Strain Report - Rat Genome Database

Name: WKY/NCrl
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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General

Strain: WKY/NCrl
Symbol:	WKY/NCrl
Strain:	WKY
Substrain:	NCrl
Ontology ID:	RS:0000731
Also known as:	MDC-01-41; WKY/NCrlBR; WKY (CRiv)
Type:	inbred
Source:	Charles River Laboratories
Origin:	Outbred Wistar stock from Kyoto School of Medicine to NIH in 1971, to Charles River in 1974 from NIH at F11
Coat Color:	Albino
Last Known Status:	Unknown

Annotation (Toggle Annotation Detail/Summary View)

Disease Annotations

RGD Manual Annotations

Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
anti-basement membrane glomerulonephritis	MODEL: induced	IDA		2312387	by nephritogenic antigen anti-GBM monoclonal antibody, b35	RGD
glomerulonephritis	MODEL: induced	IAGP		2293335		RGD
nephritis	MODEL: induced	IAGP		2293335		RGD

Phenotype Annotations

Mammalian Phenotype

Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
glomerular crescent		IAGP		2293335		RGD
glomerulonephritis	susceptibility	IDA		2293335		RGD

Phenotype Values via Phenominer

Related Phenotype Data for Term "WKY/NCrl" (RS:0000731)

Rat Strains:

WKY/NCrl

Clinical Measurements:

absolute change in blood pH
absolute change in body temperature
absolute change in heart rate
absolute change in mean arterial blood pressure
absolute change in partial pressure of blood carbon dioxide
absolute change in partial pressure of blood oxygen
absolute change in plasma renin activity level
acetylcholine-induced blood vessel dilation expressed as percent of force at maximum constriction
aorta wall phosphylated eNOS level to total eNOS level ratio
arterial blood flow rate
blood eosinophil count
blood fructosamine level
blood glucose level
blood hemoglobin level
blood lymphocyte count
blood monocyte count
blood neutrophil count
blood pH
body temperature
body weight
calculated pulmonary vascular resistance normalized to body weight
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50)
concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)
creatinine clearance
diastolic blood pressure
dose of methacholine at which pulmonary conductance is half its pretreatment value (ED50)
FAPGG metabolism-surface area product
food intake weight to body weight ratio
fractional change in blood vessel diameter per unit change in intravascular pressure
heart contraction pressure
heart effluent lactate dehydrogenase activity level normalized to heart weight
heart left ventricle infarction weight to total heart left ventricle weight ratio
heart rate
heart right ventricle weight to left ventricle weight ratio
heart weight to body weight ratio
heart wet weight
hematocrit
hypoxia-induced blood vessel dilation expressed as percent of force at maximum constriction
kidney wet weight
left ventricular developed pressure
left ventricular diastolic blood pressure
left ventricular systolic blood pressure
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50)
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)
lung dry weight to body weight ratio
maximum contractile force per wet weight of aorta
mean arterial blood pressure
mean corpuscular hemoglobin concentration
mean corpuscular hemoglobin level
mean corpuscular volume
mesenteric artery phosphylated eNOS level to total eNOS level ratio
methylene blue metabolism-surface area product after auto-oxidation
methylene blue metabolism-surface area product without auto-oxidation
methylene blue to FAPGG metabolism-surface area product ratio
minute ventilation (VE)
partial pressure of blood carbon dioxide (Pco2)
partial pressure of blood oxygen (Po2)
percent change in arterial blood flow rate
percent change in heart rate
percent change in left ventricular developed pressure
percent change in left ventricular systolic blood pressure
percent change in respiration rate
percent change in tidal volume
percent change in ventilation
plasma anion gap
plasma creatinine level
plasma renin activity level
red blood cell count
respiration rate
serum alanine aminotransferase activity level
serum albumin level
serum alkaline phosphatase activity level
serum aspartate aminotransferase activity level
serum bicarbonate level
serum calcium level
serum chloride level
serum globulin level
serum glucose level
serum phosphate level
serum potassium level
serum sodium level
serum total cholesterol level
serum total protein level
serum urea nitrogen level
single kidney wet weight as percentage of body weight
sodium nitroprusside-induced blood vessel dilation expressed as percent of force at maximum constriction
systolic blood pressure
tidal volume
time to onset of heart contraction
time to peak heart contraction
total serum bilirubin level
total white blood cell count
urine albumin excretion rate
urine sodium excretion rate
urine total protein excretion rate
voluntary horizontal locomotion rate in an experimental apparatus
water intake drink rate to body weight ratio

