Ccl2 (C-C motif chemokine ligand 2) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Ccl2 (C-C motif chemokine ligand 2) Rattus norvegicus
Analyze
Symbol: Ccl2
Name: C-C motif chemokine ligand 2
RGD ID: 3645
Description: Enables chemokine activity and heparin binding activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to lipid; and leukocyte chemotaxis. Located in several cellular components, including endocytic vesicle; perikaryon; and perinuclear region of cytoplasm. Colocalizes with C-fiber. Used to study several diseases, including artery disease (multiple); diabetic angiopathy; interstitial lung disease (multiple); kidney disease (multiple); and pancreatitis (multiple). Biomarker of several diseases, including artery disease (multiple); cerebrovascular disease (multiple); lung disease (multiple); metabolic dysfunction-associated steatotic liver disease (multiple); and pancreatitis (multiple). Human ortholog(s) of this gene implicated in several diseases, including Henoch-Schoenlein purpura; aggressive periodontitis; autoimmune disease (multiple); end stage renal disease; and gastrointestinal system cancer (multiple). Orthologous to human CCL2 (C-C motif chemokine ligand 2); PARTICIPATES IN angiotensin II signaling pathway; vascular endothelial growth factor signaling pathway; granulocyte-macrophage colony-stimulating factor signaling pathway; INTERACTS WITH (+)-pilocarpine; (+)-schisandrin B; (R,R,R)-alpha-tocopherol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: C-C motif chemokine 2; chemokine (C-C motif) ligand 2; immediate-early serum-responsive JE protein; immediate-early serum-responsive protein JE; MCP-1; monocyte chemoattractant protein 1; monocyte chemoattractant protein-1; monocyte chemotactic protein 1; Scya2; Sigje; small inducible cytokine A2; Small inducible gene JE; small-inducible cytokine A2
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Green Monkey
Alliance Genes
More Info more info ...
Candidate Gene For: Eau3 Eae18b Eau9 Bp374
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81067,503,077 - 67,504,875 (+)NCBIGRCr8
mRatBN7.21067,005,424 - 67,007,222 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1067,005,424 - 67,007,226 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1071,626,649 - 71,628,447 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01071,131,996 - 71,133,794 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01066,593,121 - 66,594,919 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01069,412,065 - 69,413,863 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1069,412,017 - 69,413,870 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01069,047,091 - 69,048,889 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41070,256,263 - 70,258,061 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1065,952,968 - 65,954,766 (+)NCBICelera
Cytogenetic Map10q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (IEP)
Acute Anterior Uveitis  (ISO)
Acute Liver Failure  (ISO)
Acute Lung Injury  (IEP)
acute myeloid leukemia  (ISO)
acute necrotizing pancreatitis  (IDA,IEP)
Acute-On-Chronic Liver Failure  (ISO)
adult respiratory distress syndrome  (ISO)
age related macular degeneration  (ISS)
aggressive periodontitis  (ISO)
Alcoholic Fatty Liver  (ISO)
alcoholic hepatitis  (ISO)
allergic conjunctivitis  (ISO)
allergic disease  (ISO)
anemia  (ISO)
Animal Hepatitis  (ISO)
anterior uveitis  (IEP,ISO)
anti-basement membrane glomerulonephritis  (IDA,IEP)
arteriosclerosis  (ISO)
asthma  (IEP,ISO)
atherosclerosis  (ISO)
autistic disorder  (ISO)
autoimmune hepatitis  (ISO)
Bacteremia  (ISO)
bacterial pneumonia  (ISO)
Behcet's disease  (ISO)
bipolar disorder  (ISO)
Brain Hypoxia-Ischemia  (IEP)
Brain Injuries  (IEP,IMP,ISO)
brain ischemia  (IEP,ISO)
Bronchial Hyperreactivity  (ISO)
bronchiolitis obliterans  (IMP)
calcinosis  (ISO)
cardiomyopathy  (IEP)
Cardiotoxicity  (ISO)
cardiovascular system disease  (ISO)
carotid artery disease  (ISO)
Carotid Artery Injuries  (IDA,ISO)
Carrington Syndrome  (ISO)
cerebral infarction  (ISO)
Chagas disease  (IEP)
Chemical and Drug Induced Liver Injury  (ISO)
cholangitis  (IEP)
Choroidal Neovascularization  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
Chronic Intermittent Hypoxia  (IEP)
chronic obstructive pulmonary disease  (ISO)
Chronic Periodontitis  (ISO)
Chronic Relapsing Experimental Autoimmune Encephalomyelitis  (IEP)
Chronic Tubulointerstitial Nephropathy  (IEP)
colitis  (IEP)
colon cancer  (IEP)
Colonic Neoplasms  (ISO)
congenital diaphragmatic hernia  (ISO)
congestive heart failure  (IEP,ISO)
contact dermatitis  (ISO)
Contusions  (IEP)
coronary artery disease  (IEP,ISO)
Coronary Artery Disease, Development of, in HIV  (ISO)
Coronavirus infectious disease  (ISO)
COVID-19  (ISO)
crescentic glomerulonephritis  (IDA,IMP)
Crohn's disease  (ISO)
cryptococcosis  (ISO)
cutaneous leishmaniasis  (ISO)
cystic fibrosis  (ISO)
Delayed Hypersensitivity  (IEP)
diabetic angiopathy  (IDA)
Diabetic Nephropathies  (IEP,ISO)
diabetic retinopathy  (IEP)
Drug-Related Side Effects and Adverse Reactions  (ISO)
Duchenne muscular dystrophy  (ISO)
end stage renal disease  (IDA,IEP,ISO)
Endometrial Neoplasms  (ISO)
endometriosis  (ISO)
endomyocardial fibrosis  (IEP)
Endotoxemia  (IEP)
Endotoxin-Induced Uveitis  (IDA)
Experimental Arthritis  (IDA,IEP,IMP)
Experimental Autoimmune Encephalomyelitis  (IEP)
Experimental Autoimmune Myocarditis  (IEP)
Experimental Autoimmune Orchitis  (IEP)
Experimental Autoimmune Uveitis  (IEP)
Experimental Autoimmune Uveoretinitis  (ISO)
Experimental Diabetes Mellitus  (IDA,IEP)
Experimental Liver Cirrhosis  (IEP,ISO)
Eye Neoplasms  (ISO)
familial hyperlipidemia  (ISO)
Febrile Neutropenia  (ISO)
fibromyalgia  (ISO)
fungal infectious disease  (ISO)
gastritis  (IDA)
genetic disease  (ISO)
Geographic Atrophy  (ISO)
gestational diabetes  (ISO)
gliosarcoma  (ISO)
glomerulonephritis  (ISO)
Granulomatous Interstitial Nephritis  (IEP)
Granulomatous Vasculitis  (IMP)
Graves ophthalmopathy  (ISO)
Guillain-Barre syndrome  (ISO)
Hearing Loss, Noise-Induced  (ISO)
heart valve disease  (ISO)
hemarthrosis  (ISO)
hemolytic-uremic syndrome  (IEP)
Henoch-Schoenlein purpura  (ISO)
hepatic encephalopathy  (IEP)
hepatocellular carcinoma  (ISO)
herpes simplex  (ISO)
herpes simplex virus keratitis  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Human Influenza  (ISO)
Hyperalgesia  (IDA,IEP,IMP,ISO)
hyperglycemia  (ISO)
hyperhomocysteinemia  (IEP)
hyperinsulinism  (IEP,ISO)
Hyperoxaluria  (ISO)
hypertension  (IDA,IEP,ISO)
Hypoxia  (IEP)
IgA glomerulonephritis  (IEP)
Inflammation  (IEP,ISO)
Inflammatory Breast Neoplasms  (ISO)
influenza  (ISO)
Insulin Resistance  (ISO)
interstitial lung disease  (IMP,ISO)
interstitial nephritis  (ISO)
Intestinal Reperfusion Injury  (IEP)
intracranial aneurysm  (IEP,IMP)
intracranial vasospasm  (IEP)
invasive aspergillosis  (ISO)
Invasive Pulmonary Aspergillosis  (IDA)
ischemia  (ISO)
kidney disease  (IMP)
Kidney Reperfusion Injury  (IDA,ISO)
Kuhnt-Junius degeneration  (ISO)
limited scleroderma  (ISO)
lipodystrophy  (ISO)
liver cirrhosis  (IEP,ISO)
liver disease  (ISO)
Liver Metastasis  (ISO)
Liver Reperfusion Injury  (IEP,ISO)
Lower Extremity Deep Vein Thrombosis  (ISO)
lung disease  (IEP)
Lung Injury  (ISO)
lupus nephritis  (ISO)
Lyme Neuroborreliosis  (ISO)
macular degeneration  (ISO)
macular retinal edema  (ISO)
membranoproliferative glomerulonephritis  (IMP)
metabolic dysfunction-associated steatohepatitis  (IEP,ISO)
metabolic dysfunction-associated steatotic liver disease  (IEP,ISO)
Metabolic Syndrome  (ISO)
middle cerebral artery infarction  (ISO)
Middle East respiratory syndrome  (ISO)
Mouth Neoplasms  (ISO)
multiple myeloma  (ISO)
Multiple Organ Failure  (IEP)
multiple sclerosis  (ISO)
myocardial infarction  (IDA,IEP,ISO)
Myocardial Ischemia  (IEP,ISO)
Myocardial Reperfusion Injury  (IEP,ISO)
myocarditis  (ISO)
Nasal Polyps  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
nephritis  (ISO)
neural tube defect  (ISO)
Neurodevelopmental Disorders  (ISO)
obesity  (IEP,ISO)
obstructive jaundice  (IDA)
obstructive sleep apnea  (ISO)
oral squamous cell carcinoma  (IEP,ISO)
orchitis  (IEP)
Oxygen-Induced Retinopathy  (IDA,ISO)
Pain  (IDA)
Painful Neuropathy  (IEP,ISO)
pancreatitis  (IEP,IMP,ISO)
Perennial Allergic Rhinitis  (ISO)
Peri-Implantitis  (ISO)
periapical periodontitis  (IEP)
Periodontal Cyst  (ISO)
periodontitis  (IEP)
Peripheral Nerve Injuries  (IEP)
Peritoneal Fibrosis  (ISO)
Plaque, Atherosclerotic  (ISO)
pleural disease  (ISO)
pneumocystosis  (ISO)
pneumonia  (ISO)
portal hypertension  (ISO)
Premature Obstetric Labor  (ISO)
proliferative diabetic retinopathy  (ISO)
Pulmonary Contusion  (IEP)
pulmonary edema  (IEP)
pulmonary embolism  (IEP)
pulmonary emphysema  (ISO)
pulmonary fibrosis  (IEP,ISO)
pulmonary hypertension  (IEP,ISO)
pulmonary tuberculosis  (ISO)
Reperfusion Injury  (IDA,ISO)
Respiratory Tract Granuloma  (IDA,ISO)
Retina Reperfusion Injury  (IDA)
retinal degeneration  (ISO)
retinal detachment  (ISO)
retinitis  (ISO)
rheumatoid arthritis  (ISO)
sarcoma  (IEP)
schizophrenia  (ISO)
sciatic neuropathy  (IEP,ISO)
Sepsis  (IEP)
severe acute respiratory syndrome  (ISO)
silicosis  (ISO)
skin melanoma  (ISO)
spina bifida  (ISO)
Spinal Cord Compression  (IEP,ISO)
squamous cell carcinoma  (ISO)
status epilepticus  (IEP,ISO)
steatotic liver disease  (ISO)
Stroke  (IEP,ISO)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
temporal arteritis  (ISO)
thrombocytopenia  (ISO)
thyroid gland disease  (ISO)
Thyroid Neoplasms  (ISO)
toxic shock syndrome  (ISO)
transient cerebral ischemia  (IDA,IEP)
Transplant Rejection  (ISO)
Triple Negative Breast Neoplasms  (ISO)
tuberculosis  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (IEP)
ureteral obstruction  (ISO)
uveitis  (IEP,ISO)
Vasculitis of the Skin  (ISO)
Venous Thrombosis  (IEP)
viral pneumonia  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-abscisic acid  (ISO)
(+)-catechin  (ISO)
(+)-pilocarpine  (EXP,ISO)
(+)-schisandrin B  (EXP)
(-)-anisomycin  (ISO)
(-)-Arctigenin  (ISO)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(24S)-24-hydroxycholesterol  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(2R,4R)-1-[(2S)-5-(diaminomethylideneamino)-2-[(3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonylamino]-1-oxopentyl]-4-methyl-2-piperidinecarboxylic acid  (ISO)
(4Z,7Z,10Z,13Z,15E,19Z)-17-hydroxydocosahexaenoic acid  (ISO)
(E)-thiamethoxam  (ISO)
(R)-lipoic acid  (ISO)
(R,R,R)-alpha-tocopherol  (EXP,ISO)
(S)-colchicine  (EXP)
(S)-nicotine  (EXP,ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
1,3,5-trimethylbenzene  (ISO)
1,3-benzothiazole-2-thiol  (ISO)
1,4-benzoquinone  (ISO)
1,4-naphthoquinone  (ISO)
1,4-phenylenediamine  (ISO)
1-[2-(3,4-dichlorophenyl)ethyl]-4-methylpiperazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
11-deoxycorticosterone  (EXP)
13-HPODE  (EXP)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
15-acetyldeoxynivalenol  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP,ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-D  (EXP,ISO)
2,4-diaminotoluene  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-acetamidofluorene  (EXP)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (ISO)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-aminopurine  (ISO)
2-arachidonoylglycerol  (ISO)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-tert-butylhydroquinone  (ISO)
22-Hydroxycholesterol  (ISO)
24,25-Dihydroxyvitamin D  (ISO)
26-hydroxycholesterol  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,4-dihydroxybenzoic acid  (ISO)
3-(1H-indol-3-yl)propanoic acid  (ISO)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (EXP)
3-acetyldeoxynivalenol  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4',5,7-Trimethoxyflavone  (ISO)
4'-hydroxydiclofenac  (ISO)
4'-Methoxychalcone  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-Hydroxybenzophenone  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-methylhistamine  (ISO)
4-nitroquinoline N-oxide  (ISO)
4-phenylbutyric acid  (ISO)
5'-S-methyl-5'-thioadenosine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP,ISO)
7,12-dimethyltetraphene  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (EXP,ISO)
7-ketocholesterol  (ISO)
7alpha-hydroxycholesterol  (ISO)
8-Br-cAMP  (EXP,ISO)
9-cis-retinoic acid  (ISO)
9-hydroxycanthin-6-one  (ISO)
acarbose  (EXP)
acetaldehyde  (ISO)
acetamide  (EXP)
acetoacetic acid  (ISO)
acetylsalicylic acid  (EXP,ISO)
acrolein  (EXP,ISO)
acrylic acid  (EXP)
acrylonitrile  (EXP,ISO)
acteoside  (ISO)
actinomycin D  (ISO)
acyclovir  (ISO)
adenine  (ISO)
Adenosine, cyclic 3',5'-[hydrogen [p(s)]-phosphorothioate]  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin G1  (ISO)
AICA ribonucleotide  (EXP,ISO)
albendazole  (ISO)
alclometasone dipropionate  (ISO)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
alexidine  (ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (EXP,ISO)
allopurinol  (EXP,ISO)
alloxan  (ISO)
alloxanthine  (ISO)
allyl alcohol  (ISO)
alpha-hexylcinnamaldehyde  (ISO)
alpha-linolenic acid  (EXP)
alpha-naphthoflavone  (ISO)
aluminium hydroxide  (ISO)
aluminium oxide  (ISO)
ambroxol  (EXP)
amiloride  (EXP,ISO)
amiodarone  (ISO)
amitrole  (ISO)
amlexanox  (ISO)
amlodipine  (EXP)
ammonium chloride  (EXP)
amprenavir  (ISO)
anagliptin  (ISO)
andrographolide  (ISO)
Anemoside B4  (ISO)
angiotensin II  (ISO)
anthocyanin  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
apigenin  (ISO)
apocynin  (ISO)
