RGD Reference Report - Chemokine synthesis in the HSV-1-infected cornea and its suppression by interleukin-10. - Rat Genome Database

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Chemokine synthesis in the HSV-1-infected cornea and its suppression by interleukin-10.

Authors: Tumpey, TM  Cheng, H  Yan, XT  Oakes, JE  Lausch, RN 
Citation: Tumpey TM, etal., J Leukoc Biol. 1998 Apr;63(4):486-92.
RGD ID: 8549472
Pubmed: PMID:9544579   (View Abstract at PubMed)

Herpes simplex virus type 1 (HSV-1) infection of the murine cornea results in a tissue-destructive inflammatory response. In this study we show that virus infection induces the synthesis of macrophage inflammatory protein-2 (MIP-2), MIP-1alpha, and monocyte chemoattractant protein-1 (MCP-1). However, only the production of MIP-2 and MIP-1alpha coincided with the influx of leukocytes into the cornea. IL-10 treatment markedly suppressed chemokine message and protein synthesis in vivo. Local administration of IL-10 also dramatically reduced the number of T cells and neutrophils migrating into the cornea and suppressed the severity of corneal disease. The inflammatory response could also be suppressed by the passive transfer of neutralizing antibody to MIP-1alpha but not MCP-1. We conclude that local IL-10 administration can suppress chemokine synthesis, thereby ameliorating corneal disease. Furthermore, our results indicate that MIP-1alpha plays a major role in herpes stromal keratitis development, whereas MCP-1 does not.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
herpes simplex  ISOCcl2 (Mus musculus)8549472; 8549472mRNA:increased expression:cornea (mouse)RGD 
herpes simplex  IEP 8549472mRNA:increased expression:cornea (mouse)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ccl2  (C-C motif chemokine ligand 2)

Genes (Mus musculus)
Ccl2  (C-C motif chemokine ligand 2)

Genes (Homo sapiens)
CCL2  (C-C motif chemokine ligand 2)

Objects referenced in this article
Gene CCL13 C-C motif chemokine ligand 13 Homo sapiens

Additional Information