GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ccl2 | increases methylation | EXP | | 6480464 | CTD | Cadmium Chloride results in increased methylation of CCL2 promoter | PMID:22457795 | Ccl2 | decreases expression | ISO | Ccl2 (Mus musculus) | 6480464 | CTD | Cadmium Chloride results in decreased expression of CCL2 mRNA | PMID:23921151 | Ccl2 | increases expression | ISO | CCL2 (Homo sapiens) | 6480464 | CTD | Cadmium Chloride results in increased expression of CCL2 mRNA | PMID:23397585 PMID:35650140 | Ccl2 | multiple interactions | ISO | Ccl2 (Mus musculus) | 6480464 | CTD | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CCL2 protein; [MT1 gene mutant form results in increased susceptibility to Cadmium Chloride] which affects the expression of CCL2 mRNA; [MT1 gene mutant form results in increased susceptibility to Cadmium Chloride] which results in increased expression of CCL2 mRNA; [MT2 gene mutant form results in increased susceptibility to Cadmium Chloride] which affects the expression of CCL2 mRNA; [MT2 gene mutant form results in increased susceptibility to Cadmium Chloride] which results in increased expression of CCL2 mRNA; [Tetradecanoylphorbol Acetate co-treated with [Cadmium Chloride results in increased abundance of Cadmium]] affects the expression of CCL2 mRNA | PMID:23921151 PMID:31904401 PMID:33359024 | Ccl2 | multiple interactions | ISO | CCL2 (Homo sapiens) | 6480464 | CTD | [Cadmium Chloride co-treated with Lipopolysaccharides] results in increased expression of CCL2 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which affects the expression of CCL2 mRNA; Cadmium Chloride promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of CCL2 protein] | PMID:26809137 PMID:35301059 PMID:36416909 | |
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