Strain Report - Rat Genome Database

Name: SHR/N
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Strain Registration

General

Strain: SHR/N
Symbol:	SHR/N
Strain:	SHR
Substrain:	N
RGD ID:	728194
RRID:	RGD_728194
Ontology ID:	RS:0000729
Type:	inbred
Source:	NIH Autoimmune Rat Model Repository and Development Center
Origin:	To N 1966 at F13 from Okamoto. Okamoto, Kyoto School of Medicine, 1963, from outbred Wistar Kyoto male with marked elevation of blood pressure mated to female with slightly elevated blood pressure; brother-sister mating with contin- ued selection for spontaneous hypertension.
Genetic Markers:	C Albino
Inbred Generations:	F49
Last Known Status:	Extinct

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

hypertension (IAGP)

Left Ventricular Hypertrophy (IAGP)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

decreased body weight (IAGP)

decreased heart rate (IAGP)

heart left ventricle hypertrophy (IAGP)

hyperactivity (IAGP)

hypoactivity (IAGP)

increased body weight (IAGP)

increased heart rate (IAGP)

increased heart ventricle size (IAGP)

increased left ventricle weight (IAGP)

increased mean systemic arterial blood pressure (IAGP)

increased systemic arterial diastolic blood pressure (IAGP)

increased systemic arterial systolic blood pressure (IAGP)

Phenotype Values via PhenoMiner Click to see Annotation Detail View

Options:

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Clinical Measurement

systolic blood pressure

diastolic blood pressure

mean arterial blood pressure

body weight

heart wet weight

heart left ventricle wet weight

heart weight to body weight ratio

heart left ventricle weight to body weight ratio

References

References - curated


1.	Hendley ED and Ohlsson WG, Am J Physiol. 1991 Aug;261(2 Pt 2):H583-9.
2.	Innes BA, etal., Hypertension 1998 Mar;31(3):741-6
3.	NIH Rat Strain Data
4.	RGD Automated Pipelines
5.	Sagvolden T, etal., Neuropharmacology. 2009 Aug 19.
6.	Ye P and West MJ, Clin Exp Pharmacol Physiol 2003 Dec;30(12):930-6.

Region

Strain QTL Data

Symbol	Name	Trait
Bp155	Blood pressure QTL 155	arterial blood pressure trait (VT:2000000)
Bp196	Blood pressure QTL 196	arterial blood pressure trait (VT:2000000)
Cm22	Cardiac mass QTL 22	heart left ventricle mass (VT:0007031)
Cm23	Cardiac mass QTL 23	heart left ventricle mass (VT:0007031)

Additional Information

Nomenclature History

Date	Current Symbol	Previous Symbol	Description	Reference	Status
2015-04-07	SHR/N	SHR/N	Name updated	68913	APPROVED
2015-04-07	SHR/N	SHR/N	Name updated	68913	APPROVED
2013-04-15	SHR/N	SHR/N	Name updated	68913	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Strain: SHR/N

Related Phenotype Data for Term "SHR/N" (RS:0000729)