protein CTD PMID:24439162 PMID:26189884 PMID:31398714 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapt microtubule-associated protein tau multiple interactions
increases cleavage		 EXP D-Aspartic Acid results in decreased expression of and affects the phosphorylation of MAPT protein; Dizocilpine Maleate inhibits the reaction [D-Aspartic Acid results in decreased expression of and affects the phosphorylation of MAPT protein]; Dizocilpine Maleate inhibits the reaction [D-Aspartic Acid results in decreased phosphorylation of MAPT protein]; Dizocilpine Maleate inhibits the reaction [D-Aspartic Acid results in increased cleavage of MAPT protein] CTD PMID:30822420 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129 		JBrowse link
G Pcna proliferating cell nuclear antigen increases expression ISO D-Aspartic Acid results in increased expression of PCNA protein CTD PMID:26189884 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Prep prolyl endopeptidase increases expression EXP D-Aspartic Acid results in increased expression of PREP protein CTD PMID:31398714 NCBI chr20:48,556,211...48,653,165
Ensembl chr20:48,556,280...48,654,466 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO SOD1 protein affects the reaction [Glycine results in increased secretion of D-Aspartic Acid] CTD PMID:12684256 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Srd5a1 steroid 5 alpha-reductase 1 increases expression EXP D-Aspartic Acid results in increased expression of SRD5A1 mRNA CTD PMID:26044185 NCBI chr 1:33,686,069...33,720,468
Ensembl chr 1:33,686,391...33,720,461 		JBrowse link
G Srd5a2 steroid 5 alpha-reductase 2 increases expression EXP D-Aspartic Acid results in increased expression of SRD5A2 mRNA CTD PMID:26044185 NCBI chr 6:21,426,225...21,465,727
Ensembl chr 6:21,426,215...21,462,112 		JBrowse link
G Srr serine racemase increases abundance
multiple interactions		 EXP
ISO		 SRR protein results in increased abundance of D-Aspartic Acid
[SRR protein results in increased metabolism of Aspartic Acid] which results in increased abundance of D-Aspartic Acid; Adenosine Triphosphate inhibits the reaction [Edetic Acid inhibits the reaction [SRR protein results in increased abundance of D-Aspartic Acid]]; Adenosine Triphosphate promotes the reaction [SRR protein results in increased abundance of D-Aspartic Acid]; Edetic Acid inhibits the reaction [SRR protein results in increased abundance of D-Aspartic Acid]; Hydroxylamine inhibits the reaction [SRR protein results in increased abundance of D-Aspartic Acid]; Pyridoxal Phosphate inhibits the reaction [Hydroxylamine inhibits the reaction [SRR protein results in increased abundance of D-Aspartic Acid]]		 CTD PMID:27387750 NCBI chr10:59,769,563...59,786,688
Ensembl chr10:59,769,571...59,787,011 		JBrowse link
G Star steroidogenic acute regulatory protein increases expression EXP D-Aspartic Acid results in increased expression of STAR mRNA; D-Aspartic Acid results in increased expression of STAR protein CTD PMID:24713504 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672 		JBrowse link
N-methyl-D-aspartic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ddo D-aspartate oxidase affects abundance ISO DDO protein affects the abundance of N-Methylaspartate CTD PMID:16516413 NCBI chr20:44,090,823...44,109,962
Ensembl chr20:44,090,914...44,133,095 		JBrowse link
G Elavl1 ELAV like RNA binding protein 1 increases phosphorylation
multiple interactions		 ISO N-Methylaspartate results in increased phosphorylation of ELAVL1 protein
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [N-Methylaspartate results in increased phosphorylation of ELAVL1 protein]; ELAV1 protein mutant form inhibits the reaction [N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein]; ELAV1 protein mutant form inhibits the reaction [N-Methylaspartate results in decreased expression of SIRT1 mRNA]; Go 6976 inhibits the reaction [N-Methylaspartate results in increased phosphorylation of ELAVL1 protein]		 CTD PMID:31945382 NCBI chr12:2,640,936...2,684,787
Ensembl chr12:2,645,061...2,684,784 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases expression
multiple interactions		 EXP N-Methylaspartate results in increased expression of MAPK1 protein modified form
thieno(2,3-c)isoquinolin-5-one inhibits the reaction [N-Methylaspartate results in increased expression of MAPK1 protein modified form]		 CTD PMID:22639866 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases expression
multiple interactions		 EXP N-Methylaspartate results in increased expression of MAPK3 protein modified form
thieno(2,3-c)isoquinolin-5-one inhibits the reaction [N-Methylaspartate results in increased expression of MAPK3 protein modified form]		 CTD PMID:22639866 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Nefl neurofilament light chain multiple interactions
decreases expression		 EXP 3-(2-((phenylamino)carbonyl)ethenyl)-4,6-dichloroindole-2-carboxylic acid inhibits the reaction [N-Methylaspartate results in decreased expression of NEFL mRNA]; 6-Cyano-7-nitroquinoxaline-2,3-dione inhibits the reaction [N-Methylaspartate results in decreased expression of NEFL mRNA]; Dizocilpine Maleate inhibits the reaction [N-Methylaspartate results in decreased expression of NEFL mRNA]; Memantine inhibits the reaction [N-Methylaspartate results in decreased expression of NEFL mRNA] CTD PMID:31969611 NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases ADP-ribosylation EXP N-Methylaspartate results in increased ADP-ribosylation of PARP1 protein CTD PMID:16903875 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions
decreases expression		 ISO 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [N-Methylaspartate results in decreased expression of SIRT1 mRNA]; Dizocilpine Maleate inhibits the reaction [N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein]; Dizocilpine Maleate inhibits the reaction [N-Methylaspartate results in decreased expression of SIRT1 mRNA]; ELAV1 protein mutant form inhibits the reaction [N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein]; ELAV1 protein mutant form inhibits the reaction [N-Methylaspartate results in decreased expression of SIRT1 mRNA]; Go 6976 inhibits the reaction [N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein]; Go 6976 inhibits the reaction [N-Methylaspartate results in decreased expression of SIRT1 mRNA]; N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein CTD PMID:31945382 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    role 19751
      biological role 19751
        biochemical role 19368
          metabolite 19344
            fundamental metabolite 12781
              aspartic acid 184
                D-aspartic acid 28
                  D-aspartic acid derivative + 7
                  D-aspartic acid residue 0
                  D-aspartoyl group 0
                  L-Lys-D-Asp 0
                  L-Orn-D-Asp 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic group 18718
                              organic divalent group 18702
                                organodiyl group 18702
                                  carbonyl group 18651
                                    carbonyl compound 18651
                                      carboxylic acid 18346
                                        amino acid 14872
                                          alpha-amino acid 12865
                                            non-proteinogenic alpha-amino acid 1753
                                              D-alpha-amino acid 34
                                                D-aspartic acid 28
                                                  D-aspartic acid derivative + 7
                                                  D-aspartic acid residue 0
                                                  D-aspartoyl group 0
                                                  L-Lys-D-Asp 0
                                                  L-Orn-D-Asp 0
paths to the root