RGD Cardiovascular Disease Portal – Rat Strain Models
	The following tables list strains which have been annotated to the Cardiovascular Disease Portal. For mutant strains, the mutated gene is listed after the strain symbol. Control strains are listed for the respective strain, for given references. The strains listed below are curated with a set of special qualifiers indicating a MODEL of disease, whether induced or spontaneously exhibited. The MODEL qualifier indicates that the curated strain is a rat model developed and used to study human disease. This requires multiple references or a detailed description of disease phenotypes to support the classification. A more extensive search for strains that exhibit specific diseases, including those not specifically defined as MODELs, can be completed using the Find Models by Disease or Phenotype tool.

Hypertension/Blood Pressure
Disease	Strain	Affected Gene	Control	Reference(s)
Diastolic Dysfunction	SS/JrHsd (MODEL:induced)		LEW/NHsd	8657131
Essential Hypertension	SHR/OlaIpcv (MODEL:spontaneous)		SHR.BN-(D5Wox12-D5Wox20)/Ipcv	2312571; 631851; 619651
Hypertension	SS/JrHsd (MODEL:induced)		LEW/NHsd	8657131
Hypertension	CRDH (MODEL:spontaneous)		WKY	1354689; 724741
Hypertension	LH/Mav (MODEL:spontaneous)		LN/Mav	1580389; 61057; 61058; 2316962; 13513906; 2313340
Hypertension	SD-Tg(Ren2)27 (MODEL:spontaneous)	Ren2	SD-Tg(Ren2)27-/-; LL/Mav; WKY	628589; 13513906
Hypertension	SHR (MODEL:spontaneous)			2316962; 61051; 13513906
Hypertension	SHR/Izm (MODEL:spontaneous)		LEW/CrlCrlj	619658
Hypertension	SHR/Mol (MODEL:spontaneous)		Wild/K	619656
Hypertension	SHR/N (MODEL:spontaneous)		WKY/N; DRY	731210; 61484
Hypertension	SHR/NCruk (MODEL:spontaneous)		WKY/Ncruk; SHR.WKY-(D1Rat420-D1Got161)/Njs	70855; 1625015
Hypertension	SHR/NlcoCrlf (MODEL:spontaneous)		LEW/NIcoCrlf	631324; 4109649
Hypertension	SHR/Ola (MODEL:spontaneous)		SHR.BN-(D1Mit3-Igf2)/Ipcv; BN-Lx/Cub	632218; 628911
Hypertension	SHR/Snk (MODEL:spontaneous)		F344/Snk	1599588; 631181
Hypertension	SHRSP/A3N (MODEL:spontaneous)		WKY/NCrl	27095952; 30296650; 28912746; 36049805
Hypertension	SHRSP/Gcrc (MODEL:spontaneous)		WKY/Gcrc	2301356; 1643008; 61041; 68910; 631154
Hypertension	SHRSP/Tkyo (MODEL:spontaneous)		WKY/Tkyo	1554311; 18337260
Hypertension	SS.BN-(D12Hmgc3-AU047911)/Mcwi (MODEL:induced)		SS-Chr 12BN/Mcwi	8693701
Hypertension	SS/Jr (MODEL)		LEW	8657072; 61040; 619649; 61516; 69710; 704345
Hypertension	SS-Chr 12BN.SS-(D12Hmgc3-D12Hmgc6)/Mcwi (MODEL:induced)		SS-Chr 12BN/Mcwi	8693701
Hypertensive Nephropathy	SS-Nppbem2Mcwi-/- (MODEL:age-related)	Nppb		12910116
Hypertensive Nephropathy	SS/JrHsdMcwi (MODEL:induced)		BN/NHsdMcwi	727992; 12802369; 12792230
Malignant Hypertension	F344-Tg(Cyp1a1-Ren2)10Jmul (MODEL)			2302144; 2302140
Pulmonary Hypertension	F344-Bmpr2em1Sage+/- (MODEL:induced)	Bmpr2		14975304
Pulmonary Hypertension	F344-Bmpr2em2Sage+/- (MODEL:induced)	Bmpr2		14975304
Renovascular Hypertension	CD (MODEL:induced)			1354518; 1354520
Stress-Induced Hypertension	SHRSP/Izm (MODEL:induced)		WKY/Izm	4889147; 2302104; 2296063; 2300017; 730283; 1578503

Heart Disease
Disease	Strain	Affected Gene	Control	Reference(s)
Cardiomegaly	SHRSP/Tkyo (MODEL:spontaneous)		WKY/Tkyo	1554311; 18337260
Danon Disease	SD-Lamp2em1 (MODEL:induced)	Lamp2		13703117
Hypertrophic Cardiomyopathy	SS-Chr 16BN/Mcwi (MODEL)			1598977
Left Ventricular Hypertrophy	LH/Mav (MODEL:spontaneous)			2316962; 13513906
Left Ventricular Hypertrophy	SD-Tg(Ren2)27 (MODEL:spontaneous)	Ren2	SD-Tg(Ren2)27-/-; LL/Mav; WKY	13513906
Left Ventricular Hypertrophy	SHR (MODEL:spontaneous)			2316962; 13513906
Left Ventricular Hypertrophy	SHR/Izm (MODEL:spontaneous)		LEW/CrlCrlj	619658
Left Ventricular Hypertrophy	SS/JrHsd (MODEL:induced)		LEW/NHsd	8657131

Vascular Disease
Disease	Strain	Affected Gene	Control	Reference(s)
Athersclerosis	LA-cp/NJcr (MODEL:spontaneous)			1642391; 21408581
Brain Ischemia	SHRSP/Gcrc (MODEL:induced)			61056; 18936990
Coronary Artery Disease	SS-Tg(ApoC3-CETP)53Opaz (MODEL)	CETP		2290427
Diabetic Retinopathy	SDT/Jcl (MODEL:spontaneous)		Crlj:CD(SD)	628479; 2312348; 19165123
Middle Cerebral Artery Infarction	SHRSP/Izm (MODEL:induced)			1600255; 2302104
Pseudoxanthoma Elasticum	SD-Abcc6em2Qlju-/- (MODEL:spontaneous)	Abcc6		13792593
Stroke	SHRSP/Bbb (MODEL:induced)		SHRSR/Bbb	2307158
Stroke	SHRSP/Gcrc (MODEL:induced)			2313614
Vascular Dementia	SHRSP/Ezo (MODEL:spontaneous)		WKY	1556766; 18936992

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.