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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3645
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccl2
Name: C-C motif chemokine ligand 2
Acc ID: CHEBI:35696
Term: cobalt dichloride
Definition: A cobalt salt in which the cobalt metal is in the +2 oxidation state and the counter-anion is chloride. It is used as an indicator for water in desiccants.
Chemical ID: MESH:C018021
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccl2multiple interactionsEXP 6480464CTDcobaltous chloride inhibits the reaction [Oxygen deficiency results in increased expression of CCL2 protein]PMID:18635243 PMID:19278353 PMID:21296072
Ccl2decreases expressionISOCCL2 (Homo sapiens)6480464CTDcobaltous chloride results in decreased expression of CCL2 mRNAPMID:14652683 PMID:19376846
Ccl2increases expressionISOCcl2 (Mus musculus)6480464CTDcobaltous chloride results in increased expression of CCL2 mRNAPMID:23684559 PMID:25966675
Ccl2increases response to substanceISOCcl2 (Mus musculus)6480464CTDCCL2 results in increased susceptibility to cobaltous chloridePMID:23043544
Ccl2increases secretionISOCCL2 (Homo sapiens)6480464CTDcobaltous chloride results in increased secretion of CCL2 proteinPMID:21110705
Ccl2multiple interactionsISOCcl2 (Mus musculus)6480464CTD2,2-bis(4-glycidyloxyphenyl)propane affects the reaction [[cobaltous chloride co-treated with lipopolysaccharide, E coli O55-B5 co-treated with Phloretin] results in increased expression of CCL2 mRNA]; 2,2-bis(4-glycidyloxyphenyl)propane affects the reaction [[cobaltous chloride co-treated with Phloretin] affects the expression of CCL2 mRNA]; 2,2-bis(4-glycidyloxyphenyl)propane affects the reaction [[cobaltous chloride co-treated with Phlorhizin] affects the expression of CCL2 mRNA]; [cobaltous chloride co-treated with chromic chloride] results in increased expression of CCL2 mRNA; [cobaltous chloride co-treated with lipopolysaccharide, E coli O55-B5 co-treated with Phloretin] results in increased expression of CCL2 mRNA; [cobaltous chloride co-treated with Phloretin] affects the expression of CCL2 mRNA; [cobaltous chloride co-treated with Phlorhizin] affects the expression of CCL2 mRNAPMID:25966675 PMID:32408695
Ccl2multiple interactionsISOCCL2 (Homo sapiens)6480464CTDcobaltous chloride results in increased expression of and results in increased secretion of CCL2 proteinPMID:23629852
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