GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ccl2 | increases expression | EXP | | 6480464 | CTD | Indomethacin results in increased expression of CCL2 mRNA; Indomethacin results in increased expression of CCL2 protein | PMID:23892052 PMID:25051504 | Ccl2 | multiple interactions | EXP | | 6480464 | CTD | [morin co-treated with Indomethacin] inhibits the reaction [Freund's Adjuvant results in increased expression of CCL2 mRNA]; cobaltiprotoporphyrin inhibits the reaction [Indomethacin results in increased expression of CCL2 mRNA]; Gallic Acid analog inhibits the reaction [Indomethacin results in increased expression of CCL2 mRNA]; Indomethacin inhibits the reaction [Freund's Adjuvant results in increased expression of CCL2 mRNA]; Indomethacin inhibits the reaction [Freund's Adjuvant results in increased expression of CCL2 protein]; Indomethacin promotes the reaction [morin inhibits the reaction [Freund's Adjuvant results in increased expression of CCL2 protein]]; morin promotes the reaction [Indomethacin inhibits the reaction [Freund's Adjuvant results in increased expression of CCL2 protein]]; zinc protoporphyrin promotes the reaction [Indomethacin results in increased expression of CCL2 mRNA] | PMID:23892052 PMID:25698669 | Ccl2 | multiple interactions | ISO | Ccl2 (Mus musculus) | 6480464 | CTD | Indomethacin inhibits the reaction [IL1B protein results in increased expression of CCL2 mRNA]; Indomethacin inhibits the reaction [IL1B protein results in increased expression of CCL2 protein]; Indomethacin inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; Indomethacin inhibits the reaction [TNF protein results in increased expression of CCL2 protein] | PMID:18799549 | Ccl2 | multiple interactions | ISO | CCL2 (Homo sapiens) | 6480464 | CTD | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of CCL2 mRNA; Dinoprostone inhibits the reaction [Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]]]; Indomethacin inhibits the reaction [IL1A protein results in increased secretion of CCL2 protein]; Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]] | PMID:11230753 PMID:21913898 PMID:28628672 | | ||||||||||||||||||||||
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