Experimental Conditions:

acetylcholine
air carbon dioxide content
air oxygen content
angiotensin
anti-glomerular basement membrane antibody
controlled exposure to ambient light
controlled exposure to darkness
controlled oxygen content Kreb's solution perfusate
controlled oxygen content physiological salt solution perfusate
controlled sodium content diet
drug dose time series
FAPGG
fasting
furosemide
glucose
Kreb's solution perfusate
methacholine
methylene blue
naive control condition
norepinephrine
perfusate suspended
phenylephrine
potassium ion
resting on treadmill
running on treadmill
salidroside
sample resting period
sodium nitroprusside
vehicle control condition
walking on treadmill

Measurement Methods:

automated blood cell counting method
automated blood gas analysis using a Bayer analyzer
automated plasma creatinine analysis
automated serum analysis
automated urine analysis
balloon tipped catheter with pressure transducer in isolated perfused heart
blood glucose analysis
body weighing method
digital rectal thermometry
digital scale post excision weight measurement
ex vivo volume measurement method
flame atomic emission spectrometry
fluid-filled catheter with pressure transducer in isolated perfused lung
intra-aortic abdominal radiotelemetry
isolated perfused heart effluent collection
isolated perfused lung vascular effluent collection
microhematocrit tube assay with visual assessment
post excision weight measurement
radioimmunoassay
scale
standard blood chemistry panel
stop flow air displacement plethysmography
urine creatinine analysis
urine protein analysis
vascular fluid filled catheter
vascular indwelling catheter method
western blot assay
whole body digital scale
wire myography
wire myography using a Digi-Med tissue force analysis system with force transducer

Disease Annotations

	anti-basement membrane glomerulonephritis (IDA)
	glomerulonephritis (IAGP)

nephritis (IAGP)

Phenotype Annotations

Mammalian Phenotype

glomerular crescent (IAGP)

glomerulonephritis (IDA)

Experimental Data Annotations

Rat Strain

WKY/NCrl (IEA)

Phenotype Values via Phenominer

Options:

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Download data table

View expanded data table

Clinical Measurement

heart rate

systolic blood pressure

diastolic blood pressure

left ventricular diastolic blood pressure

left ventricular systolic blood pressure

mean arterial blood pressure

body weight

body temperature

left ventricular developed pressure

red blood cell count

blood hemoglobin level

blood neutrophil count

blood lymphocyte count

blood monocyte count

blood eosinophil count

hematocrit

mean corpuscular volume

blood glucose level

plasma anion gap

heart wet weight

heart weight to body weight ratio

lung dry weight to body weight ratio

heart right ventricle weight to left ventricle weight ratio

plasma renin activity level

minute ventilation (VE)

kidney wet weight

arterial blood flow rate

tidal volume

partial pressure of blood carbon dioxide (Pco2)

percent change in ventilation

respiration rate

mean corpuscular hemoglobin level

mean corpuscular hemoglobin concentration

absolute change in partial pressure of blood carbon dioxide

absolute change in partial pressure of blood oxygen

absolute change in blood pH

serum total cholesterol level

total white blood cell count

total serum bilirubin level

blood pH

partial pressure of blood oxygen (Po2)

serum bicarbonate level

serum chloride level

serum potassium level

serum sodium level

serum calcium level

percent change in respiration rate

percent change in tidal volume

absolute change in mean arterial blood pressure

absolute change in heart rate

plasma creatinine level

serum phosphate level

serum glucose level

serum albumin level

serum alanine aminotransferase activity level

serum alkaline phosphatase activity level

serum aspartate aminotransferase activity level

serum urea nitrogen level

absolute change in plasma renin activity level

single kidney wet weight as percentage of body weight

serum total protein level

time to onset of heart contraction

time to peak heart contraction

heart contraction pressure

heart left ventricle infarction weight to total heart left ventricle weight ratio

