Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3645
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccl2
Name: C-C motif chemokine ligand 2
Acc ID: CHEBI:4031
Term: cyclosporin A
Definition: A cyclic nonribosomal peptide of eleven amino acids; an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection. Also causes reversible inhibition of immunocompetent lymphocytes in the G0- and G1-phase of the cell cycle.
Chemical ID: MESH:D016572
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccl2decreases expressionEXP 6480464CTDCyclosporine results in decreased expression of CCL2 mRNA; Cyclosporine results in decreased expression of CCL2 proteinPMID:25051504
Ccl2increases expressionEXP 6480464CTDCyclosporine results in increased expression of CCL2 mRNAPMID:27585667
Ccl2multiple interactionsEXP 6480464CTDethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [Cyclosporine results in increased expression of CCL2 mRNA]PMID:27585667
Ccl2decreases expressionISOCCL2 (Homo sapiens)6480464CTDCyclosporine results in decreased expression of CCL2 mRNAPMID:22147139 PMID:27989131
Ccl2increases expressionISOCcl2 (Mus musculus)6480464CTDCyclosporine results in increased expression of CCL2 mRNA; Cyclosporine results in increased expression of CCL2 proteinPMID:23958496 PMID:27585667
Ccl2multiple interactionsISOCcl2 (Mus musculus)6480464CTD7-oxozeanol inhibits the reaction [Cyclosporine results in increased expression of CCL2 mRNA]; 7-oxozeanol inhibits the reaction [Cyclosporine results in increased expression of CCL2 protein]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Cyclosporine results in increased expression of CCL2 mRNA]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Cyclosporine results in increased expression of CCL2 protein]; Cyclosporine affects the reaction [sodium arsenite affects the expression of CCL2 mRNA]; ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [Cyclosporine results in increased expression of CCL2 mRNA]; Glycyrrhizic Acid inhibits the reaction [Cyclosporine results in increased expression of CCL2 mRNA]; parthenolide inhibits the reaction [Cyclosporine results in increased expression of CCL2 mRNA]; pyrazolanthrone inhibits the reaction [Cyclosporine results in increased expression of CCL2 mRNA]; pyrazolanthrone inhibits the reaction [Cyclosporine results in increased expression of CCL2 protein]; salubrinal inhibits the reaction [Cyclosporine results in increased expression of CCL2 mRNA]; sulforaphane inhibits the reaction [Cyclosporine results in increased expression of CCL2 mRNA]; TLR4 gene mutant form inhibits the reaction [Cyclosporine results in increased expression of CCL2 mRNA]PMID:23958496 PMID:27585667 PMID:36557995
Ccl2multiple interactionsISOCCL2 (Homo sapiens)6480464CTDCyclosporine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of CCL2 protein]PMID:36416909
Go Back to source page   Continue to Ontology report