GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ccl2 | affects expression | EXP | | 6480464 | CTD | Diclofenac affects the expression of CCL2 mRNA | PMID:25051504 | Ccl2 | increases expression | EXP | | 6480464 | CTD | Diclofenac results in increased expression of CCL2 protein | PMID:25051504 | Ccl2 | multiple interactions | EXP | | 6480464 | CTD | [Water deficiency co-treated with Diclofenac] results in increased expression of CCL2 protein; Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 mRNA]; Gum Arabic inhibits the reaction [[Water deficiency co-treated with Diclofenac] results in increased expression of CCL2 protein] | PMID:23939143 PMID:31042592 | Ccl2 | increases expression | ISO | Ccl2 (Mus musculus) | 6480464 | CTD | Diclofenac results in increased expression of CCL2 mRNA | PMID:22285467 PMID:27671914 | Ccl2 | increases expression | ISO | CCL2 (Homo sapiens) | 6480464 | CTD | Diclofenac analog results in increased expression of CCL2 mRNA | PMID:24104198 | Ccl2 | increases secretion | ISO | CCL2 (Homo sapiens) | 6480464 | CTD | Diclofenac analog results in increased secretion of CCL2 protein | PMID:24104198 | Ccl2 | multiple interactions | ISO | CCL2 (Homo sapiens) | 6480464 | CTD | SB 203580 inhibits the reaction [Diclofenac analog results in increased expression of CCL2 mRNA]; U 0126 inhibits the reaction [Diclofenac analog results in increased expression of CCL2 mRNA] | PMID:24104198 | | ||||||||||||||||||||||
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