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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3645
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccl2
Name: C-C motif chemokine ligand 2
Acc ID: CHEBI:63041
Term: manganese(II) chloride
Definition: An inorganic chloride in which manganese(II) is coordinated to two chloride ions. In its anhydrous state manganese(II) chloride is a polymeric solid, which adopts a layered cadmium chloride-like structure.
Chemical ID: MESH:C025340
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccl2decreases secretionEXP 6480464CTDmanganese chloride results in decreased secretion of CCL2 proteinPMID:23329836
Ccl2multiple interactionsISOCcl2 (Mus musculus)6480464CTDmanganese chloride inhibits the reaction [Glucose results in increased secretion of CCL2 protein]PMID:23329836
Ccl2multiple interactionsISOCCL2 (Homo sapiens)6480464CTDmanganese chloride inhibits the reaction [CCL2 protein results in increased expression of ICAM1 protein]; manganese chloride inhibits the reaction [Glucose results in increased secretion of CCL2 protein]PMID:23329836
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