Strain Report - Rat Genome Database
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Strain: WKY/NCrl

Symbol: WKY/NCrl
Strain: WKY
Substrain: NCrl
RGD ID: 1358112
RRID: RGD_1358112
Ontology ID: RS:0000731
Also known as: MDC-01-41; WKY/NCrlBR; WKY (CRiv)
Type: inbred
Source: Charles River Laboratories
Origin: Outbred Wistar stock from Kyoto School of Medicine to NIH in 1971, to Charles River in 1974 from NIH at F11
Coat Color: Albino
Last Known Status: Unknown





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Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
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Clinical Measurement
heart rate
systolic blood pressure
diastolic blood pressure
left ventricular diastolic blood pressure
left ventricular systolic blood pressure
mean arterial blood pressure
body weight
body temperature
left ventricular developed pressure
red blood cell count
blood hemoglobin level
blood neutrophil count
blood lymphocyte count
blood monocyte count
blood eosinophil count
hematocrit
mean corpuscular volume
blood glucose level
plasma anion gap
heart wet weight
heart weight to body weight ratio
lung dry weight to body weight ratio
heart right ventricle weight to left ventricle weight ratio
plasma renin activity level
minute ventilation (VE)
kidney wet weight
end-systolic volume
arterial blood flow rate
end-diastolic volume
tidal volume
partial pressure of blood carbon dioxide (Pco2)
percent change in ventilation
respiration rate
mean corpuscular hemoglobin level
mean corpuscular hemoglobin concentration
absolute change in partial pressure of blood carbon dioxide
absolute change in partial pressure of blood oxygen
absolute change in blood pH
serum total cholesterol level
total white blood cell count
total serum bilirubin level
blood pH
partial pressure of blood oxygen
serum bicarbonate level
serum chloride level
serum potassium level
serum sodium level
serum calcium level
percent change in respiration rate
percent change in tidal volume
absolute change in mean arterial blood pressure
absolute change in heart rate
plasma creatinine level
serum phosphate level
serum glucose level
serum albumin level
serum alanine aminotransferase activity level
serum alkaline phosphatase activity level
serum aspartate aminotransferase activity level
serum urea nitrogen level
absolute change in plasma renin activity level
single kidney wet weight as percentage of body weight
serum total protein level
time to onset of heart contraction
time to peak heart contraction
heart contraction pressure
heart left ventricle infarction weight to total heart left ventricle weight ratio
absolute change in body temperature
calculated pulmonary vascular resistance normalized to body weight
FAPGG metabolism-surface area product
methylene blue metabolism-surface area product without auto-oxidation
methylene blue metabolism-surface area product after auto-oxidation
methylene blue to FAPGG metabolism-surface area product ratio
dose of methacholine at which pulmonary conductance is half its pretreatment value (ED50)
fractional change in blood vessel diameter per unit change in intravascular pressure
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50)
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50)
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)
concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)
maximum contractile force per wet weight of aorta
acetylcholine-induced blood vessel dilation expressed as percent of force at maximum constriction
sodium nitroprusside-induced blood vessel dilation expressed as percent of force at maximum constriction
hypoxia-induced blood vessel dilation expressed as percent of force at maximum constriction
percent change in heart rate
percent change in arterial blood flow rate
percent change in left ventricular developed pressure
percent change in left ventricular systolic blood pressure
urine total protein excretion rate
urine albumin excretion rate
urine sodium excretion rate
creatinine clearance
heart effluent lactate dehydrogenase activity level normalized to heart weight
percentage of deaths in a study population during a period of time
serum globulin level
mesenteric artery phosphylated eNOS level to total eNOS level ratio
aorta wall phosphylated eNOS level to total eNOS level ratio
blood fructosamine level
water intake drink rate to body weight ratio

References


Region

Strain QTL Data
Symbol Name Trait
Glom15 Glomerulus QTL 15 kidney glomerulus integrity trait   (VT:0010546)    
Glom16 Glomerulus QTL 16 kidney glomerulus integrity trait   (VT:0010546)    
Glom22 Glomerulus QTL 22 urine protein amount   (VT:0005160)    
Glom23 Glomerulus QTL 23 urine protein amount   (VT:0005160)    
Glom24 Glomerulus QTL 24 kidney glomerulus integrity trait   (VT:0010546)    
Glom25 Glomerulus QTL 25 urine protein amount   (VT:0005160)    
Glom26 Glomerulus QTL 26 urine protein amount   (VT:0005160)    
Glom27 Glomerulus QTL 27 kidney glomerulus integrity trait   (VT:0010546)    
Kidm41 Kidney mass QTL 41 kidney mass   (VT:0002707)    
Ppulsi1 Prepulse inhibition QTL 1 prepulse inhibition trait   (VT:0003088)    
Ppulsi2 Prepulse inhibition QTL 2 prepulse inhibition trait   (VT:0003088)    
Pur17 Proteinuria QTL 17 urine protein amount   (VT:0005160)    
Damaging Variants
Number of Damaging Variants
SampleRnor_6.0Rnor_5.0RGSC_v3.4
WKY/NCrl (ICL) 813
WKY/NCrl (KNAW) 937
WKY/NCrl (RGD) 1196


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_behavior exhibit bradycardia accompanying a startle-induced pressor response, whereas SHR demonstrate tachycardia 1358985
strain_behavior tactile stimulation results in jumping event, the magnitude of which habituates to repeated stimuli 1358984
strain_life_disease The blood pressure of females is 120 mmHg and of males is 121 mmHg. 629526
strain_other The average weight of females is 174g and of males 242g. 629526