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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3645
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccl2
Name: C-C motif chemokine ligand 2
Acc ID: CHEBI:17833
Term: gentamycin
Definition: Any of a group of aminoglycoside antibiotics produced by fermentation of some Micromonospora spp.
Chemical ID: MESH:D005839
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccl2affects expressionEXP 6480464CTDGentamicins affects the expression of CCL2 mRNAPMID:25051504
Ccl2decreases expressionEXP 6480464CTDGentamicins results in decreased expression of CCL2 proteinPMID:25051504
Ccl2increases expressionEXP 6480464CTDGentamicins results in increased expression of CCL2 mRNA; Gentamicins results in increased expression of CCL2 proteinPMID:16401625 PMID:22061828 PMID:33387578
Ccl2multiple interactionsEXP 6480464CTDKLK1 protein inhibits the reaction [Gentamicins results in increased expression of CCL2 protein]PMID:16401625
Ccl2increases expressionISOCcl2 (Mus musculus)6480464CTDGentamicins results in increased expression of CCL2 mRNAPMID:17442725
Ccl2multiple interactionsISOCcl2 (Mus musculus)6480464CTDGentamicins promotes the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]; Gentamicins promotes the reaction [Lipopolysaccharides results in increased expression of CCL2 protein]PMID:17442725
Ccl2multiple interactionsISOCCL2 (Homo sapiens)6480464CTDGentamicins inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein]; Gentamicins promotes the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]PMID:17699551
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