RGD Reference Report - Combined association of CCR2-V64I and MCP-1-2518A/G polymorphisms with generalised aggressive periodontitis in Chinese. - Rat Genome Database

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Combined association of CCR2-V64I and MCP-1-2518A/G polymorphisms with generalised aggressive periodontitis in Chinese.

Authors: Zhu, XL  Meng, HX  Xu, L  Zhang, L  Chen, ZB  Shi, D  Feng, XH 
Citation: Zhu XL, etal., Chin J Dent Res. 2010;13(2):109-14.
RGD ID: 8661707
Pubmed: PMID:21264360   (View Abstract at PubMed)

OBJECTIVE: to examine the possible association of CCR2-V64I and MCP-1-2518A/G polymorphisms with generalised aggressive periodontitis (GAgP) in the Chinese population. METHODS: one hundred and twenty-four GAgP patients and 94 healthy subjects were included in the study. A peripheral blood sample was obtained from each subject and genomic DNA was isolated. Gene polymorphisms of CCR2-V64I and MCP-1-2518A/G were analysed by standard polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. RESULTS: a possible combined effect of CCR2-V64I and MCP-1-2518A/G was observed in the female GAgP patients, as the odds ratio for VV genotype (CCR2) and G+ genotype ( MCP-1) was 0.2 (P = 0.023). Individuals carrying VV genotype and G+ genotype were at reduced risk for GAgP. A possible combined effect of genotype and smoking was observed in the male GAgP patients, as the odds ratio for VV genotype (CCR2) and smoking, or G+ genotype (MCP-1) and smoking were 7.4 (P = 0.022) and 4.9 (P = 0.030), respectively. CONCLUSION: the combined association of CCR2-V64I and MCP-1-2518A/G polymorphisms may play an important role in determining GAgP susceptibility in Chinese females. A possible combined effect of genotype and smoking on GAgP susceptibility was suggested in males.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
aggressive periodontitis susceptibilityIAGP 8661707DNA:polymorphism and haplotype::2518A>G(human) RGD 
aggressive periodontitis susceptibilityIAGP 8661707DNA:polymorphism and haplotype:cds:p.V64I(human)RGD 
aggressive periodontitis susceptibilityISOCCL2 (Homo sapiens)8661707; 8661707DNA:polymorphism and haplotype::2518A>G(human)RGD 
aggressive periodontitis susceptibilityISOCCR2 (Homo sapiens)8661707; 8661707DNA:polymorphism and haplotype:cds:p.V64I(human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ccl2  (C-C motif chemokine ligand 2)
Ccr2  (C-C motif chemokine receptor 2)

Genes (Mus musculus)
Ccl2  (C-C motif chemokine ligand 2)
Ccr2  (C-C motif chemokine receptor 2)

Genes (Homo sapiens)
CCL2  (C-C motif chemokine ligand 2)
CCR2  (C-C motif chemokine receptor 2)

Objects referenced in this article
Gene Ccl12 C-C motif chemokine ligand 12 Mus musculus
Gene Ccl12 C-C motif chemokine ligand 12 Rattus norvegicus

Additional Information