RGD Reference Report - Cytokine-chemokine networks in experimental mycobacterial and schistosomal pulmonary granuloma formation. - Rat Genome Database

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Cytokine-chemokine networks in experimental mycobacterial and schistosomal pulmonary granuloma formation.

Authors: Chiu, BC  Freeman, CM  Stolberg, VR  Komuniecki, E  Lincoln, PM  Kunkel, SL  Chensue, SW 
Citation: Chiu BC, etal., Am J Respir Cell Mol Biol. 2003 Jul;29(1):106-16. Epub 2003 Jan 10.
RGD ID: 4145441
Pubmed: PMID:12600821   (View Abstract at PubMed)
PMCID: PMC3677198   (View Article at PubMed Central)
DOI: DOI:10.1165/rcmb.2002-0241OC   (Journal Full-text)

Type-1 and type-2 lung granulomas, respectively, elicited by bead immobilized Mycobacteria bovis and Schistosoma mansoni egg antigens (Ags) display different patterns of chemokine expression. This study tested the hypothesis that chemokine expression patterns were related to upstream cytokine signaling. Using quantitative transcript analysis, we defined expression profiles for 16 chemokines and then examined the in vivo effects of neutralizing antibodies against interferon-gamma (IFN-gamma), interleukin (IL)-4, IL-10, IL-12, and IL-13. Transcripts for CXCL2, -5, -9, -10, and -11 and the CCL chemokine, CCL3, and lymphotactin (XCL1), were largely enhanced by Th1-related cytokines, IFN-gamma or IL-12. Transcripts for CCL11, CCL22, CCL17, and CCL1 were enhanced largely by Th2-related cytokines, IL-4, IL-10, or IL-13. Transcripts for CCL4, CCL2, CCL8, CCL7, and CCL12 were potentially induced by either Th1- or Th2-related cytokines, although some of these showed biased expression. IFN-gamma and IL-4 enhanced the greatest complement of transcripts, and their neutralization had the greatest anti-inflammatory effect on type-1 and type-2 granulomas, respectively. Th1/Th2 cross-regulation was evident because endogenous Th2 cytokines inhibited type-1, whereas Th1 cytokines inhibited type-2 biased chemokines. These findings reveal a complex cytokine-chemokine regulatory network that dictates profiles of local chemokine expression during T cell-mediated granuloma formation.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Respiratory Tract Granuloma  ISOCcl1 (Mus musculus)4145441; 4145441associated with Schistosomiasis mansoniRGD 
Respiratory Tract Granuloma  ISOCcl11 (Mus musculus)4145441associated with Schistosomiasis mansoniRGD 
Respiratory Tract Granuloma  ISOCcl2 (Mus musculus)4145441; 4145441associated with Schistosomiasis mansoniRGD 
Respiratory Tract Granuloma  ISOCcl22 (Mus musculus)4145441; 4145441associated with Mycobacterium InfectionsRGD 
Respiratory Tract Granuloma  IEP 4145441; 4145441associated with Schistosomiasis mansoniRGD 
Respiratory Tract Granuloma  ISOCcl11 (Mus musculus)4145441mRNA:increased expression:lungRGD 
Respiratory Tract Granuloma  IEP 4145441mRNA:increased expression:lungRGD 
Respiratory Tract Granuloma  IEP 4145441associated with Mycobacterium InfectionsRGD 

Objects Annotated

Genes (Rattus norvegicus)
Ccl1  (C-C motif chemokine ligand 1)
Ccl11  (C-C motif chemokine ligand 11)
Ccl2  (C-C motif chemokine ligand 2)
Ccl22  (C-C motif chemokine ligand 22)

Genes (Mus musculus)
Ccl1  (C-C motif chemokine ligand 1)
Ccl11  (C-C motif chemokine ligand 11)
Ccl2  (C-C motif chemokine ligand 2)
Ccl22  (C-C motif chemokine ligand 22)

Genes (Homo sapiens)
CCL1  (C-C motif chemokine ligand 1)
CCL11  (C-C motif chemokine ligand 11)
CCL2  (C-C motif chemokine ligand 2)
CCL22  (C-C motif chemokine ligand 22)

Objects referenced in this article
Gene CCL13 C-C motif chemokine ligand 13 Homo sapiens

Additional Information