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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3645
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccl2
Name: C-C motif chemokine ligand 2
Acc ID: CHEBI:31941
Term: oxaliplatin
Definition: A platinum coordination entity that is a commonly used chemothrepeutic drug for treatment of colorectal cancer.
Chemical ID: MESH:C030110
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccl2increases expressionEXP 6480464CTDOxaliplatin results in increased expression of CCL2 mRNAPMID:25729387 PMID:35574720
Ccl2multiple interactionsEXP 6480464CTD[Oxaliplatin co-treated with Topotecan] results in increased expression of CCL2 mRNA; Aspirin inhibits the reaction [Oxaliplatin results in increased expression of CCL2 mRNA]; kaempferol inhibits the reaction [Oxaliplatin results in increased expression of CCL2 mRNA]PMID:25729387 PMID:35574720
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