GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ccl2 | increases expression | EXP | | 6480464 | CTD | sodium arsenite results in increased expression of CCL2 mRNA; sodium arsenite results in increased expression of CCL2 protein | PMID:15689417 PMID:25058445 | Ccl2 | multiple interactions | EXP | | 6480464 | CTD | Allopurinol inhibits the reaction [sodium arsenite results in increased expression of CCL2 mRNA]; Atorvastatin inhibits the reaction [sodium arsenite results in increased expression of CCL2 protein]; CAT protein inhibits the reaction [sodium arsenite results in increased expression of CCL2 mRNA]; Dimethyl Sulfoxide inhibits the reaction [sodium arsenite results in increased expression of CCL2 mRNA]; N(G)-nitroarginine-4-nitroanilide analog inhibits the reaction [sodium arsenite results in increased expression of CCL2 mRNA] | PMID:15689417 PMID:25058445 | Ccl2 | affects expression | ISO | Ccl2 (Mus musculus) | 6480464 | CTD | sodium arsenite affects the expression of CCL2 mRNA | PMID:36557995 | Ccl2 | decreases expression | ISO | CCL2 (Homo sapiens) | 6480464 | CTD | sodium arsenite results in decreased expression of CCL2 mRNA | PMID:12016162 PMID:12760830 PMID:16507463 PMID:23876855 PMID:25493608 PMID:37956786 | Ccl2 | increases expression | ISO | Ccl2 (Mus musculus) | 6480464 | CTD | sodium arsenite results in increased expression of CCL2 mRNA | PMID:21911445 PMID:28843991 | Ccl2 | increases expression | ISO | CCL2 (Homo sapiens) | 6480464 | CTD | sodium arsenite results in increased expression of CCL2 mRNA | PMID:15689417 PMID:22714537 PMID:28595984 PMID:34032870 | Ccl2 | increases secretion | ISO | CCL2 (Homo sapiens) | 6480464 | CTD | sodium arsenite results in increased secretion of CCL2 protein | PMID:15689417 PMID:28973481 | Ccl2 | multiple interactions | ISO | Ccl2 (Mus musculus) | 6480464 | CTD | [APOE gene mutant form affects the susceptibility to sodium arsenite] which results in increased expression of CCL2 protein; [sodium arsenite results in increased abundance of Arsenic] which results in increased secretion of CCL2 protein; Cyclosporine affects the reaction [sodium arsenite affects the expression of CCL2 mRNA]; sodium arsenite promotes the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]; sodium arsenite results in increased expression of and results in increased secretion of CCL2 protein | PMID:19682479 PMID:30635848 PMID:35364107 PMID:35777461 PMID:36557995 | Ccl2 | multiple interactions | ISO | CCL2 (Homo sapiens) | 6480464 | CTD | [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of CCL2 mRNA; Enalapril inhibits the reaction [sodium arsenite results in increased secretion of CCL2 protein]; ERN1 affects the reaction [sodium arsenite results in increased secretion of CCL2 protein]; HIF1A affects the reaction [sodium arsenite results in increased secretion of CCL2 protein]; Valsartan inhibits the reaction [sodium arsenite results in increased secretion of CCL2 protein]; XBP1 affects the reaction [sodium arsenite results in increased secretion of CCL2 protein] | PMID:28973481 PMID:36669534 | | ||||||||||||||||||||||
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