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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3645
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccl2
Name: C-C motif chemokine ligand 2
Acc ID: CHEBI:63112
Term: fingolimod hydrochloride
Definition: The hydrochloride salt of 2-amino-2-[2-(4-octylphenyl) ethyl]-1,3-propanediol (fingolimod).
Chemical ID: MESH:D000068876
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccl2increases expressionISOCcl2 (Mus musculus)6480464CTDFingolimod Hydrochloride results in increased expression of CCL2 proteinPMID:23043544
Ccl2increases response to substanceISOCcl2 (Mus musculus)6480464CTDCCL2 results in increased susceptibility to Fingolimod HydrochloridePMID:23043544
Ccl2multiple interactionsISOCcl2 (Mus musculus)6480464CTD3-amino-4-(3-hexylphenylamino)-4-oxobutylphosphonic acid inhibits the reaction [Fingolimod Hydrochloride results in increased expression of CCL2 protein]; [lipopolysaccharide, Escherichia coli O111 B4 co-treated with Okadaic Acid co-treated with Fingolimod Hydrochloride] results in increased expression of and results in increased secretion of CCL2 proteinPMID:23043544 PMID:33069748
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