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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3645
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccl2
Name: C-C motif chemokine ligand 2
Acc ID: CHEBI:51403
Term: 1,4-phenylenediamine
Definition: A phenylenediamine in which the amino functions are at positions 1 and 4 of the benzene nucleus.
Chemical ID: MESH:C029728
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccl2increases expressionISOCcl2 (Mus musculus)6480464CTD4-phenylenediamine results in increased expression of CCL2 proteinPMID:34826398
Ccl2increases secretionISOCcl2 (Mus musculus)6480464CTD4-phenylenediamine results in increased secretion of CCL2 proteinPMID:22245253
Ccl2increases secretionISOCCL2 (Homo sapiens)6480464CTD4-phenylenediamine results in increased secretion of CCL2 proteinPMID:34826398
Ccl2multiple interactionsISOCCL2 (Homo sapiens)6480464CTDMRGPRX2 protein affects the reaction [4-phenylenediamine results in increased secretion of CCL2 protein]PMID:34826398
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