Strain Report - Rat Genome Database

Name: WKY/NCrl
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Strain Registration

General

Strain: WKY/NCrl
Symbol:	WKY/NCrl
Strain:	WKY
Substrain:	NCrl
RGD ID:	1358112
Citation ID:	RRID:RGD_1358112
Ontology ID:	RS:0000731
Also known as:	MDC-01-41; WKY/NCrlBR; WKY (CRiv)
Type:	inbred
Source:	Charles River Laboratories
Origin:	Outbred Wistar stock from Kyoto School of Medicine to NIH in 1971, to Charles River in 1974 from NIH at F11
Coat Color:	Albino
Last Known Status:	Unknown

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

glomerulonephritis (IAGP)

hypertension (IAGP)

proteinuria (IAGP)

Toxemia (IAGP)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

decreased systemic arterial systolic blood pressure (IAGP)

glomerular crescent (IAGP)

increased ceruloplasmin level (IAGP)

Phenotype Values via PhenoMiner Click to see Annotation Detail View

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Clinical Measurement

heart rate

systolic blood pressure

diastolic blood pressure

left ventricular diastolic blood pressure

left ventricular systolic blood pressure

mean arterial blood pressure

body weight

body temperature

left ventricular developed pressure

red blood cell count

blood hemoglobin level

blood neutrophil count

blood lymphocyte count

blood monocyte count

blood eosinophil count

hematocrit

mean corpuscular volume

blood glucose level

plasma anion gap

heart wet weight

heart weight to body weight ratio

lung dry weight to body weight ratio

heart right ventricle weight to left ventricle weight ratio

plasma renin activity level

minute ventilation

kidney wet weight

end-systolic volume

arterial blood flow rate

end-diastolic volume

tidal volume

partial pressure of blood carbon dioxide (Pco2)

percent change in ventilation

respiration rate

mean corpuscular hemoglobin

mean corpuscular hemoglobin concentration

absolute change in partial pressure of blood carbon dioxide

absolute change in partial pressure of blood oxygen

absolute change in blood pH

serum total cholesterol level

total white blood cell count

serum total bilirubin level

blood pH

partial pressure of blood oxygen

serum bicarbonate level

serum chloride level

serum potassium level

serum sodium level

serum calcium level

percent change in respiration rate

percent change in tidal volume

absolute change in mean arterial blood pressure

absolute change in heart rate

plasma creatinine level

serum phosphate level

serum glucose level

serum albumin level

serum alanine aminotransferase activity level

serum alkaline phosphatase activity level

serum aspartate aminotransferase activity level

serum urea nitrogen level

single kidney wet weight to body weight ratio

serum total protein level

time to onset of heart contraction

time to peak heart contraction

heart contraction pressure

heart left ventricle infarction weight to total heart left ventricle weight ratio

absolute change in body temperature

calculated pulmonary vascular resistance normalized to body weight

FAPGG metabolism-surface area product

methylene blue metabolism-surface area product without auto-oxidation

methylene blue metabolism-surface area product after auto-oxidation

methylene blue to FAPGG metabolism-surface area product ratio

dose of methacholine at which pulmonary conductance is half its pretreatment value

fractional change in blood vessel diameter per unit change in intravascular pressure

concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50)

logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50)

concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)

logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)

concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)

logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)

maximum contractile force per wet weight of aorta

acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel

sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel

hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel

percent change in heart rate

percent change in arterial blood flow rate

percent change in left ventricular developed pressure

percent change in left ventricular systolic blood pressure

urine total protein excretion rate

urine albumin excretion rate

urine sodium excretion rate

creatinine clearance

heart effluent lactate dehydrogenase activity level normalized to heart weight

serum globulin level

mesenteric artery phosphorylated eNOS level to total eNOS level ratio

aorta wall phosphorylated eNOS level to total eNOS level ratio

serum fructosamine level

water intake drink rate to body weight ratio

kidney wet weight to body weight ratio

number of spontaneous locomotor movements per unit time

norepinephrine-induced blood vessel contractile force expressed as percent of force of contraction to KCL

negative logarithm of the molar concentration of norepinephrine at which the force of blood vessel contraction is half the maximum value

ratio of deaths related to left ventricular hypertrophy to total study population during a period of time

References

References - curated


1.	Aitman TJ, etal., Nature. 2006 Feb 16;439(7078):851-5.
2.	Barone FC, etal., Pharmacology. 2007;80(2-3):166-76. doi: 10.1159/000103384. Epub 2007 Jun 4.
3.	Chen TD, etal., Genetics. 2017 Jun;206(2):1139-1151. doi: 10.1534/genetics.116.197376. Epub 2017 Apr 26.
4.	Kose H, etal., Exp Anim. 2009 Apr;58(2):193-8.
5.	Newman ZL, etal., PLoS Pathog. 2010 May 20;6(5):e1000906. doi: 10.1371/journal.ppat.1000906.
6.	Personal communication with Charles River Laboratories
7.	PhysGen strains
8.	RGD Automated Pipelines
9.	Saar K, etal., Nat Genet. 2008 May;40(5):560-6.
10.	Schlick NE, etal., Am J Physiol Cell Physiol. 2006 Dec;291(6):C1183-92. Epub 2006 Jul 19.

Region

Strain QTL Data

Symbol	Name	Trait
Glom15	Glomerulus QTL 15	kidney glomerulus integrity trait (VT:0010546)
Glom16	Glomerulus QTL 16	kidney glomerulus integrity trait (VT:0010546)
Glom22	Glomerulus QTL 22	urine protein amount (VT:0005160)
Glom23	Glomerulus QTL 23	urine protein amount (VT:0005160)
Glom24	Glomerulus QTL 24	kidney glomerulus integrity trait (VT:0010546)
Glom25	Glomerulus QTL 25	urine protein amount (VT:0005160)
Glom26	Glomerulus QTL 26	urine protein amount (VT:0005160)
Glom27	Glomerulus QTL 27	kidney glomerulus integrity trait (VT:0010546)
Kidm41	Kidney mass QTL 41	kidney mass (VT:0002707)
Ppulsi1	Prepulse inhibition QTL 1	prepulse inhibition trait (VT:0003088)
Ppulsi2	Prepulse inhibition QTL 2	prepulse inhibition trait (VT:0003088)
Pur17	Proteinuria QTL 17	urine protein amount (VT:0005160)

Damaging Variants

	Number of Damaging Variants
Sample	Rnor_6.0	Rnor_5.0	RGSC_v3.4
WKY/NCrl (ICL)			801
WKY/NCrl (KNAW)		933
WKY/NCrl (RGD)	1203
WKY/NCrl (2019)	3039
WKY/NCrl (2019)

Additional Information

RGD Curation Notes

Note Type	Note	Reference
strain_behavior	exhibit bradycardia accompanying a startle-induced pressor response, whereas SHR demonstrate tachycardia	1358985
strain_behavior	tactile stimulation results in jumping event, the magnitude of which habituates to repeated stimuli	1358984
strain_life_disease	The blood pressure of females is 120 mmHg and of males is 121 mmHg.	629526
strain_other	The average weight of females is 174g and of males 242g.	629526

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Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Strain: WKY/NCrl

Related Phenotype Data for Term "WKY/NCrl" (RS:0000731)