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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3645
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccl2
Name: C-C motif chemokine ligand 2
Acc ID: CHEBI:76995
Term: alpha-naphthoflavone
Definition: An extended flavonoid resulting from the formal fusion of a benzene ring with the h side of flavone. A synthetic compound, it is an inhibitor of aromatase (EC 1.14.14.14).
Chemical ID: MESH:C011512
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccl2decreases expressionISOCCL2 (Homo sapiens)6480464CTDalpha-naphthoflavone results in decreased expression of CCL2 mRNAPMID:22262711
Ccl2increases expressionISOCCL2 (Homo sapiens)6480464CTDalpha-naphthoflavone results in increased expression of CCL2 mRNAPMID:22262711
Ccl2multiple interactionsISOCCL2 (Homo sapiens)6480464CTDalpha-naphthoflavone inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CCL2 mRNA]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CCL2 mRNA]PMID:22262711
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