Archazolid B  (ISO)
argatroban  (ISO)
aripiprazole  (ISO)
aristolochic acid A  (EXP)
aristolochic acids  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
asbestos  (ISO)
aspalathin  (ISO)
aspartame  (ISO)
astressin 2B  (ISO)
atazanavir sulfate  (ISO)
atorvastatin calcium  (EXP,ISO)
atrazine  (EXP)
aurantio-obtusin  (ISO)
azathioprine  (ISO)
azithromycin  (ISO)
Bardoxolone methyl  (ISO)
baricitinib  (ISO)
barium sulfate  (EXP)
bathocuproine disulfonic acid  (ISO)
beclomethasone  (ISO)
benazepril  (EXP)
benzalkonium chloride  (ISO)
benzene  (EXP,ISO)
benzene-1,2,4-triol  (ISO)
benzethonium chloride  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzofurans  (ISO)
benzoic acid  (ISO)
benzylpenicillin  (ISO)
berberine  (ISO)
Bergenin  (ISO)
beta-D-glucan  (ISO)
beta-D-glucosamine  (EXP,ISO)
beta-naphthoflavone  (EXP,ISO)
betamethasone  (ISO)
bezafibrate  (ISO)
bicalutamide  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisoprolol  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP,ISO)
boron nitride  (ISO)
bortezomib  (ISO)
BQ 123  (ISO)
Brevianamide A  (ISO)
bromodichloromethane  (ISO)
Bucillamine  (ISO)
budesonide  (EXP,ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
butyric acid  (EXP,ISO)
C60 fullerene  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium selenide  (ISO)
Calcimycin  (ISO)
calcitriol  (ISO)
calcium atom  (ISO)
calcium dichloride  (ISO)
calcium oxalate  (EXP)
calcium silicate  (EXP)
calcium(0)  (ISO)
Calphostin C  (ISO)
camostat  (EXP)
camptothecin  (ISO)
cannabidiol  (ISO)
capsaicin  (EXP,ISO)
capsazepine  (ISO)
CARBENOXOLONE  (ISO)
carbon nanotube  (EXP,ISO)
carbonyl sulfide  (EXP)
carmustine  (ISO)
carnosine  (ISO)
carrageenan  (ISO)
catechol  (ISO)
celecoxib  (EXP,ISO)
cephaeline  (ISO)
ceric oxide  (EXP,ISO)
cerivastatin  (ISO)
ceruletide  (ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
chlorambucil  (ISO)
chlornitrofen  (EXP)
chlorobenzene  (ISO)
chloroethene  (ISO)
chloroform  (ISO)
chlorogenic acid  (ISO)
chloroquine  (ISO)
chlorothalonil  (ISO)
chlorpyrifos  (EXP)
cholesterol  (EXP,ISO)
choline  (EXP,ISO)
chondroitin sulfate  (ISO)
chromium(3+) trichloride  (ISO)
chromium(6+)  (ISO)
chrysin 5,7-dimethyl ether  (ISO)
ciguatoxin CTX1B  (ISO)
cilostazol  (ISO)
cimetidine  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (EXP,ISO)
citric acid  (ISO)
clobenpropit  (ISO)
clofibrate  (ISO)
clonidine  (ISO)
clonidine (amino form)  (ISO)
clonidine (imino form)  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP,ISO)
codeine  (ISO)
compound 48/80  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
corticosterone  (EXP,ISO)
cortisol  (EXP,ISO)
cortisone  (ISO)
coumermycin A1  (ISO)
crocidolite asbestos  (EXP,ISO)
crotonaldehyde  (ISO)
CU-O LINKAGE  (ISO)
cucurbitacin B  (ISO)
Cuprizon  (EXP)
curcumin  (EXP,ISO)
cyanocob(III)alamin  (EXP)
cycloheximide  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cyhalothrin  (EXP)
D-glucose  (EXP,ISO)
dantrolene  (EXP)
dapagliflozin  (EXP)
daunorubicin  (ISO)
Decursin  (ISO)
deferiprone  (EXP,ISO)
deguelin  (EXP)
deoxycholic acid  (ISO)
Deoxycorticosterone acetate  (EXP)
deoxynivalenol  (ISO)
dequalinium  (ISO)
desferrioxamine B  (EXP)
dexamethasone  (EXP,ISO)
dexmedetomidine  (ISO)
dextran sulfate  (ISO)
dextromethorphan  (ISO)
diallyl disulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
dibenziodolium  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (ISO)
dichloroacetic acid  (ISO)
dichromium trioxide  (ISO)
diclofenac  (EXP,ISO)
Didecyldimethylammonium  (ISO)
dienogest  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (EXP,ISO)
digitoxigenin  (ISO)
digitoxin  (ISO)
digoxigenin  (ISO)
digoxin  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
diisopropyl fluorophosphate  (EXP,ISO)
dimemorfan  (EXP,ISO)
dimethoate  (ISO)
dimethyl fumarate  (ISO)
dimethyl sulfoxide  (EXP,ISO)
dimethyl-(phenylmethyl)-[2-[2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy]ethyl]ammonium  (ISO)
dimethylarsinous acid  (ISO)
diminazene diaceturate  (ISO)
dinitrogen  (ISO)
diosgenin  (ISO)
dioxygen  (EXP,ISO)
diprotium oxide  (EXP)
dipyridamole  (EXP,ISO)
disulfiram  (ISO)
dobutamine  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
edaravone  (EXP,ISO)
efavirenz  (ISO)
elemental selenium  (ISO)
ellagic acid  (ISO)
emetine  (ISO)
enalapril  (EXP,ISO)
endosulfan  (EXP)
entinostat  (ISO)
enzacamene  (ISO)
ergosta-4,6,8(14),22-tetraen-3-one  (ISO)
ergosterol  (EXP)
eriodictyol  (ISO)
erlotinib hydrochloride  (ISO)
erythromycin A  (ISO)
esculetin  (ISO)
ethambutol  (EXP)
ethanol  (EXP,ISO)
ethionamide  (EXP)
Ethyl icosapentate  (ISO)
ethylene glycol  (EXP,ISO)
ethylisopropylamiloride  (ISO)
eugenol  (ISO)
eupatilin  (ISO)
euxanthone  (ISO)
fasudil  (ISO)
febuxostat  (ISO)
felodipine  (ISO)
fenbendazole  (ISO)
fenofibrate  (ISO)
fenvalerate  (ISO)
ferric oxide  (ISO)
ferroheme b  (ISO)
ferulic acid  (ISO)
Fidarestat  (ISO)
fingolimod hydrochloride  (ISO)
fipronil  (EXP)
flavone  (ISO)
flavonoids  (EXP)
flucloxacillin  (ISO)
fludrocortisone  (ISO)
flumequine  (ISO)
fluoranthene  (ISO)
fluoxetine  (ISO)
Fluridone  (ISO)
flutamide  (EXP)
fluticasone  (ISO)
fluvastatin  (EXP)
folic acid  (EXP,ISO)
formaldehyde  (ISO)
fructose  (EXP,ISO)
fulvestrant  (ISO)
furan  (EXP)
Fusarenone X  (ISO)
gadodiamide hydrate  (EXP,ISO)
gadolinium trichloride  (EXP)
gallic acid  (EXP,ISO)
Garcinol  (ISO)
gefitinib  (ISO)
gemcitabine  (ISO)
gemfibrozil  (EXP)
genistein  (EXP,ISO)
gentamycin  (EXP,ISO)
Gingerenone A  (ISO)
glucagon  (ISO)
glucose  (EXP,ISO)
glutathione  (ISO)
glycerol  (ISO)
glycidol  (EXP)
glycine betaine  (EXP)
glycyrrhizinic acid  (ISO)
glyoxylic acid  (EXP)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
gossypol  (ISO)
graphene oxide  (ISO)
graphite  (EXP,ISO)
GW 4064  (ISO)
GW 501516  (ISO)
GW 7647  (ISO)
gypenoside LXXV  (ISO)
halothane  (EXP)
harmaline  (ISO)
heme b  (ISO)
hemin  (ISO)
heparin  (EXP)
hesperetin  (ISO)
Hexachloro-1,3-butadiene  (EXP)
hexadecanoic acid  (EXP,ISO)
Hexadimethrine bromide  (EXP)
histamine  (ISO)
homocysteine  (ISO)
Honokiol  (EXP)
HU-308  (ISO)
hydrochlorothiazide  (EXP)
hydrogen chloride  (EXP)
hydrogen peroxide  (ISO)
hydrogen sulfide  (ISO)
hydroquinone  (ISO)
hydroxamic acid  (EXP)
hydroxychloroquine  (ISO)
ibuprofen  (ISO)
icosanoid  (EXP)
Ile(5)-angiotensin II  (ISO)
imiquimod  (ISO)
indinavir  (ISO)
indometacin  (EXP,ISO)
indoxyl sulfate  (EXP,ISO)
iodixanol  (ISO)
iodoacetic acid  (ISO)
iohexol  (ISO)
ionomycin  (ISO)
irbesartan  (ISO)
iron atom  (EXP,ISO)
iron(0)  (EXP,ISO)
iron(III) citrate  (ISO)
Isoangustone A  (ISO)
isoeugenol  (ISO)
isoflurane  (EXP)
isoprenaline  (ISO)
isotretinoin  (EXP)
ivermectin  (ISO)
kaempferol  (EXP,ISO)
kaempferol 3-O-beta-D-glucoside  (ISO)
kainic acid  (EXP)
ketoconazole  (EXP,ISO)
L-arginine  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (EXP,ISO)
lanatoside C  (ISO)
lead diacetate  (ISO)
lead(0)  (EXP)
Leonurine  (ISO)
leptomycin B  (ISO)
leukotriene B4  (ISO)
leukotriene C4  (ISO)
lidocaine  (ISO)
lignin  (ISO)
limonin  (ISO)
linoleic acid  (ISO)
linuron  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
lipoteichoic acid  (EXP,ISO)
liquiritigenin  (EXP,ISO)
liquiritin  (EXP,ISO)
lithium chloride  (ISO)
loganin  (ISO)
lopinavir  (ISO)
lorcaserin  (ISO)
losartan  (EXP,ISO)
luteolin  (ISO)
LY294002  (ISO)
m-xylene  (EXP,ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP,ISO)
mangiferin  (ISO)
manidipine  (EXP)
mebendazole  (ISO)
Mecamylamine  (EXP)
mechlorethamine  (EXP)
meclocycline  (ISO)
medroxyprogesterone acetate  (EXP)
MeIQx  (ISO)
melamine  (ISO)
melatonin  (ISO)
mephedrone  (EXP)
mercury dichloride  (EXP,ISO)
metam  (ISO)
metformin  (EXP,ISO)
methadone  (EXP)
methapyrilene  (EXP)
methimazole  (EXP,ISO)
methionine sulfoximine  (ISO)
methotrexate  (EXP,ISO)
methoxyacetic acid  (EXP)
methoxychlor  (ISO)
methyl beta-cyclodextrin  (ISO)
methyl methacrylate  (ISO)
methyl salicylate  (ISO)
Methylbenzethonium chloride  (ISO)
methylglyoxal  (ISO)
methylmercury chloride  (ISO)
metyrapone  (EXP)
mevalonic acid  (ISO)
microcystin-LR  (ISO)
mifepristone  (EXP)
minocycline  (ISO)
mitomycin C  (ISO)
MJN110  (ISO)
MK 571  (ISO)
mono(2-ethyl-5-oxohexyl) phthalate  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monocrotaline  (EXP)
monosodium L-glutamate  (ISO)
montelukast  (EXP,ISO)
morin  (EXP)
morphine  (EXP)
Morroniside  (ISO)
Muraglitazar  (EXP)
mycophenolic acid  (EXP)
mycotoxin  (ISO)
myricitrin  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N,O-dimethyltyramine  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-ethyl-5'-carboxamidoadenosine  (ISO)
N-methyl-N-nitrosourea  (EXP,ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N-tosyl-L-phenylalanyl chloromethyl ketone  (EXP,ISO)
naloxone  (ISO)
naphthalene  (ISO)
naphthalenes  (EXP)
naproxen  (EXP)
naringin  (EXP,ISO)
nebivolol  (ISO)
nelfinavir  (ISO)
neocuproine  (ISO)
neoechinulin A  (ISO)
nickel atom  (EXP,ISO)
nickel dichloride  (ISO)
nickel subsulfide  (ISO)
nickel sulfate  (ISO)
niclosamide  (EXP,ISO)
nicotinamide  (ISO)
nicotine  (EXP,ISO)
nicotinic acid  (EXP,ISO)
nimesulide  (EXP,ISO)
nitrofen  (EXP)
nitrogen dioxide  (ISO)
nitroprusside  (ISO)
Nivalenol  (ISO)
nocodazole  (ISO)
nonane  (EXP)
Nonidet P-40  (ISO)
Nonylphenol  (ISO)
notoginsenoside R1  (ISO)
NS-398  (ISO)
NSC 23766  (ISO)
obeticholic acid  (ISO)
octadecanoic acid  (ISO)
okadaic acid  (ISO)
olaparib  (ISO)
oroxylin A  (EXP)
ouabain  (EXP)
oxalic acid  (ISO)
oxaliplatin  (EXP)
oxytetracycline  (ISO)
ozone  (EXP,ISO)
Pachymic acid  (ISO)
paclitaxel  (ISO)
palmatine  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
paricalcitol  (EXP,ISO)
parthenolide  (EXP,ISO)
PCB138  (ISO)
PD 168393  (ISO)
PD123319  (EXP)
pemetrexed  (ISO)
pentachlorophenol  (ISO)
pentanal  (ISO)
Pentoxifylline  (EXP,ISO)
peptidoglycan  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
perindopril  (ISO)
permethrin  (ISO)
PF-956980  (ISO)
phenethyl caffeate  (ISO)
phenethyl isothiocyanate  (ISO)
phenformin  (EXP)
phenobarbital  (EXP)
phenol  (ISO)
phentermine  (ISO)
phenylephrine  (EXP)
phenytoin  (EXP)
phloretin  (ISO)
phlorizin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphatidylcholine  (ISO)
phthalic anhydride  (ISO)
phylloquinone  (EXP)
physostigmine  (ISO)
phytoestrogen  (ISO)
picolinic acid  (ISO)
pioglitazone  (ISO)
piperidines  (ISO)
Pirarubicin  (EXP)
pirinixic acid  (ISO)
pitavastatin  (ISO)
pitavastatin(1-)  (ISO)
plumbagin  (EXP)
poly(I:C)  (EXP,ISO)
polymyxin B2  (ISO)
pomalidomide  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
pravastatin  (ISO)
prednisolone  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
probenecid  (EXP,ISO)
probucol  (ISO)
procyanidin B2  (EXP)
procyanidin B3  (ISO)
progesterone  (EXP,ISO)
propan-2-ol  (ISO)
propanal  (ISO)
propidium  (ISO)
Proscillaridin  (ISO)
prostaglandin E2  (ISO)
prostaglandin I2  (ISO)
psicose  (ISO)
puromycin  (ISO)
Pyridostigmine bromide  (ISO)
pyrrolidine dithiocarbamate  (EXP,ISO)
pyrvinium  (ISO)
quartz  (EXP,ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (EXP)
quercetin 3-O-beta-D-glucopyranoside  (EXP)
rac-lactic acid  (ISO)
raloxifene  (EXP,ISO)
ramipril  (ISO)
razoxane  (EXP)
reactive oxygen species  (EXP,ISO)
rebaudioside A  (ISO)
remdesivir  (ISO)
resolvin D1  (ISO)
resolvin D2  (ISO)
resveratrol  (EXP,ISO)
ribavirin  (ISO)
rifampicin  (EXP)
rimonabant  (EXP,ISO)
ritonavir  (ISO)
rofecoxib  (ISO)
roflumilast  (ISO)
rolipram  (EXP)
rosuvastatin calcium  (EXP)
rotenone  (EXP,ISO)
rucaparib  (ISO)
rutin  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP,ISO)
salicylic acid  (EXP,ISO)
Salinomycin  (ISO)
Salmeterol xinafoate  (ISO)
salubrinal  (ISO)
saroglitazar  (ISO)
sarpogrelate  (ISO)
SB 203580  (EXP,ISO)
SB 431542  (ISO)
SCH772984  (EXP)
scoparone  (ISO)
selenium atom  (ISO)
serpentine asbestos  (EXP,ISO)
sevoflurane  (EXP)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP,ISO)
Sinomenine  (ISO)
sirtinol  (ISO)
SL-327  (EXP)
sodium arsenite  (EXP,ISO)
sodium atom  (EXP)
sodium chlorate  (ISO)
sodium chloride  (ISO)
sodium cholate  (EXP,ISO)
sodium dichromate  (ISO)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (EXP)
Sodium oleate  (ISO)
sodium stibogluconate  (ISO)
SR 144528  (ISO)
stavudine  (ISO)
steviol  (ISO)
stevioside  (ISO)
streptozocin  (EXP,ISO)
styrene  (ISO)
succimer  (ISO)
sucrose  (ISO)
sulfaphenazole  (ISO)
sulfapyridine  (ISO)
sulfasalazine  (EXP)
sulforaphane  (ISO)
sulfur dioxide  (EXP)
sumatriptan  (EXP)
sunitinib  (ISO)
superoxide  (ISO)
tacrolimus hydrate  (EXP,ISO)
tagatose  (ISO)
tamoxifen  (EXP,ISO)
taurocholic acid  (ISO)
telmisartan  (EXP,ISO)
temozolomide  (ISO)
terameprocol  (ISO)
terbinafine  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
Tetramethylthiourea  (ISO)
tetraphene  (ISO)
tetrathiomolybdate(2-)  (ISO)
thalidomide  (ISO)
thapsigargin  (EXP,ISO)
theophylline  (ISO)
thiamethoxam  (ISO)
thioacetamide  (EXP,ISO)
Tiopronin  (ISO)
Tiron  (ISO)
titanium atom  (EXP,ISO)
titanium dioxide  (EXP,ISO)
TMC-120A  (ISO)
tofacitinib  (ISO)
Tolmetin glucuronide  (ISO)
toluene  (ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (EXP)
trans-caffeic acid  (ISO)
trans-isoeugenol  (ISO)
trans-piceid  (ISO)
tremolite asbestos  (ISO)
triamcinolone  (ISO)
tributylstannane  (ISO)
trichloroethene  (EXP,ISO)
triclosan  (ISO)
trimethyltin  (ISO)
triphenylstannane  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
troglitazone  (EXP,ISO)
trovafloxacin  (ISO)
Tungsten carbide  (ISO)
tunicamycin  (ISO)
undecane  (EXP)
uranium atom  (EXP)
