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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3645 Species: Rattus norvegicus RGD Object: Gene Symbol: Ccl2 Name: chemokine (C-C motif) ligand 2

Acc ID: CHEBI:16643 Term: L-methionine Definition: The L-enantiomer of methionine. CasRN: 63-68-3 Chemical ID: MESH:D008715

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:11275	6480464	CTD	Bezafibrate inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of CCL2 mRNA]	PMID:18513333
multiple interactions	ISO	RGD:11275	6480464	CTD	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CCL2 mRNA	PMID:20938992
multiple interactions	ISO	RGD:11275	6480464	CTD	CCL2 protein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of ACTA2 protein] CCL2 protein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of COL1A1 mRNA] CCL2 protein inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of CTGF mRNA]	PMID:20697377
multiple interactions	ISO	RGD:11275	6480464	CTD	[Methionine deficiency co-treated with Choline deficiency] results in increased expression of CCL2 mRNA Tamoxifen inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of CCL2 mRNA]	PMID:23038002