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Strain: LH/Mav

Symbol: LH/Mav
Strain: LH
Substrain: Mav
RGD ID: 10021
Citation ID: RRID:RGD_10021
Ontology ID: RS:0000556
Previously known as: MDC-03-55; Lyon Hypertensive
Type: inbred
Source: Laboratoire de Physiologie, 8 Avenue Rockfeller, 69373 Lyon Cedex 08, France
Origin: In 1969 outbred Sprague-Dawley rats were selected for high systolic blood pressure using an indirect plethysmographic technique in pre-warmed unrestrained conscious rats. Three pairs were originally selected, and selection was continued with brother x sister mating. Strain LN was maintained as a normotensive control, and LL as a hypotensive strain. (see Vincent et al 1984, and Vincent and Sassard, 1994 for reviews).
Last Known Status: Unknown

Disease Annotations     Click to see Annotation Detail View


References - curated
# Reference Title Reference Citation
1. Mapping the genetic determinants of hypertension, metabolic diseases, and related phenotypes in the lyon hypertensive rat. Bilusic M, etal., Hypertension 2004 Nov;44(5):695-701. Epub 2004 Sep 27.
2. Transcriptional alterations in the left ventricle of three hypertensive rat models. Cerutti C, etal., Physiol Genomics. 2006 Nov 27;27(3):295-308. doi: 10.1152/physiolgenomics.00318.2005. Epub 2006 Aug 1.
3. Genetic determinants of diastolic and pulse pressure map to different loci in Lyon hypertensive rats. Dubay C, etal., Nat Genet 1993 Apr;3(4):354-7
4. Renoprotection persists after cessation of treatment with very low doses of perindopril in Lyon hypertensive rats. Egan EJ, etal., Acta Pharmacol Sin. 2008 Nov;29(11):1296-300. doi: 10.1111/j.1745-7254.2008.00862.x.
5. Renal and metabolic disorders depend on the renin-angiotensin system in Lyon hypertensive rats associated with diabetes. Emonnot L, etal., Am J Hypertens. 2008 Jun;21(6):657-62. doi: 10.1038/ajh.2008.155. Epub 2008 Apr 3.
6. Inbred Strains Festing, MFW, Inbred Strains, The Laboratory Rat, 1979, Baker HK, Lindsey JR, Weisbroth SH, 55-72, Academic Press
7. Update to previous Strain Data Festing, MFW, Personal Communication Update, Feb-2000
8. Implication of chromosome 13 on hypertension and associated disorders in Lyon hypertensive rats. Gilibert S, etal., J Hypertens. 2009 Jun;27(6):1186-93.
10. Genomic structure of nucleotide diversity among Lyon rat models of metabolic syndrome. Ma MC, etal., BMC Genomics. 2014 Mar 14;15:197. doi: 10.1186/1471-2164-15-197.
11. Molecular identification and functional characterization of rat multidrug and toxin extrusion type transporter 1 as an organic cation/H+ antiporter in the kidney. Ohta KY, etal., Drug Metab Dispos. 2006 Nov;34(11):1868-74. Epub 2006 Aug 23.
12. RGD Strain RSO annotation pipeline RGD Automated Pipelines
13. SNP and haplotype mapping for genetic analysis in the rat. Saar K, etal., Nat Genet. 2008 May;40(5):560-6.
14. Opportunities and limitations of genetic analysis of hypertensive rat strains. Saavedra JM J Hypertens. 2009 Jun;27(6):1129-33.
15. Blood pressure and baroreflex sensitivity in conscious hypertensive rats of Lyon strain. Su DF, etal., Am J Physiol. 1986 Dec;251(6 Pt 2):H1111-7.
16. A pharmacogenetic approach to blood pressure in Lyon hypertensive rats. A chromosome 2 locus influences the response to a calcium antagonist. Vincent M, etal., J Clin Invest 1997 Oct 15;100(8):2000-6
17. High blood pressure and metabolic disorders are associated in the Lyon hypertensive rat. Vincent M, etal., J Hypertens. 1993 Nov;11(11):1179-85.