ursodeoxycholic acid  (ISO)
vadimezan  (ISO)
valproic acid  (ISO)
valsartan  (EXP,ISO)
vanadyl sulfate  (EXP,ISO)
vanillin  (ISO)
vemurafenib  (ISO)
venetoclax  (ISO)
verteporfin  (ISO)
vincaleukoblastine  (EXP)
vincristine  (EXP,ISO)
vitamin E  (ISO)
vorinostat  (ISO)
water  (EXP)
withaferin A  (ISO)
wortmannin  (ISO)
xanthohumol  (ISO)
XL147  (ISO)
Y-27632  (ISO)
zalcitabine  (EXP)
zidovudine  (ISO)
zileuton  (ISO)
zinc atom  (ISO)
zinc oxide  (EXP,ISO)
zinc protoporphyrin  (EXP,ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)
ziram  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ regeneration  (IEP)
astrocyte cell migration  (ISO)
cellular response to ATP  (IEP)
cellular response to dexamethasone stimulus  (IEP)
cellular response to estradiol stimulus  (IEP)
cellular response to fatty acid  (IEP)
cellular response to fibroblast growth factor stimulus  (ISO)
cellular response to glucose stimulus  (IEP)
cellular response to high density lipoprotein particle stimulus  (IEP)
cellular response to insulin stimulus  (IEP)
cellular response to interleukin-1  (IBA,IEP,ISO)
cellular response to interleukin-6  (IEP)
cellular response to lipopolysaccharide  (IEP,ISO)
cellular response to lipoprotein particle stimulus  (IEP)
cellular response to macrophage colony-stimulating factor stimulus  (IEP)
cellular response to platelet-derived growth factor stimulus  (IEP)
cellular response to retinoic acid  (IEP)
cellular response to tumor necrosis factor  (IBA,IEP,ISO)
cellular response to type II interferon  (IBA,IEP,ISO)
cellular response to xenobiotic stimulus  (IEP)
chemokine-mediated signaling pathway  (IBA,IMP)
chemokinesis  (TAS)
chronic inflammatory response  (IEP)
cytokine-mediated signaling pathway  (IMP,ISO)
cytoskeleton organization  (ISO)
eosinophil chemotaxis  (IBA)
G protein-coupled receptor signaling pathway  (IBA)
glial cell migration  (IMP)
helper T cell extravasation  (ISO)
inflammatory response  (IBA)
intracellular calcium ion homeostasis  (IDA)
leukocyte migration involved in inflammatory response  (IMP)
lymphocyte chemotaxis  (IBA,IDA)
macrophage chemotaxis  (IDA,ISO)
mammary gland involution  (IEP)
maternal process involved in female pregnancy  (IEP)
maternal process involved in parturition  (IEP)
monocyte chemotaxis  (IBA,ISO)
negative regulation of angiogenesis  (ISO)
negative regulation of G1/S transition of mitotic cell cycle  (ISO)
negative regulation of glial cell apoptotic process  (ISO)
negative regulation of natural killer cell chemotaxis  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of vascular endothelial cell proliferation  (ISO)
neutrophil chemotaxis  (IBA,IMP)
osteoclast differentiation  (HEP)
positive regulation of apoptotic cell clearance  (ISO)
positive regulation of calcium ion import  (ISO)
positive regulation of cell adhesion  (IDA)
positive regulation of cell-cell adhesion  (IDA)
positive regulation of cellular extravasation  (IDA)
positive regulation of collagen biosynthetic process  (IDA)
positive regulation of endothelial cell apoptotic process  (ISO)
positive regulation of endothelial cell proliferation  (IMP)
positive regulation of ERK1 and ERK2 cascade  (IBA)
positive regulation of gene expression  (ISO)
positive regulation of immune complex clearance by monocytes and macrophages  (ISO)
positive regulation of leukocyte mediated cytotoxicity  (IMP)
positive regulation of leukocyte migration  (IDA,IMP)
positive regulation of macrophage chemotaxis  (IDA,ISO)
positive regulation of monocyte chemotaxis  (IDA,ISO)
positive regulation of nitric-oxide synthase biosynthetic process  (ISO)
positive regulation of protein targeting to membrane  (IDA)
positive regulation of synaptic transmission  (IDA)
positive regulation of synaptic transmission, glutamatergic  (ISO,ISS)
positive regulation of T cell activation  (ISO)
positive regulation of tumor necrosis factor production  (IMP)
positive regulation of wound healing  (IMP)
regulation of cell shape  (ISO)
regulation of vascular endothelial growth factor production  (ISO)
response to activity  (IEP)
response to amino acid  (IEP)
response to bacterium  (ISO)
response to cyclosporin A  (IEP)
response to ethanol  (IEP)
response to gamma radiation  (IEP)
response to glucocorticoid  (IEP)
response to hypoxia  (IEP)
response to isolation stress  (IEP)
response to lipopolysaccharide  (IEP)
response to mechanical stimulus  (IEP)
response to progesterone  (IEP)
response to tumor necrosis factor  (IEP)
response to vitamin B3  (IEP)
response to wounding  (ISO)
response to xenobiotic stimulus  (IEP)
sensory perception of pain  (ISO,ISS)
transforming growth factor beta receptor signaling pathway  (IMP)
vascular endothelial growth factor receptor signaling pathway  (IMP)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Minocycline prevents retinal inflammation and vascular permeability following ischemia-reperfusion injury. Abcouwer SF, etal., J Neuroinflammation. 2013 Dec 10;10:149. doi: 10.1186/1742-2094-10-149.
2. Similar pattern of MCP-1 expression in spinal cords and eyes of Lewis rats with experimental autoimmune encephalomyelitis associated anterior uveitis. Adamus G, etal., J Neurosci Res. 1997 Nov 15;50(4):531-8.
3. MCP-1 promoter polymorphism in Spanish patients with systemic lupus erythematosus. Aguilar F, etal., Tissue Antigens. 2001 Nov;58(5):335-8.
4. ANG II receptor blockade enhances anti-inflammatory macrophages in anti-glomerular basement membrane glomerulonephritis. Aki K, etal., Am J Physiol Renal Physiol. 2010 Apr;298(4):F870-82. Epub 2010 Jan 13.
5. Agmatine induces gastric protection against ischemic injury by reducing vascular permeability in rats. Al Masri AA and El Eter E, World J Gastroenterol. 2012 May 14;18(18):2188-96. doi: 10.3748/wjg.v18.i18.2188.
6. Plasma high mobility group box 1 protein reflects fibrosis in pediatric nonalcoholic fatty liver disease. Alisi A, etal., Expert Rev Mol Diagn. 2014 Jul;14(6):763-71. doi: 10.1586/14737159.2014.928205. Epub 2014 Jun 13.
7. An animal model of age-related macular degeneration in senescent Ccl-2- or Ccr-2-deficient mice. Ambati J, etal., Nat Med. 2003 Nov;9(11):1390-7. Epub 2003 Oct 19.
8. MCP-1 gene haplotype association in biopsy proven giant cell arteritis. Amoli MM, etal., J Rheumatol. 2005 Mar;32(3):507-10.
9. Impact of monocyte chemoattractant protein-1 deficiency on cerebral aneurysm formation. Aoki T, etal., Stroke. 2009 Mar;40(3):942-51. Epub 2009 Jan 22.
10. Predictive value of interleukin-5 and monocyte chemotactic protein-1 for bacteremia in children with febrile neutropenia. Aquino VM, etal., J Pediatr Hematol Oncol. 2012 Aug;34(6):e241-5. doi: 10.1097/MPH.0b013e31824e498d.
11. Intraocular expression and release of high-mobility group box 1 protein in retinal detachment. Arimura N, etal., Lab Invest. 2009 Mar;89(3):278-89. Epub 2009 Jan 12.
12. Associations of impaired behaviors with elevated plasma chemokines in autism spectrum disorders. Ashwood P, etal., J Neuroimmunol. 2011 Mar;232(1-2):196-9. doi: 10.1016/j.jneuroim.2010.10.025. Epub 2010 Nov 20.
13. Elevated circulating levels of C-C chemokines in patients with congestive heart failure. Aukrust P, etal., Circulation. 1998 Mar 31;97(12):1136-43.
14. Maternal exposure to particulate matter increases postnatal ozone-induced airway hyperreactivity in juvenile mice. Auten RL, etal., Am J Respir Crit Care Med. 2009 Dec 15;180(12):1218-26. Epub 2009 Sep 17.
15. Increased presence of dendritic cells and dendritic cell chemokines in the sinus mucosa of chronic rhinosinusitis with nasal polyps and allergic fungal rhinosinusitis. Ayers CM, etal., Int Forum Allergy Rhinol. 2011 Jul-Aug;1(4):296-302. doi: 10.1002/alr.20046. Epub 2011 Apr 11.
16. Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury. Baeck C, etal., Gut. 2012 Mar;61(3):416-26. doi: 10.1136/gutjnl-2011-300304. Epub 2011 Aug 3.
17. Effect of exercise on cardiac tissue oxidative and inflammatory mediators in chronic kidney disease. Bai Y, etal., Am J Nephrol. 2009;29(3):213-21. Epub 2008 Sep 17.
18. Highly regionalized neuronal expression of monocyte chemoattractant protein-1 (MCP-1/CCL2) in rat brain: evidence for its colocalization with neurotransmitters and neuropeptides. Banisadr G, etal., J Comp Neurol. 2005 Aug 29;489(3):275-92.
19. Constitutive neuronal expression of CCR2 chemokine receptor and its colocalization with neurotransmitters in normal rat brain: functional effect of MCP-1/CCL2 on calcium mobilization in primary cultured neurons. Banisadr G, etal., J Comp Neurol. 2005 Nov 14;492(2):178-92.
20. Revisiting the prognostic value of monocyte chemotactic protein 1 and interleukin-6 in the sepsis-3 era. Barre M, etal., J Crit Care. 2018 Feb;43:21-28. doi: 10.1016/j.jcrc.2017.08.024. Epub 2017 Aug 15.
21. Treating viral exacerbations of chronic obstructive pulmonary disease: insights from a mouse model of cigarette smoke and H1N1 influenza infection. Bauer CM, etal., PLoS One. 2010 Oct 12;5(10):e13251.
22. Effect of amphotericin B treatment on kinetics of cytokines and parameters of fungal load in neutropenic rats with invasive pulmonary aspergillosis. Becker MJ, etal., J Antimicrob Chemother. 2003 Sep;52(3):428-34. Epub 2003 Aug 13.
23. MCP-1 and CCR2 gene variants in oral squamous cell carcinoma. Bektas-Kayhan K, etal., Oral Dis. 2012 Jan;18(1):55-9. doi: 10.1111/j.1601-0825.2011.01843.x. Epub 2011 Aug 24.
24. Delayed functional expression of neuronal chemokine receptors following focal nerve demyelination in the rat: a mechanism for the development of chronic sensitization of peripheral nociceptors. Bhangoo S, etal., Mol Pain. 2007 Dec 12;3:38.
25. MCP-1 but not CINC synthesis is increased in rat pancreatic acini in response to cerulein hyperstimulation. Bhatia M, etal., Am J Physiol Gastrointest Liver Physiol 2002 Jan;282(1):G77-85.
26. Nonsteroidal anti-inflammatory drug induces proinflammatory damage in gastric mucosa through NF-kappaB activation and neutrophil infiltration: anti-inflammatory role of heme oxygenase-1 against nonsteroidal anti-inflammatory drug. Bindu S, etal., Free Radic Biol Med. 2013 Dec;65:456-67. doi: 10.1016/j.freeradbiomed.2013.07.027. Epub 2013 Jul 23.
27. Low plasma levels of monocyte chemoattractant protein-1 (MCP-1), tumor necrosis factor-alpha (TNFalpha), and vascular endothelial growth factor (VEGF) in patients with alpha1-antitrypsin deficiency-related fibromyalgia. Blanco I, etal., Clin Rheumatol. 2010 Feb;29(2):189-97. doi: 10.1007/s10067-009-1318-5. Epub 2009 Nov 19.
28. Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19. Blanco-Melo D, etal., Cell. 2020 May 28;181(5):1036-1045.e9. doi: 10.1016/j.cell.2020.04.026. Epub 2020 May 15.
29. Antifungal and airway remodeling roles for murine monocyte chemoattractant protein-1/CCL2 during pulmonary exposure to Asperigillus fumigatus conidia. Blease K, etal., J Immunol. 2001 Feb 1;166(3):1832-42.
30. Chemokine MCP1/CCL2 gene polymorphism influences Henoch-Schonlein purpura susceptibility in Iranian Azeri-Turkish patients. Bonyadi M, etal., Int J Dermatol. 2015 Nov;54(11):1269-74. doi: 10.1111/ijd.12940. Epub 2015 Jul 30.
31. TNFalpha inhibits apoptotic cell clearance in the lung, exacerbating acute inflammation. Borges VM, etal., Am J Physiol Lung Cell Mol Physiol. 2009 Oct;297(4):L586-95. Epub 2009 Jul 31.
32. Vascular endothelial growth factor and monocyte chemoattractant protein-1 in Behcet's patients with venous thrombosis. Bozoglu E, etal., Clin Exp Rheumatol. 2005 Jul-Aug;23(4 Suppl 38):S42-8.
33. Expression of the chemokines MCP-1/JE and cytokine-induced neutrophil chemoattractant in early acute pancreatitis. Brady M, etal., Pancreas 2002 Oct;25(3):260-9.
34. Production of monocyte chemotactic protein-1 by rat brain macrophages. Calvo CF, etal., Eur J Neurosci. 1996 Aug;8(8):1725-34.
35. Lung inflammation is induced by renal ischemia and reperfusion injury as part of the systemic inflammatory syndrome. Campanholle G, etal., Inflamm Res. 2010 Oct;59(10):861-9. Epub 2010 Apr 16.
36. Central nervous system injury triggers hepatic CC and CXC chemokine expression that is associated with leukocyte mobilization and recruitment to both the central nervous system and the liver. Campbell SJ, etal., Am J Pathol. 2005 May;166(5):1487-97.
37. Expression of caveolin-1 in human adipose tissue is upregulated in obesity and obesity-associated type 2 diabetes mellitus and related to inflammation. Catalan V, etal., Clin Endocrinol (Oxf). 2008 Feb;68(2):213-9. Epub 2007 Sep 4.
38. The MCP-1 -2518 (A to G) single nucleotide polymorphism is not associated with myocardial infarction in the Czech population. Cermakova Z, etal., Int J Immunogenet. 2005 Oct;32(5):315-8.
39. Sequential evaluation of serum monocyte chemotactic protein 1 among asymptomatic state and acute exacerbation and remission of asthma in children. Chan CK, etal., J Asthma. 2009 Apr;46(3):225-8.
40. Monocyte chemoattractant protein-1 released from alveolar macrophages mediates the systemic inflammation of acute alveolar hypoxia. Chao J, etal., Am J Respir Cell Mol Biol. 2011 Jul;45(1):53-61. doi: 10.1165/rcmb.2010-0264OC. Epub 2010 Sep 2.
41. Monocyte chemoattractant protein-1 is expressed in pancreatic islets from prediabetic NOD mice and in interleukin-1 beta-exposed human and rat islet cells. Chen MC, etal., Diabetologia. 2001 Mar;44(3):325-32.
42. Role of macrophage infiltration in the orbital fat of patients with Graves' ophthalmopathy. Chen MH, etal., Clin Endocrinol (Oxf). 2008 Aug;69(2):332-7. doi: 10.1111/j.1365-2265.2008.03219.x. Epub 2008 Feb 12.
