RGD Reference Report - Association of polymorphisms in monocyte chemoattractant protein-1 promoter with diabetic kidney failure in Korean patients with type 2 diabetes mellitus.

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Association of polymorphisms in monocyte chemoattractant protein-1 promoter with diabetic kidney failure in Korean patients with type 2 diabetes mellitus.
Authors:	Moon, JY Jeong, L Lee, S Jeong, K Lee, T Ihm, CG Suh, J Kim, J Jung, YY Chung, JH
Citation:	Moon JY, etal., J Korean Med Sci. 2007 Oct;22(5):810-4.
RGD ID:	2306990
Pubmed:	PMID:17982227 (View Abstract at PubMed)
PMCID:	PMC2693845 (View Article at PubMed Central)
DOI:	DOI:10.3346/jkms.2007.22.5.810 (Journal Full-text)
Monocyte chemoattractant protein-1 (MCP-1) is suggested to be involved in the progression of diabetic nephropathy. We investigated the association of the -2518 A/G polymorphism in the MCP-1 gene with progressive kidney failure in Korean patients with type 2 diabetes mellitus (DM). We investigated -2518 A/G polymorphism of the MCP-1 gene in type 2 DM patients with progressive kidney failure (n=112) compared with matched type 2 DM patients without nephropathy (diabetic control, n=112) and healthy controls (n=230). The overall genotypic distribution of -2518 A/G in the MCP-1 gene was not different in patients with type 2 DM compared to healthy controls. Although the genotype was not significantly different between the patients with kidney failure and the diabetic control (p=0.07), the A allele was more frequent in patients with kidney failure than in DM controls (42.0 vs. 32.1%, p=0.03). The carriage of A allele was significantly associated with kidney failure (68.8 vs. 54.5%, OR 1.84, 95% CI 1.07-3.18). In logistic regression analysis, carriage of A allele retained a significant association with diabetic kidney failure. Our result shows that the -2518 A allele of the MCP-1 gene is associated with kidney failure in Korean patients with type 2 DM.

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Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
end stage renal disease	susceptibility	IAGP		2306990	associated with Diabetes Mellitus more ...	RGD
end stage renal disease	susceptibility	ISO	CCL2 (Homo sapiens)	2306990; 2306990	associated with Diabetes Mellitus more ...	RGD

Objects Annotated

Genes (Rattus norvegicus)

Ccl2 (C-C motif chemokine ligand 2)

Genes (Mus musculus)

Ccl2 (C-C motif chemokine ligand 2)

Genes (Homo sapiens)

CCL2 (C-C motif chemokine ligand 2)

Objects referenced in this article

Gene	CCL13	C-C motif chemokine ligand 13	Homo sapiens

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Association of polymorphisms in monocyte chemoattractant protein-1 promoter with diabetic kidney failure in Korean patients with type 2 diabetes mellitus.