RGD Reference Report - A neuropeptide Y locus on chromosome 4 cosegregates with blood pressure in the spontaneously hypertensive rat. - Rat Genome Database

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A neuropeptide Y locus on chromosome 4 cosegregates with blood pressure in the spontaneously hypertensive rat.

Authors: Katsuya, T  Higaki, J  Zhao, Y  Miki, T  Mikami, H  Serikawa, T  Ogihara, T 
Citation: Katsuya T, etal., Biochem Biophys Res Commun 1993 Apr 15;192(1):261-7.
RGD ID: 631181
Pubmed: PMID:8476428   (View Abstract at PubMed)
DOI: DOI:10.1006/bbrc.1993.1408   (Journal Full-text)

Recent advances in molecular biology have allowed the study of the candidate genes for essential hypertension. To identify the genes responsible for basal blood pressure in the spontaneously hypertensive rat strain, the rat model of genetic hypertension, we performed a cosegregation analysis between the genotype and blood pressure in a set of male F2 progeny obtained from SHR and Wistar-Kyoto rats, a reference normotensive strain. Our investigation revealed that a locus on the chromosome 4 cosegregates with the blood pressure in SHR, especially at neuropeptide Y locus. The degree of cosegregation with all values of blood pressure without sodium loading was moderate but consistent. We propose that neuropeptide Y locus on chromosome 4 is a new candidate for the hypertensive effect in original SHR.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Bp135Rathypertension  IDA  RGD 
SHR/SnkRathypertension MODEL: spontaneousIAGP compared to WKY/Snk control strainRGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Bp135Ratincreased systemic arterial blood pressure  QTM  RGD 
SHR/SnkRatincreased systemic arterial blood pressure  IAGP  RGD 
Objects Annotated

QTLs
Bp135  (Blood pressure QTL 135)

Strains
SHR/Snk  (NA)
WKY/Snk  (NA)


Additional Information