43. CCR2-64I gene polymorphism increase susceptibility to oral cancer. Chen MK, etal., Oral Oncol. 2011 Jul;47(7):577-82. doi: 10.1016/j.oraloncology.2011.04.008. Epub 2011 May 12.
44. Cytokine-chemokine networks in experimental mycobacterial and schistosomal pulmonary granuloma formation. Chiu BC, etal., Am J Respir Cell Mol Biol. 2003 Jul;29(1):106-16. Epub 2003 Jan 10.
45. The chemokine CCL2 activates p38 mitogen-activated protein kinase pathway in cultured rat hippocampal cells. Cho J and Gruol DL, J Neuroimmunol. 2008 Aug 13;199(1-2):94-103. Epub 2008 Jun 27.
46. NIACIN AMELIORATES OXIDATIVE STRESS, INFLAMMATION, PROTEINURIA, AND HYPERTENSION IN RATS WITH CHRONIC RENAL FAILURE. Cho KH, etal., Am J Physiol Renal Physiol. 2009 May 6.
47. Effect of Sipjeondaebo-tang on cancer-induced anorexia and cachexia in CT-26 tumor-bearing mice. Choi YK, etal., Mediators Inflamm. 2014;2014:736563. doi: 10.1155/2014/736563. Epub 2014 May 14.
48. An investigation of the inflammatory cytokine and chemokine network in systemic sclerosis. Codullo V, etal., Ann Rheum Dis. 2011 Jun;70(6):1115-21. Epub 2011 Feb 1.
49. HIV-infected patients with lipodystrophy have higher rates of carotid atherosclerosis: the role of monocyte chemoattractant protein-1. Coll B, etal., Cytokine. 2006 Apr;34(1-2):51-5. Epub 2006 May 12.
50. Production and effects of alpha-melanocyte-stimulating hormone during acute lung injury. Colombo G, etal., Shock. 2007 Mar;27(3):326-33.
51. Induction of mast cell activation and CC chemokine responses in remodeling tracheal allografts. Cruz AC, etal., Am J Respir Cell Mol Biol. 2004 Aug;31(2):154-61. Epub 2004 Apr 1.
52. Monocyte chemoattractant protein 1 (MCP-1) expression occurs in toxic rat liver injury and human liver disease. Czaja MJ, etal., J Leukoc Biol. 1994 Jan;55(1):120-6.
53. Angiotensin AT1 receptor antagonists exert anti-inflammatory effects in spontaneously hypertensive rats. Dai Q, etal., Br J Pharmacol. 2007 Dec;152(7):1042-8. Epub 2007 Oct 8.
54. Spinal CCL2 pronociceptive action is no longer effective in CCR2 receptor antagonist-treated rats. Dansereau MA, etal., J Neurochem. 2008 Jul;106(2):757-69. Epub 2008 Apr 17.
55. Microglia and macrophages are increased in response to ischemia-induced retinopathy in the mouse retina. Davies MH, etal., Mol Vis. 2006 May 10;12:467-77.
56. ETS-1 and ETS-2 are upregulated in a transgenic mouse model of pigmented ocular neoplasm. De la Houssaye G, etal., Mol Vis. 2008;14:1912-28. Epub 2008 Oct 29.
57. FT011, a Novel Cardiorenal Protective Drug, Reduces Inflammation, Gliosis and Vascular Injury in Rats with Diabetic Retinopathy. Deliyanti D, etal., PLoS One. 2015 Jul 29;10(7):e0134392. doi: 10.1371/journal.pone.0134392. eCollection 2015.
58. Systemic inflammation without gliosis mediates cognitive deficits through impaired BDNF expression in bile duct ligation model of hepatic encephalopathy. Dhanda S, etal., Brain Behav Immun. 2018 May;70:214-232. doi: 10.1016/j.bbi.2018.03.002. Epub 2018 Mar 5.
59. MCP-1, CCR2 and CCR5 polymorphisms in Tunisian patients with atopic asthma. Dhaouadi T, etal., Iran J Allergy Asthma Immunol. 2013 Mar;12(1):29-36. doi: 012.01/ijaai.2936.
60. Xanthohumol ameliorates atherosclerotic plaque formation, hypercholesterolemia, and hepatic steatosis in ApoE-deficient mice. Doddapattar P, etal., Mol Nutr Food Res. 2013 Oct;57(10):1718-28. doi: 10.1002/mnfr.201200794. Epub 2013 May 3.
61. Angiotensin AT1 receptor antagonist irbesartan decreases lesion size, chemokine expression, and macrophage accumulation in apolipoprotein E-deficient mice. Dol F, etal., J Cardiovasc Pharmacol. 2001 Sep;38(3):395-405.
62. Upregulation of retinal neuronal MCP-1 in the rodent model of diabetic retinopathy and its function in vitro. Dong N, etal., Invest Ophthalmol Vis Sci. 2012 Nov 9;53(12):7567-75. doi: 10.1167/iovs.12-9446.
63. Retinal neuronal MCP-1 induced by AGEs stimulates TNF-alpha expression in rat microglia via p38, ERK, and NF-kappaB pathways. Dong N, etal., Mol Vis. 2014 May 2;20:616-28. eCollection 2014.
64. Monocyte chemoattractant protein 1 (MCP-1/CCL2) contributes to thymus atrophy in acute myeloid leukemia. Driss V, etal., Eur J Immunol. 2015 Feb;45(2):396-406. doi: 10.1002/eji.201444736. Epub 2014 Dec 4.
65. High-mobility group box-1 and biomarkers of inflammation in the vitreous from patients with proliferative diabetic retinopathy. El-Asrar AM, etal., Mol Vis. 2011;17:1829-38. Epub 2011 Jul 6.
66. TNF-alpha inhibition reduces renal injury in DOCA-salt hypertensive rats. Elmarakby AA, etal., Am J Physiol Regul Integr Comp Physiol. 2008 Jan;294(1):R76-83. Epub 2007 Nov 7.
67. Expression of chemokine and receptors in Lewis rats with experimental autoimmune anterior uveitis. Fang IM, etal., Exp Eye Res. 2004 Jun;78(6):1043-55.
68. The role of the beta chemokines in experimental obliterative bronchiolitis. Farivar AS, etal., Exp Mol Pathol. 2003 Dec;75(3):210-6.
69. Serum concentrations and peripheral secretion of the beta chemokines monocyte chemoattractant protein 1 and macrophage inflammatory protein 1alpha in alcoholic liver disease. Fisher NC, etal., Gut. 1999 Sep;45(3):416-20. doi: 10.1136/gut.45.3.416.
70. Proinflammatory genetic profiles in subjects with history of ischemic stroke. Flex A, etal., Stroke. 2004 Oct;35(10):2270-5. Epub 2004 Aug 12.
71. Pulmonary granuloma formation in the rat is partially dependent on monocyte chemoattractant protein 1. Flory CM, etal., Lab Invest. 1993 Oct;69(4):396-404.
72. Immune-compromised state in the rat pancreas after chronic alcohol exposure: the role of peroxisome proliferator-activated receptor gamma. Fortunato F, etal., J Pathol. 2007 Dec;213(4):441-52.
73. Inflammation Profiling of Critically Ill Coronavirus Disease 2019 Patients. Fraser DD, etal., Crit Care Explor. 2020 Jun 22;2(6):e0144. doi: 10.1097/CCE.0000000000000144. eCollection 2020 Jun.
74. Urinary MCP-1/creatinine in Henoch-Schonlein purpura and its relationship with nephritis. Fuentes Y, etal., Pediatr Nephrol. 2014 Jun;29(6):1047-52. doi: 10.1007/s00467-013-2740-0. Epub 2014 Jan 12.
75. Monocyte chemotactic and activating factor/monocyte chemoattractant protein-1-mediated histamine release from human nasal mucosa. Fujikura T and Otsuka H, Arch Otolaryngol Head Neck Surg. 1998 Dec;124(12):1331-5.
76. Association of vitreous inflammatory factors with diabetic macular edema. Funatsu H, etal., Ophthalmology. 2009 Jan;116(1):73-9.
77. Enhanced expression and production of monocyte chemoattractant protein-1 in myocarditis. Fuse K, etal., Clin Exp Immunol. 2001 Jun;124(3):346-52.
78. Monocyte chemoattractant protein-1 is a mediator of acute excitotoxic injury in neonatal rat brain. Galasso JM, etal., Neuroscience. 2000;101(3):737-44.
79. Joint effect of MCP-1 genotype GG and MMP-1 genotype 2G/2G increases the likelihood of developing pulmonary tuberculosis in BCG-vaccinated individuals. Ganachari M, etal., PLoS One. 2010 Jan 25;5(1):e8881.
80. Spinal injection of TNF-alpha-activated astrocytes produces persistent pain symptom mechanical allodynia by releasing monocyte chemoattractant protein-1. Gao YJ, etal., Glia. 2010 Nov 15;58(15):1871-80. doi: 10.1002/glia.21056.
81. Adenosine A2A receptor activation and macrophage-mediated experimental glomerulonephritis. Garcia GE, etal., FASEB J. 2008 Feb;22(2):445-54. Epub 2007 Sep 26.
82. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
83. Expression of monocyte chemoattractant protein-1 and macrophage colony-stimulating factor in normal and inflamed rat testis. Gerdprasert O, etal., Mol Hum Reprod 2002 Jun;8(6):518-24.
84. Costimulation of fibroblast collagen and transforming growth factor beta1 gene expression by monocyte chemoattractant protein-1 via specific receptors. Gharaee-Kermani M, etal., J Biol Chem. 1996 Jul 26;271(30):17779-84.
85. DNA-dependent protein kinase inhibition blocks asthma in mice and modulates human endothelial and CD4(+) T-cell function without causing severe combined immunodeficiency. Ghonim MA, etal., J Allergy Clin Immunol. 2015 Feb;135(2):425-40. doi: 10.1016/j.jaci.2014.09.005. Epub 2014 Oct 19.
86. Monocyte chemoattractant protein-1 has prosclerotic effects both in a mouse model of experimental diabetes and in vitro in human mesangial cells. Giunti S, etal., Diabetologia. 2008 Jan;51(1):198-207. Epub 2007 Oct 30.
87. Mechanisms of host defense following severe acute respiratory syndrome-coronavirus (SARS-CoV) pulmonary infection of mice. Glass WG, etal., J Immunol. 2004 Sep 15;173(6):4030-9. doi: 10.4049/jimmunol.173.6.4030.
88. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
89. Critical protective role for MCP-1 in pneumonic Burkholderia mallei infection. Goodyear A, etal., J Immunol. 2010 Feb 1;184(3):1445-54. Epub 2009 Dec 30.
90. Synergistic induction of monocyte chemoattractant protein-1 (MCP-1) by platelet-derived growth factor and interleukin-1. Goppelt-Struebe M and Stroebel M, FEBS Lett. 1995 Nov 6;374(3):375-8.
91. Time course of chemokine expression in acutely rejecting rat kidneys. Grau V, etal., Transplant Proc 1999 May;31(3):1571.
92. Acute and persisting Th2-like immune response after fractionated colorectal gamma-irradiation. Gremy O, etal., World J Gastroenterol. 2008 Dec 14;14(46):7075-85.
93. Concentration of interferon-inducible T cell chemoattractant and monocyte chemotactic protein-1 in serum and cerebrospinal fluid of patients with Lyme borreliosis. Grygorczuk S, etal., Rocz Akad Med Bialymst. 2005;50:173-8.
94. Monocyte chemoattractant protein-1 (MCP-1/CCL2) in experimental autoimmune orchitis. Guazzone VA, etal., J Reprod Immunol 2003 Dec;60(2):143-57.
95. Chemokine signaling involving chemokine (C-C motif) ligand 2 plays a role in descending pain facilitation. Guo W, etal., Neurosci Bull. 2012 Apr;28(2):193-207. doi: 10.1007/s12264-012-1218-6.
96. Relationship among MIF, MCP-1, viral loads, and HBs Ag levels in chronic hepatitis B patients. Güneş H, etal., Turk J Med Sci. 2015;45(3):634-7.
97. Cytokine regulation of MCP-1 expression in brain and retinal microvascular endothelial cells. Harkness KA, etal., J Neuroimmunol. 2003 Sep;142(1-2):1-9.
98. Serum chemokine and cytokine levels as indicators of disease activity in patients with systemic sclerosis. Hasegawa M, etal., Clin Rheumatol. 2011 Feb;30(2):231-7. Epub 2010 Nov 4.
99. A SARS-CoV-2 Infection Model in Mice Demonstrates Protection by Neutralizing Antibodies. Hassan AO, etal., Cell. 2020 Jun 10. pii: S0092-8674(20)30742-X. doi: 10.1016/j.cell.2020.06.011.
100. Phagocytic activity and monocyte chemotactic protein expression by pulmonary macrophages in persistent pulmonary cryptococcosis. He W, etal., Infect Immun 2003 Feb;71(2):930-6.
101. 22-Oxacalcitriol prevents progression of peritoneal fibrosis in a mouse model. Hirose M, etal., Perit Dial Int. 2013 Mar-Apr;33(2):132-42. doi: 10.3747/pdi.2011.00234. Epub 2012 Oct 2.
102. Sialic Acid Reduces Acute Endotoxemia-induced Liver Dysfunction in the Rat. Ho CH, etal., Shock. 2008 Dec 4.
103. The pathogenesis of pulmonary contusion: an open chest model in the rat. Hoth JJ, etal., J Trauma. 2006 Jul;61(1):32-44; discussion 44-5.
104. Monocyte chemoattractant protein-1 -2518 A/G single nucleotide polymorphism in Chinese Han patients with ocular Behcet's disease. Hou S, etal., Hum Immunol. 2010 Jan;71(1):79-82. doi: 10.1016/j.humimm.2009.09.354. Epub .
105. Involvement of spinal monocyte chemoattractant protein-1 (MCP-1) in cancer-induced bone pain in rats. Hu JH, etal., Neurosci Lett. 2012 May 23;517(1):60-3. doi: 10.1016/j.neulet.2012.04.026. Epub 2012 Apr 15.
106. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Huang C, etal., Lancet. 2020 Feb 15;395(10223):497-506. doi: 10.1016/S0140-6736(20)30183-5. Epub 2020 Jan 24.
107. An interferon-gamma-related cytokine storm in SARS patients. Huang KJ, etal., J Med Virol. 2005 Feb;75(2):185-94. doi: 10.1002/jmv.20255.
108. Inhibition of microRNA-210 suppresses pro-inflammatory response and reduces acute brain injury of ischemic stroke in mice. Huang L, etal., Exp Neurol. 2018 Feb;300:41-50. doi: 10.1016/j.expneurol.2017.10.024. Epub 2017 Oct 27.
109. Chronic ethanol ingestion induces aortic inflammation/oxidative endothelial injury and hypertension in rats. Husain K, etal., Hum Exp Toxicol. 2010 Oct 4.
110. The therapeutic effect of nano-encapsulated and nano-emulsion forms of carvacrol on experimental liver fibrosis. Hussein J, etal., Biomed Pharmacother. 2017 Jun;90:880-887. doi: 10.1016/j.biopha.2017.04.020. Epub 2017 Apr 21.
111. Homocysteine stimulates monocyte chemoattractant protein-1 expression in the kidney via nuclear factor-kappaB activation. Hwang SY, etal., Am J Physiol Renal Physiol. 2008 Jan;294(1):F236-44. Epub 2007 Oct 31.
112. Captopril suppresses inflammation in endotoxin-induced uveitis in rats. Ilieva I, etal., Exp Eye Res. 2006 Sep;83(3):651-7. Epub 2006 May 12.
113. Blocking of monocyte chemoattractant protein-1 (MCP-1) activity attenuates the severity of acute pancreatitis in rats. Ishibashi T, etal., J Gastroenterol. 2008;43(1):79-85. Epub 2008 Feb 24.
114. Hypoxic-ischemic injury induces monocyte chemoattractant protein-1 expression in neonatal rat brain. Ivacko J, etal., J Cereb Blood Flow Metab. 1997 Jul;17(7):759-70.
115. Assessment of genetic effects of polymorphisms in the MCP-1 gene on serum MCP-1 levels and myocardial infarction in Japanese. Iwai N, etal., Circ J. 2006 Jul;70(7):805-9.
116. Acute Respiratory Infection in Human Dipeptidyl Peptidase 4-Transgenic Mice Infected with Middle East Respiratory Syndrome Coronavirus. Iwata-Yoshikawa N, etal., J Virol. 2019 Mar 5;93(6). pii: JVI.01818-18. doi: 10.1128/JVI.01818-18. Print 2019 Mar 15.
117. Curcumin supplementation lowers TNF-alpha, IL-6, IL-8, and MCP-1 secretion in high glucose-treated cultured monocytes and blood levels of TNF-alpha, IL-6, MCP-1, glucose, and glycosylated hemoglobin in diabetic rats. Jain SK, etal., Antioxid Redox Signal. 2009 Feb;11(2):241-9.
