Strain Report - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Strain Registration

Strain: WKY/Gcrc

Symbol: WKY/Gcrc
Strain: WKY
Substrain: Gcrc
Full Name: Wistar-Kyoto
RGD ID: 734760
Citation ID: RRID:RGD_734760
Ontology ID: RS:0000761
Also Known As: WKYGla; A2656 ; MDC-03-31
Type: inbred
Available Source: Not Available
Origination: University of Glasgow, Western Infirmary, Glasgow, UK
Description: WKY strain is maintained at the University of Glasgow since December 1991. This colony is the result of the strain specific brother-sister mating of 13 WKY (6 males and 7 females of each) that were obtained from Dr D.F. Bohr (Department of Physiology, University of Michigan, Ann Arbor) where they had been maintained as inbred colonies for more than 15 years. Their breeding stocks were originally obtained from NIH
Last Known Status: Unknown





References

References - curated
# Reference Title Reference Citation
1. Quantitative trait loci in genetically hypertensive rats. Possible sex specificity. Clark JS, etal., Hypertension 1996 Nov;28(5):898-906
2. The genetics of cardiovascular disease. Delles C, etal., Trends Endocrinol Metab. 2008 Sep 24.
3. Candidate Genes That Determine Response to Salt in the Stroke-Prone Spontaneously Hypertensive Rat. Congenic Analysis. Graham D, etal., Hypertension. 2007 Oct 15;.
4. Applicability of a "speed" congenic strategy to dissect blood pressure quantitative trait loci on rat chromosome 2. Jeffs B, etal., Hypertension 2000 Jan;35(1 Pt 2):179-87.
5. Dissecting the genetic components of a quantitative trait locus for blood pressure and renal pathology on rat chromosome 3. Koh-Tan HH, etal., J Hypertens. 2017 Feb;35(2):319-329. doi: 10.1097/HJH.0000000000001155.
6. Microarray analysis of rat chromosome 2 congenic strains. McBride MW, etal., Hypertension 2003 Mar;41(3 Pt 2):847-53.
7. Differences in the Evolution of the Ischemic Penumbra in Stroke-Prone Spontaneously Hypertensive and Wistar-Kyoto Rats. McCabe C, etal., Stroke. 2009 Sep 24.
8. RGD Strain RSO annotation pipeline RGD Automated Pipelines
9. SNP and haplotype mapping for genetic analysis in the rat. Saar K, etal., Nat Genet. 2008 May;40(5):560-6.

Region

Strain QTL Data
Symbol Name Trait
Bp13 Blood pressure QTL 13 blood pressure trait   (VT:0000183)    
Bp14 Blood pressure QTL 14 arterial blood pressure trait   (VT:2000000)    
Bp15 Blood pressure QTL 15 blood pressure trait   (VT:0000183)    
Strain Samples in RGD with Damaging Variants (Polyphen)
AssemblySample 
RGSC_v3.4 WKY/Gcrc (ICL) View Damaging Variants
Rnor_5.0 WKY/Gcrc (KNAW) View Damaging Variants
Rnor_6.0 WKY/Gcrc (RGD) View Damaging Variants


Additional Information