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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3645
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccl2
Name: C-C motif chemokine ligand 2
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccl2increases methylationEXP 6480464CTDCadmium Chloride results in increased methylation of CCL2 promoterPMID:22457795
Ccl2decreases expressionISOCcl2 (Mus musculus)6480464CTDCadmium Chloride results in decreased expression of CCL2 mRNAPMID:23921151
Ccl2increases expressionISOCCL2 (Homo sapiens)6480464CTDCadmium Chloride results in increased expression of CCL2 mRNAPMID:23397585 PMID:35650140
Ccl2multiple interactionsISOCcl2 (Mus musculus)6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CCL2 protein; [MT1 gene mutant form results in increased susceptibility to Cadmium Chloride] which affects the expression of CCL2 mRNA; [MT1 gene mutant form results in increased susceptibility to Cadmium Chloride] which results in increased expression of CCL2 mRNA; [MT2 gene mutant form results in increased susceptibility to Cadmium Chloride] which affects the expression of CCL2 mRNA; [MT2 gene mutant form results in increased susceptibility to Cadmium Chloride] which results in increased expression of CCL2 mRNA; [Tetradecanoylphorbol Acetate co-treated with [Cadmium Chloride results in increased abundance of Cadmium]] affects the expression of CCL2 mRNAPMID:23921151 PMID:31904401 PMID:33359024
Ccl2multiple interactionsISOCCL2 (Homo sapiens)6480464CTD[Cadmium Chloride co-treated with Lipopolysaccharides] results in increased expression of CCL2 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which affects the expression of CCL2 mRNA; Cadmium Chloride promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of CCL2 protein]PMID:26809137 PMID:35301059 PMID:36416909
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