118. Distinct chemokine and cytokine gene expression pattern of murine dendritic cells and macrophages in response to Mycobacterium tuberculosis infection. Jang S, etal., J Leukoc Biol. 2008 Nov;84(5):1264-70. Epub 2008 Aug 14.
119. Upregulation of monocyte chemotactic protein-1 and CC chemokine receptor 2 in the central nervous system is closely associated with relapse of autoimmune encephalomyelitis in Lewis rats. Jee Y, etal., J Neuroimmunol. 2002 Jul;128(1-2):49-57.
120. Association of monocyte chemoattractant protein-1 (MCP-1) 2518A/G polymorphism with proliferative diabetic retinopathy in Korean type 2 diabetes. Jeon HJ, etal., Yonsei Med J. 2013 May 1;54(3):621-5. doi: 10.3349/ymj.2013.54.3.621.
121. Expression of monocyte chemoattractant protein-1 in rat dorsal root ganglia and spinal cord in experimental models of neuropathic pain. Jeon SM, etal., Brain Res. 2009 Jan 28;1251:103-11. Epub 2008 Nov 27.
122. Expression of monocyte chemoattractant protein-1 and its induction by tumor necrosis factor receptor 1 in sensory neurons in the ventral rhizotomy model of neuropathic pain. Jeon SM, etal., Neuroscience. 2011 Sep 8;190:354-66. doi: 10.1016/j.neuroscience.2011.06.036. Epub 2011 Jun 25.
123. MIP-1alpha and MCP-1 Induce Migration of Human Umbilical Cord Blood Cells in Models of Stroke. Jiang L, etal., Curr Neurovasc Res. 2008 May;5(2):118-24.
124. Characterization of cytokine/chemokine profiles of severe acute respiratory syndrome. Jiang Y, etal., Am J Respir Crit Care Med. 2005 Apr 15;171(8):850-7. doi: 10.1164/rccm.200407-857OC. Epub 2005 Jan 18.
125. [Effects of hydrogen sulfide on vascular inflammation in pulmonary hypertension induced by high pulmonary blood flow: experiment with rats] Jin HF, etal., Zhonghua Yi Xue Za Zhi. 2008 Aug 19;88(32):2235-9.
126. Chronic inflammation upregulates chemokine receptors and induces neutrophil migration to monocyte chemoattractant protein-1. Johnston B, etal., J Clin Invest. 1999 May;103(9):1269-76.
127. Monocyte chemoattractant protein 1, intercellular adhesion molecule 1, and vascular cell adhesion molecule 1 in exudative age-related macular degeneration. Jonas JB, etal., Arch Ophthalmol. 2010 Oct;128(10):1281-6. doi: 10.1001/archophthalmol.2010.227.
128. Potential role of monocyte chemoattractant protein 1/JE in monocyte/macrophage-dependent IgA immune complex alveolitis in the rat. Jones ML, etal., J Immunol. 1992 Sep 15;149(6):2147-54.
129. Plasma and whole-blood chemokine levels in patients with Behcet's disease. Kaburaki T, etal., Graefes Arch Clin Exp Ophthalmol. 2003 May;241(5):353-8. Epub 2003 Apr 23.
130. Monocyte chemoattractant protein-1 gene delivery enhances antitumor effects of herpes simplex virus thymidine kinase/ganciclovir system in a model of colon cancer. Kagaya T, etal., Cancer Gene Ther. 2006 Apr;13(4):357-66.
131. Roles and relationship of macrophages and monocyte chemotactic and activating factor/monocyte chemoattractant protein-1 in the ischemic and reperfused rat heart. Kakio T, etal., Lab Invest. 2000 Jul;80(7):1127-36.
132. Lithospermic acid B ameliorates the development of diabetic nephropathy in OLETF rats. Kang ES, etal., Eur J Pharmacol. 2008 Jan 28;579(1-3):418-25. Epub 2007 Nov 1.
133. Inhibitor kappa B kinase beta dependent cytokine upregulation in nociceptive neurons contributes to nociceptive hypersensitivity after sciatic nerve injury. Kanngiesser M, etal., J Pain. 2012 May;13(5):485-97. doi: 10.1016/j.jpain.2012.02.010.
134. Reciprocal regulation of ATPgammaS-induced monocyte chemoattractant protein-1 production by ERK and p38 MAP kinases in rat corticostriatal slice cultures. Katayama T, etal., J Neurosci Res. 2009 May 15;87(7):1573-81. doi: 10.1002/jnr.21982.
135. Diclofenac, a selective COX-2 inhibitor, inhibits DMH-induced colon tumorigenesis through suppression of MCP-1, MIP-1alpha and VEGF. Kaur J and Sanyal SN, Mol Carcinog. 2011 Jan 25. doi: 10.1002/mc.20736.
136. Monocyte chemoattractant protein-1-dependent increase of V alpha 14 NKT cells in lungs and their roles in Th1 response and host defense in cryptococcal infection. Kawakami K, etal., J Immunol. 2001 Dec 1;167(11):6525-32.
137. Chemokine and chemokine receptor expression during experimental autoimmune uveoretinitis in mice. Keino H, etal., Graefes Arch Clin Exp Ophthalmol. 2003 Feb;241(2):111-5. Epub 2003 Jan 28.
138. Higher activity by opaque endometriotic lesions than nonopaque lesions. Khan KN, etal., Acta Obstet Gynecol Scand. 2004 Apr;83(4):375-82.
139. Neutrophils and reactive oxygen intermediates mediate glucan-induced pulmonary granuloma formation through the local induction of monocyte chemoattractant protein-1. Kilgore KS, etal., Lab Invest. 1997 Feb;76(2):191-201.
140. Depletion of MCP-1 increases development of herpetic stromal keratitis by innate immune modulation. Kim B, etal., J Leukoc Biol. 2006 Dec;80(6):1405-15. Epub 2006 Sep 22.
141. Plasma levels of MCP-1 and adiponectin in obstructive sleep apnea syndrome. Kim J, etal., Arch Otolaryngol Head Neck Surg. 2010 Sep;136(9):896-9.
142. Expression of monocyte chemoattractant protein-1 and macrophage inflammatory protein-1 after focal cerebral ischemia in the rat. Kim JS, etal., J Neuroimmunol. 1995 Feb;56(2):127-34.
143. Histone deacetylase 3 mediates allergic skin inflammation by regulating expression of MCP1 protein. Kim Y, etal., J Biol Chem. 2012 Jul 27;287(31):25844-59. doi: 10.1074/jbc.M112.348284. Epub 2012 Jun 7.
144. Alleviation of monocrotaline-induced pulmonary hypertension by antibodies to monocyte chemotactic and activating factor/monocyte chemoattractant protein-1. Kimura H, etal., Lab Invest. 1998 May;78(5):571-81.
145. Nicotinic alpha-7 acetylcholine receptor deficiency exacerbates hepatic inflammation and fibrosis in a mouse model of non-alcoholic steatohepatitis. Kimura K, etal., J Diabetes Investig. 2019 May;10(3):659-666. doi: 10.1111/jdi.12964. Epub 2018 Dec 16.
146. Circulating levels of MCP-1 are increased in women with gestational diabetes. Klein K, etal., Prenat Diagn. 2008 Sep;28(9):845-51.
147. Pioglitazone attenuates diabetic nephropathy through an anti-inflammatory mechanism in type 2 diabetic rats. Ko GJ, etal., Nephrol Dial Transplant. 2008 Sep;23(9):2750-60. Epub 2008 Apr 3.
148. The role of monocyte chemoattractant protein-1 in biliary atresia. Kobayashi H, etal., J Pediatr Surg. 2006 Dec;41(12):1967-72. doi: 10.1016/j.jpedsurg.2006.08.018.
149. Angiotensin-receptor blockade reduces border zone myocardial monocyte chemoattractant protein-1 expression and macrophage infiltration in post-infarction ventricular remodeling. Kohno T, etal., Circ J. 2008 Oct;72(10):1685-92. Epub 2008 Aug 28.
150. Comparison of cytokine levels from undiluted vitreous of untreated patients with retinal vein occlusion. Koss MJ, etal., Acta Ophthalmol. 2012 Mar;90(2):e98-e103. doi: 10.1111/j.1755-3768.2011.02292.x. Epub 2011 Nov 8.
151. Association of serum MCP-1 concentration and MCP-1 polymorphism with insulin resistance in Japanese individuals with obese type 2 diabetes. Kouyama K, etal., Kobe J Med Sci. 2008 Feb 8;53(6):345-54.
152. Monocyte chemoattractant protein-1 in the aqueous humour of patients with age-related macular degeneration. Kramer M, etal., Clin Experiment Ophthalmol. 2012 Aug;40(6):617-25. doi: 10.1111/j.1442-9071.2011.02747.x. Epub 2012 Feb 20.
153. A Monocyte chemoattractant protein-1 (MCP-1) polymorphism and outcome after renal transplantation. Kruger B, etal., J Am Soc Nephrol. 2002 Oct;13(10):2585-9.
154. Astrocytic P2Y(1) receptor is involved in the regulation of cytokine/chemokine transcription and cerebral damage in a rat model of cerebral ischemia. Kuboyama K, etal., J Cereb Blood Flow Metab. 2011 Sep;31(9):1930-41. doi: 10.1038/jcbfm.2011.49. Epub 2011 Apr 13.
155. Molecular regulation of monocyte chemoattractant protein-1 expression in pancreatic beta-cells. Kutlu B, etal., Diabetes 2003 Feb;52(2):348-55.
156. Hypertensive myocardial fibrosis and diastolic dysfunction: another model of inflammation? Kuwahara F, etal., Hypertension. 2004 Apr;43(4):739-45. Epub 2004 Feb 16.
157. HIV infection is associated with higher levels of monocyte chemoattractant protein-1 and eotaxin among people with recent hepatitis C virus infection. Lamoury FM, etal., BMC Infect Dis. 2016 Jun 1;16:241. doi: 10.1186/s12879-016-1567-2.
158. Cdc42 GTPases facilitate TNF-alpha-mediated secretion of CCL2 from peripheral nerve microvascular endoneurial endothelial cells. Langert KA, etal., J Peripher Nerv Syst. 2013 Sep;18(3):199-208. doi: 10.1111/jns5.12032.
159. Oral methylthioadenosine administration attenuates fibrosis and chronic liver disease progression in Mdr2-/- mice. Latasa MU, etal., PLoS One. 2010 Dec 29;5(12):e15690. doi: 10.1371/journal.pone.0015690.
160. Effect of glucocorticoid pretreatment on oxidative liver injury and survival in jaundiced rats with endotoxin cholangitis. Lee CW, etal., World J Surg. 2006 Dec;30(12):2217-26. doi: 10.1007/s00268-006-0143-0.
161. Blocking the monocyte chemoattractant protein-1/CCR2 chemokine pathway induces permanent survival of islet allografts through a programmed death-1 ligand-1-dependent mechanism. Lee I, etal., J Immunol. 2003 Dec 15;171(12):6929-35.
162. Early up-regulation of chemokine expression in fulminant hepatic failure. Leifeld L, etal., J Pathol. 2003 Mar;199(3):335-44. doi: 10.1002/path.1298.
163. Melatonin reduces the expression of chemokines in rat with trinitrobenzene sulfonic acid-induced colitis. Li JH, etal., Saudi Med J. 2008 Aug;29(8):1088-94.
164. Colchicine Attenuates Inflammatory Cells Infiltration and Extracellular Matrix Accumulation in Diabetic Nephropathy. Li JJ, etal., Am J Physiol Renal Physiol. 2009 Apr 15.
165. Blocking of monocyte chemoattractant protein-1 during tubulointerstitial nephritis resulted in delayed neutrophil clearance. Li P, etal., Am J Pathol. 2005 Sep;167(3):637-49.
166. Intravenous transfusion of endothelial colony-forming cells attenuates vascular degeneration after cerebral aneurysm induction. Li S, etal., Brain Res. 2014 Dec 17;1593:65-75. doi: 10.1016/j.brainres.2014.09.077. Epub 2014 Oct 12.
167. Clinical and pathological investigation of severe COVID-19 patients. Li S, etal., JCI Insight. 2020 May 19. pii: 138070. doi: 10.1172/jci.insight.138070.
168. Caveolin-1 increases proinflammatory chemoattractants and blood-retinal barrier breakdown but decreases leukocyte recruitment in inflammation. Li X, etal., Invest Ophthalmol Vis Sci. 2014 Aug 26;55(10):6224-34. doi: 10.1167/iovs.14-14613.
169. Effects of bone marrow-derived endothelial progenitor cell transplantation on vein microenvironment in a rat model of chronic thrombosis. Li XQ, etal., Chin Med J (Engl). 2007 Dec 20;120(24):2245-9.
170. [Effect of aging on pulmonary ICAM-1 and MCP-1 expressions in rats with lipopolysaccharide- induced acute lung injury]. Lin SP, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2010 Mar;30(3):584-7.
171. The effect of simvastatin on the serum monocyte chemoattractant protein-1 and intracellular adhesion molecule-1 levels in diabetic rats. Lin Y, etal., J Diabetes Complications. 2009 May-Jun;23(3):214-8. Epub 2008 Apr 16.
172. TLR4 mediates inflammation and hepatic fibrosis induced by chronic intermittent hypoxia in rats. Lin ZP, etal., Mol Med Rep. 2020 Aug;22(2):651-660. doi: 10.3892/mmr.2020.11134. Epub 2020 May 7.
173. [Relationship between the level of MCP-1 expression in sera of RA patients and ILD]. Ling T, etal., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2010 Jan;26(1):59-60.
174. The expression of MCP-1 and CCR2 in induced rats periapical lesions. Liu L, etal., Arch Oral Biol. 2014 May;59(5):492-9. doi: 10.1016/j.archoralbio.2014.02.008. Epub 2014 Feb 22.
175. MCP1 -2518 polymorphism and chronic obstructive pulmonary disease in Taiwanese men. Liu SF, etal., Exp Lung Res. 2010 Jun;36(5):277-83.
176. Expression of monocyte chemoattractant protein-1 in the cerebral artery after experimental subarachnoid hemorrhage. Lu H, etal., Brain Res. 2009 Mar 25;1262:73-80. Epub 2009 Jan 21.
177. Suppression of constitutive but not Il-1beta-inducible expression of monocyte chemoattractant protein-1 in mesangial cells by retinoic acids: intervention in the activator protein-1 pathway. Lucio-Cazana J, etal., J Am Soc Nephrol. 2001 Apr;12(4):688-94.
178. Lipoprotein-X stimulates monocyte chemoattractant protein-1 expression in mesangial cells via nuclear factor-kappa B. Lynn EG, etal., Kidney Int. 2001 Aug;60(2):520-32.
179. Liu Shen capsule shows antiviral and anti-inflammatory abilities against novel coronavirus SARS-CoV-2 via suppression of NF-κB signaling pathway. Ma Q, etal., Pharmacol Res. 2020 Apr 30;158:104850. doi: 10.1016/j.phrs.2020.104850.
180. Involvement of CCL2/CCR2 macrophage recruitment in amodiaquine-induced liver injury. Mak A and Uetrecht J, J Immunotoxicol. 2019 Jan 21:1-6. doi: 10.1080/1547691X.2018.1516014.
181. Crucial role of CCL3/MIP-1alpha in the recurrence of autoimmune anterior uveitis induced with myelin basic protein in Lewis rats. Manczak M, etal., J Autoimmun. 2002 Jun;18(4):259-70.
182. An essential role for monocyte chemoattractant protein-1 in alcoholic liver injury: regulation of proinflammatory cytokines and hepatic steatosis in mice. Mandrekar P, etal., Hepatology. 2011 Dec;54(6):2185-97. doi: 10.1002/hep.24599.
183. Characterization of monocyte chemoattractant protein-1 expression following a kainate model of status epilepticus. Manley NC, etal., Brain Res. 2007 Nov 28;1182:138-43. Epub 2007 Sep 22.
184. Monocyte chemoattractant protein-1 (MCP-1) gene transduction: an effective tumor vaccine strategy for non-intracranial tumors. Manome Y, etal., Cancer Immunol Immunother. 1995 Oct;41(4):227-35.
185. Paraoxonase-1 is related to inflammation, fibrosis and PPAR delta in experimental liver disease. Marsillach J, etal., BMC Gastroenterol. 2009 Jan 14;9:3.
186. Membrane-bound form of monocyte chemoattractant protein-1 enhances antitumor effects of suicide gene therapy in a model of hepatocellular carcinoma. Marukawa Y, etal., Cancer Gene Ther. 2012 May;19(5):312-9. doi: 10.1038/cgt.2012.3. Epub 2012 Mar 9.
