Strain Report - Rat Genome Database

Name: LH/Mav
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Strain Registration

General

Strain: LH/Mav
Symbol:	LH/Mav
Strain:	LH
Substrain:	Mav
RGD ID:	10021
Citation ID:	RRID:RGD_10021
Ontology ID:	RS:0000556
Previously known as:	MDC-03-55; Lyon Hypertensive
Type:	inbred
Source:	Laboratoire de Physiologie, 8 Avenue Rockfeller, 69373 Lyon Cedex 08, France
Origin:	In 1969 outbred Sprague-Dawley rats were selected for high systolic blood pressure using an indirect plethysmographic technique in pre-warmed unrestrained conscious rats. Three pairs were originally selected, and selection was continued with brother x sister mating. Strain LN was maintained as a normotensive control, and LL as a hypotensive strain. (see Vincent et al 1984, and Vincent and Sassard, 1994 for reviews).
Last Known Status:	Unknown

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

diabetes mellitus (IAGP)

Hypercholesterolemia (IAGP)

hyperinsulinism (IAGP)

hypertension (IAGP)

Hypertriglyceridemia (IAGP)

Left Ventricular Hypertrophy (IAGP)

obesity (IAGP)

Polyuria (IAGP)

proteinuria (IAGP)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

decreased renin activity (IAGP)

hyperglycemia (IAGP)

hyperlipidemia (IAGP)

impaired glucose tolerance (IAGP)

increased body weight (IAGP)

increased circulating cholesterol level (IAGP)

increased circulating creatinine level (IAGP)

increased circulating HDL cholesterol level (IAGP)

increased circulating insulin level (IAGP)

increased circulating LDL cholesterol level (IAGP)

increased circulating phospholipid level (IAGP)

increased circulating triglyceride level (IAGP)

increased circulating VLDL cholesterol level (IAGP)

increased heart left ventricle weight (IAGP)

increased insulin secretion (IAGP)

increased kidney weight (IAGP)

increased mean systemic arterial blood pressure (IAGP)

increased systemic arterial diastolic blood pressure (IAGP)

increased systemic arterial systolic blood pressure (IAGP)

increased urine protein level (IAGP)

increased urine sodium level (IAGP)

salt-sensitive hypertension (IAGP)

Phenotype Values via PhenoMiner Click to see Annotation Detail View

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Clinical Measurement

systolic blood pressure

diastolic blood pressure

mean arterial blood pressure

body weight

plasma glucose level

blood glucose level

plasma renin activity level

timed urine volume

pulse pressure

both kidneys wet weight to body weight ratio

plasma insulin level

heart left ventricle weight to body weight ratio

plasma creatinine level

plasma triglyceride level

plasma total cholesterol level

urine total protein excretion rate

urine albumin excretion rate

urine protein excretion rate

urine creatinine excretion rate

creatinine clearance

renal blood flow rate

creatinine clearance to body weight ratio

urine sodium excretion rate to body weight ratio

urine total protein excretion rate to body weight ratio

renal blood flow rate to kidney weight ratio

timed urine volume to body weight ratio

urine protein level to urine creatinine level ratio

glomerular filtration rate to kidney weight ratio

urine sodium level to body weight ratio

urine sodium level to urine potassium level ratio

aorta weight to body weight ratio

urine albumin level to urine total protein level ratio

renal vascular resistance to kidney weight ratio

plasma insulin level to plasma glucose level ratio

References

References - curated

#	Reference Title	Reference Citation
1.	Mapping the genetic determinants of hypertension, metabolic diseases, and related phenotypes in the lyon hypertensive rat.	Bilusic M, etal., Hypertension 2004 Nov;44(5):695-701. Epub 2004 Sep 27.
2.	Transcriptional alterations in the left ventricle of three hypertensive rat models.	Cerutti C, etal., Physiol Genomics. 2006 Nov 27;27(3):295-308. doi: 10.1152/physiolgenomics.00318.2005. Epub 2006 Aug 1.
3.	Genetic determinants of diastolic and pulse pressure map to different loci in Lyon hypertensive rats.	Dubay C, etal., Nat Genet 1993 Apr;3(4):354-7
4.	Renoprotection persists after cessation of treatment with very low doses of perindopril in Lyon hypertensive rats.	Egan EJ, etal., Acta Pharmacol Sin. 2008 Nov;29(11):1296-300. doi: 10.1111/j.1745-7254.2008.00862.x.
5.	Renal and metabolic disorders depend on the renin-angiotensin system in Lyon hypertensive rats associated with diabetes.	Emonnot L, etal., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3.
6.	Inbred Strains	Festing, MFW, Inbred Strains, The Laboratory Rat, 1979, Baker HK, Lindsey JR, Weisbroth SH, 55-72, Academic Press
7.	Update to previous Strain Data	Festing, MFW, Personal Communication Update, Feb-2000
8.	Implication of chromosome 13 on hypertension and associated disorders in Lyon hypertensive rats.	Gilibert S, etal., J Hypertens. 2009 Jun;27(6):1186-93.
9.	THE EFFECTS OF CHROMOSOME 17 ON FEATURES OF THE METABOLIC SYNDROME IN THE LYON HYPERTENSIVE (LH) RAT.	Gilibert S, etal., Physiol Genomics. 2008 Feb 19;.
10.	Genomic structure of nucleotide diversity among Lyon rat models of metabolic syndrome.	Ma MC, etal., BMC Genomics. 2014 Mar 14;15:197. doi: 10.1186/1471-2164-15-197.
11.	Molecular identification and functional characterization of rat multidrug and toxin extrusion type transporter 1 as an organic cation/H+ antiporter in the kidney.	Ohta KY, etal., Drug Metab Dispos. 2006 Nov;34(11):1868-74. Epub 2006 Aug 23.
12.	RGD Strain RSO annotation pipeline	RGD Automated Pipelines
13.	SNP and haplotype mapping for genetic analysis in the rat.	Saar K, etal., Nat Genet. 2008 May;40(5):560-6.
14.	Opportunities and limitations of genetic analysis of hypertensive rat strains.	Saavedra JM J Hypertens. 2009 Jun;27(6):1129-33.
15.	Blood pressure and baroreflex sensitivity in conscious hypertensive rats of Lyon strain.	Su DF, etal., Am J Physiol. 1986 Dec;251(6 Pt 2):H1111-7.
16.	A pharmacogenetic approach to blood pressure in Lyon hypertensive rats. A chromosome 2 locus influences the response to a calcium antagonist.	Vincent M, etal., J Clin Invest 1997 Oct 15;100(8):2000-6
17.	High blood pressure and metabolic disorders are associated in the Lyon hypertensive rat.	Vincent M, etal., J Hypertens. 1993 Nov;11(11):1179-85.

