RGD Reference Report - Enhanced sympathetic control of renal function in rats congenic for the hypertension-related region on chromosome 1. - Rat Genome Database

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Enhanced sympathetic control of renal function in rats congenic for the hypertension-related region on chromosome 1.

Authors: Wang, T  Kobayashi, Y  Nabika, T  Takabatake, T 
Citation: Wang T, etal., Clin Exp Pharmacol Physiol. 2005 Dec;32(12):1055-60.
RGD ID: 2296063
Pubmed: PMID:16445571   (View Abstract at PubMed)
DOI: DOI:10.1111/j.1440-1681.2005.04304.x   (Journal Full-text)

Recent studies suggest that a quantitative trait locus (QTL) for blood pressure (BP) on rat chromosome 1 is associated with exaggerated sympathetic nervous activity. The aim of the present study was to examine whether this QTL can affect BP by altering sympathetic control of renal function. Male stroke-prone spontaneously hypertensive rats of Izumo origin (SHRSP/Izm), Wistar-Kyoto rats (WKY/Izm) and rats from a WKY/Izm congenic strain that contains an SHRSP/Izm chromosomal segment between D1Wox29 and D1Arb21 (WKYpch1.0) were used. Clearance and micropuncture experiments were performed in anaesthetized rats after acute unilateral renal denervation (DN). Mean BP in sham-operated WKYpch1.0 was significantly higher than that in WKY/Izm. The DN procedure elicited a greater reduction in renal noradrenaline levels in SHRSP/Izm and WKYpch1.0 than in WKY/Izm. In both SHRSP/Izm and WKYpch1.0, DN decreased renal vascular resistance and filtration fraction, whereas it increased renal blood flow and urinary and fractional excretion of sodium. Unilateral renal denervation did not affect these parameters in WKY/Izm. Unilateral renal denervation decreased the tubuloglomerular feedback (TGF) responsiveness only in SHRSP/Izm, whereas it increased the non-perfused early proximal flow rate in SHRSP/Izm and WKYpch1.0. The results of the present study indicate that the renal sympathetic nervous system exerts enhanced tonic control of the renal vasculature and tubular function in SHRSP/Izm and WKYpch1.0, but not in WKY/Izm. Neural impact on the TGF response in WKYpch1.0 is indiscernible. Thus, a gene or genes in the QTL may influence BP, at least in part, through renal vasoconstriction and sodium retention mediated by the enhanced activity of the renal sympathetic nerves.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
hypertension MODEL: spontaneousIAGP 2296063as compared to WKY/Izm after sham denervationRGD 
hypertension MODEL: controlIAGP 2296063compared to SHRSP/IzmRGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
abnormal renal sodium reabsorption susceptibilityIAGPsurgical denervation2296063compared to WKY/Izm and WKY.SHRSP-D1Wox29-D1Arb21/IzmRGD 
abnormal tubuloglomerular feedback response inducedIAGPsham surgical control condition2296063compared to WKY/Izm and WKY.SHRSP-D1Wox29-D1Arb21/Izm after sham surgeryRGD 
decreased body weight inducedIAGPcontrolled air oxygen content2296063compared to WKY/Izm and WKY.SHRSP-D1Wox29-D1Arb21/Izm after sham surgeryRGD 
decreased kidney weight inducedIAGPcontrolled air oxygen content2296063compared to WKY/Izm and WKY.SHRSP-D1Wox29-D1Arb21/Izm after sham surgeryRGD 
decreased noradrenaline level inducedIAGPsurgical denervation2296063; 2296063; 2296063compared to sham surgeryRGD 
decreased renal plasma flow rate inducedIAGPsham surgical control condition2296063compared to WKY/Izm and WKY.SHRSP-D1Wox29-D1Arb21/Izm after sham surgeryRGD 
decreased renal vascular resistance inducedIAGPsurgical denervation2296063compared to WKY.SHRSP-D1Wox29-D1Arb21/Izm with sham surgeryRGD 
decreased tubuloglomerular feedback response inducedIAGPsurgical denervation2296063compared to WKY/IzmRGD 
increased hematocrit inducedIAGPsham surgical control condition2296063compared to WKY/Izm and WKY.SHRSP-D1Wox29-D1Arb21/Izm after sham surgeryRGD 
increased mean systemic arterial blood pressure inducedIAGPsham surgical control condition2296063compared to WKY/Izm and WKY.SHRSP-D1Wox29-D1Arb21/Izm after sham surgeryRGD 
increased mean systemic arterial blood pressure inducedIAGPsham surgical control condition2296063compared to WKY/IzmRGD 
increased renal plasma flow rate inducedIAGPsurgical denervation2296063 RGD 
increased renal plasma flow rate inducedIAGPsurgical denervation2296063compared to sham surgery.RGD 
increased renal vascular resistance inducedIAGPsham surgical control condition2296063compared to WKY/Izm and WKY.SHRSP-D1Wox29-D1Arb21/Izm after sham surgeryRGD 
increased urine sodium level inducedIAGPsurgical denervation2296063; 2296063compared to sham surgery.RGD 
increased urine sodium level inducedIAGPsham surgical control condition2296063compared to WKY/Izm and WKY.SHRSP-D1Wox29-D1Arb21/Izm after sham surgeryRGD 
polyuria inducedIAGPsurgical denervation2296063compared to sham surgeryRGD 
Objects Annotated

Strains
SHRSP/Izm  (NA)
WKY.SHRSP-(D1Wox29-D1Arb21)/Izm  (NA)
WKY/Izm  (Wistar-Kyoto)

Objects referenced in this article
Strain SHR/Izm null Rattus norvegicus

Additional Information