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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3645
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccl2
Name: C-C motif chemokine ligand 2
Acc ID: CHEBI:28262
Term: dimethyl sulfoxide
Definition: A 2-carbon sulfoxide in which the sulfur atom has two methyl substituents.
Chemical ID: MESH:D004121
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccl2decreases expressionEXP 6480464CTDDimethyl Sulfoxide results in decreased expression of CCL2 mRNAPMID:10925121
Ccl2multiple interactionsEXP 6480464CTDDimethyl Sulfoxide inhibits the reaction [sodium arsenite results in increased expression of CCL2 mRNA]PMID:15689417
Ccl2increases secretionISOCCL2 (Homo sapiens)6480464CTDDimethyl Sulfoxide results in increased secretion of CCL2 proteinPMID:26860701
Ccl2multiple interactionsISOCCL2 (Homo sapiens)6480464CTDDimethyl Sulfoxide inhibits the reaction [IL1B protein results in increased secretion of CCL2 protein]; Dimethyl Sulfoxide inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]; Dimethyl Sulfoxide inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein]; Dimethyl Sulfoxide inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; Tetrachlorodibenzodioxin promotes the reaction [Dimethyl Sulfoxide results in increased secretion of CCL2 protein]PMID:14576080 PMID:17529908 PMID:21878375 PMID:26860701
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