RGD Reference Report - Quantitative trait loci in genetically hypertensive rats. Possible sex specificity. - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

Quantitative trait loci in genetically hypertensive rats. Possible sex specificity.

Authors: Clark, JS  Jeffs, B  Davidson, AO  Lee, WK  Anderson, NH  Bihoreau, MT  Brosnan, MJ  Devlin, AM  Kelman, AW  Lindpaintner, K  Dominiczak, AF 
Citation: Clark JS, etal., Hypertension 1996 Nov;28(5):898-906
RGD ID: 61041
Pubmed: PMID:8901842   (View Abstract at PubMed)

We performed a total genome screen in an F2 cross derived from the stroke-prone spontaneously hypertensive rat and the normotensive Wistar-Kyoto rat. Blood pressure at baseline and after 1% NaCl was measured by radiotelemetry; other phenotypes included heart rate, motor activity, left ventricle weight to body weight ratio, and vascular smooth muscle cell polyploidy, a measure of vascular hypertrophy. Quantitative trait loci affecting a given phenotype were mapped relative to microsatellite markers by using the MAPMAKER/QTL 1.1 computer package. We identified three blood pressure quantitative trait loci, two on rat chromosome 2 and one on rat chromosome 3. The quantitative trait loci close to genetic markers D2Mgh12 ("suggestive" linkage, with a maximal logarithm of the odds [LOD] score of 3.1) and D3Mgh16 (significant linkage, with a maximal LOD score of 5.6) showed possible sex specificity in the male F2 cohort only. This was confirmed by the likelihood ratio test for the difference in locus effects between the sexes. We also identified a new quantitative trait locus for LV hypertrophy on rat chromosome 14 ("suggestive" linkage, with a maximal LOD score of 3.1). The sex specificity of blood pressure quantitative trait loci will be important in designing congenic strains and substrains for fine genetic mapping and for identifying genes that regulate blood pressure.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
hypertension  IDA 61041; 61041; 61041 RGD 
hypertension MODEL: spontaneousIAGP 61041compared to control strain WKY/GcrcRGD 
hypertension MODEL: controlIAGP 61041compared to spontaneously hypertensive strain SHRSP/GcrcRGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
decreased mean systemic arterial blood pressure  IAGP 61041compared to spontaneously hypertensive strain SHRSP/GcrcRGD 
decreased susceptibility to hypertension  IAGP 61041compared to spontaneously hypertensive strain SHRSP/GcrcRGD 
decreased systemic arterial diastolic blood pressure  IAGP 61041compared to spontaneously hypertensive strain SHRSP/GcrcRGD 
decreased systemic arterial systolic blood pressure  IAGP 61041compared to spontaneously hypertensive strain SHRSP/GcrcRGD 
increased mean systemic arterial blood pressure susceptibilityIAGP 61041compared to control strain WKY/GcrcRGD 
increased pulse pressure susceptibilityIAGP 61041compared to control strain WKY/GcrcRGD 
increased susceptibility to hypertension susceptibilityIAGP 61041compared to control strain WKY/GcrcRGD 
increased systemic arterial blood pressure  QTM 61041; 61041; 61041 RGD 
increased systemic arterial diastolic blood pressure susceptibilityIAGP 61041compared to control strain WKY/GcrcRGD 
increased systemic arterial systolic blood pressure susceptibilityIAGP 61041compared to control strain WKY/GcrcRGD 
salt-sensitive hypertension severityIAGPcontrolled sodium content drinking water61041compared to control strain WKY/Gcrc and more severe in malesRGD 

Related Phenotype Data for this Reference

Phenominer Options:  View all phenotype data for this reference  |  Download all phenotype data for this reference

Select a value below to view phenotype data for a specific strain, measurment, or condition.

Objects Annotated

QTLs
Bp13  (Blood pressure QTL 13)
Bp14  (Blood pressure QTL 14)
Bp15  (Blood pressure QTL 15)

Strains
SHRSP/Gcrc  (Spontaneously hypertensive rat, stroke prone)
WKY/Gcrc  (Wistar-Kyoto)

Objects referenced in this article
Marker D2Mit6 D2Mit6 Rattus norvegicus
Marker D2Mgh14 D2Mgh14 Rattus norvegicus
Marker D3Mgh16 D3Mgh16 Rattus norvegicus
Marker D2Mgh12 D2Mgh12 Rattus norvegicus
Gene Cpb1 carboxypeptidase B1 Rattus norvegicus

Additional Information