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Strain Registration

Strain: SHR.BN-(D1Mit3-Igf2)/Ipcv

Symbol: SHR.BN-(D1Mit3-Igf2)/Ipcv
Strain: SHR.BN-(D1Mit3-Igf2)/Ipcv
RGD ID: 628908
Citation ID: RRID:RGD_628908
Ontology ID: RS:0000721
Alleles: Scnn1b;   Scnn1g;   Sa
Also Known As: SHR.BN-D1Mit3/Igf2; SHR.BN-(D1Mit3-Igf2)/Ipcv
Type: congenic
Available Source: Not Available
Origination: Czech Academy of Sciences, Prague, Czech Republic
Description: Segment of chromosome 1 from the normotensive BN/Cr was transferred to SHR. After 10 generations of backcrossing to SHR, the differential segment was fixed with the flanking markers.These were maintained in the homozygous state by brother x sister mating.
Coat Color: c
Last Known Status: Unknown
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21144,267,353 - 197,831,802RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01156,446,196 - 215,839,081RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01162,692,213 - 222,733,868RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41146,971,846 - 202,915,231RGD_MAPPER_PIPELINERGSC3.4

Congenic Strains
SHR.BN-(D1Mit3-Igf2)/1lpcv




Phenotype Annotations     Click to see Annotation Detail View

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
Options:  View chart  |  Download data table  |  View expanded data table


References

References - curated
# Reference Title Reference Citation
1. Congenic strains for genetic analysis of hypertension and dyslipidemia in the spontaneously hypertensive rat. Pravenec M, etal., Transplant Proc 1999 May;31(3):1555-6.
2. RGD Strain RSO annotation pipeline RGD Automated Pipelines
3. Genetic isolation of a chromosome 1 region affecting blood pressure in the spontaneously hypertensive rat. St Lezin E, etal., Hypertension 1997 Oct;30(4):854-9.
4. Effect of renin gene transfer on blood pressure in the spontaneously hypertensive rat. St Lezin E, etal., Hypertension 1998 Jan;31(1 Pt 2):373-7.
5. Genetic isolation of a chromosome 1 region affecting susceptibility to hypertension-induced renal damage in the spontaneously hypertensive rat. St Lezin E, etal., Hypertension 1999 Aug;34(2):187-91.
6. Genetic isolation of a chromosome 1 region affecting blood pressure in the spontaneously hypertensive rat. St. Lezin E, etal., Hypertension 1997 Oct;30(4):854-9

Region

Position Markers

Flank 1 / 1 (D1Mit3)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21144,267,353 - 144,267,490 (-)MAPPER
mRatBN7.21144,267,353 - 144,267,916 (-)MAPPER
Rnor_6.01156,446,647 - 156,446,783NCBI
Rnor_6.01156,446,196 - 156,446,783NCBI
Rnor_5.01162,692,213 - 162,692,800UniSTS
Rnor_5.01162,692,664 - 162,692,800UniSTS
RGSC_v3.41146,971,846 - 146,971,983RGD
RGSC_v3.41146,971,847 - 146,971,983UniSTS
RGSC_v3.11147,050,253 - 147,050,389RGD
Celera1142,487,594 - 142,487,730UniSTS
RH 3.4 Map11128.0UniSTS
RH 3.4 Map11128.0RGD
RH 2.0 Map1740.1RGD
SHRSP x BN Map175.6399RGD
FHH x ACI Map167.73RGD
Cytogenetic Map1 RGD

Flank 2 / 1 (Igf2)
Rat AssemblyChrPosition (strand)Source
GRCr81207,243,873 - 207,261,263 (-)NCBI
mRatBN7.21197,814,409 - 197,831,802 (-)NCBI
mRatBN7.2 Ensembl1197,814,410 - 197,823,018 (-)Ensembl
UTH_Rnor_SHR_Utx1206,187,237 - 206,197,377 (-)NCBI
UTH_Rnor_SHRSP_BbbUtx_1.01213,273,145 - 213,283,290 (-)NCBI
UTH_Rnor_WKY_Bbb_1.01205,947,308 - 205,957,453 (-)NCBI
Rnor_6.01215,828,102 - 215,839,081 (-)NCBI
Rnor_6.0 Ensembl1215,828,102 - 215,846,911 (-)Ensembl
Rnor_5.01222,722,921 - 222,733,868 (-)NCBI
RGSC_v3.41202,906,624 - 202,915,231 (-)NCBI
RGSC_v3.11203,094,689 - 203,103,297 (-)NCBI
Celera1195,432,460 - 195,442,561 (-)NCBI
Cytogenetic Map1q41NCBI
Strain QTL Data
Symbol Name Trait
Bp26 Blood pressure QTL 26 arterial blood pressure trait   (VT:2000000)    
Rends1 Renal damage susceptibility QTL 1 kidney glomerulus integrity trait   (VT:0010546)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_life_disease Significant decrease in the systolic and diastolic blood pressure is observed as compared to the SHR. 61512
strain_life_disease Significant decrease in the systolic and diastolic blood pressure is observed as compared to the SHR. 619652
strain_phys_biochem The cardiac mass and the heart rate are not different from the SHR strain. 61512
strain_phys_biochem The cardiac mass and the heart rate are not different from the SHR strain. 619652