Strain QTL Data
Symbol Name Trait
Bp240 Blood pressure QTL 240 arterial blood pressure trait   (VT:2000000)    
Bp241 Blood pressure QTL 241 arterial blood pressure trait   (VT:2000000)    
Bp242 Blood pressure QTL 242 arterial blood pressure trait   (VT:2000000)    
Bp243 Blood pressure QTL 243 arterial blood pressure trait   (VT:2000000)    
Bp244 Blood pressure QTL 244 arterial blood pressure trait   (VT:2000000)    
Bp245 Blood pressure QTL 245 arterial blood pressure trait   (VT:2000000)    
Bp246 Blood pressure QTL 246 arterial blood pressure trait   (VT:2000000)    
Bp247 Blood pressure QTL 247 arterial blood pressure trait   (VT:2000000)    
Bp5 Blood pressure QTL 5 arterial blood pressure trait   (VT:2000000)    
Bp6 Blood pressure QTL 6 arterial blood pressure trait   (VT:2000000)    
Bw31 Body weight QTL 31 body mass   (VT:0001259)    
Bw32 Body weight QTL 32 body mass   (VT:0001259)    
Bw33 Body weight QTL 33 body mass   (VT:0001259)    
Bw34 Body weight QTL 34 body mass   (VT:0001259)    
Bw35 Body weight QTL 35 body mass   (VT:0001259)    
Bw36 Body weight QTL 36 body mass   (VT:0001259)    
Cm32 Cardiac mass QTL 32 heart left ventricle mass   (VT:0007031)    
Cm33 Cardiac mass QTL 33 heart left ventricle mass   (VT:0007031)    
Cm34 Cardiac mass QTL 34 heart left ventricle mass   (VT:0007031)    
Cm35 Cardiac mass QTL35 heart left ventricle mass   (VT:0007031)    
Cm36 Cardiac mass QTL 36 heart left ventricle mass   (VT:0007031)    
Insul1 Insulin level QTL 1 blood insulin amount   (VT:0001560)    
Kidm12 Kidney mass QTL 12 kidney mass   (VT:0002707)    
Kidm13 Kidney mass QTL 13 kidney mass   (VT:0002707)    
Kidm14 Kidney mass QTL 14 kidney mass   (VT:0002707)    
Kidm15 Kidney mass QTL 15 kidney mass   (VT:0002707)    
Kidm16 Kidney mass QTL 16 kidney mass   (VT:0002707)    
Kidm17 Kidney mass QTL 17 kidney mass   (VT:0002707)    
Kidm18 Kidney mass QTL 18 kidney mass   (VT:0002707)    
Kidm19 Kidney mass QTL 19 kidney mass   (VT:0002707)    
Kidm20 Kidney mass QTL 20 kidney mass   (VT:0002707)    
Kidm21 Kidney mass QTL 21 kidney mass   (VT:0002707)    
Lmblg1 Limb length QTL 1 tibia length   (VT:0004357)    
Lmblg2 Limb length QTL 2 tibia length   (VT:0004357)    
Rf46 Renal function QTL 46 blood creatinine amount   (VT:0005328)    
Rf47 Renal function QTL 47 kidney renin amount   (VT:0010559)    
Rf48 Renal function QTL 48 blood creatinine amount   (VT:0005328)    
Rf49 Renal function QTL 49 blood creatinine amount   (VT:0005328)    
Rf50 Renal function QTL 50 urine output   (VT:0003620)    
Scl30 Serum cholesterol level QTL 30 blood cholesterol amount   (VT:0000180)    
Scl31 Serum cholesterol level QTL 31 blood cholesterol amount   (VT:0000180)    
Scl32 Serum cholesterol level QTL 32 blood HDL cholesterol amount   (VT:0000184)    
Scl68 Serum cholesterol level QTL 68 blood VLDL cholesterol amount   (VT:0005144)    
Scort1 Serum corticosterone level QTL 1 blood corticosterone amount   (VT:0005345)    
Spl4 Serum phospholipid level QTL 4 blood phospholipid amount   (VT:0006084)    
Spl5 Serum phospholipid level QTL 5 blood LDL phospholipid amount   (VT:0010505)    
Spl7 Serum phospholipid level QTL 7 blood phospholipid amount   (VT:0006084)    
Spl8 Serum phospholipid level QTL 8 blood VLDL phospholipid amount   (VT:0010507)    
Srn6 Serum renin concentration QTL 6 blood renin amount   (VT:0003349)    
Stl13 Serum triglyceride level QTL 13 blood triglyceride amount   (VT:0002644)    

Additional Information