187. Transforming growth factor-beta1 enhances the secretion of monocyte chemoattractant protein-1 by the IEC-18 intestinal epithelial cell line. Matagrano LB, etal., In Vitro Cell Dev Biol Anim. 2003 Mar-Apr;39(3-4):183-6.
188. Circulating monocytes from systemic sclerosis patients with interstitial lung disease show an enhanced profibrotic phenotype. Mathai SK, etal., Lab Invest. 2010 Jun;90(6):812-23. Epub 2010 Apr 19.
189. Regulation of oxidative stress and inflammation by hepatic adiponectin receptor 2 in an animal model of nonalcoholic steatohepatitis. Matsunami T, etal., Int J Clin Exp Pathol. 2010 May 22;3(5):472-81.
190. Increased monocyte chemoattractant protein 1 (MCP-1/CCL-2) serum level in acute myeloid leukemia. Mazur G, etal., Neoplasma. 2007;54(4):285-9.
191. CCL2 polymorphisms are associated with serum monocyte chemoattractant protein-1 levels and myocardial infarction in the Framingham Heart Study. McDermott DH, etal., Circulation. 2005 Aug 23;112(8):1113-20.
192. Inactivation of IL-6 and soluble IL-6 receptor by neutrophil derived serine proteases in cystic fibrosis. McGreal EP, etal., Biochim Biophys Acta. 2010 Jul-Aug;1802(7-8):649-58. Epub 2010 May 7.
193. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
194. Estrogen modulates inflammatory mediator expression and neutrophil chemotaxis in injured arteries. Miller AP, etal., Circulation. 2004 Sep 21;110(12):1664-9. Epub 2004 Sep 7.
195. Persistent airway inflammation and emphysema progression on CT in ex-smokers observed for 4 years. Miller M, etal., Chest. 2010 Oct 21.
196. Trehalose: a biophysics approach to modulate the inflammatory response during endotoxic shock. Minutoli L, etal., Eur J Pharmacol. 2008 Jul 28;589(1-3):272-80. Epub 2008 Apr 12.
197. Tumor progression is associated with increasing CD11b+ cells and CCL2 in Lewis rat sarcoma. Mishra R, etal., Anticancer Res. 2015 Feb;35(2):703-11.
198. In vivo effect of surfactant on inflammatory cytokines during endotoxin-induced lung injury in rodents. Mittal N and Sanyal SN, J Immunotoxicol. 2011 Oct-Dec;8(4):274-83. Epub 2011 Jul 18.
199. Anti-inflammatory effect of angiotensin type 1 receptor antagonist on endotoxin-induced uveitis in rats. Miyazaki A, etal., Graefes Arch Clin Exp Ophthalmol. 2008 May;246(5):747-57. Epub 2007 Dec 18.
200. Association of polymorphisms in monocyte chemoattractant protein-1 promoter with diabetic kidney failure in Korean patients with type 2 diabetes mellitus. Moon JY, etal., J Korean Med Sci. 2007 Oct;22(5):810-4.
201. 22-S-Hydroxycholesterol protects against ethanol-induced liver injury by blocking the auto/paracrine activation of MCP-1 mediated by LXRα. Na TY, etal., J Pathol. 2015 Apr;235(5):710-20. doi: 10.1002/path.4494. Epub 2015 Jan 5.
202. Monocyte chemoattractant protein 1 mediates retinal detachment-induced photoreceptor apoptosis. Nakazawa T, etal., Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2425-30. Epub 2007 Feb 6.
203. MCP-1 antibody treatment enhances damage and impedes repair of the alveolar epithelium in influenza pneumonitis. Narasaraju T, etal., Am J Respir Cell Mol Biol. 2010 Jun;42(6):732-43. Epub 2009 Jul 17.
204. Renal response to repetitive exposure to heme proteins: chronic injury induced by an acute insult. Nath KA, etal., Kidney Int. 2000 Jun;57(6):2423-33.
205. Heme protein-induced chronic renal inflammation: suppressive effect of induced heme oxygenase-1. Nath KA, etal., Kidney Int. 2001 Jan;59(1):106-17.
206. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
207. Chemokine response in children with SARS. Ng PC, etal., Arch Dis Child. 2005 Apr;90(4):422-3. doi: 10.1136/adc.2004.053660.
208. Lipid metabolism and inflammation modulated by Vitamin D in liver of diabetic rats. Ning C, etal., Lipids Health Dis. 2015 Apr 18;14:31. doi: 10.1186/s12944-015-0030-5.
209. Monocyte chemoattractant protein-1 (MCP-1) deficiency enhances alternatively activated M2 macrophages and ameliorates insulin resistance and fatty liver in lipoatrophic diabetic A-ZIP transgenic mice. Nio Y, etal., Diabetologia. 2012 Dec;55(12):3350-8. doi: 10.1007/s00125-012-2710-2. Epub 2012 Sep 16.
210. Effects of pitavastatin on monocyte chemoattractant protein-1 in hyperlipidemic patients. Nomura S, etal., Blood Coagul Fibrinolysis. 2009 Sep;20(6):440-7. doi: 10.1097/MBC.0b013e32832e0618.
211. Monocyte chemoattractant protein-1 is excreted in excessive amounts in the urine of patients with lupus nephritis. Noris M, etal., Lab Invest. 1995 Dec;73(6):804-9.
212. Alternatively activated macrophages and collagen remodeling characterize the postpartum involuting mammary gland across species. O'Brien J, etal., Am J Pathol. 2010 Mar;176(3):1241-55. Epub 2010 Jan 28.
213. Genetic variants of CC chemokine genes in experimental autoimmune encephalomyelitis, multiple sclerosis and rheumatoid arthritis. Ockinger J, etal., Genes Immun. 2010 Mar;11(2):142-54. Epub 2009 Oct 29.
214. Disruption of tumor necrosis factor-alpha gene diminishes the development of atherosclerosis in ApoE-deficient mice. Ohta H, etal., Atherosclerosis. 2005 May;180(1):11-7. Epub 2005 Jan 20.
215. Administration of a substituted adamantyl urea inhibitor of soluble epoxide hydrolase protects the kidney from damage in hypertensive Goto-Kakizaki rats. Olearczyk JJ, etal., Clin Sci (Lond). 2009 Jan;116(1):61-70.
216. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
217. Prevention of myocardial reperfusion injury in rats by an antibody against monocyte chemotactic and activating factor/monocyte chemoattractant protein-1. Ono K, etal., Lab Invest. 1999 Feb;79(2):195-203.
218. Monocyte chemoattractant protein 1 and chemokine receptor CCR2 productions in Guillain-Barre syndrome and experimental autoimmune neuritis. Orlikowski D, etal., J Neuroimmunol. 2003 Jan;134(1-2):118-27.
219. Expression of monocyte chemoattractant protein-1 in proximal tubular epithelial cells in a rat model of progressive kidney failure. Ota T, etal., J Lab Clin Med. 2002 Jul;140(1):43-51.
220. IL-1 beta, IL-6, KC and MCP-1 are elevated in synovial fluid from haemophilic mice with experimentally induced haemarthrosis. Ovlisen K, etal., Haemophilia. 2009 May;15(3):802-10.
221. High-mobility group box-1 protein promotes granulomatous nephritis in adenine-induced nephropathy. Oyama Y, etal., Lab Invest. 2010 Jun;90(6):853-66. doi: 10.1038/labinvest.2010.64. Epub 2010 Mar 15.
222. Monocyte chemoattractant protein-1 promoter -2518 polymorphism may have an influence on clinical heterogeneity of bipolar I disorder in the Korean population. Pae CU, etal., Neuropsychobiology 2004;49(3):111-4.
223. Endogenous VEGF-A is responsible for mitogenic effects of MCP-1 on vascular smooth muscle cells. Parenti A, etal., Am J Physiol Heart Circ Physiol. 2004 May;286(5):H1978-84. Epub 2003 Dec 23.
224. Brown Norway rat asthma model of diphenylmethane-4,4'-diisocyanate (MDI): impact of vehicle for topical induction. Pauluhn J Regul Toxicol Pharmacol. 2008 Feb;50(1):144-54. Epub 2007 Sep 21.
225. Possible new role of monocyte chemoattractant protein-1 in hemodialysis patients with cardiovascular disease. Pawlak K, etal., Am J Nephrol. 2004 Nov-Dec;24(6):635-40. Epub 2004 Dec 22.
226. Monocyte chemoattractant protein-1 -2518 A/G single nucleotide polymorphism might be associated with renal disease and thrombocytopenia of SLE. Piotrowski P, etal., J Biomed Biotechnol. 2010;2010:130265. doi: 10.1155/2010/130265. Epub 2010 Apr 21.
227. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
228. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
229. Monocyte chemoattractant protein-1 increases microglial infiltration and aggressiveness of gliomas. Platten M, etal., Ann Neurol. 2003 Sep;54(3):388-92.
230. Inhibition of renal rho kinase attenuates ischemia/reperfusion-induced injury. Prakash J, etal., J Am Soc Nephrol. 2008 Nov;19(11):2086-97. doi: 10.1681/ASN.2007070794. Epub 2008 Jul 23.
231. Blockade of endothelin ET(A)/ET(B) receptors favors a role for endothelin during acute Trypanosoma cruzi infection in rats. Rachid MA, etal., Microbes Infect. 2006 Jul;8(8):2113-9. Epub 2006 Jun 6.
232. Superimposed gastric aspiration increases the severity of inflammation and permeability injury in a rat model of lung contusion. Raghavendran K, etal., J Surg Res. 2009 Aug;155(2):273-82. Epub 2008 Sep 16.
233. The evolution of isolated bilateral lung contusion from blunt chest trauma in rats: cellular and cytokine responses. Raghavendran K, etal., Shock. 2005 Aug;24(2):132-8.
234. Inhibition of T cell recruitment and cutaneous delayed-type hypersensitivity-induced inflammation with antibodies to monocyte chemoattractant protein-1. Rand ML, etal., Am J Pathol. 1996 Mar;148(3):855-64.
235. Muscle responds to an antibody reactive with the acetylcholine receptor by up-regulating monocyte chemoattractant protein 1: a chemokine with the potential to influence the severity and course of experimental myasthenia gravis. Reyes-Reyna S, etal., J Immunol 2002 Aug 1;169(3):1579-86.
236. GOA pipeline RGD automated data pipeline
237. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
238. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
239. The temporal expression, cellular localization, and inhibition of the chemokines MIP-2 and MCP-1 after traumatic brain injury in the rat. Rhodes JK, etal., J Neurotrauma. 2009 Apr;26(4):507-25.
240. Use of inflammatory molecules to predict the occurrence of fever in onco-hematological patients with neutropenia. Ribeiro AF, etal., Braz J Med Biol Res. 2013 Feb;46(2):200-6. Epub 2013 Feb 1.
241. Effects of angiotensin-1 converting enzyme inhibition on oxidative stress and bradykinin receptor expression during doxorubicin-induced cardiomyopathy in rats. Richard C, etal., J Cardiovasc Pharmacol. 2008 Sep;52(3):278-85.
242. Increased cytokines, chemokines and soluble adhesion molecules in exhaled breath condensate of asthmatic children. Robroeks CM, etal., Clin Exp Allergy. 2010 Jan;40(1):77-84.
243. Melanoma susceptibility and progression: Association study between polymorphisms of the chemokine (CCL2) and chemokine receptors (CX3CR1, CCR5). Rodero M, etal., J Dermatol Sci. 2007 Apr;46(1):72-6. Epub 2006 Dec 13.
244. MCP-1 and MIP3-alpha serum levels in acute liver failure and molecular adsorbent recirculating system (MARS) treatment: a pilot study. Roth GA, etal., Scand J Gastroenterol. 2009;44(6):745-51. doi: 10.1080/00365520902770086.
245. Therapeutic Effects of Evasin-1, a Chemokine Binding Protein, in Bleomycin-Induced Pulmonary Fibrosis. Russo RC, etal., Am J Respir Cell Mol Biol. 2010 Sep 10.
246. Spleen tyrosine kinase promotes acute neutrophil-mediated glomerular injury via activation of JNK and p38 MAPK in rat nephrotoxic serum nephritis. Ryan J, etal., Lab Invest. 2011 Dec;91(12):1727-38. doi: 10.1038/labinvest.2011.137. Epub 2011 Sep 5.
247. Gingival levels of monocyte chemoattractant protein-1 (MCP-1) in diabetes mellitus and periodontitis: an experimental study in rats. Sakallioglu EE, etal., Clin Oral Investig. 2008 Mar;12(1):83-9. Epub 2007 Sep 18.
248. [The behavior of intra-leukocyte peroxidase after irradiation with radar microwaves in intra-articular exudates]. Santolini BM, etal., Minerva Ortop. 1971 Dec;22(12):459-62.
249. Hepatitis C virus-induced changes in microRNA 107 (miRNA-107) and miRNA-449a modulate CCL2 by targeting the interleukin-6 receptor complex in hepatitis. Sarma NJ, etal., J Virol. 2014 Apr;88(7):3733-43. doi: 10.1128/JVI.03060-13. Epub 2014 Jan 15.
250. Increased expression of CCAAT/enhancer binding protein-beta and -delta and monocyte chemoattractant protein-1 genes in aortas from hyperinsulinaemic rats. Sato Y, etal., Diabetologia. 2007 Feb;50(2):481-9. Epub 2006 Dec 16.
251. Perioperative glycine treatment attenuates ischemia/reperfusion injury and ameliorates smooth muscle dysfunction in intestinal transplantation. Schaefer N, etal., Transplantation. 2008 May 15;85(9):1300-10.
252. The cannabinoid receptor-1 antagonist rimonabant inhibits platelet activation and reduces pro-inflammatory chemokines and leukocytes in Zucker rats. Schafer A, etal., Br J Pharmacol. 2008 Jul;154(5):1047-54. Epub 2008 May 12.
253. Bronchoalveoloar lavage fluid cytokines and chemokines as markers and predictors for the outcome of interstitial lung disease in systemic sclerosis patients. Schmidt K, etal., Arthritis Res Ther. 2009;11(4):R111. Epub 2009 Jul 17.
254. Monocyte chemoattractant protein-1 mediates collagen deposition in experimental glomerulonephritis by transforming growth factor-beta. Schneider A, etal., Kidney Int. 1999 Jul;56(1):135-44.
255. Monocyte chemoattractant protein-1 and RANTES are chemotactic for graft infiltrating lymphocytes during acute lung allograft rejection. Sekine Y, etal., Am J Respir Cell Mol Biol. 2000 Dec;23(6):719-26.
256. CCR2(+) monocytes infiltrate atrophic lesions in age-related macular disease and mediate photoreceptor degeneration in experimental subretinal inflammation in Cx3cr1 deficient mice. Sennlaub F, etal., EMBO Mol Med. 2013 Nov;5(11):1775-93. doi: 10.1002/emmm.201302692. Epub 2013 Oct 21.
257. Inhibition of monocyte chemoattractant protein-1 ameliorates rat adjuvant-induced arthritis. Shahrara S, etal., J Immunol. 2008 Mar 1;180(5):3447-56.
258. Altered serum transforming growth factor-beta1 and monocyte chemoattractant protein-1 levels in obstructive jaundice. Sheen-Chen SM, etal., World J Surg. 2004 Oct;28(10):967-70. Epub 2004 Sep 29.
259. Inhibition of p38 mitogen-activated protein kinase is effective in the treatment of experimental crescentic glomerulonephritis and suppresses monocyte chemoattractant protein-1 but not IL-1beta or IL-6. Sheryanna A, etal., J Am Soc Nephrol. 2007 Apr;18(4):1167-79. Epub 2007 Feb 21.
260. Hepatic interferon regulatory factor 8 expression mediates liver ischemia/reperfusion injury in mice. Shi G, etal., Biochem Pharmacol. 2021 Oct;192:114728. doi: 10.1016/j.bcp.2021.114728. Epub 2021 Aug 13.
261. Effects of induction therapy on wound healing at bronchial anastomosis sites in rats. Shirafuji T, etal., Jpn J Thorac Cardiovasc Surg. 2003 Jun;51(6):217-24.
262. Inhibition of development of experimental aortic abdominal aneurysm in rat model by atorvastatin through inhibition of macrophage migration. Shiraya S, etal., Atherosclerosis. 2009 Jan;202(1):34-40. Epub 2008 Apr 6.
263. Hypoxic preconditioning with cobalt attenuates hypobaric hypoxia-induced oxidative damage in rat lungs. Shukla D, etal., High Alt Med Biol. 2009 Spring;10(1):57-69.
264. Monocyte chemoattractant protein-1 (CCL-2) integrates mechanical and endocrine signals that mediate term and preterm labor. Shynlova O, etal., J Immunol. 2008 Jul 15;181(2):1470-9.
