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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3645
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccl2
Name: C-C motif chemokine ligand 2
Acc ID: CHEBI:2663
Term: amiodarone
Definition: A member of the class of 1-benzofurans that is 1-benzofuran substituted by a butyl group at position 2 and a 4-[2-(diethylamino)ethoxy]-3,5-diiodobenzoyl group at position 3. It is a cardiovascular drug used for the treatment of cardiac dysrhythmias.
Chemical ID: MESH:D000638
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccl2increases expressionISOCCL2 (Homo sapiens)6480464CTDAmiodarone results in increased expression of CCL2 mRNAPMID:23397585
Ccl2multiple interactionsISOCcl2 (Mus musculus)6480464CTD[Amiodarone co-treated with Dexamethasone] results in increased expression of CCL2 mRNAPMID:25900201
Ccl2multiple interactionsISOCCL2 (Homo sapiens)6480464CTDAmiodarone inhibits the reaction [CRP protein results in increased expression of CCL2 protein]PMID:19225199
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