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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3645
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccl2
Name: C-C motif chemokine ligand 2
Acc ID: CHEBI:28088
Term: genistein
Definition: A 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.
Chemical ID: MESH:D019833
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccl2decreases expressionEXP 6480464CTDGenistein results in decreased expression of CCL2 mRNAPMID:12846738
Ccl2decreases expressionISOCcl2 (Mus musculus)6480464CTDGenistein results in decreased expression of CCL2 mRNAPMID:21048042
Ccl2decreases secretionISOCCL2 (Homo sapiens)6480464CTDGenistein results in decreased secretion of CCL2 proteinPMID:20816778
Ccl2multiple interactionsISOCCL2 (Homo sapiens)6480464CTDGenistein inhibits the reaction [LEP protein results in increased expression of CCL2]; Genistein inhibits the reaction [Oxygen deficiency results in increased expression of CCL2 mRNA]; Genistein promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of CCL2 protein]PMID:11342529 PMID:23452621 PMID:36416909
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