265. Differential expression of chemokines and chemokine receptors in inflammatory periapical diseases. Silva TA, etal., Oral Microbiol Immunol. 2005 Oct;20(5):310-6.
266. Interferon-gamma potentiates NMDA receptor signaling in spinal dorsal horn neurons via microglia-neuron interaction. Sonekatsu M, etal., Mol Pain. 2016 Apr 18;12. pii: 12/0/1744806916644927. doi: 10.1177/1744806916644927. Print 2016.
267. Kupffer cell depletion protects against the steatosis, but not the liver damage, induced by marginal-copper, high-fructose diet in male rats. Song M, etal., Am J Physiol Gastrointest Liver Physiol. 2015 Jun 1;308(11):G934-45. doi: 10.1152/ajpgi.00285.2014. Epub 2015 Mar 26.
268. The evolving systemic and local biomarker milieu at different stages of disease progression in rat adjuvant-induced arthritis. Stolina M, etal., J Clin Immunol. 2009 Mar;29(2):158-74. Epub 2008 Aug 26.
269. Atorvastatin enhances interleukin-10 levels and improves cardiac function in rats after acute myocardial infarction. Stumpf C, etal., Clin Sci (Lond). 2009 Jan;116(1):45-52.
270. Role of leukotriene B4 receptors in the development of atherosclerosis: potential mechanisms. Subbarao K, etal., Arterioscler Thromb Vasc Biol. 2004 Feb;24(2):369-75. Epub 2003 Dec 1.
271. Chemokine CCL2/MCP-1 negatively regulates metastasis in a highly bone marrow-metastatic mouse breast cancer model. Takahashi M, etal., Clin Exp Metastasis. 2009;26(7):817-28. Epub 2009 Jul 24.
272. Mizoribine Suppresses the Progression of Experimental Peritoneal Fibrosis in a Rat Model. Takahashi S, etal., Nephron Exp Nephrol. 2009 Apr 23;112(2):e59-e69.
273. Urinary monocyte chemoattractant protein-1 (MCP-1) and connective tissue growth factor (CCN2) as prognostic markers for progression of diabetic nephropathy. Tam FW, etal., Cytokine. 2009 Apr 29.
274. Prolonged cold ischemia in rat cardiac allografts promotes ischemia-reperfusion injury and the development of graft coronary artery disease in a linear fashion. Tanaka M, etal., J Heart Lung Transplant. 2005 Nov;24(11):1906-14. Epub 2005 Jul 27.
275. Enhanced production of monocyte chemoattractant protein-1 in the dorsal root ganglia in a rat model of neuropathic pain: possible involvement in the development of neuropathic pain. Tanaka T, etal., Neurosci Res. 2004 Apr;48(4):463-9.
276. Early enhanced expression of interferon-inducible protein-10 (CXCL-10) and other chemokines predicts adverse outcome in severe acute respiratory syndrome. Tang NL, etal., Clin Chem. 2005 Dec;51(12):2333-40. doi: 10.1373/clinchem.2005.054460. Epub 2005 Sep 29.
277. Cytokine profiles of bronchoalveolar lavage fluid in patients with pneumocystis pneumonia. Tasaka S, etal., Microbiol Immunol. 2010 Jul;54(7):425-33.
278. Eotaxin and monocyte chemoattractant protein-1 in chronic eosinophilic pneumonia. Tateno H, etal., Eur Respir J. 2001 May;17(5):962-8.
279. A laboratory model of toxin-induced hemolytic uremic syndrome. Taylor CM, etal., Kidney Int. 1999 Apr;55(4):1367-74.
280. Blocking the CCL2-CCR2 Axis Using CCL2-Neutralizing Antibody Is an Effective Therapy for Hepatocellular Cancer in a Mouse Model. Teng KY, etal., Mol Cancer Ther. 2017 Feb;16(2):312-322. doi: 10.1158/1535-7163.MCT-16-0124. Epub 2016 Dec 15.
281. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
282. Altered chemokine response in an animal model of multiple organ dysfunction syndrome induced by zymosan. Thomas NJ, etal., J Pediatr Surg. 2005 Mar;40(3):464-9.
283. Reduced plaque formation induced by rosiglitazone in an STZ-diabetes mouse model of atherosclerosis is associated with downregulation of adhesion molecules. Tikellis C, etal., Atherosclerosis. 2008 Jul;199(1):55-64. Epub 2008 Feb 21.
284. HDL-associated lysosphingolipids inhibit NAD(P)H oxidase-dependent monocyte chemoattractant protein-1 production. Tolle M, etal., Arterioscler Thromb Vasc Biol. 2008 Aug;28(8):1542-8. doi: 10.1161/ATVBAHA.107.161042. Epub 2008 May 15.
285. Blocking mast cell-mediated type I hypersensitivity in experimental allergic conjunctivitis by monocyte chemoattractant protein-1/CCR2. Tominaga T, etal., Invest Ophthalmol Vis Sci. 2009 Nov;50(11):5181-8. doi: 10.1167/iovs.09-3637. Epub 2009 Jun 24.
286. Cardiopulmonary alterations in mRNA expression for interleukin-1beta, the interleukin-6 superfamily and CXC-chemokines during development of postischaemic heart failure in the rat. Tonnessen T, etal., Clin Physiol Funct Imaging. 2003 Sep;23(5):263-8.
287. Immune cell recruitment following acoustic trauma. Tornabene SV, etal., Hear Res. 2006 Dec;222(1-2):115-24. Epub 2006 Nov 1.
288. Expression of monocyte chemoattractant protein-1 in the corpus luteum of the rat. Townson DH, etal., Biol Reprod. 1996 Feb;54(2):513-20.
289. CCL2 promotes P2X4 receptor trafficking to the cell surface of microglia. Toyomitsu E, etal., Purinergic Signal. 2012 Jun;8(2):301-10. doi: 10.1007/s11302-011-9288-x. Epub 2012 Jan 6.
290. Enhanced antitumor effects of a bicistronic adenovirus vector expressing both herpes simplex virus thymidine kinase and monocyte chemoattractant protein-1 against hepatocellular carcinoma. Tsuchiyama T, etal., Cancer Gene Ther. 2003 Apr;10(4):260-9. doi: 10.1038/sj.cgt.7700571.
291. Anti-monocyte chemoattractant protein-1 gene therapy prevents dimethylnitrosamine-induced hepatic fibrosis in rats. Tsuruta S, etal., Int J Mol Med. 2004 Nov;14(5):837-42.
292. Strong association of a functional polymorphism in the monocyte chemoattractant protein 1 promoter gene with lupus nephritis. Tucci M, etal., Arthritis Rheum. 2004 Jun;50(6):1842-9.
293. Chemokine synthesis in the HSV-1-infected cornea and its suppression by interleukin-10. Tumpey TM, etal., J Leukoc Biol. 1998 Apr;63(4):486-92.
294. Murine ccl2/cx3cr1 deficiency results in retinal lesions mimicking human age-related macular degeneration. Tuo J, etal., Invest Ophthalmol Vis Sci. 2007 Aug;48(8):3827-36.
295. Anti-monocyte chemoattractant protein-1 gene therapy inhibits restenotic changes (neointimal hyperplasia) after balloon injury in rats and monkeys. Usui M, etal., FASEB J. 2002 Nov;16(13):1838-40. Epub 2002 Sep 5.
296. The chemokine CCL2 modulates Ca2+ dynamics and electrophysiological properties of cultured cerebellar Purkinje neurons. van Gassen KL, etal., Eur J Neurosci. 2005 Jun;21(11):2949-57.
297. Proinflammatory gene expression at chronic periodontitis and peri-implantitis sites in patients with or without type 2 diabetes. Venza I, etal., J Periodontol. 2010 Jan;81(1):99-108. doi: 10.1902/jop.2009.090358.
298. Chemokines in acute anterior uveitis. Verma MJ, etal., Curr Eye Res. 1997 Dec;16(12):1202-8.
299. Social isolation stress facilitates chemically induced oral carcinogenesis. Verza FA, etal., PLoS One. 2021 Jan 7;16(1):e0245190. doi: 10.1371/journal.pone.0245190. eCollection 2021.
300. Fgr deficiency results in defective eosinophil recruitment to the lung during allergic airway inflammation. Vicentini L, etal., J Immunol. 2002 Jun 15;168(12):6446-54.
301. Distribution in ocular structures and optic pathways of immunocompetent and glial cells in an experimental allergic encephalomyelitis (EAE) relapsing model. Villarroya H, etal., J Neurosci Res. 2001 Mar 15;63(6):525-35.
302. Changes in plasma chemokine C-C motif ligand 2 levels during treatment with eicosapentaenoic acid predict outcome in patients undergoing surgery for colorectal cancer liver metastasis. Volpato M, etal., Oncotarget. 2016 May 10;7(19):28139-50. doi: 10.18632/oncotarget.8579.
303. Intervention of crescentic glomerulonephritis by antibodies to monocyte chemotactic and activating factor (MCAF/MCP-1). Wada T, etal., FASEB J. 1996 Oct;10(12):1418-25.
304. Persistence of lung inflammation and lung cytokines with high-resolution CT abnormalities during recovery from SARS. Wang CH, etal., Respir Res. 2005 May 11;6:42. doi: 10.1186/1465-9921-6-42.
305. Endothelial dysfunction, macrophage infiltration and NADPH oxidase-dependent superoxide production were attenuated by erythropoietin in streptozotocin-induced diabetic rat aorta. Wang J, etal., Pharmacology. 2013;91(1-2):48-58. doi: 10.1159/000343963. Epub 2012 Nov 15.
306. Clinical significance and different levels of urinary monocyte chemoattractant protein-1 in type 2 diabetes mellitus. Wang QY and Chen FQ, Diabetes Res Clin Pract. 2009 Feb;83(2):215-9. Epub 2008 Dec 20.
307. Triptolide inhibits CC chemokines expressed in rat adjuvant-induced arthritis. Wang Y, etal., Int Immunopharmacol. 2006 Dec 5;6(12):1825-32. Epub 2006 Aug 31.
308. Analysis of monocyte chemoattractant protein 1-mediated lung injury using rat lung organ cultures. Warren JS, etal., Am J Pathol. 1993 Sep;143(3):894-906.
309. Cardiac inflammation contributes to right ventricular dysfunction following experimental pulmonary embolism in rats. Watts JA, etal., J Mol Cell Cardiol. 2006 Aug;41(2):296-307. Epub 2006 Jun 30.
310. Role of the CCL2/MCP-1 -2518A>G gene polymorphism in HLA-B27 associated uveitis. Wegscheider BJ, etal., Mol Vis. 2005 Nov 1;11:896-900.
311. Excitatory monocyte chemoattractant protein-1 signaling is up-regulated in sensory neurons after chronic compression of the dorsal root ganglion. White FA, etal., Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):14092-7. Epub 2005 Sep 20.
312. Evidence for less irritation to the peritoneal membrane in rats dialyzed with solutions low in glucose degradation products. Wieczorowska-Tobis K, etal., Perit Dial Int. 2004 Jan-Feb;24(1):48-57.
313. Identification of a retinal aldosterone system and the protective effects of mineralocorticoid receptor antagonism on retinal vascular pathology. Wilkinson-Berka JL, etal., Circ Res. 2009 Jan 2;104(1):124-33. doi: 10.1161/CIRCRESAHA.108.176008. Epub 2008 Nov 26.
314. Influenza A virus infection inhibits the efficient recruitment of Th2 cells into the airways and the development of airway eosinophilia. Wohlleben G, etal., J Immunol. 2003 May 1;170(9):4601-11.
315. Existence of a regulatory loop between MCP-1 and TGF-beta in glomerular immune injury. Wolf G, etal., Am J Physiol Renal Physiol 2002 Nov;283(5):F1075-84.
316. DNA vaccination with naked DNA encoding MCP-1 and RANTES protects against renal injury in adriamycin nephropathy. Wu H, etal., Kidney Int. 2005 Jun;67(6):2178-86.
317. Nifedipine inhibited angiotensin II-induced monocyte chemoattractant protein 1 expression: involvement of inhibitor of nuclear factor kappa B kinase and nuclear factor kappa B-inducing kinase. Wu L, etal., J Hypertens. 2006 Jan;24(1):123-30.
318. Regulation of inhibitory protein-kappaB and monocyte chemoattractant protein-1 by angiotensin II type 2 receptor-activated Src homology protein tyrosine phosphatase-1 in fetal vascular smooth muscle cells. Wu L, etal., Mol Endocrinol. 2004 Mar;18(3):666-78. Epub 2003 Dec 18.
319. Protein kinase C beta inhibitor LY333531 attenuates intercellular adhesion molecule-1 and monocyte chemotactic protein-1 expression in the kidney in diabetic rats. Wu Y, etal., J Pharmacol Sci. 2006 Aug;101(4):335-43. Epub 2006 Aug 5.
320. Estrogen modulates TNF-alpha-induced inflammatory responses in rat aortic smooth muscle cells through estrogen receptor-beta activation. Xing D, etal., Am J Physiol Heart Circ Physiol. 2007 Jun;292(6):H2607-12. Epub 2007 Jan 19.
321. [Effects of N-acetylcysteine on mRNA expression of monocyte chemotactic protein and macrophage inflammatory protein 2 in acute necrotizing pancreatitis: experiment with rats] Xu CF, etal., Zhonghua Yi Xue Za Zhi. 2008 Mar 11;88(10):711-5.
322. Role of KCa3.1 Channels in Macrophage Polarization and Its Relevance in Atherosclerotic Plaque Instability. Xu R, etal., Arterioscler Thromb Vasc Biol. 2017 Feb;37(2):226-236. doi: 10.1161/ATVBAHA.116.308461. Epub 2016 Dec 29.
323. Inhibition of laser-induced choroidal neovascularization by atorvastatin by downregulation of monocyte chemotactic protein-1 synthesis in mice. Yamada K, etal., Invest Ophthalmol Vis Sci. 2007 Apr;48(4):1839-43.
324. A synthetic selective inhibitor of factor Xa, DX-9065a, reduces monocyte chemoattractant protein-1 expression after ischemia-reperfusion injury in rat liver. Yamaguchi Y, etal., Dig Dis Sci. 1999 Dec;44(12):2568-76. doi: 10.1023/a:1026667912632.
325. Monocyte chemoattractant protein-1 enhances expression of intercellular adhesion molecule-1 following ischemia-reperfusion of the liver in rats. Yamaguchi Y, etal., Hepatology. 1998 Mar;27(3):727-34.
326. Role of monocyte chemoattractant protein-1 and its receptor,CCR-2, in the pathogenesis of bleomycin-induced scleroderma. Yamamoto T and Nishioka K, J Invest Dermatol. 2003 Sep;121(3):510-6.
327. Tumor-derived monocyte chemoattractant protein-1 induces intratumoral infiltration of monocyte-derived macrophage subpopulation in transplanted rat tumors. Yamashiro S, etal., Am J Pathol. 1994 Oct;145(4):856-67.
328. Intradermal injection of monocyte chemoattractant protein-1 induces emigration and differentiation of blood monocytes in rat skin. Yamashiro S, etal., Int Arch Allergy Immunol. 1998 Jan;115(1):15-23.
329. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica Yang H, etal., Zhongguo Zhong Yao Za Zhi. 2008 Dec;33(23):2817-20.
330. Chemokine and chemokine receptor expression during colony stimulating factor-1-induced osteoclast differentiation in the toothless osteopetrotic rat: a key role for CCL9 (MIP-1gamma) in osteoclastogenesis in vivo and in vitro. Yang M, etal., Blood. 2006 Mar 15;107(6):2262-70. doi: 10.1182/blood-2005-08-3365. Epub 2005 Nov 22.
331. Plasma IP-10 and MCP-3 levels are highly associated with disease severity and predict the progression of COVID-19. Yang Y, etal., J Allergy Clin Immunol. 2020 Apr 29. pii: S0091-6749(20)30576-5. doi: 10.1016/j.jaci.2020.04.027.
332. Chemokine gene polymorphisms in idiopathic anterior uveitis. Yeo TK, etal., Cytokine. 2006 Jul;35(1-2):29-35. Epub 2006 Sep 6.
333. Indole-3-propionic acid suppresses indoxyl sulfate-induced expression of fibrotic and inflammatory genes in proximal tubular cells. Yisireyili M, etal., Nagoya J Med Sci. 2017 Nov;79(4):477-486. doi: 10.18999/nagjms.79.4.477.
334. Aqueous humor levels of asymmetric dimethylarginine (ADMA) are positively associated with monocyte chemoattractant protein-1 (MCP-1) in patients with uveitis. Yoshida Y, etal., Br J Ophthalmol. 2008 Jan;92(1):93-4. Epub 2007 Jun 25.
