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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3645
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccl2
Name: C-C motif chemokine ligand 2
Acc ID: CHEBI:3423
Term: carmustine
Definition: A member of the class of N-nitrosoureas that is 1,3-bis(2-chloroethyl)urea in which one of the nitrogens is substituted by a nitroso group.
Chemical ID: MESH:D002330
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccl2affects activityISOCCL2 (Homo sapiens)6480464CTDCarmustine affects the activity of CCL2 proteinPMID:17522861
Ccl2affects response to substanceISOCCL2 (Homo sapiens)6480464CTDCCL2 mRNA affects the susceptibility to CarmustinePMID:16365179
Ccl2decreases expressionISOCCL2 (Homo sapiens)6480464CTDCarmustine results in decreased expression of CCL2 proteinPMID:17522861
Ccl2increases expressionISOCCL2 (Homo sapiens)6480464CTDCarmustine results in increased expression of CCL2 mRNAPMID:15980968
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