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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3645
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccl2
Name: C-C motif chemokine ligand 2
Acc ID: CHEBI:47807
Term: sulforaphane
Definition: An isothiocyanate having a 4-(methylsulfinyl)butyl group attached to the nitrogen.
Chemical ID: MESH:C016766
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccl2decreases expressionISOCCL2 (Homo sapiens)6480464CTDsulforaphane metabolite results in decreased expression of CCL2 mRNA; sulforaphane results in decreased expression of CCL2 mRNAPMID:32387680
Ccl2increases expressionISOCCL2 (Homo sapiens)6480464CTDsulforaphane results in increased expression of CCL2 mRNAPMID:26833863 PMID:35724838
Ccl2multiple interactionsISOCcl2 (Mus musculus)6480464CTDsulforaphane inhibits the reaction [Cyclosporine results in increased expression of CCL2 mRNA]; sulforaphane inhibits the reaction [Tacrolimus results in increased expression of CCL2 mRNA]PMID:23958496
Ccl2multiple interactionsISOCCL2 (Homo sapiens)6480464CTDsulforaphane inhibits the reaction [[Tobacco Smoke Pollution co-treated with Particulate Matter] results in increased expression of CCL2 mRNA]; sulforaphane metabolite inhibits the reaction [[Tobacco Smoke Pollution co-treated with Particulate Matter] results in increased expression of CCL2 mRNA]PMID:32387680
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