absolute change in body temperature

calculated pulmonary vascular resistance normalized to body weight

FAPGG metabolism-surface area product

methylene blue metabolism-surface area product without auto-oxidation

methylene blue metabolism-surface area product after auto-oxidation

methylene blue to FAPGG metabolism-surface area product ratio

dose of methacholine at which pulmonary conductance is half its pretreatment value (ED50)

fractional change in blood vessel diameter per unit change in intravascular pressure

concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50)

logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50)

concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)

logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)

concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)

logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)

maximum contractile force per wet weight of aorta

acetylcholine-induced blood vessel dilation expressed as percent of force at maximum constriction

sodium nitroprusside-induced blood vessel dilation expressed as percent of force at maximum constriction

hypoxia-induced blood vessel dilation expressed as percent of force at maximum constriction

percent change in heart rate

percent change in arterial blood flow rate

percent change in left ventricular developed pressure

percent change in left ventricular systolic blood pressure

urine total protein excretion rate

urine albumin excretion rate

urine sodium excretion rate

creatinine clearance

heart effluent lactate dehydrogenase activity level normalized to heart weight

serum globulin level

mesenteric artery phosphylated eNOS level to total eNOS level ratio

aorta wall phosphylated eNOS level to total eNOS level ratio

voluntary horizontal locomotion rate in an experimental apparatus

blood fructosamine level

water intake drink rate to body weight ratio

References - curated

1.	Aitman TJ, etal., Nature. 2006 Feb 16;439(7078):851-5.
2.	Behmoaras J, etal., Nat Genet. 2008 May;40(5):553-9.
3.	Kose H, etal., Exp Anim. 2009 Apr;58(2):193-8.
4.	Personal communication with Charles River Laboratories
5.	PhysGen strains
6.	RGD Automated Pipelines
7.	Saar K, etal., Nat Genet. 2008 May;40(5):560-6.
8.	Schlick NE, etal., Am J Physiol Cell Physiol. 2006 Dec;291(6):C1183-92. Epub 2006 Jul 19.

Region

Strain QTL Data

Symbol	Name	Trait
Glom15	Glomerulus QTL 15	kidney glomerulus integrity trait (VT:0010546)
Glom16	Glomerulus QTL 16	kidney glomerulus integrity trait (VT:0010546)
Glom22	Glomerulus QTL 22	urine protein amount (VT:0005160)
Glom23	Glomerulus QTL 23	urine protein amount (VT:0005160)
Glom24	Glomerulus QTL 24	kidney glomerulus integrity trait (VT:0010546)
Glom25	Glomerulus QTL 25	urine protein amount (VT:0005160)
Glom26	Glomerulus QTL 26	urine protein amount (VT:0005160)
Glom27	Glomerulus QTL 27	kidney glomerulus integrity trait (VT:0010546)
Kidm41	Kidney mass QTL 41	kidney mass (VT:0002707)
Ppulsi1	Prepulse inhibition QTL 1	prepulse inhibition trait (VT:0003088)
Ppulsi2	Prepulse inhibition QTL 2	prepulse inhibition trait (VT:0003088)
Pur17	Proteinuria QTL 17	urine protein amount (VT:0005160)

Damaging Variants

	Number of Damaging Variants
Sample	Rnor_6.0	Rnor_5.0	RGSC_v3.4
WKY/NCrl (ICL)			813
WKY/NCrl (KNAW)		937
WKY/NCrl (RGD)	1196

Additional Information

RGD Curation Notes

Note Type	Note	Reference
strain_behavior	exhibit bradycardia accompanying a startle-induced pressor response, whereas SHR demonstrate tachycardia	1358985
strain_behavior	tactile stimulation results in jumping event, the magnitude of which habituates to repeated stimuli	1358984
strain_life_disease	The blood pressure of females is 120 mmHg and of males is 121 mmHg.	629526
strain_other	The average weight of females is 174g and of males 242g.	629526

More on this Strain
	Strain Nomenclature
	Strain Registration

RGD Object Information
RGD ID:	1358112
Created:	2005-04-28
Species:	Rattus norvegicus
Last Modified:	2005-05-13
Status:	ACTIVE

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.

Strain: WKY/NCrl

RGD Manual Annotations

Related Phenotype Data for Term "WKY/NCrl" (RS:0000731)