GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ccl2 | decreases expression | ISO | CCL2 (Homo sapiens) | 6480464 | CTD | Zinc results in decreased expression of CCL2 protein | PMID:18215484 PMID:20427734 | Ccl2 | increases expression | ISO | Ccl2 (Mus musculus) | 6480464 | CTD | Zinc deficiency results in increased expression of CCL2 mRNA | PMID:30635848 | Ccl2 | multiple interactions | ISO | Ccl2 (Mus musculus) | 6480464 | CTD | [Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CCL2 mRNA; [Zinc co-treated with Nickel co-treated with Cobalt] affects the reaction [Dietary Fats affects the expression of CCL2 mRNA]; TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CCL2 mRNA] | PMID:23503329 | Ccl2 | multiple interactions | ISO | CCL2 (Homo sapiens) | 6480464 | CTD | IL6 promoter polymorphism affects the reaction [Zinc results in decreased expression of CCL2 protein]; MT1A gene polymorphism affects the reaction [Zinc results in decreased expression of CCL2 protein]; Zinc inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of CCL2 protein]; Zinc inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased secretion of CCL2 protein] | PMID:18215484 PMID:21035309 | | ||||||||||||||||||||||
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