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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3645
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccl2
Name: C-C motif chemokine ligand 2
Acc ID: CHEBI:28217
Term: acrylonitrile
Definition: A nitrile that is hydrogen cyanide in which the hydrogen has been replaced by an ethenyl group.
Chemical ID: MESH:D000181
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccl2increases expressionEXP 6480464CTDAcrylonitrile results in increased expression of CCL2 mRNAPMID:26332274
Ccl2multiple interactionsEXP 6480464CTDAcetylcysteine inhibits the reaction [Acrylonitrile results in increased expression of CCL2 mRNA]; alpha-Tocopherol inhibits the reaction [Acrylonitrile results in increased expression of CCL2 mRNA]; Plant Extracts inhibits the reaction [Acrylonitrile results in increased expression of CCL2 mRNA]PMID:26332274
Ccl2decreases expressionISOCCL2 (Homo sapiens)6480464CTDAcrylonitrile results in decreased expression of CCL2 mRNAPMID:16173056
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