RGD Reference Report - Monocyte chemoattractant protein-1 enhances expression of intercellular adhesion molecule-1 following ischemia-reperfusion of the liver in rats. - Rat Genome Database

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Monocyte chemoattractant protein-1 enhances expression of intercellular adhesion molecule-1 following ischemia-reperfusion of the liver in rats.

Authors: Yamaguchi, Y  Matsumura, F  Takeya, M  Ichiguchi, O  Kuratsu, JI  Horiuchi, T  Akizuki, E  Matsuda, T  Okabe, K  Ohshiro, H  Liang, J  Mori, K  Yamada, S  Takahashi, K  Ogawa, M 
Citation: Yamaguchi Y, etal., Hepatology. 1998 Mar;27(3):727-34.
RGD ID: 8549627
Pubmed: PMID:9500701   (View Abstract at PubMed)
DOI: DOI:10.1002/hep.510270314   (Journal Full-text)

Intercellular adhesion molecule-1 (ICAM-1) is important in neutrophil-dependent injury. We investigated the effects of monocyte chemoattractant protein-1 (MCP-1) produced by Kupffer cells on ICAM-1 expression after ischemia-reperfusion in rat liver by occluding the portal vein for 30 minutes. Serum concentrations of MCP-1 increased persistently. By Northern analysis, MCP-1 mRNA increased early and persisted. Kupffer cells harvested 6 hours after reperfusion also expressed this transcript. The transcript and protein also were produced by Kupffer cells from naive controls in response to reactive oxygen species. ICAM-1 mRNA transcripts increased, peaked 3 hours after reperfusion, and decreased gradually thereafter. The level of ICAM-1 mRNA transcripts in the WK-5 rat endothelial cell line were markedly enhanced by MCP-1. These results suggest that MCP-1 released by Kupffer cells early after ischemia-reperfusion modulates neutrophil-dependent tissue injury via ICAM-1.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Liver Reperfusion Injury  ISOCcl2 (Rattus norvegicus)8549627; 8549627mRNA more ...RGD 
Liver Reperfusion Injury  IEP 8549627mRNA more ...RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ccl2  (C-C motif chemokine ligand 2)

Genes (Mus musculus)
Ccl2  (C-C motif chemokine ligand 2)

Genes (Homo sapiens)
CCL2  (C-C motif chemokine ligand 2)

Objects referenced in this article
Gene CCL13 C-C motif chemokine ligand 13 Homo sapiens

Additional Information