Region

Strain QTL Data

Symbol	Name	Trait
Bp240	Blood pressure QTL 240	arterial blood pressure trait (VT:2000000)
Bp241	Blood pressure QTL 241	arterial blood pressure trait (VT:2000000)
Bp242	Blood pressure QTL 242	arterial blood pressure trait (VT:2000000)
Bp243	Blood pressure QTL 243	arterial blood pressure trait (VT:2000000)
Bp244	Blood pressure QTL 244	arterial blood pressure trait (VT:2000000)
Bp245	Blood pressure QTL 245	arterial blood pressure trait (VT:2000000)
Bp246	Blood pressure QTL 246	arterial blood pressure trait (VT:2000000)
Bp247	Blood pressure QTL 247	arterial blood pressure trait (VT:2000000)
Bp5	Blood pressure QTL 5	arterial blood pressure trait (VT:2000000)
Bp6	Blood pressure QTL 6	arterial blood pressure trait (VT:2000000)
Bw31	Body weight QTL 31	body mass (VT:0001259)
Bw32	Body weight QTL 32	body mass (VT:0001259)
Bw33	Body weight QTL 33	body mass (VT:0001259)
Bw34	Body weight QTL 34	body mass (VT:0001259)
Bw35	Body weight QTL 35	body mass (VT:0001259)
Bw36	Body weight QTL 36	body mass (VT:0001259)
Cm32	Cardiac mass QTL 32	heart left ventricle mass (VT:0007031)
Cm33	Cardiac mass QTL 33	heart left ventricle mass (VT:0007031)
Cm34	Cardiac mass QTL 34	heart left ventricle mass (VT:0007031)
Cm35	Cardiac mass QTL35	heart left ventricle mass (VT:0007031)
Cm36	Cardiac mass QTL 36	heart left ventricle mass (VT:0007031)
Insul1	Insulin level QTL 1	blood insulin amount (VT:0001560)
Kidm12	Kidney mass QTL 12	kidney mass (VT:0002707)
Kidm13	Kidney mass QTL 13	kidney mass (VT:0002707)
Kidm14	Kidney mass QTL 14	kidney mass (VT:0002707)
Kidm15	Kidney mass QTL 15	kidney mass (VT:0002707)
Kidm16	Kidney mass QTL 16	kidney mass (VT:0002707)
Kidm17	Kidney mass QTL 17	kidney mass (VT:0002707)
Kidm18	Kidney mass QTL 18	kidney mass (VT:0002707)
Kidm19	Kidney mass QTL 19	kidney mass (VT:0002707)
Kidm20	Kidney mass QTL 20	kidney mass (VT:0002707)
Kidm21	Kidney mass QTL 21	kidney mass (VT:0002707)
Lmblg1	Limb length QTL 1	tibia length (VT:0004357)
Lmblg2	Limb length QTL 2	tibia length (VT:0004357)
Rf46	Renal function QTL 46	blood creatinine amount (VT:0005328)
Rf47	Renal function QTL 47	kidney renin amount (VT:0010559)
Rf48	Renal function QTL 48	blood creatinine amount (VT:0005328)
Rf49	Renal function QTL 49	blood creatinine amount (VT:0005328)
Rf50	Renal function QTL 50	urine output (VT:0003620)
Scl30	Serum cholesterol level QTL 30	blood cholesterol amount (VT:0000180)
Scl31	Serum cholesterol level QTL 31	blood cholesterol amount (VT:0000180)
Scl32	Serum cholesterol level QTL 32	blood HDL cholesterol amount (VT:0000184)
Scl68	Serum cholesterol level QTL 68	blood VLDL cholesterol amount (VT:0005144)
Scort1	Serum corticosterone level QTL 1	blood corticosterone amount (VT:0005345)
Spl4	Serum phospholipid level QTL 4	blood phospholipid amount (VT:0006084)
Spl5	Serum phospholipid level QTL 5	blood LDL phospholipid amount (VT:0010505)
Spl7	Serum phospholipid level QTL 7	blood phospholipid amount (VT:0006084)
Spl8	Serum phospholipid level QTL 8	blood VLDL phospholipid amount (VT:0010507)
Srn6	Serum renin concentration QTL 6	blood renin amount (VT:0003349)
Stl13	Serum triglyceride level QTL 13	blood triglyceride amount (VT:0002644)

Additional Information

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Strain: LH/Mav

Mammalian Phenotype

Related Phenotype Data for Term "LH/Mav" (RS:0000556)