335. Molecular cloning of rat monocyte chemoattractant protein-1 (MCP-1) and its expression in rat spleen cells and tumor cell lines. Yoshimura T, etal., Biochem Biophys Res Commun 1991 Jan 31;174(2):504-9.
336. Chemokine MCP1/CCL2 and RANTES/CCL5 gene polymorphisms influence Henoch-Schonlein purpura susceptibility and severity. Yu HH, etal., J Formos Med Assoc. 2015 Apr;114(4):347-52. doi: 10.1016/j.jfma.2012.12.007. Epub 2013 Feb 1.
337. The role of redox status on chemokine expression in acute pancreatitis. Yubero S, etal., Biochim Biophys Acta. 2009 Feb;1792(2):148-54. Epub 2008 Dec 9.
338. Targeting peripheral immune response reduces the severity of necrotizing acute pancreatitis. Yubero S, etal., Crit Care Med. 2009 Jan;37(1):240-5. doi: 10.1097/CCM.0b013e31819320fc.
339. Sinomenine, an antirheumatic alkaloid, ameliorates clinical signs of disease in the Lewis rat model of acute experimental autoimmune encephalolmyelitis. Zeng Y, etal., Biol Pharm Bull. 2007 Aug;30(8):1438-44.
340. [Effects of astragalus on renal tubulointerestitial lesions and expression of NF-kappaB and MCP-1 in renal tissues in rat experimental IgA nephropathy] Zhang GZ, etal., Zhongguo Dang Dai Er Ke Za Zhi. 2008 Apr;10(2):173-8.
341. Exosome-mediated targeted delivery of miR-210 for angiogenic therapy after cerebral ischemia in mice. Zhang H, etal., J Nanobiotechnology. 2019 Feb 19;17(1):29. doi: 10.1186/s12951-019-0461-7.
342. CCL2-CCR2 signaling promotes hepatic ischemia/reperfusion injury. Zhang J, etal., J Surg Res. 2016 May 15;202(2):352-62. doi: 10.1016/j.jss.2016.02.029. Epub 2016 Mar 3.
343. Lung monocyte chemoattractant protein-1 gene expression in bleomycin-induced pulmonary fibrosis. Zhang K, etal., J Immunol. 1994 Nov 15;153(10):4733-41.
344. Chemokine CCL2 and its receptor CCR2 in the medullary dorsal horn are involved in trigeminal neuropathic pain. Zhang ZJ, etal., J Neuroinflammation. 2012 Jul 9;9:136. doi: 10.1186/1742-2094-9-136.
345. Anti-monocyte chemoattractant protein 1 gene therapy attenuates experimental chronic pancreatitis induced by dibutyltin dichloride in rats. Zhao HF, etal., Gut. 2005 Dec;54(12):1759-67.
346. The role of KCa3.1 channels in cardiac fibrosis induced by pressure overload in rats. Zhao LM, etal., Pflugers Arch. 2015 Nov;467(11):2275-85. doi: 10.1007/s00424-015-1694-4. Epub 2015 Feb 27.
347. Combined association of CCR2-V64I and MCP-1-2518A/G polymorphisms with generalised aggressive periodontitis in Chinese. Zhu XL, etal., Chin J Dent Res. 2010;13(2):109-14.
348. Serum monocyte chemoattractant protein-1 concentrations associate with diabetes status but not arterial stiffness in children with type 1 diabetes. Zineh I, etal., Diabetes Care. 2009 Mar;32(3):465-7. Epub 2008 Dec 17.
349. Therapeutic effects of dichloromethane fraction of Securidaca inappendiculata on adjuvant-induced arthritis in rat. Zuo J, etal., J Ethnopharmacol. 2014 Apr 28;153(2):352-8. doi: 10.1016/j.jep.2014.02.015. Epub 2014 Feb 26.
Additional References at PubMed
PMID:2106664   PMID:7545673   PMID:8631787   PMID:8662823   PMID:9366570   PMID:9407497   PMID:10072545   PMID:10925302   PMID:12071442   PMID:12135683   PMID:12196270   PMID:12207323  
PMID:12271471   PMID:12377739   PMID:12390882   PMID:12409843   PMID:12753088   PMID:12761250   PMID:12870648   PMID:12899200   PMID:14978197   PMID:15178559   PMID:15183841   PMID:15205118  
PMID:15240134   PMID:15504940   PMID:15829559   PMID:15880558   PMID:15917991   PMID:15930146   PMID:16102724   PMID:16132691   PMID:16265704   PMID:16282363   PMID:16638301   PMID:16758320  
PMID:16797058   PMID:16886721   PMID:16968890   PMID:17164575   PMID:17191078   PMID:17303665   PMID:17403137   PMID:17460389   PMID:17516154   PMID:17530714   PMID:17581219   PMID:17632282  
PMID:17690108   PMID:17883394   PMID:17916652   PMID:17977946   PMID:18024959   PMID:18048593   PMID:18049032   PMID:18157868   PMID:18185105   PMID:18256274   PMID:18338959   PMID:18413206  
PMID:18420193   PMID:18421085   PMID:18441197   PMID:18554968   PMID:18563318   PMID:18586982   PMID:18622025   PMID:18629611   PMID:18726687   PMID:18942743   PMID:18957386   PMID:19050284  
PMID:19125409   PMID:19139201   PMID:19207862   PMID:19211873   PMID:19215923   PMID:19238998   PMID:19389872   PMID:19404405   PMID:19443842   PMID:19477239   PMID:19535570   PMID:19604316  
PMID:19627007   PMID:19627010   PMID:19683237   PMID:19736311   PMID:19823951   PMID:19950591   PMID:20003523   PMID:20034406   PMID:20034917   PMID:20041150   PMID:20081877   PMID:20150963  
PMID:20356868   PMID:20368270   PMID:20384770   PMID:20395830   PMID:20420568   PMID:20538789   PMID:20571857   PMID:20691665   PMID:21105875   PMID:21115617   PMID:21147091   PMID:21162127  
PMID:21302491   PMID:21317391   PMID:21351537   PMID:21367920   PMID:21418993   PMID:21487675   PMID:21490228   PMID:21600925   PMID:21729288   PMID:21858029   PMID:21868333   PMID:21963836  
PMID:21963947   PMID:22005927   PMID:22326498   PMID:22328150   PMID:22328773   PMID:22417871   PMID:22527942   PMID:22595559   PMID:22801372   PMID:22812249   PMID:22960654   PMID:23012479  
PMID:23049171   PMID:23056550   PMID:23129286   PMID:23187120   PMID:23242502   PMID:23291264   PMID:23339567   PMID:23395675   PMID:23400803   PMID:23460341   PMID:23519994   PMID:23594826  
PMID:23831969   PMID:23892723   PMID:24006456   PMID:24037783   PMID:24420912   PMID:24462503   PMID:24464584   PMID:24637038   PMID:24724624   PMID:24980870   PMID:25329075   PMID:25449579  
PMID:25466836   PMID:25567426   PMID:25575056   PMID:25651887   PMID:25672988   PMID:25780042   PMID:25817785   PMID:25830624   PMID:26062549   PMID:26138996   PMID:26402697   PMID:26432893  
PMID:26556523   PMID:26644089   PMID:26974138   PMID:26979053   PMID:27104804   PMID:27160403   PMID:27429111   PMID:27693081   PMID:27862629   PMID:28033741   PMID:28272428   PMID:28286770  
PMID:28587818   PMID:29142497   PMID:29295871   PMID:29637744   PMID:29993042   PMID:30151700   PMID:30201767   PMID:30353658   PMID:30687013   PMID:30980241   PMID:31005664   PMID:31075560  
PMID:31287373   PMID:31366997   PMID:31438731   PMID:31805255   PMID:31883300   PMID:31914700   PMID:31992448   PMID:32150444   PMID:32422289   PMID:32454160   PMID:32650794   PMID:32741247  
PMID:32820306   PMID:33181267   PMID:33577025   PMID:33941753   PMID:34773653   PMID:34830041   PMID:35094663   PMID:36219898   PMID:36470227   PMID:37437927   PMID:37497210   PMID:38148075  


Genomics

Comparative Map Data
Ccl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81067,503,077 - 67,504,875 (+)NCBIGRCr8
mRatBN7.21067,005,424 - 67,007,222 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1067,005,424 - 67,007,226 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1071,626,649 - 71,628,447 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01071,131,996 - 71,133,794 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01066,593,121 - 66,594,919 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01069,412,065 - 69,413,863 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1069,412,017 - 69,413,870 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01069,047,091 - 69,048,889 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41070,256,263 - 70,258,061 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1065,952,968 - 65,954,766 (+)NCBICelera
Cytogenetic Map10q26NCBI
CCL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381734,255,285 - 34,257,203 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1734,255,274 - 34,257,208 (+)EnsemblGRCh38hg38GRCh38
GRCh371732,582,304 - 32,584,222 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361729,606,409 - 29,608,335 (+)NCBINCBI36Build 36hg18NCBI36
Build 341729,606,408 - 29,608,331NCBI
Celera1729,492,130 - 29,494,042 (+)NCBICelera
Cytogenetic Map17q12NCBI
HuRef1728,767,599 - 28,769,525 (+)NCBIHuRef
CHM1_11732,646,183 - 32,648,095 (+)NCBICHM1_1
T2T-CHM13v2.01735,201,562 - 35,203,480 (+)NCBIT2T-CHM13v2.0
Ccl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391181,926,403 - 81,928,278 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1181,926,397 - 81,928,279 (+)EnsemblGRCm39 Ensembl
GRCm381182,035,577 - 82,037,452 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1182,035,571 - 82,037,453 (+)EnsemblGRCm38mm10GRCm38
MGSCv371181,849,079 - 81,850,954 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361181,851,769 - 81,853,422 (+)NCBIMGSCv36mm8
Celera1191,649,026 - 91,650,901 (+)NCBICelera
Cytogenetic Map11B5NCBI
cM Map1149.82NCBI
CCL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21930,208,206 - 30,210,212 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11732,089,476 - 32,091,422 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01722,528,154 - 22,530,091 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11722,821,336 - 22,823,271 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1722,820,890 - 22,823,384 (-)Ensemblpanpan1.1panPan2
CCL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1939,008,187 - 39,009,932 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha938,231,467 - 38,233,216 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0939,822,383 - 39,824,132 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1938,608,720 - 38,610,469 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0938,897,447 - 38,899,196 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0938,976,777 - 38,978,526 (-)NCBIUU_Cfam_GSD_1.0
CCL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1240,798,109 - 40,800,026 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11240,798,109 - 40,800,013 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21242,514,202 - 42,516,108 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CCL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11627,763,354 - 27,765,437 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1627,763,555 - 27,765,416 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660752,254,637 - 2,256,540 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Ccl2
16 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:28
Count of miRNA genes:21
Interacting mature miRNAs:28
Transcripts:ENSRNOT00000009448
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104194452678307017Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)104287676679813922Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)104944455181709989Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104944455181709989Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)104944455181709989Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
1331839Eae18bExperimental allergic encephalomyelitis QTL 18b5.80.03nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)106124830367785171Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)106134527681714865Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
61402Niddm3Non-insulin dependent diabetes mellitus QTL 34.58blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)106134541382564856Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
2298481Eau9Experimental allergic uveoretinitis QTL 90.0169uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)106592723382565079Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)106631944767750281Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)106631944767750281Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)106631944767750281Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)106631944767750281Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)106631944767750281Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)106631944768164786Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)106631944768164786Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)106631944768164786Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)106631944768164786Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106674365598003205Rat
631565Hcuc4Hepatic copper content QTL 44.15liver copper amount (VT:0003065)liver copper weight to liver dry weight ratio (CMO:0001512)106694181373452992Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)106697895567750281Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat

Markers in Region
D10Kyo2   No map positions available.
PMC145384P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21067,006,270 - 67,006,928 (+)MAPPERmRatBN7.2
Rnor_6.01069,412,912 - 69,413,569NCBIRnor6.0
Rnor_5.01069,047,938 - 69,048,595UniSTSRnor5.0
RGSC_v3.41070,257,110 - 70,257,767UniSTSRGSC3.4
Celera1065,953,815 - 65,954,472UniSTS
Cytogenetic Map10q26UniSTS
Scya2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21067,005,939 - 67,006,013 (+)MAPPERmRatBN7.2
Rnor_6.01069,412,581 - 69,412,654NCBIRnor6.0
Rnor_5.01069,047,607 - 69,047,680UniSTSRnor5.0
RGSC_v3.41070,256,779 - 70,256,852UniSTSRGSC3.4
Celera1065,953,484 - 65,953,557UniSTS
Cytogenetic Map10q26UniSTS
RH134870  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21067,006,913 - 67,007,108 (+)MAPPERmRatBN7.2
Rnor_6.01069,413,555 - 69,413,749NCBIRnor6.0
Rnor_5.01069,048,581 - 69,048,775UniSTSRnor5.0
RGSC_v3.41070,257,753 - 70,257,947UniSTSRGSC3.4
Celera1065,954,458 - 65,954,652UniSTS
Cytogenetic Map10q26UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 1 2 2 6 2 3
Low 2 38 49 35 17 35 8 11 37 27 31 8 8
Below cutoff 2 6 6 6 33 2 6

Sequence


RefSeq Acc Id: ENSRNOT00000009448   ⟹   ENSRNOP00000009448
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1067,005,424 - 67,007,226 (+)Ensembl
Rnor_6.0 Ensembl1069,412,017 - 69,413,870 (+)Ensembl
RefSeq Acc Id: NM_031530   ⟹   NP_113718
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81067,503,077 - 67,504,875 (+)NCBI
mRatBN7.21067,005,424 - 67,007,222 (+)NCBI
Rnor_6.01069,412,065 - 69,413,863 (+)NCBI
Rnor_5.01069,047,091 - 69,048,889 (+)NCBI
RGSC_v3.41070,256,263 - 70,258,061 (+)RGD
Celera1065,952,968 - 65,954,766 (+)RGD
Sequence:
RefSeq Acc Id: NP_113718   ⟸   NM_031530
- Peptide Label: precursor
- UniProtKB: Q549R5 (UniProtKB/Swiss-Prot),   P14844 (UniProtKB/Swiss-Prot),   A6HHD2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000009448   ⟸   ENSRNOT00000009448
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P14844-F1-model_v2 AlphaFold P14844 1-148 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697507
Promoter ID:EPDNEW_R8032
Type:multiple initiation site
Name:Ccl2_1
Description:C-C motif chemokine ligand 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01069,412,065 - 69,412,125EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3645 AgrOrtholog
BioCyc Gene G2FUF-23937 BioCyc
Ensembl Genes ENSRNOG00000007159 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055025618 UniProtKB/Swiss-Prot
  ENSRNOG00060019323 UniProtKB/Swiss-Prot
  ENSRNOG00065019591 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000009448 ENTREZGENE
  ENSRNOT00000009448.4 UniProtKB/Swiss-Prot
  ENSRNOT00055044192 UniProtKB/Swiss-Prot
  ENSRNOT00060033398 UniProtKB/Swiss-Prot
  ENSRNOT00065032989 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.50.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Chemokine_b/g/d UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chemokine_CC_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chemokine_IL8-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Interleukin_8-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24770 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 24770 ENTREZGENE
PANTHER C-C MOTIF CHEMOKINE 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12015 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IL8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ccl2 PhenoGen
PROSITE SMALL_CYTOKINES_CC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007159 RatGTEx
  ENSRNOG00055025618 RatGTEx
  ENSRNOG00060019323 RatGTEx
  ENSRNOG00065019591 RatGTEx
SMART SCY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Interleukin 8-like chemokines UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
TIGR TC205265
UniProt A6HHD2 ENTREZGENE, UniProtKB/TrEMBL
  CCL2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q549R5 ENTREZGENE
UniProt Secondary Q549R5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-08 Ccl2  C-C motif chemokine ligand 2  Ccl2  chemokine (C-C motif) ligand 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Ccl2  chemokine (C-C motif) ligand 2  Scya2  small inducible cytokine A2  Symbol and Name updated 625702 APPROVED
2002-06-10 Scya2  small inducible cytokine A2      Name updated 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression increases slightly during renal allografts and isografts 61510
gene_expression mRNA is isolated from the glomeruli of perfused kidneys 625742
gene_physical_interaction may bind with Tgf beta during glomerular immune injury 625742
gene_process induces Tgf-beta expression 625742
gene_regulation expression is upregulated by NF-kappaB in an IL-1beta-induced manner 634051
gene_regulation expression is upregulated by Con A 634050
gene_regulation protein synthesis is increased by cerulein hyperstimulation in rat pancreatic acini through a calcium-dependent mechanism involving NF-kB activation 625742
gene_regulation antibody against acetylcholine receptor increases protein production both in cultured LE1 myocytes and in skeletal muscle in Lewis rats 625742