RGD Reference Report - Quantitative trait loci in genetically hypertensive rats. Possible sex specificity. - Rat Genome Database

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Quantitative trait loci in genetically hypertensive rats. Possible sex specificity.

Authors: Clark, JS  Jeffs, B  Davidson, AO  Lee, WK  Anderson, NH  Bihoreau, MT  Brosnan, MJ  Devlin, AM  Kelman, AW  Lindpaintner, K  Dominiczak, AF 
Citation: Clark JS, etal., Hypertension 1996 Nov;28(5):898-906
RGD ID: 61041
Pubmed: PMID:8901842   (View Abstract at PubMed)

We performed a total genome screen in an F2 cross derived from the stroke-prone spontaneously hypertensive rat and the normotensive Wistar-Kyoto rat. Blood pressure at baseline and after 1% NaCl was measured by radiotelemetry; other phenotypes included heart rate, motor activity, left ventricle weight to body weight ratio, and vascular smooth muscle cell polyploidy, a measure of vascular hypertrophy. Quantitative trait loci affecting a given phenotype were mapped relative to microsatellite markers by using the MAPMAKER/QTL 1.1 computer package. We identified three blood pressure quantitative trait loci, two on rat chromosome 2 and one on rat chromosome 3. The quantitative trait loci close to genetic markers D2Mgh12 ("suggestive" linkage, with a maximal logarithm of the odds [LOD] score of 3.1) and D3Mgh16 (significant linkage, with a maximal LOD score of 5.6) showed possible sex specificity in the male F2 cohort only. This was confirmed by the likelihood ratio test for the difference in locus effects between the sexes. We also identified a new quantitative trait locus for LV hypertrophy on rat chromosome 14 ("suggestive" linkage, with a maximal LOD score of 3.1). The sex specificity of blood pressure quantitative trait loci will be important in designing congenic strains and substrains for fine genetic mapping and for identifying genes that regulate blood pressure.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Bp13Rathypertension  IDA  RGD 
Bp14Rathypertension  IDA  RGD 
Bp15Rathypertension  IDA  RGD 
SHRSP/GcrcRathypertension MODEL: spontaneousIAGP compared to control strain WKY/GcrcRGD 
WKY/GcrcRathypertension MODEL: controlIAGP compared to spontaneously hypertensive strain SHRSP/GcrcRGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
WKY/GcrcRatdecreased mean systemic arterial blood pressure  IAGP compared to spontaneously hypertensive strain SHRSP/GcrcRGD 
WKY/GcrcRatdecreased susceptibility to hypertension  IAGP compared to spontaneously hypertensive strain SHRSP/GcrcRGD 
WKY/GcrcRatdecreased systemic arterial diastolic blood pressure  IAGP compared to spontaneously hypertensive strain SHRSP/GcrcRGD 
WKY/GcrcRatdecreased systemic arterial systolic blood pressure  IAGP compared to spontaneously hypertensive strain SHRSP/GcrcRGD 
SHRSP/GcrcRatincreased mean systemic arterial blood pressure susceptibilityIAGP compared to control strain WKY/GcrcRGD 
SHRSP/GcrcRatincreased pulse pressure susceptibilityIAGP compared to control strain WKY/GcrcRGD 
SHRSP/GcrcRatincreased susceptibility to hypertension susceptibilityIAGP compared to control strain WKY/GcrcRGD 
Bp13Ratincreased systemic arterial blood pressure  QTM  RGD 
Bp14Ratincreased systemic arterial blood pressure  QTM  RGD 
Bp15Ratincreased systemic arterial blood pressure  QTM  RGD 
SHRSP/GcrcRatincreased systemic arterial diastolic blood pressure susceptibilityIAGP compared to control strain WKY/GcrcRGD 
SHRSP/GcrcRatincreased systemic arterial systolic blood pressure susceptibilityIAGP compared to control strain WKY/GcrcRGD 
SHRSP/GcrcRatsalt-sensitive hypertension severityIAGPcontrolled sodium content drinking watercompared to control strain WKY/Gcrc and more severe in malesRGD 

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Objects Annotated

QTLs
Bp13  (Blood pressure QTL 13)
Bp14  (Blood pressure QTL 14)
Bp15  (Blood pressure QTL 15)

Strains
SHRSP/Gcrc  (Spontaneously hypertensive rat, stroke prone)
WKY/Gcrc  (Wistar-Kyoto)

Objects referenced in this article
Marker D2Mit6 D2Mit6 Rattus norvegicus
Marker D2Mgh14 D2Mgh14 Rattus norvegicus
Marker D3Mgh16 D3Mgh16 Rattus norvegicus
Marker D2Mgh12 D2Mgh12 Rattus norvegicus
Gene Cpb1 carboxypeptidase B1 Rattus norvegicus

Additional Information