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Strain: SS-Chr 16BN/Mcwi

Symbol: SS-Chr 16BN/Mcwi
Strain: SS-Chr 16BN
Substrain: Mcwi
RGD ID: 629524
Citation ID: RRID:RGD_629524
Ontology ID: RS:0000797
Also known as: SS-16BN/Mcwi; SS-16BN/Mcwi;SS-Chr 16BN/Mcwi; SS-Chr 16BN/Mcwi
Type: consomic
Source: PhysGen
Origin: A cross of SS and BN strains which results in a SS genomic background with a BN chromosome introgressed
Coat Color: albino
Last Known Status: Live Animals; Cryopreserved Sperm





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Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

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Clinical Measurement
heart rate
left ventricular diastolic blood pressure
left ventricular systolic blood pressure
mean arterial blood pressure
body weight
body temperature
left ventricular developed pressure
red blood cell count
blood hemoglobin level
blood neutrophil count
blood lymphocyte count
blood monocyte count
blood eosinophil count
hematocrit
mean corpuscular volume
plasma anion gap
heart wet weight
heart weight to body weight ratio
lung dry weight to body weight ratio
heart right ventricle weight to left ventricle weight ratio
plasma renin activity level
minute ventilation
arterial blood flow rate
tidal volume
partial pressure of blood carbon dioxide (Pco2)
percent change in ventilation
respiration rate
mean corpuscular hemoglobin
mean corpuscular hemoglobin concentration
absolute change in partial pressure of blood carbon dioxide
absolute change in partial pressure of blood oxygen
absolute change in blood pH
serum total cholesterol level
total white blood cell count
serum total bilirubin level
blood pH
partial pressure of blood oxygen
serum bicarbonate level
serum chloride level
serum potassium level
serum sodium level
serum calcium level
percent change in respiration rate
percent change in tidal volume
absolute change in mean arterial blood pressure
absolute change in heart rate
plasma creatinine level
serum phosphate level
serum glucose level
serum albumin level
serum alanine aminotransferase activity level
serum alkaline phosphatase activity level
serum aspartate aminotransferase activity level
serum urea nitrogen level
serum total protein level
time to onset of heart contraction
time to peak heart contraction
heart contraction pressure
heart left ventricle infarction weight to total heart left ventricle weight ratio
absolute change in body temperature
calculated pulmonary vascular resistance normalized to body weight
FAPGG metabolism-surface area product
methylene blue metabolism-surface area product without auto-oxidation
methylene blue metabolism-surface area product after auto-oxidation
methylene blue to FAPGG metabolism-surface area product ratio
dose of methacholine at which pulmonary conductance is half its pretreatment value
fractional change in blood vessel diameter per unit change in intravascular pressure
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50)
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50)
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)
concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)
maximum contractile force per wet weight of aorta
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel
sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel
hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel
percent change in heart rate
percent change in arterial blood flow rate
percent change in left ventricular developed pressure
percent change in left ventricular systolic blood pressure
urine total protein excretion rate
urine albumin excretion rate
urine sodium excretion rate
urine potassium excretion rate
creatinine clearance
heart effluent lactate dehydrogenase activity level normalized to heart weight
serum globulin level

References


Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_drgs_chems The aortic rings of animals on low-salt diet and high-salt diet were more sensitive to phenylephrine as compared to the parental SS. These were more sensitive to acetylcholine when on low-salt diet. 1598768
strain_drgs_chems Addition of spironolactone in low doses to captopril treatment prevented the progression of ventricular dysfunction and heart hypertrophy. 1598977
strain_life_disease The blood pressure of females is 119 mmHg and of males is 120 mmHg. 629526
strain_other The average weight of females is 202g and of males 311g. 629526
strain_phys_biochem The aortic rings of animals on low-salt diet were more sensitive to phenlyephrine and acetylcholine as compared to the parental SS. 1598768
strain_reproduction The average litter size is 7.9 pups and the average generation time is 46 days. 629526

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-12 SS-Chr 16BN/Mcwi    SS-Chr 16BN/Mcwi    Name updated 68913 APPROVED
2013-08-12 SS-Chr 16BN/Mcwi    SS-Chr 16BN/Mcwi    Name updated 68913 APPROVED