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Strain: LN/Mav

Symbol: LN/Mav
Strain: LN
Substrain: Mav
RGD ID: 10022
Citation ID: RRID:RGD_10022
Ontology ID: RS:0000560
Previously known as: MDC-03-56; Lyon normotensive
Type: inbred
Source: Laboratoire de Physiologie, 8 Avenue Rockfeller, 69373 Lyon Cedex 08, France
Origin: In 1969 outbred Sprague-Dawley rats were selected for high systolic blood pressure using an indirect plethysmographic technique in pre-warmed unrestrained conscious rats. Three pairs were originally selected, and selection was continued with brother x sister mating. Strain LN was maintained as a normotensive control, and LL as a hypotensive strain. (see Vincent et al 1984, and Vincent and Sassard, 1994 for reviews).
Inbred Generations: F27.
Last Known Status: Unknown

Experimental Data Annotations    Click to see Annotation Detail View

Rat Strain
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
LN/Mav  IEA 7241799 RGD 

Phenotype Values via Phenominer Click to see Annotation Detail View

Related Phenotype Data for Term "LN/Mav" (RS:0000560)

Rat Strains:
Clinical Measurements:
Experimental Conditions:
Measurement Methods:
Disease Annotations     Click to see Annotation Detail View
hypertension  (IAGP)

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
Options:  View chart  |  Download data table  |  View expanded data table


References - curated
# Reference Title Reference Citation
1. Mapping the genetic determinants of hypertension, metabolic diseases, and related phenotypes in the lyon hypertensive rat. Bilusic M, etal., Hypertension 2004 Nov;44(5):695-701. Epub 2004 Sep 27.
2. Genetic determinants of diastolic and pulse pressure map to different loci in Lyon hypertensive rats. Dubay C, etal., Nat Genet 1993 Apr;3(4):354-7
3. Inbred Strains Festing, MFW, Inbred Strains, The Laboratory Rat, 1979, Baker HK, Lindsey JR, Weisbroth SH, 55-72, Academic Press
4. Update to previous Strain Data Festing, MFW, Personal Communication Update, Feb-2000
5. Genomic structure of nucleotide diversity among Lyon rat models of metabolic syndrome. Ma MC, etal., BMC Genomics. 2014 Mar 14;15:197. doi: 10.1186/1471-2164-15-197.
6. RGD Strain RSO annotation pipeline RGD Automated Pipelines
7. SNP and haplotype mapping for genetic analysis in the rat. Saar K, etal., Nat Genet. 2008 May;40(5):560-6.
8. Blood pressure and baroreflex sensitivity in conscious hypertensive rats of Lyon strain. Su DF, etal., Am J Physiol. 1986 Dec;251(6 Pt 2):H1111-7.
9. A pharmacogenetic approach to blood pressure in Lyon hypertensive rats. A chromosome 2 locus influences the response to a calcium antagonist. Vincent M, etal., J Clin Invest 1997 Oct 15;100(8):2000-6
10. High blood pressure and metabolic disorders are associated in the Lyon hypertensive rat. Vincent M, etal., J Hypertens. 1993 Nov;11(11):1179-85.


Strain QTL Data
Symbol Name Trait
Bp240 Blood pressure QTL 240 arterial blood pressure trait   (VT:2000000)    
Bp241 Blood pressure QTL 241 arterial blood pressure trait   (VT:2000000)    
Bp242 Blood pressure QTL 242 arterial blood pressure trait   (VT:2000000)    
Bp243 Blood pressure QTL 243 arterial blood pressure trait   (VT:2000000)    
Bp244 Blood pressure QTL 244 arterial blood pressure trait   (VT:2000000)    
Bp245 Blood pressure QTL 245 arterial blood pressure trait   (VT:2000000)    
Bp246 Blood pressure QTL 246 arterial blood pressure trait   (VT:2000000)    
Bp247 Blood pressure QTL 247 arterial blood pressure trait   (VT:2000000)    
Bp5 Blood pressure QTL 5 arterial blood pressure trait   (VT:2000000)    
Bp6 Blood pressure QTL 6 arterial blood pressure trait   (VT:2000000)    
Bw31 Body weight QTL 31 body mass   (VT:0001259)    
Bw32 Body weight QTL 32 body mass   (VT:0001259)    
Bw33 Body weight QTL 33 body mass   (VT:0001259)    
Bw34 Body weight QTL 34 body mass   (VT:0001259)    
Bw35 Body weight QTL 35 body mass   (VT:0001259)    
Bw36 Body weight QTL 36 body mass   (VT:0001259)    
Cm32 Cardiac mass QTL 32 heart left ventricle mass   (VT:0007031)    
Cm33 Cardiac mass QTL 33 heart left ventricle mass   (VT:0007031)    
Cm34 Cardiac mass QTL 34 heart left ventricle mass   (VT:0007031)    
Cm35 Cardiac mass QTL35 heart left ventricle mass   (VT:0007031)    
Cm36 Cardiac mass QTL 36 heart left ventricle mass   (VT:0007031)    
Insul1 Insulin level QTL 1 blood insulin amount   (VT:0001560)    
Kidm12 Kidney mass QTL 12 kidney mass   (VT:0002707)    
Kidm13 Kidney mass QTL 13 kidney mass   (VT:0002707)    
Kidm14 Kidney mass QTL 14 kidney mass   (VT:0002707)    
Kidm15 Kidney mass QTL 15 kidney mass   (VT:0002707)    
Kidm16 Kidney mass QTL 16 kidney mass   (VT:0002707)    
Kidm17 Kidney mass QTL 17 kidney mass   (VT:0002707)    
Kidm18 Kidney mass QTL 18 kidney mass   (VT:0002707)    
Kidm19 Kidney mass QTL 19 kidney mass   (VT:0002707)    
Kidm20 Kidney mass QTL 20 kidney mass   (VT:0002707)    
Kidm21 Kidney mass QTL 21 kidney mass   (VT:0002707)    
Lmblg1 Limb length QTL 1 tibia length   (VT:0004357)    
Lmblg2 Limb length QTL 2 tibia length   (VT:0004357)    
Rf46 Renal function QTL 46 blood creatinine amount   (VT:0005328)    
Rf47 Renal function QTL 47 kidney renin amount   (VT:0010559)    
Rf48 Renal function QTL 48 blood creatinine amount   (VT:0005328)    
Rf49 Renal function QTL 49 blood creatinine amount   (VT:0005328)    
Rf50 Renal function QTL 50 urine output   (VT:0003620)    
Scl30 Serum cholesterol level QTL 30 blood cholesterol amount   (VT:0000180)    
Scl31 Serum cholesterol level QTL 31 blood cholesterol amount   (VT:0000180)    
Scl32 Serum cholesterol level QTL 32 blood HDL cholesterol amount   (VT:0000184)    
Scl68 Serum cholesterol level QTL 68 blood VLDL cholesterol amount   (VT:0005144)    
Scort1 Serum corticosterone level QTL 1 blood corticosterone amount   (VT:0005345)    
Spl4 Serum phospholipid level QTL 4 blood phospholipid amount   (VT:0006084)    
Spl5 Serum phospholipid level QTL 5 blood LDL phospholipid amount   (VT:0010505)    
Spl7 Serum phospholipid level QTL 7 blood phospholipid amount   (VT:0006084)    
Spl8 Serum phospholipid level QTL 8 blood VLDL phospholipid amount   (VT:0010507)    
Srn6 Serum renin concentration QTL 6 blood renin amount   (VT:0003349)    
Stl13 Serum triglyceride level QTL 13 blood triglyceride amount   (VT:0002644)    

Additional Information