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Strain Registration

Strain: WKY/NCrl

Symbol: WKY/NCrl
Strain: WKY
Substrain: NCrl
RGD ID: 1358112
Citation ID: RRID:RGD_1358112
Ontology ID: RS:0000731
Previously known as: MDC-01-41; WKY/NCrlBR; WKY (CRiv)
Type: inbred
Source: Charles River Laboratories
Origin: Outbred Wistar stock from Kyoto School of Medicine to NIH in 1971, to Charles River in 1974 from NIH at F11
Coat Color: Albino
Last Known Status: Unknown





Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
Options:  View chart  |  Download data table  |  View expanded data table

Clinical Measurement
heart rate
systolic blood pressure
diastolic blood pressure
left ventricular diastolic blood pressure
left ventricular systolic blood pressure
mean arterial blood pressure
body weight
body temperature
left ventricular developed pressure
red blood cell count
blood hemoglobin level
blood neutrophil count
blood lymphocyte count
blood monocyte count
blood eosinophil count
hematocrit
mean corpuscular volume
blood glucose level
plasma anion gap
heart wet weight
heart weight to body weight ratio
lung dry weight to body weight ratio
heart right ventricle weight to left ventricle weight ratio
plasma renin activity level
minute ventilation
kidney wet weight
end-systolic volume
arterial blood flow rate
end-diastolic volume
tidal volume
partial pressure of blood carbon dioxide (Pco2)
percent change in ventilation
respiration rate
mean corpuscular hemoglobin
mean corpuscular hemoglobin concentration
absolute change in partial pressure of blood carbon dioxide
absolute change in partial pressure of blood oxygen
absolute change in blood pH
serum total cholesterol level
total white blood cell count
serum total bilirubin level
blood pH
partial pressure of blood oxygen
serum bicarbonate level
serum chloride level
serum potassium level
serum sodium level
serum calcium level
percent change in respiration rate
percent change in tidal volume
absolute change in mean arterial blood pressure
absolute change in heart rate
plasma creatinine level
serum phosphate level
serum glucose level
serum albumin level
serum alanine aminotransferase activity level
serum alkaline phosphatase activity level
serum aspartate aminotransferase activity level
serum urea nitrogen level
single kidney wet weight to body weight ratio
serum total protein level
time to onset of heart contraction
time to peak heart contraction
heart contraction pressure
heart left ventricle infarction weight to total heart left ventricle weight ratio
absolute change in body temperature
calculated pulmonary vascular resistance normalized to body weight
FAPGG metabolism-surface area product
methylene blue metabolism-surface area product without auto-oxidation
methylene blue metabolism-surface area product after auto-oxidation
methylene blue to FAPGG metabolism-surface area product ratio
dose of methacholine at which pulmonary conductance is half its pretreatment value
fractional change in blood vessel diameter per unit change in intravascular pressure
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50)
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50)
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)
concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)
maximum contractile force per wet weight of aorta
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel
sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel
hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel
percent change in heart rate
percent change in arterial blood flow rate
percent change in left ventricular developed pressure
percent change in left ventricular systolic blood pressure
urine total protein excretion rate
urine albumin excretion rate
urine sodium excretion rate
creatinine clearance
heart effluent lactate dehydrogenase activity level normalized to heart weight
serum globulin level
mesenteric artery phosphorylated eNOS level to total eNOS level ratio
aorta wall phosphorylated eNOS level to total eNOS level ratio
serum fructosamine level
water intake drink rate to body weight ratio
kidney wet weight to body weight ratio
number of spontaneous locomotor movements per unit time
norepinephrine-induced blood vessel contractile force expressed as percent of force of contraction to KCL
negative logarithm of the molar concentration of norepinephrine at which the force of blood vessel contraction is half the maximum value
ratio of deaths related to left ventricular hypertrophy to total study population during a period of time

References

References - curated
# Reference Title Reference Citation
1. Copy number polymorphism in Fcgr3 predisposes to glomerulonephritis in rats and humans. Aitman TJ, etal., Nature. 2006 Feb 16;439(7078):851-5.
2. Carvedilol prevents and reverses hypertrophy-induced cardiac dysfunction. Barone FC, etal., Pharmacology. 2007;80(2-3):166-76. doi: 10.1159/000103384. Epub 2007 Jun 4.
3. Identification of Ceruloplasmin as a Gene that Affects Susceptibility to Glomerulonephritis Through Macrophage Function. Chen TD, etal., Genetics. 2017 Jun;206(2):1139-1151. doi: 10.1534/genetics.116.197376. Epub 2017 Apr 26.
4. Genetic mapping found major QTLs for antibody-induced glomerulonephritis in WKY rats. Kose H, etal., Exp Anim. 2009 Apr;58(2):193-8.
5. Susceptibility to anthrax lethal toxin-induced rat death is controlled by a single chromosome 10 locus that includes rNlrp1. Newman ZL, etal., PLoS Pathog. 2010 May 20;6(5):e1000906. doi: 10.1371/journal.ppat.1000906.
6. Strains registered by Charles River Laboratories International, Inc. Personal communication with Charles River Laboratories
7. PhysGen Strains PhysGen strains
8. RGD Strain RSO annotation pipeline RGD Automated Pipelines
9. SNP and haplotype mapping for genetic analysis in the rat. Saar K, etal., Nat Genet. 2008 May;40(5):560-6.
10. Sequence analysis of the complete mitochondrial DNA in 10 commonly used inbred rat strains. Schlick NE, etal., Am J Physiol Cell Physiol. 2006 Dec;291(6):C1183-92. Epub 2006 Jul 19.

Region

Strain QTL Data
Symbol Name Trait
Glom15 Glomerulus QTL 15 kidney glomerulus integrity trait   (VT:0010546)    
Glom16 Glomerulus QTL 16 kidney glomerulus integrity trait   (VT:0010546)    
Glom22 Glomerulus QTL 22 urine protein amount   (VT:0005160)    
Glom23 Glomerulus QTL 23 urine protein amount   (VT:0005160)    
Glom24 Glomerulus QTL 24 kidney glomerulus integrity trait   (VT:0010546)    
Glom25 Glomerulus QTL 25 urine protein amount   (VT:0005160)    
Glom26 Glomerulus QTL 26 urine protein amount   (VT:0005160)    
Glom27 Glomerulus QTL 27 kidney glomerulus integrity trait   (VT:0010546)    
Kidm41 Kidney mass QTL 41 kidney mass   (VT:0002707)    
Ppulsi1 Prepulse inhibition QTL 1 prepulse inhibition trait   (VT:0003088)    
Ppulsi2 Prepulse inhibition QTL 2 prepulse inhibition trait   (VT:0003088)    
Pur17 Proteinuria QTL 17 urine protein amount   (VT:0005160)    
Damaging Variants
Number of Damaging Variants
SampleRnor_6.0Rnor_5.0RGSC_v3.4
WKY/NCrl (ICL) 805
WKY/NCrl (KNAW) 953
WKY/NCrl (RGD) 1243
WKY/NCrl (2019) 3113
WKY/NCrl (2019)


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_behavior exhibit bradycardia accompanying a startle-induced pressor response, whereas SHR demonstrate tachycardia 1358985
strain_behavior tactile stimulation results in jumping event, the magnitude of which habituates to repeated stimuli 1358984
strain_life_disease The blood pressure of females is 120 mmHg and of males is 121 mmHg. 629526
strain_other The average weight of females is 174g and of males 242g. 629526