RGD Reference Report - Establishment of a new animal model of metabolic syndrome: SHRSP fatty (fa/fa) rats. - Rat Genome Database

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Establishment of a new animal model of metabolic syndrome: SHRSP fatty (fa/fa) rats.

Authors: Hiraoka-Yamamoto, J  Nara, Y  Yasui, N  Onobayashi, Y  Tsuchikura, S  Ikeda, K 
Citation: Hiraoka-Yamamoto J, etal., Clin Exp Pharmacol Physiol. 2004 Jan-Feb;31(1-2):107-9.
RGD ID: 2300017
Pubmed: PMID:14756693   (View Abstract at PubMed)

1. We established a new animal model of metabolic syndrome, SHRSP fatty (fa/fa) rats, by crossing stroke-prone spontaneously hypertensive rats of the Izumo strain (SHRSP/Izm) to Zucker fatty (ZF) (fa/fa) rats. 2. The SHRSP fatty (fa/fa) rats have a missense mutation of the leptin receptor gene and plasma leptin concentrations are augmented. The SHRSP fatty (fa/fa) rats develop obesity and hypertension simultaneously. 3. Plasma metabolic parameters, including glucose, insulin and total cholesterol and triglyceride levels, were markedly elevated in SHRSP fatty (fa/fa) rats compared with SHRSP/Izm rats. Plasma triglyceride concentrations in SHRSP fatty (fa/fa) rats were significantly elevated compared with those in ZF (fa/fa) rats. The weight of adipose tissues in SHRSP fatty (fa/fa) rats was greater than that of SHRSP/Izm rats. The phenotype of SHRSP fatty (fa/fa) rats is similar to that of human metabolic syndrome.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
SHRSP.ZUC-(D5Rat4-D5Rat36)/IzmDmcrRatHypercholesterolemia susceptibilityIAGP compared to SHRSP/IzmRGD 
Slc:ZUC-Leprfa-/-RatHypercholesterolemia MODEL: spontaneousIAGP compared to SHRSP/IzmRGD 
SHRSP.ZUC-(D5Rat4-D5Rat36)/IzmDmcrRathyperinsulinism susceptibilityIAGP compared to SHRSP/IzmRGD 
Slc:ZUC-Leprfa-/-Rathyperinsulinism MODEL: spontaneousIAGP compared to SHRSP/IzmRGD 
SHRSP.ZUC-(D5Rat4-D5Rat36)/IzmDmcrRathypertension susceptibilityIAGP compared to Slc:ZUC-LeprfaRGD 
SHRSP/IzmRathypertension MODEL: spontaneousIAGP compared to Slc:ZUC-LeprfaRGD 
SHRSP.ZUC-(D5Rat4-D5Rat36)/IzmDmcrRatMetabolic Syndrome MODELIAGP compared to SHRSP/Izm and Slc:ZUC-LeprfaRGD 
SHRSP.ZUC-(D5Rat4-D5Rat36)/IzmDmcrRatobesity susceptibilityIAGP compared to SHRSP/IzmRGD 
Slc:ZUC-Leprfa-/-Ratobesity MODEL: spontaneousIAGP compared to SHRSP/IzmRGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
SHRSP.ZUC-(D5Rat4-D5Rat36)/IzmDmcrRatdecreased systemic arterial systolic blood pressure  IAGP as compared to SHRSP/IzmRGD 
Slc:ZUC-Leprfa-/-Ratdecreased systemic arterial systolic blood pressure  IAGP compared to SHRSP/IzmRGD 
SHRSP.ZUC-(D5Rat4-D5Rat36)/IzmDmcrRatincreased body weight  IAGP as compared to SHRSP/IzmRGD 
Slc:ZUC-Leprfa-/-Ratincreased body weight  IAGP compared to SHRSP/IzmRGD 
SHRSP.ZUC-(D5Rat4-D5Rat36)/IzmDmcrRatincreased circulating cholesterol level  IAGP as compared to SHRSP/IzmRGD 
Slc:ZUC-Leprfa-/-Ratincreased circulating cholesterol level  IAGP compared to SHRSP/IzmRGD 
SHRSP.ZUC-(D5Rat4-D5Rat36)/IzmDmcrRatincreased circulating glucose level  IAGP as compared to SHRSP/IzmRGD 
Slc:ZUC-Leprfa-/-Ratincreased circulating glucose level  IAGP compared to SHRSP/IzmRGD 
SHRSP.ZUC-(D5Rat4-D5Rat36)/IzmDmcrRatincreased circulating insulin level  IAGP as compared to SHRSP/IzmRGD 
Slc:ZUC-Leprfa-/-Ratincreased circulating insulin level  IAGP compared to SHRSP/IzmRGD 
SHRSP.ZUC-(D5Rat4-D5Rat36)/IzmDmcrRatincreased circulating leptin level  IAGP compared to SHRSP/Izm and Slc:ZUC-LeprfaRGD 
Slc:ZUC-Leprfa-/-Ratincreased circulating leptin level  IAGP compared to SHRSP/IzmRGD 
SHRSP.ZUC-(D5Rat4-D5Rat36)/IzmDmcrRatincreased circulating triglyceride level  IAGP compared to SHRSP/Izm and Slc:ZUC-LeprfaRGD 
Slc:ZUC-Leprfa-/-Ratincreased circulating triglyceride level  IAGP compared to SHRSP/IzmRGD 
SHRSP.ZUC-(D5Rat4-D5Rat36)/IzmDmcrRatincreased epididymal fat pad weight  IAGP compared to SHRSP/IzmRGD 
Slc:ZUC-Leprfa-/-Ratincreased epididymal fat pad weight  IAGP compared to SHRSP/IzmRGD 
SHRSP.ZUC-(D5Rat4-D5Rat36)/IzmDmcrRatincreased liver weight  IAGP compared to SHRSP/IzmRGD 
Slc:ZUC-Leprfa-/-Ratincreased liver weight  IAGP compared to SHRSP/IzmRGD 
SHRSP.ZUC-(D5Rat4-D5Rat36)/IzmDmcrRatincreased mesenteric fat pad weight  IAGP compared to SHRSP/IzmRGD 
Slc:ZUC-Leprfa-/-Ratincreased mesenteric fat pad weight  IAGP compared to SHRSP/IzmRGD 
Objects Annotated

Strains
SHRSP.ZUC-(D5Rat4-D5Rat36)/IzmDmcr  (NA)
SHRSP/Izm  (NA)
Slc:ZUC-Leprfa-/-  (Zucker fatty rats)


Additional Information